How to do alkali forced degradation Sample with alkali solution added and kept in oven for degradation time or diluent also added and kept in oven for degradation study. Can you explain sir
Can u please tell me the Different types of RS method,in which case to we go for the diluted standard method,and area normalisation method,and impurity vs impurity method..
You will not be able to justify co-eluting peak with principal compound. You need to revise method to separate out co-eluting peak from principal peak.
"You did a great job! sir what a informative presentation."
Sir kindly make video on CAD detector method development in hplc.
This is wonderful ❤
How to overcome these mass balance issues??.. Plz explain
Fantastic explanation 👏 Sir
Please tell us about the different techniques to check peak purity other than purity angle and threshold or with mass spectroscopic method.
Nice video sir, very clear voice and clarity, one day you will cross 1M subscribers.
Sir, you gave clear all probable reasons to get variation in mass balance.
Can please explain about analytical qbd
For Api assay method ,force degradation study will be conduct🧐🧐🧐
Sir please what is your reference? I have looked on ICH Q1E and I don’t find it
For analytical calculation which guidelines chapter have to see. Can you refer
Really very informative tnx
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How to do alkali forced degradation
Sample with alkali solution added and kept in oven for degradation time or diluent also added and kept in oven for degradation study. Can you explain sir
0:34
Can u please tell me the Different types of RS method,in which case to we go for the diluted standard method,and area normalisation method,and impurity vs impurity method..
Sir if degradation impurity have no chromphorcity then what to do for identification.
Sir can u tell me about metal degradation,like with cupper and iron
In case of higher mass balance where aduct is formed with main ingredient, what do we expect about peak purity, is it passing or failing?
If aduct yields single peak and if there are no co-eluting peaks- you should not have any issues with peak purity
Degradent peak RRF value consider as 1
Sir in case of degradation impurity is co eluting with main peak then peak purity is fail.then how to it justfied
You will not be able to justify co-eluting peak with principal compound. You need to revise method to separate out co-eluting peak from principal peak.
Plz tell RRF calculation