Biomarkers Of Kidney Function: Creatinine, Cystatin C, What's Optimal?
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- Опубліковано 10 лют 2024
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Papers referenced in the video:
Structural and physiological changes of the kidney with age and its impact on chronic conditions and COVID-19 pubmed.ncbi.nlm.nih.gov/37031...
Age-related changes in clinical parameters and their associations with common complex diseases pubmed.ncbi.nlm.nih.gov/26623...
Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age
www.ncbi.nlm.nih.gov/pmc/arti...
Variation in serum creatinine level is correlated to risk of type 2 diabetes
pubmed.ncbi.nlm.nih.gov/24396...
Age and cystatin C in healthy adults: a collaborative study
pubmed.ncbi.nlm.nih.gov/19749...
Cystatin C and long-term mortality among subjects with normal creatinine-based estimated glomerular filtration rates: NHANES III (Third National Health and Nutrition Examination Survey)
pubmed.ncbi.nlm.nih.gov/21109...
Biological age estimation using circulating blood biomarkers
www.nature.com/articles/s4200... - Наука та технологія
My Cystatin C was 0.65 so I’m happy to hear this news
The video i didn't know I needed... my Creatinine is 1.35 and I thought it was because I took creatine. I have more muscle mass than 90% of those around me so this helps. THANKS!
It's important that you're not dehydrated when you get your blood drawn or you can get high creatinine.
Yeah same.
can't wait for the next video, thank you
Another awesome video. Just got kidney warnings from Prenuvo MRI and iollo metabolomics (both of which are great imo), and ill be getting my first Cystatin C test soon
Figure 1 of the Bortz paper where they show the selection proportions makes for some interesting reading. That's a technical point I know, but it shows some of the parameters are worth paying particular attention to.
Thanks for that video! My creatinine is 1,3 mg/dl, GFR is 67, but I train a lot. I am adding cystatin to my next blood work!
You are right about red blood cell dist width - when I used your calculator, my age was 35 but once I inputted RBC width it jumped to 39 (I am 47). There was a surprise :)
Thank you for the insights. I gotta add cystatin c to my bloodwork
Quite informative and interesting
Thanks @KThalman
I just discovered you and your very informative UA-cam Channel. I'm especially interested in kidney function. Can you please tell me if you have a video where you talk about BUN and its relationship to how it all works.
Apparently kidney function is positivity associated with alpha-klotho which may be a major player in preserving brain health (Ref Dena Dubal's research) as well as general longevity. Saw a lecture by Tamara Isakova from about 2 years ago in which she showed a graph of eGFR vs Klotho. Nice positive correlation. So kidney health is important on many levels. According to Prof Dubal, exercise robustly increases alpha-Klotho, even more so than the favorable SNP. It makes sense that kidney health marker would be tracked and we do what we can to maintain. Recent discussion (UA-cam) between Dena Dubal and Mark Mattson on Klotho and brain aging was very informative.
I agree about kidney health-not just for brain health, but CVD risk, too, and on its own, kidney function declines during aging...
Perfect timing (for me).at 66yo, I starting supplementing with creatine / CrossFit and my eGFR/createnine dropped from 85 to 59. My eGFR/cystatin-c stayed steady at 85. Even though I “know” I’m killing my eGFR/createnine I’m stopping supplementing for 4 weeks and just reassuring myself my kidneys are still tip-top.
Thanks Michael. Will be adding Cys-C to my blood work. My eGFR has been consistently in mid to upper 90s, for years, with creatinine around 0.7. Turning 70 this year. Was a little disappointed to see that albumin and glucose didn't move the needle much in this study. on SHBG, which tends to run high for me, and probably accounts for low Free Test, I see that high Log SHBG is fairly significant. If you can at some point would appreciate helping us interpret data which is presented in log format vs normal units.
Thanks Peter-what's your log SHBG data? I'll look up the conversion
@@conqueragingordietrying1797 I just noticed that this study listed Log SHBG in the graph so wondered how to read study values reported as log. My last LabCorp SHBG value was 85 nmol/L, out of range high, accompanied with low Free T (8.3 pg/ml) but High Total T (811 ng/dL). So don't need my results converted. Working on identifying dietary factors which may be driving this. Thanks.
@@peterz53 high SHBG is a tough problem to solve by all accounts. The only solution I've heard mentioned is eliminating chronic infections, whatever and however that works. And yes log (value) is very annoying, is that log base 10 or e? Using those transformations weakens the strength of evidence as well, so they are last resorts in this kind of analysis.
Michael - always excellent updates. Like you i do a lot of exercise with heavy weights and running but like 20 years older at 70 years and BMI at 20. So maybe a factor in some kidney function parameters. My BUN is high 26 mg/dl. Other blood kidney parameters think ok - cystatin c @ 0.86 mg/dl with then a eGFR of 91, creatinine 1.03 mg/dl. In urine creatinine at one test 54.9 mg/dl & second test creatinine at 15 mg/dl, in urine albumin
Hi, I just discovered your channel and what you do is amazing, I would like to start tracking my progress through blood tests in conjunction with food, etc. to better understand your method, from which video I should start from? Thank you
Hi @andreacolombo2918, I'm not sure that 1 video delineates it, but I'd recommend daily diet tracking, and then lining up the average intake in-between blood tests with the later test. Then, after around 5 tests, evaluating correlations with diet (or other stuff-supplements, sleep, fitness metrics), followed by following the correlations (increasing or decreasing intake).
After about 20 tests, the truth for what can impact what starts to become more evident...
perfect I'll do like this thank you@@conqueragingordietrying1797
hi... sorry if unrelated but do u track vitamin D regularely? do we know the optimal level of vitamin D?
Great video! What dietary factors have the greatest influence or your cystatin c? Or is that the subject of a future video? I’ve also never heard you say you supplement with creatine which is a highly utilized supplement.
Thanks @tylero9568. Unfortunately, that was my 1st ever Cystatin C measurement, so I don't have correlations...
I don't supplement with creatine, but I did in my 20s
@@conqueragingordietrying1797 Mike should have some idea from the uremic metabolite correlations from iollo, which may partly translate to cysC. There's not much in the literature on Cystatin C and diet.
I know you only touched on kidney function briefly, but the other day I was thinking about how it might be possible to manipulate osmotic pressure to create some kind of detoxifying bath to compensate for reduced kidney function. It might be useful at least until we can figure out why kidney function declines with age. Although, I don't really know enough about the subject to know if it'd be possible or even safe to try to suck bodily waste out through the skin like that.
6ft 240lb a lot of muscle mass. My egfr is 68 and 1.4 creatinine. I need toget this test
very interesting (as usual) Will you be assessing foods/nutrients that improve Cystatin C levels? (75 y/o my cystatin c is 1.03.) Also my creatinine levels have been relatively high due to supplementing with 5grams of creatine daily.
Thanks @startingtoday4663. I only have 1 blood test for cystatin C, so I can't show correlations without more data...
How/where does one get a cystatin-c test? And what is the effect of Creatine supplementation on so these kidney function tests?
If you ask your GP, they can order it. If not, there are lots of companies that offer it-you'd then take the lab form to either Quest or LabCorp (in the US)
this week I learn high creatinine levels and high uric acid levels are the two variables most associated with bringing down your chances of reaching age 100 . common factor of this 2 biomarkets is high meat consumption. which tally with many animal studies of danger of high meat intakes .
Wrong..
@@DK-pr9ny which part wrong. I give specifics. u give generalities.
eGFR increases with protein intake. Did you see any correlation regarding protein, and besides that with sysBP, FFbody mass, BFat%, vit A, Omega-3, or fructose intake?
I though that was related to excretory overload, so its probably not a recommended strategy for improving eGFR.
@@jamesgilmore8192 agree, did not want to imply that. Rather the opposite, as high protein might falsely indicate a good kidney function
I noticed from your graph that cholesterol is a positive contributor to biological aging. Do you know if this is LDL,HDL, TOTAL? Thanks
Hey @Maple597, total cholesterol
@@conqueragingordietrying1797 thank you!
Volume is much better now :) Interesting about Cystatin C, on my amateurish correlation of biomarkers to age I missed that one, I'll go back and see why it wasn't significantly correlated.
Thanks for pointing that out @allurbase, I might've fixed the sound problem by manually increasing it within Settings
Hi, do you know how much iodine do you take x day? Because i can’t find in your videos. Thank you
Hi @user-ni5gh2sl8k, I don't track it, so I'm not sure...
I may start tracking it though, as adding free T3 to every blood test is on the to-do list
@@conqueragingordietrying1797 Iodine is practically zero in most foods. Mike's intake is roughly around 100mcg/day mostly from sardines and yogurt. Urine measurements are the best way to quantify intake, and there are all cause mortality curves on urine iodine.
Does eGFR have any significance? I'm 49 with 105 eGFR and 0.9 creatinine. Haven't measured Cys-C.
eGFR is important, but so is measuring cystatin C, especially within the context of creatinine's variability after 40y
Clinically it's used as a cut-off for CKD referrals where I am. For longevity it's less clear, but the equations are tethered to rigorous kidney function tests.
Very interesting. My Creatine is relatively high (1.2) but my Cystatin C is fine (0.7). Given the variability in creatine measurements after 40 and its correlation with muscle, why would Dr. Levine include Creatine and not Cystatin C in her calculator?
Cystatin C isn't a commonly performed test-I'm not sure if it was available in the NHANES cohort, which she used to derive PhenoAge. Note that she didn't arbitrarily pick biomarkers, she let the stats pick the best model.
The study Mike presented uses the UK biobank which could account for some differences. Phenoage is from NHANES.
What test measures cystatin c?
It's specifically, a "cystatin c" blood test
My cystatin c was .94 last year and this week it was 1.02. How is this number?
~0.7 is youthful, Cystatin C increases during aging, and higher values are associated with an increased all-cause mortality risk
That data is in the video
@@conqueragingordietrying1797 I'm 41
My gfr dropped from 106 to 80 in two years, 45 yrs old😮