You are so awesome!!! Thank you so much for explaining this so well. I am so thankful to have found you at the beginning of my semester for my class. So thorough!!! Thank you again, Ray!! 🥰
I wish you were my instructor. Thank you for taking the time to do this. I'm a visual learner and I like they way you explained the process. I've been in class for 3 weeks and learn way more in this short time!
I cannot thank you enough, that was the most excellent way to describe this process. I definitely have a better understanding. Thanks for the animations and the revolving door thought to establish a connection! Thank you!
I love how you use many different types of examples to teach. Unlike previous comments I appreciate the repetition because I did not understand this at all before watching your video. I will be subscribing to your channel.
You are an excellent teacher! I've been watching your videos and they have helped me tremendously.... Sometimes the books can be "too busy", and they don't give good explanations, or ones that are understandable. You do such a great job of breaking it down and putting things in laymen terms, and you've helped me be more successful in my A&P. Thank you so much for taking the time to put these informative videos together and share them with students everywhere!
Thank you so much for explaining this topic so well. I was confused with the resting membrane potential for a long time.This video is excellent because it helps me clarity my ambiguity now!
This video really helped me a lot! currently taking physiology and reading from a book is not really my best learning preference. Thanks for putting everything into simple terms for easy understanding!
thanks for explaining!the images you used are great, your drawings are helpful and your voice is really clear! this video really helped; midterms are coming up!
want u to know i clapped at the end of the video, thx for explaining this so well. only thing is that i wish u explained hyper-polarization and the chart for it.
extremely well explained! what I miss is: what about the function of Cl-? and u mentioned Anions at the start forcing the K to stay there, maybe some more information regarding why the K is in the cell in the first place?
This video cleared a lot of confusion! Thank you! I have a few questions: What is the reason for the membrane potential to be upset? Is it because Na+ has a natural tendency to enter the cell because it wants to travel down its gradient or does Na+ enter the cell for another reason? When are voltage gated ion channels used? Would the sodium potassium pump be considered a voltage gated ion channel or is it more of a carrier ion channel?
What is the reason for the membrane potential to be upset? They have a crucial role in excitable cells such as neuronal and muscle tissues, allowing a rapid and coordinated depolarization in response to triggering a voltage change. Is it because Na+ has a natural tendency to enter the cell because it wants to travel down its gradient or does Na+ enter the cell for another reason? Na+ enters like you say because of concentration gradient but also because of charge. It is attracted to the negative change in the cell. Collectively this is often referred to as the electrochemical gradient. If there is an unequal distribution of charges across the membrane, then the difference in electric potential generates a force that drives ion diffusion until the charges are balanced on both sides of the membrane. When are voltage gated ion channels used? Voltage-gated ion channels are found in the membrane and they are usually ion-specific. You can find them in a nerve cell along the axon and at the synapse. As you may know they help to propagate the electrical signal, Action Potential. They become active when there are changes in the electrical membrane potential right next to the channel. The voltage makes the protein change shape and therefore regulates their opening and closing. Would the sodium potassium pump be considered a voltage gated ion channel or is it more of a carrier ion channel? I understand it to be more of an ion channel in order to maintain the cell membrane potential. The cells use it to keep a low concentration of sodium ions and high levels of potassium ions within the cell.
thanks you for this video too. I have a question: Sodium-Potassium pomp, the great exit of K, the entrance of Cl, all contribute to the increase of intracellular negativity. What does stop this process to -70 mV?
Hi! Your vid is awesome - I have a question, though: Why, if it has to work so hard with the sodium-potassium pump, does the cell still have passive ion channels? wouldn't it be working less if it just shut off those? Thanks and keep up the wonderful work you do!
Hyperpolarization is a change in a cell's membrane potential that makes it more negative. It is the opposite of a depolarization. It inhibits action potentials by increasing the stimulus required to move the membrane potential to the action potential threshold.
@@zuhairafsar2540 Hypokalemia or depressed potassium levels due are mostly due to poor intake of potassium. Enumerating the cause of increased entry into neurons due to increases in the activity of the Na-K-ATPase pump.
You are so awesome!!! Thank you so much for explaining this so well. I am so thankful to have found you at the beginning of my semester for my class. So thorough!!! Thank you again, Ray!! 🥰
Great video! Very thorough, clear, concise and extremely helpful! I'm sure students everywhere are loving you right now!
I wish you were my instructor. Thank you for taking the time to do this. I'm a visual learner and I like they way you explained the process. I've been in class for 3 weeks and learn way more in this short time!
Thank you so much Mr. Cinti for the neatness of your work , you are the best .
i won't walk away without saying thank you. You make this concept way more interesting than my prof. did
Thank you so much.
I cannot thank you enough, that was the most excellent way to describe this process. I definitely have a better understanding. Thanks for the animations and the revolving door thought to establish a connection! Thank you!
GOOD STUFF!!!!! This is the most thorough explain I have ever seen...I am humbly a fan of this video!!
really clarifies this for me. great video thanks
First year Respiratory Therapy student, great video, and the repetitiveness is good, helps people understand better!
Cameron Blac
This is the most helpful video that I have seen on this topic and I have seen a lot of them! Thank you, you are going to help me through Physio lol
I love how you use many different types of examples to teach. Unlike previous comments I appreciate the repetition because I did not understand this at all before watching your video. I will be subscribing to your channel.
This is a brilliant way to explain this. Well done!
You are an excellent teacher! I've been watching your videos and they have helped me tremendously.... Sometimes the books can be "too busy", and they don't give good explanations, or ones that are understandable. You do such a great job of breaking it down and putting things in laymen terms, and you've helped me be more successful in my A&P. Thank you so much for taking the time to put these informative videos together and share them with students everywhere!
Thank you so much for explaining this topic so well. I was confused with the resting membrane potential for a long time.This video is excellent because it helps me clarity my ambiguity now!
Good video. Helps explain something I couldn't understand from my professor.
You are the best teacher ever
Your lecture is so easy to follow. Thank you so much for the video. It helps a lot.
Thank you for a great explanation! I was very confused but now feel confident in my understanding of this concept!!!
You're a wonderful instructor, thanks so much for posting!
This video really helped me a lot! currently taking physiology and reading from a book is not really my best learning preference. Thanks for putting everything into simple terms for easy understanding!
love your teaching style thank you for helping me understand and the extra repetition
thank you! I had such a mass in my head but you've cleared almost everything!
I am from Russia, and i wanna say thanks you for this video!
Thank you for this video! You are a fantastic instructor.
thanks for explaining!the images you used are great, your drawings are helpful and your voice is really clear! this video really helped; midterms are coming up!
Thank you a lot, this is a brilliant explanation, it helped me a lot to understand and easy to remember it. You are a wonderful instructor.
Very great video !!! Helped me with my Neurobiology of Synapses course !! Thank u so much !
god bless you this video has broken everything down into clear understandable pieces!
Thank you so much sir. You made this concept much more clear
Excellent presentation!
Thank you for the clear and detailed explanation.
THANK YOU I DONT FEEL LOST ANYMORE
want u to know i clapped at the end of the video, thx for explaining this so well. only thing is that i wish u explained hyper-polarization and the chart for it.
thank you so much!!!!!!!!
you are better than my teacher !!
Totally enjoyed this video! Thankyou for the awesome work and for clearing things up for me! :D
OMG thank you so much! Very easy to understand and follow.
Your quite amazing. This was a hard concept for me and now I fully understand it. I really appreciate your help :)
wonderful animation,very easy to understand..Thanks
Very helpful and clear explanations. Great video thank you!
Thank you sooo much, sir!!!Your explanation has made me understand this topic better. :)
Thank you so much I finally got it. I like your teaching style. 😊
extremely well explained!
what I miss is: what about the function of Cl-? and u mentioned Anions at the start forcing the K to stay there, maybe some more information regarding why the K is in the cell in the first place?
Really enjoyed this, thanks. What element/s are the anions please?
this really helped me understand the whole idea of RMP.. thankuu
thank you for this wonderful work; great help and simple explanation. thank you
Thanks a lot. It really helped me understand it better.
Outstanding work!!!!!
This video cleared a lot of confusion! Thank you! I have a few questions:
What is the reason for the membrane potential to be upset? Is it because Na+ has a natural tendency to enter the cell because it wants to travel down its gradient or does Na+ enter the cell for another reason?
When are voltage gated ion channels used? Would the sodium potassium pump be considered a voltage gated ion channel or is it more of a carrier ion channel?
What is the reason for the membrane potential to be upset?
They have a crucial role in excitable cells such as neuronal and muscle tissues, allowing a rapid and coordinated depolarization in response to triggering a voltage change.
Is it because Na+ has a natural tendency to enter the cell because it wants to travel down its gradient or does Na+ enter the cell for another reason?
Na+ enters like you say because of concentration gradient but also because of charge. It is attracted to the negative change in the cell. Collectively this is often referred to as the electrochemical gradient. If there is an unequal distribution of charges across the membrane, then the difference in electric potential generates a force that drives ion diffusion until the charges are balanced on both sides of the membrane.
When are voltage gated ion channels used?
Voltage-gated ion channels are found in the membrane and they are usually ion-specific. You can find them in a nerve cell along the axon and at the synapse. As you may know they help to propagate the electrical signal, Action Potential. They become active when there are changes in the electrical membrane potential right next to the channel. The voltage makes the protein change shape and therefore regulates their opening and closing.
Would the sodium potassium pump be considered a voltage gated ion channel or is it more of a carrier ion channel?
I understand it to be more of an ion channel in order to maintain the cell membrane potential. The cells use it to keep a low concentration of sodium ions and high levels of potassium ions within the cell.
@@raycinti5031 Thank you so much, Mr. Cinti!
Thank You! your video helped me a ton...
This helped me for my test. Thanks!!
Excellent sir. Thank you!
Thank you, this video is really helpful.
this video is the best thing since sliced bread
Fantastic. very clear.
Great video!
Maravilloso diseño. !!
excellent explanation!
thanks you for this video too. I have a question: Sodium-Potassium pomp, the great exit of K, the entrance of Cl, all contribute to the increase of intracellular negativity. What does stop this process to -70 mV?
Love this video! Thank you!
thank you sir
Hi! Your vid is awesome - I have a question, though: Why, if it has to work so hard with the sodium-potassium pump, does the cell still have passive ion channels? wouldn't it be working less if it just shut off those? Thanks and keep up the wonderful work you do!
I'm from Germany and this helped me a lot 😂😂😂👍👍
Thank you, great video!
better than my textbook!!!!!
very clear, thanks!
what happens to the nerve's activity and resting membrane potential in times of hyper and hypo kalemia?
Hyperpolarization is a change in a cell's membrane potential that makes it more negative. It is the opposite of a depolarization. It inhibits action potentials by increasing the stimulus required to move the membrane potential to the action potential threshold.
@@raycinti5031 I'm sorry, I meant in situations of high extracellular and low extracellular potassium?
@@zuhairafsar2540 Hypokalemia or depressed potassium levels due are mostly due to poor intake of potassium. Enumerating the cause of increased entry into neurons due to increases in the activity of the Na-K-ATPase pump.
@@raycinti5031 thanks
Wow really helped me! thank you very much!
Amazing, thanks
Could you explain why potassium ions leaking out would make you lose the membrane potential?
It might be a stupid question,but why does the membrane have to be polar(the outside more positive than the inside of the cell)?
Thank you!
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Thanks so much!
you're awesome!! thank you!!
helped a lot!!! thank you
its really help me to understand
thank u so much, amazing video
Many thanks 🙏
Thank you.....god bless you
Thank you very much
Awesome! Thanks
helped a lot!!! bless you :)
Thank you ! Great great
Who was on the phone?
thank you
thak you so mush
Very good video, but a bit repetitive,
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great video but too much repetition making it unnecessarily long , which is not a good thing
Tooooo long, really boring!
thanking you sir
Great video!
Thank you. Great vid.