Chargaff's rule explained

Chargaff's rules state that DNA from any cell of all organisms should have a 1:1 ratio of pyrimidine and purine bases and, more specifically, that the amount of guanine should be equal to cytosine and the amount of adenine should be equal to thymine. This pattern is found in both strands of the DNA.

[@1farhinmomtazriana25]

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[@GeneticsLessons]

Glad to help

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[@GeneticsLessons]

You're welcome! Thanks for watching.

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[@jsnlgrrtt]

Thank you for the clear explanation.

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[@annepupraveen8172]

@Nikolay's Genetics Lessons , hi sir how did you write the base on starting of the session you didn't explain in any of your videos . you could write and directly go to counting of base pairs pls explain AGCCTTAGA 😭😭😭😭 I dint understand

[@GeneticsLessons]

I just took random sequence.

[@annepupraveen8172]

@@GeneticsLessons first of all ver thank you to reply my question 🙏🙏
why don't you take 10 are 15 A and C bases and the two strand are comes same number

[@GeneticsLessons]

It is just random and is not important.

[@i_almana8658]

Thanks man

[@GeneticsLessons]

You're welcome!

[@snigdhabanerjee5395]

If the value of A+G/C+T is less than 1 or higher than 1 it will be single stranded??

[@GeneticsLessons]

Yes.

[@ramona283]

What if A+T/C+G is equal to 1? How can I say if its double stranded or single stranded?

[@GeneticsLessons]

There is no way to say if it is double stranded or single stranded based on this information. The ratio can be any and it is not going to help to answer this question.

[@ramona283]

@@GeneticsLessons thank you for tha info! But I wonder, can this ratio (A+T or U/C+G is equal to 1) help me determine whether its a DNA or an RNA?

[@GeneticsLessons]

@@ramona283 No. Just imagine 10 base pair long double stranded DNA with 9 C and 1 A on one strand than on the other we will have 9 G and one T so 18/2 and this is Double stranded DNA - we can change these ratio and it is still going to be double stranded DNA. The different story if we take ratio of AG/TC it is going to be 1+9/1+9 =1 so AT/TC or TC/AT in dsDNA is always 1 and if not it is single stranded DNA.

[@kalpanamurmu91]

Thanks you so much .

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[@GeneticsLessons]

More to come!

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thnX

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