+Radi Bear (Radioactive TeddyBear) You will not get me this time. I am no longer dependent on authority figures who recognize my talent at memorizing complex biochemical pathways!
+AvengerXP Neither is acetone if you have any idea of our metabolic cycles, nor hydrogen peroxide if you've ever taken a biology class... ever. Citric acid especially since it's the second (major) step in glycolysis (for most cells) and respiration, which high school biology should have taught you, i could go on here, but why bother lol.
+AvengerXP And the last one especially... if you don't know the extreme importance of it, and that we need at least a couple grams of creatine from our diet daily to function properly.... i don't even know. lol.
Yeah i suppose, I guess as someone with a bachelors in physiology (well and materials science) and a graduate student in biomedical engineering that learned about most of these in great detail the nuance has worn off and seem too obvious, i guess that's my bad. lol
I laughed SO HARD at the Kreb's Cycle comment. I had to study it for the millionth time in A&P a few weeks ago, now again in Biochem. I texted me friend saying, "I don't care how many times I learn the Kreb's cycle. I hate it every single time." Glad I'm not alone 😂😂😂
***** Nope, they are distinct flavours with seperate receptors and seperate purposes. Basically bitter tastes indicate poison or at least it did hundreds of thousands of years ago. That's why things with a strong bitter taste are awful unless you are used to them and bitter foods tend to always be an acquired taste. Sourness, on the other hand, detects acidity which is useful for telling if certain foods have gone offf etc. Sourness tastes sharp, tangy and well like the flavour you get from eating the flesh of citrus fruit. Bitterness tastes earthy, burnt, unpleasant and is accompanied by an an urge to spit out whatever you have in your mouth (at least until you get used to it in a paticular food or drink). Sourness tastes sharp, tangy and can be pleasant or unpleasant depending on the strength of the flavour and what accompanies it. Often sourness is used to complement sweetness in various desserts or, of course, naturally in most fruits.
Hey scishow team, i would love it if you could make an in depth video on muscle growth. Maybe you could talk about how it happens, how to maximize it, etc
+al whits They don't even have a clue man. Hard for people who have never done it to comprehend it... but it is by far the most amazing thing that is in existence... pure consciousness... hyperspace puts everything into perspective. Stay tripping my friend :)
+al whits there's not that much to tell about DMT, not because it's not interesting, it's uber interesting, it's because due to the &^*(*#&$(@ war on drugs, science is unable to experiment and understand these compounds. One of the very few experiments done by Rick Strassman, was written about in a book and a documentary called "DMT, the Spirit molecule". And that's about it... Thanks war on drugs, for stopping not the use of drugs, but only scientific inquiry.
I'm 40, my grandaddy during ww2 called it weed . My dad, Vietnam vet he called it grass, I'm generation x, I call it pot or just marijuana since it's legal here
what a great episode!! been binge watching this channel like crazy, and i think i've seen every video in the last 3 years almost by now. but this one stands out, even among the space ones as being particularly informative, love u sci show! keep it up!
+Coppertunes The fibres get transported there from both your underwear and your shirt, by your belly hair. Apparently, you have grey underwear, or a colour that blends with your shirt to turn grey.
+Coppertunes Not grey in my experience, though it's certainly preferentially dark. But my guess would be that the colour is rubbed off differently (ever got blue legs from your jeans?), or is deeper in the shirt (the lint comes from fibers rubbed off the surface, dyes are deeper). It's not like the dye changes the colour of the cotton - it just coats it. What you're seeing is the colour of "clean" cotton.
I don't consider what I do shivering I just shake it everywhere I can when I'm almost done throwing the piss everywhere I try to get to the ceiling but it's rare, it's good for your hair as well, it stings in your nose though. My dad used to pee on my feet because he always said it's good for my skin and that it made him feel better so if a stall is available I always pee down my leg into my socks so my skin gets better
So... If DMT is found in our body, could that possibly be responsible in part for our dreaming? And the less DMT found in us at a given time could dictate things such as the vividness of the dream, and how likely we are to actually believe that we had dreamt the previous night? Sorry if I just made people facepalm, just a curiosity.
I thought the same. I'm pretty sure at least one of the scientists who discovered that chemical also thought the same and... it wasn't what we thought right know... or maybe there is hope and they're trying to figure it out, who knows.
+Daniel Harrow Well, that is what it actually is for. Or, at least, as far as we know. www.erowid.org/chemicals/dmt/dmt_article2.shtml So far, we have at least partially documented the release of DMT in R.E.M sleep. It releases in small amounts that give us the non addictive trip we associate with dreams. Also, as a bonus fact, apparently it releases in massive quantities when we die, causing us to go on the wildest trip a human could go on. So die happy. It's kinda important. But, although it's been proven, we can't truly know until we die. There's been some theorizing around the whole death thing, saying that when it releases when we die, that's when our soul, our consciousness, whatever, is flung out. I kind of believe this, but being a teen and all, I'm really just experimenting with beliefs. Either way, I wrote an essay on it that could totally change the way you think about this stuff because I back what I say up with facts. It's cool, and if you wanted, it's right here. docs.google.com/document/d/1RUCDoJB0-GQJjInok-XZxlSdV0sDzr46LXZulmiDn50/edit?usp=sharing
+Silverizael In the video he mentioned that studies have shown that prolonged exposure to formaldehyde led to increased chances of getting cancer. Since he also said that small amounts are produced by the body, I was wondering if you could get the same prolonged exposure through the build up of formaldehyde in tissues. The reasoning being that cellular processes had broken down due to some unknown factor.
I once got acetone in my eye. I literally screamed when it happened and those eye showers that chemistry labs in schools have, those are really helpful.
There're a lot of cuts and edits. Each cut comprises of about 1-3 sentences. So even if they don't use a teleprompter, they'd only need to memorize a few sentences per cut. Lots of youtubers do that. It's people who can go on for 15-60 unedited minutes, for example TED-talk presenters, that are script-memorizing beasts.
Could you eat just super-compressed food for the rest of your life? ie: take a food and put a ton of pressure on it until it's in a cube/spherical shape. Also, would it make you feel full, or would you feel hungry the whole time? And would you gain lots of weight by eating it, or would most just 'pass right through you'?
+Seth Winfrey The reason people get the munchies is basically this. What most people don't know is that THC, the active ingredient the smokers are looking for, breaks down into a god awful mess of different compounds with different effects and different half lives when it actually gets to your liver (If you thought the Krebs cycle was bad, you don't want to memorize those, believe me...). And some of those act as appetite enhancers.
You should do an entire episode dedicated to DMT. I'm very curious why this powerful psychedelic is made by our body since there isn't a clear answer to it. Also want to know if it's harmful since it's an extremely illegal substance
+Pierce Connors DMT is a simple molecule very closely related to tryptamine and therefore tryptophan (one of the twenty-two key amino acids needed for your body to function in general). Tryptamine exists and is also mildly "psychoactive" and the dimethylated analogue would logically exist due to the methylating enzymes that your body produces to methylate specific compounds. Occasionally, stuff goes past it like DMT. It is illegalised by the US government when they blanketed all psychedelic compounds as it was closely related to insurrection and protests (and hippies) back in the 70s... what with the Vietnam war.
Pierce Connors it's similar in structure to serotonin and melatonin. but legal status =/= safety. you'd have to look more into history of drugs in America to understand war on drugs
I've had Diabetic Ketoacidosis quite a few times -it's landed me in ICU and HDU. It is the single most painful and horrible thing that has ever happened to me as a T1 Diabetic, and thankfully being put on an insulin pump has enabled me to stave off DKA and stay out of hospital. It hasn't stopped my friends and family from sniffing my breath and even my skin to make sure I don't smell like nail varnish remover, though, haha.
We actually know what DMT is for. It's used by your brain to take you out in times of intense shock. that is why many have weird experiences that sound like acid trips, while they can't really remember what happened. We also use very minute amounts for dreams. But the two moments in which most of us get a serious dose is when we are born and when we die. birth is very stressful, especially for the child, the brain gets squeezed and you go from warm and comfortable cozy, to cold, bright, noisy and intimidating. the other is when we die. if your brain can see death coming, it will put you to easy with some DMT, which is why so many have the sense of seeing their lives, or even living whole lives someplace else, while their mind slowly enters the void.
+Gamerguy8585 Not a weird question at all people ask it all the time. SciShow made a video on it before but I also recommend looking at Healthcare Triage's episodes on the subject.
Fat is an energy store. You get rid of one type of energy by converting it into a different type. A common choice from the resulting energy is kinetic energy.
Formaldehyde? No duh. Taking O-chem right now, it's actually a really common organic product or byproduct. O-chem... oh dear God, my O-chem final is wednesday morning isn't it?! And heck yeah Acetone is in my blood; that stuff smells amazing! I tried to avoid it in lab, but I don't exactly ensure I won't get a tiny whiff or two... ;) The only thing even better is hexanes, like for TLC development. *FUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu...*
+Micah Philson Ah, I finished my final Ochem course last quarter. Those were good times... maybe, haha. I'm glad now though, since I now actually more or less understand what all this stuff is. Good luck on your final. O7
OfNaught I really like O-chem, it's just really difficult. It would take me a few years of classes just to actually understand the notes from this year alone. I hate the college system. I'm only now understanding concepts in gen-chem I had over a year ago. They don't actually teach you things very well at all. Well, that and I'm taking 14 credit hours this semester, but with labs, reci's, etc, I'm actually taking 24 hours in classes. Lab took more time outside of class than any lecture!
+Micah Philson Mmmm nah. My brain is feeling explody enough from all the networking and technology stuff that has been crammed into it the past two years.
The way he said "Let's talk about DRUGS" just killed me XD And that ending tho... talking about how some people don't need the extra creatine supplementation and then said SciShow needs help, I was like "Wha, u need us to buy ya'll some creatine?" XDDD
I thought HCl is used not to digest , but to activate Pepsin, the most reactive enzymes in the digestive system. It is so efficient in breaking down proteins that it is produced in an inactivated state, and the HCl is used to activate it.
+Alama Joradon My guess is because it's mostly diluted at that point. The food and saliva dilute it enough to prevent it from doing any damage outside your body. That is not to say that it lost it's acidity though. If you ever had a painful burning feeling in your stomach, you know how dangerous it is when stomach acid leaved your stomach. It is not a nice feeling and the acidity is definitely noticeable.
+Alama Joradon Because it's too dilute. Did you even watch the video? He said that the pH of stomach acid is the same as battery acid and you don't see battery acid burning holes through everything.
idk how you guys crank out such awesome videos at this rate. Not gunna lie, Mental Floss is my 1st love and they brought me here (shout out John) but Sci show- very impressive. Addiction is eminent...
Yannik Mroos All my uncles are over 6' and went bald. All but my father who is 5'10 and full head of hair. I'm the tallest male in my family at 6'5'', and my hair is thinning already, and has been for few years. For some reason being tall and bald skipped my dad. Although, his father died in his 60s or 70s with a head full of hair still too, so.
Acetone does get used in the body, through detoxification in the liver it can be converted to precursors that can be pushed through gluconeogenesis... however this is slow so a lot of it is exhaled or peed out due to it being very volatile are easy to escape the body.
Fascinating - really tight job of putting this one together. Thanks again, guys. Are there any interviews/podcasts/behind the scenes that have Michael in them?
The thing is that, considering the amount of water in my body and the Ka of HCl, there realistically isn't any significant amount of HCl in my body -- there may be hydronium ions and chloride ions, but the hydronium could as easily be associated with another anion as with chloride.
"Dear people who complain about the 'chemicals' they're exposed to. EVERYTHING IS CHEMICALS! Water, your body, omega-3 fatty acids, raspberries. Chemicals." - Hank Green, 2013 This is the quote I always remember when I see the word "chemicals".
It is said that DMT is responsable for dreaming because we used as a drug it can create profound psychedelic experiences and create new connections in the brain. Resting and dreaming, with small natural amounts will help to place memories and reflect on them in different ways
I heard somewhere that the dmt your body makes is for times where important things happen suck as birth or death or near death experiences as you go through this odd state where everything seems weird which seems to be facilitated by dmt being released into the bloodstream but I’m not sure, does anyone else have any thoughts?
they say that when you go to sleep dimethyltryptamine is released to calm your body down just as you fall asleep.. This could also explain why we dream because its a side effect of the drug that our body used... Really its strange looking into ourselves and learning things... and even then there is still mysteries of how our body works.
I just learned about some allegations against Matthew Santoro, and instead of leaving a negative comment with him (which is already being done plenty), I'd rather leave a positive one with you guys for always properly stating your sources, and basing your stories on properly substantiated data. I've always appriciated the links to the experimental articles you use.
Hydrogen peroxide produced by the body also helps to keep your lungs clean, your colon regulated by filtering microbiota, and for the biosynthesis of thyroid hormones that require oxidation as an important step in synthesis
As a slight enthusiast of recreational drugs, I can confidently say that nothing (so far) comes close to DMT. I have never felt so jacked, tense, and tripped out as when my group of four friends smoked 0.1 grams each. The hallucinations were so vivid it felt like a dream that you remember perfectly. The trip lasted less than a half hour so it's not a major time commitment like LSD, LSA, or mushrooms that cause 4 to 12 hour trips.
At 4:28 the guy said citric acid is responsible for the bitter flavor in lemons but I think he means tart because bitter is a property of alkaline materials
Some Emergency Medical Technician second gueesed my knowlegde of Acetone in our breath causeing it to be fruity. Thank you SciShow for affirming this knowledge. Your the best. Make more videos on Cannbis world. Awesome research on the Endocannabinoids.!!!!!!!!! I will remeber this forever!!!!!! Best,
Endocannabinoids act as a kind of "cool down system" for your brain. It works in the opposite direction as conventional neurotransmission. These cannabinoids are just pieces of cellmembrane being synthesized in de post synaptic cell and sent to the pre synaptic cell binding to so called CB receptors. There it signals to the pre synaptic cell to stop releasing neurotransmitters. If this neurotransmitter is an inhibitory one, the post synaptic cell will of course get more active.
¨bacteria cell wall is negative repelling anything that is of the same charge, but hypochlorous acid is neutral so it can slip right through¨ that's what she said.
Maybe DMT is produced while we sleep as a byproduct of our brain (and the rest of nervous system) "cleaning" itself, removing the waste, hence found in cerebrospinal fluid. But since it's a powerful psychodelic, it stimulates some sense input processing centers in the brain, therefore dreams occur. Basically like naturally dropping acid while sleeping.
I heard of a chemical when glancing through a textbook about exercise and has to do with that it called the PC energy system. Now I hear how it works. Nice.
some people have hypothesized DMT is responsible for dreaming- basically our body gives us psychedelic experiences every night while we sleep! Pretty cool actually
The citric acid additive in a lot of foods isn't necessarily equal to the citric acid found in produce... it is usually made from mold and can contribute to anxiety and depression
Honestly, I'm surprised erythritol wasn't listed in this video. I find it stranger that the body makes a low-calorie sweetener than that it makes an acid to break down our food.
I used to take night classes and had to drive home late at night. On more occasions than I'd care to admit I would make the 25 minute drive and wake up in my driveway at home and barely remember how I got there. Irresponsible and scary... Yes. But also amazing. Is there any science behind how we can do that and what is happening in our brains during human autopilot?
As someone who has worked in Health and Safety, I'm a little sad that you used the old style of the corrosive hazard pictogram (square with orange background) instead of the new GHS one (white triangle)
We meet again Krebs Cycle. *draws sword*
Krebs Cycle: I'm not alone
(calvin cycle, electron transport chain, and light dependent photosynthesis walks out from behind)
+Radi Bear (Radioactive TeddyBear) Me to Krebs Cycle: Now that's just too far, even for you.
+Radi Bear (Radioactive TeddyBear) You will not get me this time. I am no longer dependent on authority figures who recognize my talent at memorizing complex biochemical pathways!
Nerds.
I'll get the canon ready
This dude's voice is like someone pouring honey on my brain
You've confused his hair with his voice.
+John Pinkerton Basically his whole person.
I like this guy but I like Hank more. I think he's rly funny.
but he's hot though..
***** Not...entirely sure I deserved that...
As soon as he mentioned Kreb Cycle, I died just a little...
+MrGiraffes Jr Well, as a Doctor, I don't know how help sick people, but I can draw them a Krebs-cycle.
+MrGiraffes Jr
honestly it reminds me of the complex crafting processes in a game like factorio.
+MrGiraffes Jr As a sophomore taking biology, I can confirm that that is exactly what the Kreb cycle does to you.
+Andrew Mayers Wtf is a Kreb cycle? Figured I'd ask the bio major lol.
+N Yodeler (NinjaYodeler) Its part of the process of turning glucose into co2 h2o and ATP.
Here comes the Acetoacetate!
CH COCH COOH!
Chugga chugga chugga chugga
Chugga chugga chugga chugga
*CH COCH COOH*
Oh my god this is glorious XD
lol thanks I needed a good laugh
Wha...?
Wow...
Hydrochloric acid is not surprising unless you have no idea how digestion works.
+AvengerXP Neither is acetone if you have any idea of our metabolic cycles, nor hydrogen peroxide if you've ever taken a biology class... ever. Citric acid especially since it's the second (major) step in glycolysis (for most cells) and respiration, which high school biology should have taught you, i could go on here, but why bother lol.
+AvengerXP And the last one especially... if you don't know the extreme importance of it, and that we need at least a couple grams of creatine from our diet daily to function properly.... i don't even know. lol.
It is kind of crazy to think about though. Having that strong of an acid running through your intestines.
Yeah i suppose, I guess as someone with a bachelors in physiology (well and materials science) and a graduate student in biomedical engineering that learned about most of these in great detail the nuance has worn off and seem too obvious, i guess that's my bad. lol
+N Yodeler (NinjaYodeler) It doesn't, the acid is neutralized when it goes into the intestine
I knew DMT would be on this
whoa
+J Kellan That's the reason why I clicked on this video with hope, as I've been told it wasn't proven yet.
+Brutal Whale by who? PshychedSubstance? Who really knows
illyounotme It is very intriguing
+J Kellan I knew about it from Joe Rogan
that was one of the weirdest ways you've said give us money at the end so far haha
+mythology2467 First creatine segway I've ever seen.
+DrEnzyme *segue
+Skeletor Jopko I done goofed.
why is my nipple hair longer than my chest hair?
+Mongis Lort Yo that legit sucks I feel you man... Ugh!
+Mongis Lort BUT HANK, WHY DO I HAVE AN ANUS AROUND MY BUTT HAIR
( ͡° ͜ʖ ͡°)
Are you amirs brother from from jake and amir
Perhaps because you have more nerves and blood flow around the areola region as opposed to your chest.
I am not joking that I had a 3 1/2 inch nipple hair one time. I was legitimately close to a world record at that time.
"As the kids are calling it, these days." Makes you realized that MIchaels is actually an adult, despite that blonde highlight.
+Grant D Is he, though?
Probably?
+Nick Nirus he's 30
+Grant D he's 30
Nick Nirus
he's 30
I laughed SO HARD at the Kreb's Cycle comment. I had to study it for the millionth time in A&P a few weeks ago, now again in Biochem. I texted me friend saying, "I don't care how many times I learn the Kreb's cycle. I hate it every single time." Glad I'm not alone 😂😂😂
what was harder? Krebs or Calvin?
Neither is necessarily difficult, they're just annoying to learn especially when you've done it 5 times already.
+Radi Bear (Radioactive TeddyBear) I was harder.
SKS pussies aren't hard
Sarah Chowske
Are you a medical student too? If you are then you would have realized by now that the kreb's cycle is the least of your worries. 😂💔
Wouldn't citric acid be sour, not bitter?
+Nate Conn Yes, yes it would.
it is they dun fucked up
+Nate Conn sour is bitter moron
*****
Nope, they are distinct flavours with seperate receptors and seperate purposes. Basically bitter tastes indicate poison or at least it did hundreds of thousands of years ago. That's why things with a strong bitter taste are awful unless you are used to them and bitter foods tend to always be an acquired taste. Sourness, on the other hand, detects acidity which is useful for telling if certain foods have gone offf etc. Sourness tastes sharp, tangy and well like the flavour you get from eating the flesh of citrus fruit. Bitterness tastes earthy, burnt, unpleasant and is accompanied by an an urge to spit out whatever you have in your mouth (at least until you get used to it in a paticular food or drink).
Sourness tastes sharp, tangy and can be pleasant or unpleasant depending on the strength of the flavour and what accompanies it. Often sourness is used to complement sweetness in various desserts or, of course, naturally in most fruits.
+Angel Valdovinos fucking moron
Hey scishow team, i would love it if you could make an in depth video on muscle growth. Maybe you could talk about how it happens, how to maximize it, etc
maximize it by using one of those inflatable arms from the spongebob episode!
Can you do an episode on DMT, you just touched upon it but I think of all the weird chemicals on this list DMT is by far the most interesting.
+al whits They don't even have a clue man. Hard for people who have never done it to comprehend it... but it is by far the most amazing thing that is in existence... pure consciousness... hyperspace puts everything into perspective. Stay tripping my friend :)
+al whits there's not that much to tell about DMT, not because it's not interesting, it's uber interesting, it's because due to the &^*(*#&$(@ war on drugs, science is unable to experiment and understand these compounds. One of the very few experiments done by Rick Strassman, was written about in a book and a documentary called "DMT, the Spirit molecule". And that's about it... Thanks war on drugs, for stopping not the use of drugs, but only scientific inquiry.
Thanks for sharing this information.
@Quincy Xzavier he is scamming you, and instagram can report you to police for hacking!
Hello
hey man you want some endocannabinoids
Nah that would be rude to take yours however some exogenous would be nice.
+Sheldoom Gaming Im more of a methylanedioxymethamphetamine person myself
DJ OakeyDoakey methylenedioxymethamphetamine*
;-; am I dumb idk wut that is
DMT is pretty crazy stuff.
that ending was so fucking smooth holy shit
"...or pot, as the kids call it these days"
Um no adults call it pot. Kids these days where I live call it weed.
+Hi I was thinking the same thing. Michael is too old for our shit.
I'm 40, my grandaddy during ww2 called it weed . My dad, Vietnam vet he called it grass, I'm generation x, I call it pot or just marijuana since it's legal here
+Hi He was 100% not joking. This is serious business. Red alert, red alert.
Weeeeeed. Nobody calls it pot around here unless they're 50+
+Hi Its Whats The fuck u want to call it it dont fucking matter
what a great episode!! been binge watching this channel like crazy, and i think i've seen every video in the last 3 years almost by now. but this one stands out, even among the space ones as being particularly informative, love u sci show! keep it up!
But why do I have lint in my bellybutton?
+Moonbeam Why is it always grey, no matter what colour of shirt you have been wearing?
+Coppertunes The fibres get transported there from both your underwear and your shirt, by your belly hair. Apparently, you have grey underwear, or a colour that blends with your shirt to turn grey.
+Moonbeam because you wear shirts
So you can put it into your pocket with your knives. DUH!
+Coppertunes Not grey in my experience, though it's certainly preferentially dark. But my guess would be that the colour is rubbed off differently (ever got blue legs from your jeans?), or is deeper in the shirt (the lint comes from fibers rubbed off the surface, dyes are deeper). It's not like the dye changes the colour of the cotton - it just coats it. What you're seeing is the colour of "clean" cotton.
WHY DO I SHIVER WHEN IM DONE PEEING. PLS SCISHOW
That's a orgasm
+IsaacScz i unsubscribed after they made the anus hair video so this time i'm gonna hit the BLOCK BUTTON
You watch too much Buzzfeed
+IsaacScz i thought i was the only one
I don't consider what I do shivering I just shake it everywhere I can when I'm almost done throwing the piss everywhere I try to get to the ceiling but it's rare, it's good for your hair as well, it stings in your nose though. My dad used to pee on my feet because he always said it's good for my skin and that it made him feel better so if a stall is available I always pee down my leg into my socks so my skin gets better
Can you guys do a Blacksmithing video I know random but I think it's a cool idea
+chris soto I don't think they would *mined*
+chris soto it'd be a cool to see the process
You're asking for it...
Because people don't *mined*
Altered State Hey, don't let the puns go in *vein*
I have failed I can't think of *ore*
(Ok yeah that was bad)
HCl isn't there to break down food, it's there because the enzymes that DO break down the food work best at low pH values.
+Zero: Dragon of the Void The pH is also going to lead to a degree of non-specific hydrolysis.
Acidic pH in the stomach, specifically the pyloric antrum, does aid in the digestion of proteins by destabilizing their 3D structure.
So... If DMT is found in our body, could that possibly be responsible in part for our dreaming? And the less DMT found in us at a given time could dictate things such as the vividness of the dream, and how likely we are to actually believe that we had dreamt the previous night?
Sorry if I just made people facepalm, just a curiosity.
I thought the same. I'm pretty sure at least one of the scientists who discovered that chemical also thought the same and... it wasn't what we thought right know... or maybe there is hope and they're trying to figure it out, who knows.
I get the DMT drip in brain.
+Daniel Harrow Well, that is what it actually is for. Or, at least, as far as we know. www.erowid.org/chemicals/dmt/dmt_article2.shtml So far, we have at least partially documented the release of DMT in R.E.M sleep. It releases in small amounts that give us the non addictive trip we associate with dreams. Also, as a bonus fact, apparently it releases in massive quantities when we die, causing us to go on the wildest trip a human could go on. So die happy. It's kinda important. But, although it's been proven, we can't truly know until we die.
There's been some theorizing around the whole death thing, saying that when it releases when we die, that's when our soul, our consciousness, whatever, is flung out. I kind of believe this, but being a teen and all, I'm really just experimenting with beliefs. Either way, I wrote an essay on it that could totally change the way you think about this stuff because I back what I say up with facts. It's cool, and if you wanted, it's right here. docs.google.com/document/d/1RUCDoJB0-GQJjInok-XZxlSdV0sDzr46LXZulmiDn50/edit?usp=sharing
+Angel Pygs DMT is non addictive itself
LTBSIDEKICK anything can be addictive. Physically, DMT is not addictive.
10 Surprising Chemicals Your Body Makes
*10. Azidoazide azide*
So is there any correlation between the breakdown of those metabolic processes involving formaldehyde and an increased risk of cancer?
I wonder the same thing.
+Cooper de Ruiter No? Why would there be?
+Silverizael In the video he mentioned that studies have shown that prolonged exposure to formaldehyde led to increased chances of getting cancer. Since he also said that small amounts are produced by the body, I was wondering if you could get the same prolonged exposure through the build up of formaldehyde in tissues. The reasoning being that cellular processes had broken down due to some unknown factor.
Gabriel Tzukishiro An extreme exposure to it can, but that's based on dosage. Small amounts don't cause cancer.
+Cooper de Ruiter if body processes did increase cancer risk it wouldn't, since everybody would have the same increase
To quote Hank Green: "EVERYTHING IS CHEMICALS"
"But do you know who does need the extra help? Sci show"
Boy you slick
I thought the kids called it "dank koosh"
+Noah Anderson (Weastwasfine) Bud, Dro, Nugs, Dabs, Purp, etc. Who calls it pot anymore? lol
+Noah Anderson (Weastwasfine) weed
+handicapitation I call it pot.
*dank kush, fire, that good, the list goes on - the kids
+dajosh42069 pot is a nark term tho
"everything is chemicals..." even romances..
My Chemical Romance jokes, whoops
Mcr
Damn, that Krebs Cycle diagram is nasty.
Surely there is an easier way to make ATP?
+seahawk124 thats not actually that nasty a version. it can get nastier.
People are lazy aha. Really, you could memorise that cycle and even further understand the basics of it in one evening.
Alistair Shaw
Oh God no! lol
Zed16
Oh, well I'm sure clinicians have to use that information on a daily basis.
+seahawk124 nope Only if you do metabolic diseases otherwiseNOPE.
I once got acetone in my eye. I literally screamed when it happened and those eye showers that chemistry labs in schools have, those are really helpful.
I KNOW I'm pointing out the obvious here but the human body is amazing.
So the body makes a dash of formaldehyde, but does it make a hint of asbestos?
I would've thought more people would get this.
+mike shaft Sadly no :/
it does have a habit of decomposing right before your very lalalala. eyes.
+Victoria Pichon Well yay. Another understands.
+Victoria Pichon Along with the people inside? What a wonderful caricature of intimacy...
Watched again at 2x speed... Just the way Michael talks it worked fine!
I was expecting a link to the Patreon and got sources. Good stuff guys.
great Segway at the end haha
Do you use a teleprompter Michael, or are you just a script-memorizing-beast?
+Carmen Austin He's just a beast.
_Rawr._
they use a teleprompter if you look closely at hanks eyes you see them move from the left to the right
There're a lot of cuts and edits. Each cut comprises of about 1-3 sentences. So even if they don't use a teleprompter, they'd only need to memorize a few sentences per cut.
Lots of youtubers do that. It's people who can go on for 15-60 unedited minutes, for example TED-talk presenters, that are script-memorizing beasts.
+Carmen Austin that patreon plug was inserted ever so smoothly, I chuckled x)
C. Leigh yes
Could you eat just super-compressed food for the rest of your life? ie: take a food and put a ton of pressure on it until it's in a cube/spherical shape. Also, would it make you feel full, or would you feel hungry the whole time? And would you gain lots of weight by eating it, or would most just 'pass right through you'?
for me the big enigma is how can people dislike scientific facts ?? or is it some trend I'm not aware of..these guys do an amazing job.
What I learned today:
Eating fatty foods = smoking pot.
+Seth Winfrey The reason people get the munchies is basically this.
What most people don't know is that THC, the active ingredient the smokers are looking for, breaks down into a god awful mess of different compounds with different effects and different half lives when it actually gets to your liver (If you thought the Krebs cycle was bad, you don't want to memorize those, believe me...). And some of those act as appetite enhancers.
You should do an entire episode dedicated to DMT. I'm very curious why this powerful psychedelic is made by our body since there isn't a clear answer to it. Also want to know if it's harmful since it's an extremely illegal substance
it's only illegal because it wakes you up to the injustices in every aspect of your everyday life
+Pierce Connors DMT is a simple molecule very closely related to tryptamine and therefore tryptophan (one of the twenty-two key amino acids needed for your body to function in general). Tryptamine exists and is also mildly "psychoactive" and the dimethylated analogue would logically exist due to the methylating enzymes that your body produces to methylate specific compounds. Occasionally, stuff goes past it like DMT.
It is illegalised by the US government when they blanketed all psychedelic compounds as it was closely related to insurrection and protests (and hippies) back in the 70s... what with the Vietnam war.
Pierce Connors it's similar in structure to serotonin and melatonin. but legal status =/= safety. you'd have to look more into history of drugs in America to understand war on drugs
It's not harmful in the least. Blame the DARE program and the war on drugs for that bad rep to psychedelics in general.
I've had Diabetic Ketoacidosis quite a few times -it's landed me in ICU and HDU. It is the single most painful and horrible thing that has ever happened to me as a T1 Diabetic, and thankfully being put on an insulin pump has enabled me to stave off DKA and stay out of hospital.
It hasn't stopped my friends and family from sniffing my breath and even my skin to make sure I don't smell like nail varnish remover, though, haha.
We actually know what DMT is for. It's used by your brain to take you out in times of intense shock. that is why many have weird experiences that sound like acid trips, while they can't really remember what happened.
We also use very minute amounts for dreams. But the two moments in which most of us get a serious dose is when we are born and when we die. birth is very stressful, especially for the child, the brain gets squeezed and you go from warm and comfortable cozy, to cold, bright, noisy and intimidating. the other is when we die. if your brain can see death coming, it will put you to easy with some DMT, which is why so many have the sense of seeing their lives, or even living whole lives someplace else, while their mind slowly enters the void.
this may sound like a weird question but using science what is the best way to lose fat?
Work out and eat healthy
+Gamerguy8585 This may sound like a weird answer but exercise and a healthy diet.
+Gamerguy8585 Not a weird question at all people ask it all the time. SciShow made a video on it before but I also recommend looking at Healthcare Triage's episodes on the subject.
Fat is an energy store. You get rid of one type of energy by converting it into a different type. A common choice from the resulting energy is kinetic energy.
+angeldude101 But combustion is so much faster for weight loss!
Formaldehyde? No duh. Taking O-chem right now, it's actually a really common organic product or byproduct.
O-chem... oh dear God, my O-chem final is wednesday morning isn't it?!
And heck yeah Acetone is in my blood; that stuff smells amazing! I tried to avoid it in lab, but I don't exactly ensure I won't get a tiny whiff or two... ;) The only thing even better is hexanes, like for TLC development.
*FUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu...*
you know you should probably stop tripping on DMT
Wild4lon In all honesty, that'll probably be the only reason I'll be able to pass this final. Gonna need my brain to self-produce the hard stuff...
+Micah Philson Ah, I finished my final Ochem course last quarter. Those were good times... maybe, haha. I'm glad now though, since I now actually more or less understand what all this stuff is.
Good luck on your final. O7
OfNaught I really like O-chem, it's just really difficult. It would take me a few years of classes just to actually understand the notes from this year alone.
I hate the college system. I'm only now understanding concepts in gen-chem I had over a year ago. They don't actually teach you things very well at all.
Well, that and I'm taking 14 credit hours this semester, but with labs, reci's, etc, I'm actually taking 24 hours in classes. Lab took more time outside of class than any lecture!
+Micah Philson Mmmm nah. My brain is feeling explody enough from all the networking and technology stuff that has been crammed into it the past two years.
The way he said "Let's talk about DRUGS" just killed me XD
And that ending tho... talking about how some people don't need the extra creatine supplementation and then said SciShow needs help, I was like "Wha, u need us to buy ya'll some creatine?" XDDD
I thought HCl is used not to digest , but to activate Pepsin, the most reactive enzymes in the digestive system. It is so efficient in breaking down proteins that it is produced in an inactivated state, and the HCl is used to activate it.
if stomach juice is acidic then why is it when we vomit it never burns a hole in the floor
Stomach acid is strong just not that strong.
+Alama Joradon The amount of acidity required to do that would burn through your stomach as well. Stomach acid is not anywhere close to that.
+Alama Joradon You're... you're not being serious are you?
+Alama Joradon My guess is because it's mostly diluted at that point. The food and saliva dilute it enough to prevent it from doing any damage outside your body. That is not to say that it lost it's acidity though. If you ever had a painful burning feeling in your stomach, you know how dangerous it is when stomach acid leaved your stomach. It is not a nice feeling and the acidity is definitely noticeable.
+Alama Joradon Because it's too dilute. Did you even watch the video? He said that the pH of stomach acid is the same as battery acid and you don't see battery acid burning holes through everything.
DMT is created so you can have dreams
+Ian Canada Huh. That actually sort of makes sense.
idk how you guys crank out such awesome videos at this rate. Not gunna lie, Mental Floss is my 1st love and they brought me here (shout out John) but Sci show- very impressive. Addiction is eminent...
As soon as he said “Psychedelic drugs” at the beginning, I knew DMT would be in it
"Pot as the kids are calling it these days"
Kids like Michael Aranda? Or does he prefer a bit of DMT...
+xinic5 HaHaHa I thought the same thing. Michael Aranda is still a kid... damn I feel old :(
+Master Therion hes 30
Yannik Mroos
wut...
I'm almost 27.... Why does he look so young and still have hair!!!
Genetics bro always.... The darn Genetics
Yannik Mroos
All my uncles are over 6' and went bald. All but my father who is 5'10 and full head of hair.
I'm the tallest male in my family at 6'5'', and my hair is thinning already, and has been for few years. For some reason being tall and bald skipped my dad. Although, his father died in his 60s or 70s with a head full of hair still too, so.
im so glad you mentioned that everything is chemicals. i hate it when people use the word chemical as something bad
Acetone does get used in the body, through detoxification in the liver it can be converted to precursors that can be pushed through gluconeogenesis... however this is slow so a lot of it is exhaled or peed out due to it being very volatile are easy to escape the body.
6:49 That cheeky advertisement, I love it!
This was made on my friend's birthday.. Time to send this as a late birthday! Hooray!
Fascinating - really tight job of putting this one together. Thanks again, guys. Are there any interviews/podcasts/behind the scenes that have Michael in them?
Excellent segue to the outtro
4:29 ***sour. A lot of people get confused about this. Example: black coffee = bitter; lemon = sour.
Just stopped reading for biochemistry test before I started watching this.... It all makes sense now
The thing is that, considering the amount of water in my body and the Ka of HCl, there realistically isn't any significant amount of HCl in my body -- there may be hydronium ions and chloride ions, but the hydronium could as easily be associated with another anion as with chloride.
Michael and Hank are my two favorite hosts
The fact that this all evolved blows my mind.
"Dear people who complain about the 'chemicals' they're exposed to. EVERYTHING IS CHEMICALS! Water, your body, omega-3 fatty acids, raspberries. Chemicals." - Hank Green, 2013
This is the quote I always remember when I see the word "chemicals".
It is said that DMT is responsable for dreaming because we used as a drug it can create profound psychedelic experiences and create new connections in the brain. Resting and dreaming, with small natural amounts will help to place memories and reflect on them in different ways
I heard somewhere that the dmt your body makes is for times where important things happen suck as birth or death or near death experiences as you go through this odd state where everything seems weird which seems to be facilitated by dmt being released into the bloodstream but I’m not sure, does anyone else have any thoughts?
You are shown various pieces of identity, and then your ego gets ripped apart and you end up merging with the deeper mind
they say that when you go to sleep dimethyltryptamine is released to calm your body down just as you fall asleep.. This could also explain why we dream because its a side effect of the drug that our body used... Really its strange looking into ourselves and learning things... and even then there is still mysteries of how our body works.
dmt is produced in the pineal gland which is in the center of the brain also known as the third eye. it helps us dream and produces lucid dreams
Nice source list!
Flawless Patrion plug.
For real though that was freaking smooth
I just learned about some allegations against Matthew Santoro, and instead of leaving a negative comment with him (which is already being done plenty), I'd rather leave a positive one with you guys for always properly stating your sources, and basing your stories on properly substantiated data.
I've always appriciated the links to the experimental articles you use.
The hydrochloric acid does not break down the protein, it provides the proper environment for enzymes like pepsin to do their jobs
From energy boosts to funds boost. I have to admit that this was an awesome transition. :)
I work with all these chemicals on an industrial level every day except for 8, 9 and 10.
What we deal with for a paycheck is crazy.
Just goes to show that too much of everything kills you, but just a little bit of everything helps you survive.
Hydrogen peroxide produced by the body also helps to keep your lungs clean, your colon regulated by filtering microbiota, and for the biosynthesis of thyroid hormones that require oxidation as an important step in synthesis
As a slight enthusiast of recreational drugs, I can confidently say that nothing (so far) comes close to DMT. I have never felt so jacked, tense, and tripped out as when my group of four friends smoked 0.1 grams each. The hallucinations were so vivid it felt like a dream that you remember perfectly. The trip lasted less than a half hour so it's not a major time commitment like LSD, LSA, or mushrooms that cause 4 to 12 hour trips.
Great vid as always. Thanks and keep up the great work!
Great episode. Not the least bit acidic in tone.
At 4:28 the guy said citric acid is responsible for the bitter flavor in lemons but I think he means tart because bitter is a property of alkaline materials
Some Emergency Medical Technician second gueesed my knowlegde of Acetone in our breath causeing it to be fruity. Thank you SciShow for affirming this knowledge. Your the best. Make more videos on Cannbis world. Awesome research on the Endocannabinoids.!!!!!!!!! I will remeber this forever!!!!!!
Best,
Endocannabinoids act as a kind of "cool down system" for your brain. It works in the opposite direction as conventional neurotransmission. These cannabinoids are just pieces of cellmembrane being synthesized in de post synaptic cell and sent to the pre synaptic cell binding to so called CB receptors. There it signals to the pre synaptic cell to stop releasing neurotransmitters. If this neurotransmitter is an inhibitory one, the post synaptic cell will of course get more active.
Chemicals and electricity.
Anyone who knows basic pharmocodynamtics understands the electromagnetic action between the atoms of molecule transition.
5:23 Michael, please never stop being so dang adorable!
i got a good laugh when he mentioned the krebs cycle thing, am currently going through my biology class, taking the final Wednesday
¨bacteria cell wall is negative repelling anything that is of the same charge, but hypochlorous acid is neutral so it can slip right through¨ that's what she said.
Maybe DMT is produced while we sleep as a byproduct of our brain (and the rest of nervous system) "cleaning" itself, removing the waste, hence found in cerebrospinal fluid. But since it's a powerful psychodelic, it stimulates some sense input processing centers in the brain, therefore dreams occur. Basically like naturally dropping acid while sleeping.
I heard of a chemical when glancing through a textbook about exercise and has to do with that it called the PC energy system.
Now I hear how it works. Nice.
Outro like the old =3 show from ray William Jonson
some people have hypothesized DMT is responsible for dreaming- basically our body gives us psychedelic experiences every night while we sleep! Pretty cool actually
The citric acid additive in a lot of foods isn't necessarily equal to the citric acid found in produce... it is usually made from mold and can contribute to anxiety and depression
Honestly, I'm surprised erythritol wasn't listed in this video. I find it stranger that the body makes a low-calorie sweetener than that it makes an acid to break down our food.
SO MUCH SCIENCE you earned a sub
The description of endocannabinoids here was pretty off-base. They're mostly for regulating activity to prevent the body from damaging itself
I used to take night classes and had to drive home late at night. On more occasions than I'd care to admit I would make the 25 minute drive and wake up in my driveway at home and barely remember how I got there. Irresponsible and scary... Yes. But also amazing. Is there any science behind how we can do that and what is happening in our brains during human autopilot?
HCl also activates pepsinogen so it turns into pepsin, which helps break down food as well.
I love this video. I'm a fan of scishow by the way. Love y'all hosts and producers. I hope I meet you in the future. 😊
That last second transition
As someone who has worked in Health and Safety, I'm a little sad that you used the old style of the corrosive hazard pictogram (square with orange background) instead of the new GHS one (white triangle)