Introduction to Major Histocompatibility Complex (MHC) | MHC Class-1, 2, 3 | Basic Science Series

0:00 Introduction
0:22 Importance
0:43 Classification
1:04 Role
1:22 Other Name
1:29 Determination
1:47 Main function
1:57 Interaction
2:07 Epitope
2:26 Sub-Groups
2:35 MHC Class 1
2:50 MHC Class 2
3:07 MHC Class 3
3:32 Conclusion
3:53 Coming soon
SEO Keywords:
MHC class 1, MHC Class 2, MHC Class 3, MHC Class 1 and 2 difference, MHC Class 1 Structure, MHC Class 1 and 2 Structure, MHC class 2 structure, MHC function, MHC Class 1 function, MHC Class 2 function, Major Histocompatibility Complex ppt, Major Histocompatibility Complex notes, Major Histocompatibility Complex notes pdf, Major Histocompatibility Complex is quizlet, Major Histocompatibility Complex function, Major Histocompatibility Complex definition, Major Histocompatibility Complex (mhc), MHC class 1 proteins, MHC class II proteins, MHC 1 and 2 structure, MHC 1 and 2 structure and function, MHC 1 and 2 function, MHC 1 and 2 antigen processing pathway, MHC 1 and 2 immunology.
Major Histocompatibility Complex (MHC) introduction | MHC Class-1, 2, 3 | | Basic Science
Series
In this presentation, we will focus on the structure and function of major histocompatibility complex class-1 molecules in detail. We will also know about the interaction with CD 8 co-receptor and the function of various domains of MHC class-1 molecule. So please watch the full presentation to understand the structure and functions of the MHC class-1 molecule.
Definition: The Major Histocompatibility Complex (MHC), also known as the Human Leukocyte Antigen (HLA) system in humans, is a group of genes that encode cell surface proteins responsible for presenting antigens to the immune system.
Genetic locus: The MHC is located on chromosome 6 in humans and is highly polymorphic, meaning it exhibits extensive genetic variation between individuals.
Types of MHC molecules: There are two main classes of MHC molecules: MHC class I and MHC class II.
MHC class I molecules: MHC class I molecules are expressed on the surface of almost all nucleated cells in the body. They present antigens derived from intracellular pathogens, such as viruses and some bacteria, to cytotoxic T cells (CD8+ T cells).
MHC class II molecules: MHC class II molecules are primarily expressed on the surface of antigen-presenting cells (APCs) such as macrophages, dendritic cells, and B cells. They present antigens derived from extracellular pathogens to helper T cells (CD4+ T cells).
Antigen presentation: MHC molecules bind to antigens, which are fragments of proteins from pathogens, and display them on the cell surface. This process is known as antigen presentation.
Recognition by T cells: T cells have receptors called T cell receptors (TCRs) that can recognize specific antigens displayed by MHC molecules. CD8+ T cells recognize antigen-MHC class I complexes, while CD4+ T cells recognize antigen-MHC class II complexes.
Role in immune response: MHC molecules play a crucial role in the adaptive immune response by allowing T cells to recognize and respond to foreign antigens. They are essential for the activation and coordination of immune cells during infection or other immune challenges.
MHC polymorphism: The MHC genes are highly polymorphic, meaning there are many different versions or alleles of these genes within a population. This polymorphism allows for a wide range of antigen presentation and enhances the immune system's ability to recognize a diverse array of pathogens.
Transplantation compatibility: MHC compatibility is a critical factor in organ and tissue transplantation. The recipient's immune system must be compatible with the MHC molecules of the donor to avoid rejection of the transplanted tissue.
Support my work at www.patreon.com/user?u=37177596
Twitter: / drkumarlokender
Facebook: / lokenderkumar.sharma
Linkedin: / dr-lokender-kumar-5852...
Disclaimer: The information provided is for educational purposes only. The content of this channel should not be considered as medical advice of any kind. Please consult your doctor for medical help. Use this information at your own risk. We hold no responsibility for any issue, concerns, or damage arising from the content of the video. Under no circumstances Basic Science Series English be responsible or liable in any way for any content, including but not limited to, any errors or omissions in the content, any loss, any damage of any kind incurred as a result of any content communicated in this video, whether by Basic Science Series English or a third party. In no event shall Basic Science Series English be liable for any special indirect or consequential damages of any damages whatsoever resulting from the content of our channel.

[@lalithkiranreddyvaka]

Being a Doc really appreciate you sir
Thanks sir made thing very easy to understand

[@BasicScienceSeries]

Thank you for your valuable feedback 🙏

[@BasicScienceSeries]

*Major Histocompatibility Complex (MHC) introduction | Refresh your immunology concept !!!*

[@preciousezennia2303]

Thank you so much
This cleared up my confusion
The hand scribbling was wonderful, it helped focus my attention on what you were writing.
Wonderful work I look forward to seeing more videos😊

[@BasicScienceSeries]

Glad it was helpful!

[@michaelmaxwell9504]

Nice clear simple explanation 👌 Thank You Dr

[@BasicScienceSeries]

Thank you for your comment 🙏🏼 can you suggest any topic for the future videos?

[@adammajaliwa3125]

Thanks 🙏, it's a short one but full of contents. "congratulations"👏👏👏

[@BasicScienceSeries]

Glad you liked it!

[@fabi9022]

thanks bro, helped me a lot

[@BasicScienceSeries]

Thank you for your valuable feedback 🙏

[@roshiniteella]

Very helpful.. Thank you so much

[@BasicScienceSeries]

Thanks alot for your kind support 🙏

[@samuelantwi2838]

VERY WELL EXPLAINED

[@BasicScienceSeries]

Glad it was helpful!

[@prakriti1018]

Very helpful 😃 Thank you sir for such a nice explanation 🙏

[@BasicScienceSeries]

Most welcome 😊So nice of you!

[@jenniferb.7589]

Nice explaination! But please next time don't use this weird scribble hand, makes it very difficult to read what you've written in time.

[@BasicScienceSeries]

Thank you for your valuable feedback 🙏

[@abdirahmanahmed2502]

Good explanation, thanks!

[@BasicScienceSeries]

Glad it was helpful!

[@caseyoneal6284]

Very helpful

[@BasicScienceSeries]

Thank you so much!

[@genevieveemefaasare8352]

thanks a lot.

[@BasicScienceSeries]

Thank you so much!

[@iqbalmasuood9017]

well done sir ..✌️✌️✌️✌️

[@BasicScienceSeries]

Thank you for your support 🙏🏼

[@bramos.m4172]

Good work 👍

[@BasicScienceSeries]

Thank you for your support 🙏🏼

[@raghulsudhagar3976]

It will be nice if u remove the transition sound.. earphone users r dead

[@BasicScienceSeries]

Thanks for the feedback! Sorry about that. New videos are different and much better. Please check and give your feedback. Thanks

[@alimamstudying9462]

Thank you

[@BasicScienceSeries]

You're welcome, thank you 🙏🏼

[@mridusmitasaikia9382]

Thank you sir

[@BasicScienceSeries]

So nice of you : ) Thank you so much for your kind support and for your comment as well..

[@NishaSharma-kq9ng]

It's very helpful video,thank you so much sir

[@BasicScienceSeries]

So nice of you

[@BasicScienceSeries]

Thanks for your support!

[@vanaparthisuhas7882]

Nice

[@BasicScienceSeries]

Thanks

[@kidsentertainment1015]

good kipit up

[@BasicScienceSeries]

Thanks for your kind feedback 🙏

[@smruti011]

Thanks sir

[@BasicScienceSeries]

Thank you so much!

[@chiragsharma4281]

Sir antigen represent karne ka kaam to APC karta h na

[@BasicScienceSeries]

Yes antigen presenting cells. Aur antigen presenting cells are the cells that process antigens. See the examples of antigen presenting cells!

[@chiragsharma4281]

Ok sir

[@samiyantegeka]

Thx so much dia

[@BasicScienceSeries]

Welcome 😊

[@CynthiaUcheoma]

Thank you so much

[@BasicScienceSeries]

You are very kind. Thank you for your comment. Thanks alot !!!

[@sanjanagupta8626]

This video really helped me a lot but please don't use this scribble hand because it's makes it difficult to read sentences... Btw really amazing video thanks a lot please keep it up🙏😇

[@BasicScienceSeries]

Ok thank you

[@onesteptosuccess8560]

Very nice explanation 💯💯💯💯💯

[@carbonfood7269]

Shi kh rhe h guru 🔥

[@carbonfood7269]

Kl h ppr

[@BasicScienceSeries]

Thanks and welcome

[@BasicScienceSeries]

Thank you so much!

[@lifeofcyn808]

Slow down.... Lol. Watched the video 5X. Thank you

[@BasicScienceSeries]

Thanks for your feedback and your comment!

[@kanayanfantv]

Indian talk too fast. Not good.

[@BasicScienceSeries]

@@kanayanfantv Thanks for the feedback!

[@kanayanfantv]

@@BasicScienceSeries Thank you too. I appreciate you being humble to correct errors. I'm not perfect too.

[@BasicScienceSeries]

@@kanayanfantv To Err Is Human! We all are full of flaws, we fall many times before we learn to walk : ) I very much appreciate your comments!

[@tariqhassan7306]

U r too fast....
Otherwise nice.

[@BasicScienceSeries]

Thank you for your feedback, I try various video formats to attract a diverse audience, I hope you'll like other content on the channel, Please check out and post your valuable feedback! Thank you..

[@kebirbenkaccem726]

Too fast for teaching

[@BasicScienceSeries]

Thank you for your valuable feedback!

[@kebirbenkaccem726]

Too fast even for AI robot.

[@BasicScienceSeries]

Thank you for your valuable feedback!

[@umaralishahbaz9521]

U need an improvement

[@BasicScienceSeries]

Thanks for your feedback. Best wishes!