If you’re sick put on a mask even if you test negative. A nurse at our clinic was hacking and coughing in several patients’ faces one morning. It didn’t even occur to her to mask up until I made her do it and sent her for a test. It was negative but I insisted she continue to mask. On Wednesday she was actually feeling sick enough to leave work and went to urgent care. Sure enough, tested positive. We should normalize wearing a mask when you’re sick, regardless of what you may have. I don’t want your run of the mill rhinovirus and I sure don’t want my immune compromised patients getting it either.
I would already be happy if people stop making such a big deal out of my mask. I can wear an FFP3 mask, no big deal. It is just that everyone is so aggressive towards your mask.
@@froukehermens2176 it's the fear of what the mask represents to them. They don't want to know the truth of what COVID will do long term. It's actually crazy since it's not going away. We never reached herd immunity and won't bc of repeat infections and spread of new variants. It's damaging our bodies the more infections we have.
I agree with you. I still wear a mask on airplanes, public bathrooms etc. Everywhere else, I use the Air Tamer air purifier around my neck. I’m the only one in a million mile radius that is using PPE though.
I was infused with Pemgarda last Friday. Husband who accompanied me to private room infusion center with Flomask and Hepa and far UV C and all staff in N95 he still tested positive Monday. All week I've been extra tired and very slight sore throat, I thought I was safe but this evening I developed a bad headache so tested again which this time was +. I've two others in a Facebook pemgarda group who have tested + as well, one of which hospitalized. Setting up a telehealth appointment for Paxlovid and refills on my asthma nebulizing medication and MCAS antihistamines I'm nearly out of. Thanks Dr. Griffin, and happy belated birthday wishes.
Churchill quote: I'm reading Jen Psaki's book and she emphasises that listening is a most important part of communicating. And I recall Daniel saying that listening carefully was an essential part of being a clinician, especially related to Long Covid patients!
Remember there are a lot of weddings and family reunions that were postponed until this summer. People have given up trying to be careful in festive settings. My husband and I, plus several family members, just tested positive after our daughter’s wedding in New York. Thanks to this great show, we knew we were at risk and got onto Paxlovid. Had to go to several pharmacies to find it in stock in the Minneapolis area, though.
I used to live in Austin and I got a text today about free Mpox vaccine being offered there. I've not heard any other media mentions yet and no longer live in the One Star state.
I use the YMCA gym and have become concerned about their sanitation procedures for the equipment. When I joined we had lots of spray bottles containing what I hope is antimicrobials and clean microfiber towels. They got e-equipment and told us to use only the microfiber towel to "clean" the equipment after use. No spray. This I think is a waste of time. Then they restricted the number of spray bottles, and most recently the squirts need to be limited to 2 or 3 on a towel to wipe the equipment. From the reading I have been doing, I think the management is remiss in using safe sanitation procedures to protect patrons. The gym is a hotspot for infectious disease, or am I imagining this? Can you give a little talk on this one day and also recommend resources to for safe microbe management at the gym?
If you are mainly concerned about SARS-CoV-2, that seems to mainly spread through the air, so ventilation of the room and potential mask wearing would be very important. If you are concerned about surfaces, use hand sanitizer before and after each piece of equipment, or bring your own container of sanitizing wipes to use as needed. Just be aware some disinfectants are not compatible with certain surfaces, with repeated use leading to damage of the surface, so you might want to ask about which product you can use.
@@redhen689 Thank you for your response. I am more concerned about surface contact and I thought SOP was to wipe before and after equipment use. I feel most vulnerable to catching something from surface contact so I wear protective clothing. Will be speaking to management today about beefing up their sanitation procedures. I think they should be providing the antimicrobial wipes as they are the one that know what is safe and effective for the surfaces.
Wait, Wait just a minute. At 38:12 there is a question that implies that 3 doses of Novavax spaced 2 months apart equals sterilizing immunity. What? If this is the case, this is huge! Why has this not been talked about? Dr. Griffin replies that having these 3 doses is a "reasonable course of action". What am I missing here? If I can get what amounts to "sterilizing immunity" from Novavax, bring it on! Can anyone please either confirm this is the case or burst my bubble here? I feel like I'm missing something. A link to the Lancet article that the questioner refers to would be great.
It sounded to me like the initial advice in 2021, where people had a prime vaccine, then a secondary, followed by a booster in the fall. However in a previous TWiV I believe there was more evidence for the new non mRNA, Novavax Covid vaccine providing longer duration of protection. I hope I said that right, if not, someone who has more knowledge in this area, please correct me. SARS-Covid-2 is an RNA virus and I’m not sure it is possible to have sterilizing immunity, as is possible with a DNA virus. Is this correct?
It was done in non-human primates, "Three immunizations with Novavax’s protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2" published in NPJ Vaccines on 20 January 2024. There are discussions of the results of this article online. Honestly, jumping from this to a physician prescribing the 3-dose series for a whole family seems like quite a leap (assuming those patients have had previous vaccinations with other covid vaccines completed). The FDA guidance cited is for immunocompromised individuals only. Agree that Vincent's and Daniel's reading and answer to this question makes it sound like a much bigger deal than it seems to currently have basis for, I wish they would have caught this and added their usual disclaimers.
@@Killabit Could you share the name of the article and date published? Your link probably got deleted as a link. I had troubles finding The Lancet article that they are mentioning. Thank you.
@@nordveien Oh sorry about that. I've never pasted links on YT before. I do see they are gone. And certainly! If you search the study name in Google, the Feb 2022 Lancet article should be the first result. The name of the study:
I just had Covid at the end of May. I just caught it again and became ill July 17. In bed still. How can I become reinfected so quickly? Is it a different variant? What can we do after infection to prevent catching it again (beyond masking). Is my immune system low due to the first infection? What can be done to build it up? Thanks!!!
@@robinirons541 I think I would have. My sx are different than a cold. That, and plus the fact that I work with patients, and there was an outbreak. I got it from them.
Wish you two would go into greater depth on how proteins from MRNA vaccines get locked into pre fusion state. Dr Offitt talks about it in his latest book but doesn't go into much depth.
The vaccine spike is locked into the prefusion state by the addition of two prolines. The spike has two subunits S1 and S2. Normally the spike is cleaved at the junction of the S1/S2 subunits, by TMPRSS2. This would allow the spike S2 to bind with the ACE2 receptor on the host cell. The spike is a trimar and has 3 S1 elements which can be in the up position permitting binding or down preventing binding. All 3 three must be in the up state to allow cleaving and binding with the host cell. Essentially the vaccine induced spike cannot bind with the host cell ACE2 receptor. Also it is not cleaved by TMPRSS2, hence does not result in free S1 as occurs with the virus S1.
Regarding the reduced mutagenicity, could the protease inhibitor have a heretofore unknown target? Some other enzyme? Or is there a relevant feedback loop?
Was anyone able to find the link to the study mentioned in one of the questions, supposedly published in the Lancet, regarding the effectiveness of getting 3 doses of Novavax spaced 2 months apart?
"Three immunizations with Novavax’s protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2", NPJ Vaccines Published: 20 January 2024.
Maybe use of air cooler conditioning decrease to much temperature at mucosal respiratory level. And If SARS COV2 infect better If tissue temperature are low ,maybe must wear surgical mask to maintain higher mucoseal respiratory temperature ?
A lot of people can't even get it at all after we were told it was available to everyone. The price hike is ridiculous and helps no one. How can this be happening during a pandemic this is one of the tools we have to try and survive it.
I was fortunate enough to get Paxlovid by Day 2 of testing positive and had a relatively mild course of disease. However, I was glad when I finished the prescription because the taste in my mouth was awful. Other than that, everthing went well.
Dr. Osterholm at CIDRAP says Covid surges are *always* driven by variants, and surges are definitely *not* seasonal. He says this is obvious because the surges hit globally simultaneously, even though the seasons are reversed in northern and southern hemispheres.
Regarding the blood donations: I would be more worried about blood from Covid positive individuals or blood from individuals with long Covid. Two studies showed that auto-antibodies from people with long Covid affected mice. However, it will be difficult to find blood from individuals who have never been infected with Covid.
The people who got dysgeuzia in the placebo group: did they get covid? I lost smell but not taste when with covid, but everything tasted so wrong or horrible.
I have a question how many infections can you have and take paxlovid every time infected what are the side effects from taking it? If we do not have the data we shouldnt be pushing it
Both the medicines in Paxlovid are well tested and of long term use. Some people take at least one of them for most of their lives. I wouldn't be too concerned about repeat 5 day uses of either of these drugs.
for you statisticians you should know in regards to v.a. patient demographics is thus - when jimmy carter president he and the v.a. and others consider your militery service "peacetime" from say 75 thru 1981 vets do not get for example a state pension in massachusetts if they were in during peace time all other times after reagan and grenada invasion heh heh considered wartime vets so theres gap in vets those years who served going to v.a. because they are cut out or back within system basically discriminates against them for serving and keeping the peace as illogical and mean this is
hey you guys way too smart for me but i listen anyways as it feels as if while I listen I feel the emotions sort of just letting you guys know it sure seems like alot of covid back around I am janitor at a v.a. dementia unit at nacht in northeast area of massachusetts day shift 9 people at the three dementia units and one guy , me, handles 330 till 1130 anyway I got covid pretty bad this time day after I saw the nurses testing all the patients and why I am posting is because whatever this variety is seems worse such as high fever lung congestion and for me a week long so far pink eye hasnt gone away pink eye came on after I tested negative for virus (covid) so .... since the v.a. tested a mrna flu vaccine on us vets at said v.a. hospital, we had to sign something how was I to know I just trusted the/technology ?....how can either pay for or get v.a. to pay or get pcr testing and testing to inform me which variety I got so I can keep track of all this its way too much to handle now adays with incompetency everywhere due to sppoiled gov workers banner held high by monopolized unionized spoiled teachers what a way to teach kids work ethics should be one or first so ya I want to get rid of this eye thing so thanks if you know answers 1, where or how can i get more involved via testing , with what exactly i am infected with Ive had 5 covid shots now last one a year ago or so so I myself want to maybe even have to pay so i can follow my infections and what types i got at what times what other specific ones also present ..... also does us vets voluntarily getting mrna type flu shot in 2019 before covid struck fyi does anybody in you guys worlds appreciate our um donation to science or some company? we should get good drugs from whatever company did this at my age 5 mg a day or so for everybody of morphine should be in your vitamins at my age this only makes sense why people wanna kill other people my other viral experiences was measles as a kid sick as hell, russian flu uss america palma spain winter of ?78 sick as hell half ship all had it i didnt get out of my rack for 3 days
If you’re sick put on a mask even if you test negative. A nurse at our clinic was hacking and coughing in several patients’ faces one morning. It didn’t even occur to her to mask up until I made her do it and sent her for a test. It was negative but I insisted she continue to mask. On Wednesday she was actually feeling sick enough to leave work and went to urgent care. Sure enough, tested positive.
We should normalize wearing a mask when you’re sick, regardless of what you may have. I don’t want your run of the mill rhinovirus and I sure don’t want my immune compromised patients getting it either.
100% agree!
I would already be happy if people stop making such a big deal out of my mask. I can wear an FFP3 mask, no big deal. It is just that everyone is so aggressive towards your mask.
@@froukehermens2176 it's the fear of what the mask represents to them. They don't want to know the truth of what COVID will do long term. It's actually crazy since it's not going away. We never reached herd immunity and won't bc of repeat infections and spread of new variants. It's damaging our bodies the more infections we have.
@@froukehermens2176 I just always think, “What business is it of anyone’s if anybody is wearing a mask?” Why would they care?
I agree with you. I still wear a mask on airplanes, public bathrooms etc. Everywhere else, I use the Air Tamer air purifier around my neck.
I’m the only one in a million mile radius that is using PPE though.
I was infused with Pemgarda last Friday. Husband who accompanied me to private room infusion center with Flomask and Hepa and far UV C and all staff in N95 he still tested positive Monday. All week I've been extra tired and very slight sore throat, I thought I was safe but this evening I developed a bad headache so tested again which this time was +. I've two others in a Facebook pemgarda group who have tested + as well, one of which hospitalized. Setting up a telehealth appointment for Paxlovid and refills on my asthma nebulizing medication and MCAS antihistamines I'm nearly out of. Thanks Dr. Griffin, and happy belated birthday wishes.
Churchill quote: I'm reading Jen Psaki's book and she emphasises that listening is a most important part of communicating. And I recall Daniel saying that listening carefully was an essential part of being a clinician, especially related to Long Covid patients!
Remember there are a lot of weddings and family reunions that were postponed until this summer. People have given up trying to be careful in festive settings. My husband and I, plus several family members, just tested positive after our daughter’s wedding in New York. Thanks to this great show, we knew we were at risk and got onto Paxlovid. Had to go to several pharmacies to find it in stock in the Minneapolis area, though.
Thank you as always
Too many people want to ignore that the forever bug is not going away and has after effects for a long time.
I’m the only one who masks at my church. I’m a Novid so far.
I used to live in Austin and I got a text today about free Mpox vaccine being offered there. I've not heard any other media mentions yet and no longer live in the One Star state.
RIP Dr Mcdougal - pioneer of the Starch diet
UNDERRATED channel 🎉
Happy belated birthday Dr. Griffin
I use the YMCA gym and have become concerned about their sanitation procedures for the equipment. When I joined we had lots of spray bottles containing what I hope is antimicrobials and clean microfiber towels. They got e-equipment and told us to use only the microfiber towel to "clean" the equipment after use. No spray. This I think is a waste of time. Then they restricted the number of spray bottles, and most recently the squirts need to be limited to 2 or 3 on a towel to wipe the equipment. From the reading I have been doing, I think the management is remiss in using safe sanitation procedures to protect patrons. The gym is a hotspot for infectious disease, or am I imagining this? Can you give a little talk on this one day and also recommend resources to for safe microbe management at the gym?
If you are mainly concerned about SARS-CoV-2, that seems to mainly spread through the air, so ventilation of the room and potential mask wearing would be very important. If you are concerned about surfaces, use hand sanitizer before and after each piece of equipment, or bring your own container of sanitizing wipes to use as needed. Just be aware some disinfectants are not compatible with certain surfaces, with repeated use leading to damage of the surface, so you might want to ask about which product you can use.
@@redhen689 Thank you for your response. I am more concerned about surface contact and I thought SOP was to wipe before and after equipment use. I feel most vulnerable to catching something from surface contact so I wear protective clothing. Will be speaking to management today about beefing up their sanitation procedures. I think they should be providing the antimicrobial wipes as they are the one that know what is safe and effective for the surfaces.
Wait, Wait just a minute. At 38:12 there is a question that implies that 3 doses of Novavax spaced 2 months apart equals sterilizing immunity. What? If this is the case, this is huge! Why has this not been talked about? Dr. Griffin replies that having these 3 doses is a "reasonable course of action". What am I missing here? If I can get what amounts to "sterilizing immunity" from Novavax, bring it on! Can anyone please either confirm this is the case or burst my bubble here? I feel like I'm missing something. A link to the Lancet article that the questioner refers to would be great.
It sounded to me like the initial advice in 2021, where people had a prime vaccine, then a secondary, followed by a booster in the fall. However in a previous TWiV I believe there was more evidence for the new non mRNA, Novavax Covid vaccine providing longer duration of protection. I hope I said that right, if not, someone who has more knowledge in this area, please correct me. SARS-Covid-2 is an RNA virus and I’m not sure it is possible to have sterilizing immunity, as is possible with a DNA virus. Is this correct?
It was done in non-human primates, "Three immunizations with Novavax’s protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2" published in NPJ Vaccines on 20 January 2024. There are discussions of the results of this article online. Honestly, jumping from this to a physician prescribing the 3-dose series for a whole family seems like quite a leap (assuming those patients have had previous vaccinations with other covid vaccines completed). The FDA guidance cited is for immunocompromised individuals only. Agree that Vincent's and Daniel's reading and answer to this question makes it sound like a much bigger deal than it seems to currently have basis for, I wish they would have caught this and added their usual disclaimers.
In this case the study was conducted in humans. I pasted it above.
@@Killabit Could you share the name of the article and date published? Your link probably got deleted as a link. I had troubles finding The Lancet article that they are mentioning. Thank you.
@@nordveien Oh sorry about that. I've never pasted links on YT before. I do see they are gone. And certainly! If you search the study name in Google, the Feb 2022 Lancet article should be the first result. The name of the study:
I just had Covid at the end of May. I just caught it again and became ill July 17. In bed still. How can I become reinfected so quickly? Is it a different variant? What can we do after infection to prevent catching it again (beyond masking). Is my immune system low due to the first infection? What can be done to build it up? Thanks!!!
I am right there with you nanette. I had it for the 2nd time, less than 5 months after the first time.
If you didn’t test in the first place,would you have even known it was covid and not a summer cold?
@@robinirons541 I think I would have. My sx are different than a cold. That, and plus the fact that I work with patients, and there was an outbreak. I got it from them.
I’m guessing you got 2 different strains.
Maybe you got the Omicron variant in May and the Flirt variant in July ?
That's a great quote!
Wish you two would go into greater depth on how proteins from MRNA vaccines get locked into pre fusion state. Dr Offitt talks about it in his latest book but doesn't go into much depth.
The vaccine spike is locked into the prefusion state by the addition of two prolines. The spike has two subunits S1 and S2. Normally the spike is cleaved at the junction of the S1/S2 subunits, by TMPRSS2. This would allow the spike S2 to bind with the ACE2 receptor on the host cell. The spike is a trimar and has 3 S1 elements which can be in the up position permitting binding or down preventing binding. All 3 three must be in the up state to allow cleaving and binding with the host cell.
Essentially the vaccine induced spike cannot bind with the host cell ACE2 receptor. Also it is not cleaved by TMPRSS2, hence does not result in free S1 as occurs with the virus S1.
@@christopherrobinson7541Thamk you for this detailed explanation!
Regarding the reduced mutagenicity, could the protease inhibitor have a heretofore unknown target? Some other enzyme? Or is there a relevant feedback loop?
That's great. Thank you very much
Interested in Novavax vaccine. Some think it's longer lasting.
I had Novavax in October and tested positive on June 30.
@@redhen689is your Covid infection on June 30,2024 less severe ? Is it mild with no pounding headaches/fever/hacking cough and insane runny nose ?
Was anyone able to find the link to the study mentioned in one of the questions, supposedly published in the Lancet, regarding the effectiveness of getting 3 doses of Novavax spaced 2 months apart?
"Three immunizations with Novavax’s protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2", NPJ Vaccines Published: 20 January 2024.
@@Costa_Conn Thank you!
Some (bacterial?) fermentation can have thermogenetic effect.
Theoretically,even gut micrbioma can induce thermogenesis.
Yay Y. Pestis!
Maybe use of air cooler conditioning decrease to much temperature at mucosal respiratory level.
And If SARS COV2 infect better If tissue temperature are low ,maybe must wear surgical mask to maintain higher mucoseal respiratory temperature ?
Just ate a cucumber as I did my early garden wander. No wash. Probably introduced all sorts of creatures.
Most of which your digestive system denatured and made harmless. Ain't stomach acids great!
Doctors here only prescribe paxlovid after a week, if you take turn to the worse and end up in hospital, even to elderly
I was prescribed it on day 2 of symptoms, but it made my nausea and vomiting worse, and then I was told to stop it.
well that isn't helpful
@@redhen689 is it not just 2 pills??
A lot of people can't even get it at all after we were told it was available to everyone. The price hike is ridiculous and helps no one. How can this be happening during a pandemic this is one of the tools we have to try and survive it.
I was fortunate enough to get Paxlovid by Day 2 of testing positive and had a relatively mild course of disease. However, I was glad when I finished the prescription because the taste in my mouth was awful. Other than that, everthing went well.
Maybe after SARS COV2 at some patients cryoglobuline IgM antibody occur ?
Dr. Osterholm at CIDRAP says Covid surges are *always* driven by variants, and surges are definitely *not* seasonal.
He says this is obvious because the surges hit globally simultaneously, even though the seasons are reversed in northern and southern hemispheres.
The hot weather doesn’t help .
The 4 years old could also try an N95 mask when in nursery. The antibiotics might affect the microbiome.
Regarding the blood donations: I would be more worried about blood from Covid positive individuals or blood from individuals with long Covid. Two studies showed that auto-antibodies from people with long Covid affected mice. However, it will be difficult to find blood from individuals who have never been infected with Covid.
@@froukehermens2176 Was thinking the same thing when they were discussing this.
The people who got dysgeuzia in the placebo group: did they get covid? I lost smell but not taste when with covid, but everything tasted so wrong or horrible.
I had the impression the covid was a thing of the past , thanks for keeping an eye on world community...the enemy is invisible but active !
Imagine science catching on ... "I know I'm a dreamer, but I'm not the only one." -- John Lennon
When are new COVID vaccines going to be available?
❤❤
I have a question how many infections can you have and take paxlovid every time infected what are the side effects from taking it? If we do not have the data we shouldnt be pushing it
That would certainly be good to know. It certainly seems to justify taking measures to not get infected in the first place.
Both the medicines in Paxlovid are well tested and of long term use. Some people take at least one of them for most of their lives. I wouldn't be too concerned about repeat 5 day uses of either of these drugs.
Maybe increasing mutation can also increase risk of increase virulence of SARS COV2 ?
for you statisticians you should know in regards to v.a. patient demographics is thus - when jimmy carter president he and the v.a. and others consider your militery service "peacetime" from say 75 thru 1981 vets do not get for example a state pension in massachusetts if they were in during peace time all other times after reagan and grenada invasion heh heh considered wartime vets so theres gap in vets those years who served going to v.a. because they are cut out or back within system basically discriminates against them for serving and keeping the peace as illogical and mean this is
hey you guys way too smart for me but i listen anyways as it feels as if while I listen I feel the emotions sort of just letting you guys know it sure seems like alot of covid back around I am janitor at a v.a. dementia unit at nacht in northeast area of massachusetts day shift 9 people at the three dementia units and one guy , me, handles 330 till 1130 anyway I got covid pretty bad this time day after I saw the nurses testing all the patients and why I am posting is because whatever this variety is seems worse such as high fever lung congestion and for me a week long so far pink eye hasnt gone away pink eye came on after I tested negative for virus (covid) so .... since the v.a. tested a mrna flu vaccine on us vets at said v.a. hospital, we had to sign something how was I to know I just trusted the/technology ?....how can either pay for or get v.a. to pay or get pcr testing and testing to inform me which variety I got so I can keep track of all this its way too much to handle now adays with incompetency everywhere due to sppoiled gov workers banner held high by monopolized unionized spoiled teachers what a way to teach kids work ethics should be one or first so ya I want to get rid of this eye thing so thanks if you know answers 1, where or how can i get more involved via testing , with what exactly i am infected with Ive had 5 covid shots now last one a year ago or so so I myself want to maybe even have to pay so i can follow my infections and what types i got at what times what other specific ones also present ..... also does us vets voluntarily getting mrna type flu shot in 2019 before covid struck fyi does anybody in you guys worlds appreciate our um donation to science or some company? we should get good drugs from whatever company did this at my age 5 mg a day or so for everybody of morphine should be in your vitamins at my age this only makes sense why people wanna kill other people my other viral experiences was measles as a kid sick as hell, russian flu uss america palma spain winter of ?78 sick as hell half ship all had it i didnt get out of my rack for 3 days
Third
First again!
Lies,lies,lies
Whatever these people should be more serious and talk water Bronparasites born