Wow, this guy just single handedly saved my physio grade & my hopes of being a good nurse. Thank you so much for posting this information!! All the teachers at my school share the same power points & materials and none of them can answer questions or explain anything in a way that makes it understandable. At the beginning of class we had 50 students and in week 6 its down to 16. I'm glad I can finally understand these topics and move forward. Thanks again!
COMT is not only there in the liver and intestines, but is very important in the CNS aswell. It has a lot to do with the etiology of schizophrenia and with the treatment of parkinson disease.
Thank you. You are quite right. The importance of COMT in the Liver and intestines is -- as I described -- that it prevents catecholamine drugs from being taken orally.
Learned again something - thanks! Is there any book that describes how changes on the molecular level of a drug changes the drug's effects/ PK (like as you stated COMT breaks down only catecholamines, hence amphetamine won't be touched)?
Hi professor Fink, I have a question. Where in the neuron are the vesicles formed? I know the vesicles release neurotransmitters and they bind to the membrane by exocytosis but HOW do the vesicles move from the inside of the neuron to the membrane?
You are asking basically two questions (which are both very good): Vesicles are made of proteins, proteins are synth. in the cell body. So the vesicles (usually - not in the case of e.g. oxytocin and ADH if I remember correctly) wander down the whole way from the cell body until they are in the nerve terminal, being ready to get filled with neurotransmitters. The moving process (how you call it) is a very complex one; if you want to understand it fully I recommend you watching Ben Garside's videos here on YT. A short summary: Every vesicle but also the membrane it will fuse with has certain proteins called SNAREs, e.g. synaptobrevin, synaptotegmin and many more. These proteins suffer a conformational change once Ca2+ influx into the nerve terminal occurs* (...) finally the membrane proteins will bind to a vesicle's proteins; once this is done (...) the vesicle fuses with the membrane and releases its content into the cleft. The now fused vesicle will be via the help of other proteins (clathrins) drawn back into the nerve terminal, where it can be refilled again. *You can partially think of it as "contractions" that will allow the vesicle fit into the membrane.
Wow, this guy just single handedly saved my physio grade & my hopes of being a good nurse. Thank you so much for posting this information!! All the teachers at my school share the same power points & materials and none of them can answer questions or explain anything in a way that makes it understandable. At the beginning of class we had 50 students and in week 6 its down to 16. I'm glad I can finally understand these topics and move forward. Thanks again!
Your lectures helped me as an undergrad taking anatomy & physio and they continue to help me through my doctoral program in PT. Thank you so much!
Man this guy is good. He breaks down a subject known to be difficult and makes it so easy to understand. Thank you sir!
When I receive a notification from Professor Fink on youtube I immediately click on the link. It's so good to learn from him!
Thank You very much, Fabiane. My sincere Best Wishes.
hey babe
You, sir, are an absolute legend. I will be binge watching every lecture you have.
Thank you for very kind words! I truly appreciate it. My sincere Best Wishes for You!
Great sir!Thanks a lot .
Great teachers are like you. My regards and love for you.
I'm proud to be one of your students. I'm from yemen &I'm living in kSA & it's my dream to complete my studing in America
yippee... great to see you back professor..
a great lecture ^^ I'm so happy I disovered your channel Pr. Fink !!
Such a clear explanation! Thank you so much
Thank you so much professor, your lecture helps me a lot ❤️
This video was great, and so well explained . Thank you ! Definitely suscribing :)
COMT is not only there in the liver and intestines, but is very important in the CNS aswell. It has a lot to do with the etiology of schizophrenia and with the treatment of parkinson disease.
Thank you. You are quite right. The importance of COMT in the Liver and intestines is -- as I described -- that it prevents catecholamine drugs from being taken orally.
Where exactly in the intestine? Oh, found it! www.proteinatlas.org/ENSG00000093010-COMT/tissue
Thank u sir🙇♀️
Learned again something - thanks!
Is there any book that describes how changes on the molecular level of a drug changes the drug's effects/ PK (like as you stated COMT breaks down only catecholamines, hence amphetamine won't be touched)?
Outstanding!!!
Hi professor Fink, I have a question. Where in the neuron are the vesicles formed? I know the vesicles release neurotransmitters and they bind to the membrane by exocytosis but HOW do the vesicles move from the inside of the neuron to the membrane?
You are asking basically two questions (which are both very good):
Vesicles are made of proteins, proteins are synth. in the cell body. So the vesicles (usually - not in the case of e.g. oxytocin and ADH if I remember correctly) wander down the whole way from the cell body until they are in the nerve terminal, being ready to get filled with neurotransmitters.
The moving process (how you call it) is a very complex one; if you want to understand it fully I recommend you watching Ben Garside's videos here on YT. A short summary: Every vesicle but also the membrane it will fuse with has certain proteins called SNAREs, e.g. synaptobrevin, synaptotegmin and many more. These proteins suffer a conformational change once Ca2+ influx into the nerve terminal occurs* (...) finally the membrane proteins will bind to a vesicle's proteins; once this is done (...) the vesicle fuses with the membrane and releases its content into the cleft. The now fused vesicle will be via the help of other proteins (clathrins) drawn back into the nerve terminal, where it can be refilled again.
*You can partially think of it as "contractions" that will allow the vesicle fit into the membrane.
thank you so much professor
Master Class....
Hello Prof. Fink! Is this video included in your physiology or pharmacology playlist?
This material comes from my PHARMACOLOGY LECTURE OUTLINE (& PLAYLIST).
When the professor does the "klap" 👏 😂
Sorry, professor, couldn't help myself... 😉
Thank you!
just PERFECT
in which order should I view his videos
Go to my web-site: www.professorfink.com
Yeasa thanks professor
you sound like steve carrell