Zombie Drug: Xylazine o mas kilala sa tawag na 'Zombie Drug' | New Medicine Causing Deadly Symptoms
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- Опубліковано 7 кві 2023
- What is Xylazine?
Xylazine is a pharmaceutical drug used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle, and other non-human mammals. Veterinarians also use xylazine as an emetic, especially in cats. It is an analog of clonidine and an agonist at the α2 class of adrenergic receptor.
In veterinary anesthesia, xylazine is often used in combination with ketamine. It is sold under many brand names worldwide, most notably the Bayer brand name Rompun. It is also marketed as Anased, Sedazine, and Chanazine. The drug interactions vary with different animals.
Xylazine has become a drug of abuse in the United States, where it is known by the street name "tranq", and particularly in Puerto Rico. The drug is being diverted from stocks used by equine veterinarians and used as a cutting agent for heroin, causing skin sores and infections at injection sites, as well as other health issues.
History
Xylazine was discovered as an antihypertensive agent in 1962 by Farbenfabriken Bayer in Leverkusen, Germany. Results from early human clinical studies confirmed that xylazine has several central nervous system depressant effects. Xylazine administration is used for sedation, anesthesia, muscle relaxation, and analgesia. It causes a significant reduction in blood pressure and heart rate in healthy volunteers.[failed verification] Due to hazardous side effects, including hypotension and bradycardia, xylazine was not approved by the Food and Drug Administration (FDA) for human use. As a result, xylazine's mechanism of action in humans remains unknown.
Xylazine was approved by the FDA for veterinary use and is now used as an animal tranquilizer. In the United States, xylazine was only approved by the FDA for veterinary use as a sedative, analgesic, and muscle relaxant in dogs, cats, horses, elk, fallow deer, mule deer, sika deer, and white-tailed deer. The sedative and analgesic effects of xylazine are related to central nervous system depression. Xylazine's muscle relaxant effect inhibits the transmission of neural impulses in the central nervous system.
In scientific research, xylazine is a component of the most common anesthetic, ketamine-xylazine (see rodent cocktail), which is used in rats, mice, hamster, and guinea pigs. The accounts of the actions and uses of xylazine in animals were reported as early as the late 1960s and early 1970s.
Medical uses
Xylazine is widely used in veterinary medicine as a sedative, muscle relaxant, and analgesic. It is frequently used in the treatment of tetanus. However it is rarely if ever used in human medical treatment. Xylazine is similar to drugs such as phenothiazine, tricyclic antidepressants, and clonidine. As an anesthetic, it is typically used in conjunction with ketamine.
Veterinary use
As a veterinary anesthetic, xylazine is administered once for intended effect before surgical procedures (trade name: Rompun)
In animals, xylazine may be administered intramuscularly or intravenously. As a veterinary anesthetic, xylazine is typically only administered once for intended effect before or during surgical procedures. Alpha-2 antagonists such as atipamezole and yohimbine may be used to reverse the effects of xylazine in animals.
Side effects
Side effects in animals include transient hypertension, hypotension, and respiratory depression. Further, the decrease of tissue sensitivity to insulin leads to xylazine-induced hyperglycemia and a reduction of tissue glucose uptake and utilization. The duration of effects in animals lasts up to 4 hours.
Pharmacokinetics
In dogs, sheep, horses, and cattle, the half-life is very short: only 1.21-5.97 minutes. Complete elimination of the drug can take up to 23.11 minutes in sheep and up to 49.51 minutes in horses. In young rats, the half life is one hour. Xylazine has a large volume of distribution (Vd). The Vd = 1.9-2.5 for horses, cattle, sheep, and dogs. Though the peak plasma concentrations are reached in 12-14 minutes in all species, the bioavailability varies between species. The half life depends on the age of the animal, as age is related to prolonged duration of anesthesia and recovery time. Toxicity occurs with repeated administration, given that the metabolic clearance of the drug is usually calculated as 7-9 times the half-life, which is 4 to 5 days for the clearance of xylazine.
en.wikipedia.org/wiki/Xylazine
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Nice one love it##bigz
This is a strange and scary drug. Thanks for the information.
Mas malala pla to kaysa shabu,sa pinas walang kang makikitang ganyan sa kanto
Grabeh na tlga yung mundo ngayon 😖
grabe naman ang pag kakasera ng mga drug addict..nakaka sera sila sa bansang canada..dahil talagang hayag sila na nag aaddict sa kalye..tas hinahayaan lang sila ng gobyerno ng canada.talagang mga patapon na ang buhay.
Thanks for doing the English captions
Grabe lakas pala ng tama nyan bro.kaya nagkalat sika tlaga.nakakaawa lng tlaga
Gusto lang pala nila matulog bakit kailngan pa mag drugs, joke! Very sad, pero bakit kahit naka yukonsila hindi sila bumabaksag
Nuh!
grabe d cla mgbbgo
Hala naka takot yan Lods Zombie 🧟♀️ 😂
hehehe
🥲🙏
not zylazine. its heroin or fentanyl that makes them like that.
As far as I know those drugs are different side effects but almost the same thing in different ways to apply. I have discription in my video that explain properly about zylazine. From definition, history and side effects.