This video on Glycolysis has helped me to understand the glycolytic pathway better, clear, complete and correct explanation. Thank you AK letctures, keep up the good work.
Thank you for your detailed explanations of the Glucose Metabolism. But I'm not sure if the structure of 1,3-BPG in the second reaction (without the enzyme GAP dehydrogenase) is correct..
Hey!! This is amazing!! You are the reason i did well in biochem!! But 12:30, when you changed it back to ADP, shouldn't it be ATP because it says " Phosphoryl transfer by 1,3 BPG to ATP" seeing as ATP is the product formed and its the one which gets phosphoryl transfered?
Just a few suggestions.... U know in the 2nd energy profile diagram the free energy of the thio ester will be less than that of the free energy of the reactant ... Then only it will be exergonic.. in ur diagram it seems that they are of equal free energy
his lectures are great.. even better than great.. but can we take a moment to see what an amazing body this guy has? one second i'm listening t o him the moment he turns his back on the camera and I lose focus xp
eragon2121 I’m very late, but that hydrogen came from the base (histidine) that stole it from Glyceraldehyde3P in the first place. The purpose of the last reaction you speak of was to restore the catalyst to its native state.
converts glucose to pyruvate, which can then be used in Citric Acid Cycle to create more NADH molecules to be used in the Oxidative phosphorylation process
Not that it actually matters anymore but these replies are wrong. 2 ATPs are put in and 4 ATP are produced. Net gain of 2 ATP (-2+4=2). 2 NADH are formed, but since the NADH is produced in the cytosol, the electrons on the cytoplasmic NADH is used to reduce FAD in the mitochondria, which in turn only produces 1.5 ATP per FADH2. So, the two NADH produced by glycolysis will produce 2 FADH2, which will produce 1.5 ATP each for 3 total ATP molecules. So, the two cytoplasmic NADH will only produce 3 ATP molecules combined.
15 minutes of complex biochemistry broken down to intricate details and the video concludes with "because 2 minus 2 gives us zero."
Best teacher in the world seriously this guy is amazing thank you so much for your hardwork
The best biochemistry professor. Thank you so much for such great explanations
This video on Glycolysis has helped me to understand the glycolytic pathway better, clear, complete and correct explanation. Thank you AK letctures, keep up the good work.
You should put Ads on your videos; i will watch it to support.
Nobel Prize Should Be Given To This Great Man.
use the donate button
Damn !!! Thanks to God for creating this man !! What a wonderful teacher , really some people are underrated ! Very much respect for him, our savior .
AK LECTURE GOD BLESS YOUR SOUL!!!!!
Still the best , lecturer of all time .. I learn something new everytime I revisit this video
This really helped me understand GAP dehydrogenase for my presentation. Thank you!
fantastic, i was so confused as to where the H+ came from and now I understand it comes from the Pi group! cheers!
After watching this I ask myself for what reason am I still visiting my university’s biochemistry department
There is a special place in hell for the 4 people who disliked this video
Emrah Trumic lmao. You can never please some people.
Truly ,thanks to ak lectures biochemistry becomes easy ,few people can never be pleased
9 now
This is helping me with my biomedicalnscience
ya ak lectures your gret
You are saving my live!!!!
dude you are amazing. thank you so much
Thank you for your detailed explanations of the Glucose Metabolism. But I'm not sure if the structure of 1,3-BPG in the second reaction (without the enzyme GAP dehydrogenase) is correct..
Yeah , i think it misses a Hydrogen in the second C . Right?
You are an incredible teacher 👌
Here's to us that can only understand things when they're explained in explicit detail like this !! :D
You are the King!!!
Thank you so much❤
Thanks for the clear video! So... No H2O is needed in the catalyzed reaction???
Thank you very much ♥️😍God bless you 💁🏻♂️♥️
Hey!! This is amazing!! You are the reason i did well in biochem!! But 12:30, when you changed it back to ADP, shouldn't it be ATP because it says " Phosphoryl transfer by 1,3 BPG to ATP" seeing as ATP is the product formed and its the one which gets phosphoryl transfered?
It's correct. Transfer of phosphate to ADP only, will form ATP.
No he has it right.
AHAHAHAHAHAHA
Thank god for you
The lecture is great. Kindly help me get the video of steps 8 to 10
The step 6 can not be called as oxidative phosphorylation right?
theam boe, good lesson I olmost cry...
Just a few suggestions.... U know in the 2nd energy profile diagram the free energy of the thio ester will be less than that of the free energy of the reactant ... Then only it will be exergonic.. in ur diagram it seems that they are of equal free energy
Very good sir
his lectures are great.. even better than great.. but can we take a moment to see what an amazing body this guy has? one second i'm listening t o him the moment he turns his back on the camera and I lose focus xp
This comment was totally unnecessary
Thank you so much for your efferot ❤️🥺
Thanks for the video. Quick question, what happens to the H+ in the last reaction?
I think it goes to form the Pi ;)
eragon2121 I’m very late, but that hydrogen came from the base (histidine) that stole it from Glyceraldehyde3P in the first place. The purpose of the last reaction you speak of was to restore the catalyst to its native state.
@@trevorjefferson4840 So, the H+ attached to the His-176 should be given away in the last step?
I think the H+ atom comes from the orthophosphate group!
great video!
is there a difference between a compound with a phosphate suffix and a compound with a -phospho- middle?
can i know why the phosphate group has an O atom attached together with it?
Very helpful,thank you!
I just wondering where to got Pi from?
The NAD+ destablises the thioester, due to the positive charge, due to the lone electron pairs on the oxygen?
altbeb yh i noticed that too
Thanks a lot!
Where did the ADP come from? I thought ATP was more present in the cell
Only in glycolysis we utilize 2 ATP and there are many processes in body in with we use ATP .
Thankyou
We put in 2 ATP and got 2. What's the benefit of the process than?
converts glucose to pyruvate, which can then be used in Citric Acid Cycle to create more NADH molecules to be used in the Oxidative phosphorylation process
We form 2 NADH as well 1 NADH give 3 ATP
And in last step when phospho enol pyurate convert into pyurate we form 2 more ATP. I am late but hope it will help u.
Not that it actually matters anymore but these replies are wrong. 2 ATPs are put in and 4 ATP are produced. Net gain of 2 ATP (-2+4=2). 2 NADH are formed, but since the NADH is produced in the cytosol, the electrons on the cytoplasmic NADH is used to reduce FAD in the mitochondria, which in turn only produces 1.5 ATP per FADH2. So, the two NADH produced by glycolysis will produce 2 FADH2, which will produce 1.5 ATP each for 3 total ATP molecules. So, the two cytoplasmic NADH will only produce 3 ATP molecules combined.
what is the long line under each step in the mechanism? If anyone could respond that would be great.
thats the enzyme's active site
The peptide backbone
awsome
thanx
Thanx❤❤😍
merci bien
fucking bless you
pls donate.
sulfhydryl :)
Awesome video!
4:00 Close! but it's a Sulfhydryl or Thiol group (-SH). No biggie, but it confused me for a second.
awsome