Anti Cancer Drug Mechanism Part 1-Alkylating Agents & Antimetabolite= GPAT|| NEET PG||CSIR NET-Hindi

Anti Cancer Drug Mechanism Part 1-Alkylating Agents & Antimetabolite
Alkylating agents are reactive to DNA and cellular proteins and the primary mode of action is mostly through cross-linking of DNA strands, inhibiting replication of DNA and transcription of RNA. Some antimetabolites are structural analogs of normal molecular essentials for cell growth. After intaking into cells the analogues change to substances to interfere with DNA or RNA synthesis.
MCQ on Anti Cancer Drug Mechanism
Q. 1 What is the mechanism of Action of 5 Flurouracil
A. It block thymidine synthetase
B. It block Helicase
C. It block Topoisomerase
D. It block DNA Polymerase
Q. 2 What is the mechanism of Action of Methotrexate
A. It block thymidine synthetase
B. It block DHFR
C. It block Topoisomerase
D. It block DNA Polymerase
Q. 3 By which bond Alkylating agents bind to nitrogen bases
A. Hydrogen Bond
B. Covalent Bond
C. Ionic Bond
D. All
Q. 4 What is the mechanism of Action of 6 Mercaptopurine
A. It block thymidine synthetase
B. It block DHFR
C. It block Purine synthesis
D. It block DNA Polymerase
Q. 5 Nitrogen Mustard act on
A. Cell Cycle
B. Purine Synthesis inhibition
C. Pyrimidine Base synthesis inhibition
D. NONE
#CellCycle
#PurineSynthesisInhibition
#PyrimidineBaseSynthesisInhibition
#Nitrogen Mustard
#AntiCancerDrugMechanismOfAction
#AlkylatingAgentsMechanismOfAction
#AntimetaboliteMechanismOfAction

[@kanishkjoshi641]

1-a,
2-b,
3-b,
4-c,
5-b.
Thank u sir for your informative video.

[@harithaaggunna775]

Sir,
Ur classes are really helpful for gpat n quick understanding.
Pls cover ANS SYSTEM SIR.
Because it has a a lot of weightage many concepts are interlinked with it..
Pls make it as early as possible sir.

[@TutorBoxChannel]

Will try

[@lalitabhati1640]

1(a)
2(b)
3(b)
4(c)
5(b)

[@harsssit4516]

Very easy explanation sir
Thanks alot

[@TutorBoxChannel]

Most welcome. plz share to your classmates

[@indianallrounder4081]

1.A 2.B 3.B 4.C 5.B

[@shaikh3667]

Sir Please cover CNS Pharmacology

[@TutorBoxChannel]

ok after covering Cancer, Immunosuppresant and Tuberculaosis i Will cover CNS Pharmacology

[@shaikh3667]

@@TutorBoxChannel thanks sir

[@drxbhupendra]

1) a
2)b
3)b
4)c
5)a

[@hafizalimuradlaghari5444]

❤🎉❤❤❤❤

[@generaltoadvanceedudepartm5982]

Nice

[@josliajose2299]

I am prepared gpat exam, i want ur class,. But i am not understand this language,... plz soeak in english.

[@TutorBoxChannel]

Ok

[@josliajose2299]

@@TutorBoxChannel, when?

[@josliajose2299]

Plz english speaking

[@TutorBoxChannel]

Ok, I will try in upcoming lectures

[@allavenkatanikhilreddy6561]

1)a
2)b
3)b
4)c
5)a