Paxlovid - How Does It Work?
Вставка
- Опубліковано 4 січ 2022
- Paxlovid - How Does It Work?
Pfizer's Paxlovid is made of two products. Ritonavir and PF-07321332 are two components of this drug. PF-07321332 is a protease for viral 3CL-Pro. While Ritonavir helps reduce the metabolism of the proteases to increase the life of this drug.
Buy me a coffee :-) www.buymeacoffee.com/DrMobeen...
Become my patron: www.patreon.com/mobeensyed?fa...
Looking to support my educational work? Donate here: paypal.me/mobeensyed?locale.x...
#drbeen #koolbeens #COVID
URL list from Wednesday, Jan. 5 2022
Paxlovid: what we know about Pfizer’s Covid-19 pill
www.pharmaceutical-technology...
Pfizer’s Novel COVID-19 Oral Antiviral Treatment Candidate Reduced Risk of Hospitalization or Death by 89% in Interim Analysis of Phase 2/3 EPIC-HR Study | Pfizer
www.pfizer.com/news/press-rel...
Ritonavir - Wikipedia
en.wikipedia.org/wiki/Ritonavir
Nirmatrelvir - Wikipedia
en.wikipedia.org/wiki/Nirmatr...
3C-like protease - Wikipedia
en.wikipedia.org/wiki/3C-like...
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis: Trends in Immunology
www.cell.com/trends/immunolog...
Antivirals for COVID-19: five questions that must be answered - The Pharmaceutical Journal
pharmaceutical-journal.com/ar...
Antivirals for COVID-19_ A critical review
cegh.net/article/S2213-3984(2...
Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture - ScienceDirect
www.sciencedirect.com/science...
(PDF) Repurposed Drugs, Molecular Vaccines, Immune-Modulators, and Nanotherapeutics to Treat and Prevent COVID-19 Associated with SARS-CoV-2, a Deadly Nanovector
www.researchgate.net/publicat...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. - Розваги
Loved the drawing! Thank you for explaining it in the way that someone without a medical background can understand. I started my Paxlovid this morning on Day 2 of Covid. I feel much better understanding what’s going on in my body. Thank you again!
Well done, sir. If you aren't or have never been - you should be a Professor...unless you don't want to, of course, lol. Incredible talent. You make extremely complicated easy to understand. Thank you.
I feel like I've been studying a degree in immunology over the last few months. Loving it!
He’s been teaching for many years. Go see his earlier vids.
I just tested positive and was thankful to get this medicine. I like to know how things work and know how complex this process is. This is a perfect video you created to explain it. Thank you for the work you put into this, it was very helpful..
In 2007 I put ritonavir through clinical trials. Who would ever of thought I might need to take it 14 years later.
The Voldemort drug that can’t be mentioned - what has happened to the world?
I always like DrBeen's cartoon illustration
A brilliant explanation as usual Mobeen. Happy New year.
Great explanation Doc. Happy New year everyone.
Absolutely loved this video. I learned so much from this animation. Great refresher about cell physiology too!
This retired MD congratulates you on a superb lecture....please do more!
Great explanation & illustrations! Thank you!
🎉 Congratulations on 500K subscribers 🎉👍👏👏👏
Thank you!
@@DrBeenMedicalLectures Only 500k to go!
Thank you the drawing and your presentation make it easy to follow and understand. 👍
Great topic and presentation!
Oh my goodness! Your “bad” drawing is way better than my good!! Keep doing what you do in the way that you do it!!
Thank you!! Brilliant teacher.
Great explanation. Thanks. As we have THAT drug cheaply and freely available in many parts of the world, we may not need 2nd drug to prolong the activity of THAT drug, we can (and havebeen ) continue it daily bd as long as is needed.
😇
Thank you for such a great video explanation
Very informative thank you for sharing
My gosh I love your drawings!😄
I love your visual. As I was afraid to take Paxlovid. I’m feeling much better about taking it now☺️ thank you!
Fisermectin? Nice but a bit pricey.
🤣
Thank you for your bravery.
Nicely presented.
Great video thanks
The artwork wrestling match is SUPER
Is Ivermectin not also a protease inhibitor? Does it not inhibit 4 different types of protease?
yes but it is very inexpensive ;)
@@musterionsurly lololololololololololololololol, gasp, YES!
Yep, follow the money!
The illustrations are so cute!
Thank you for this explanation. Would love to see you do one on the mechanism of rebound Covid after Paxlivid cessation.
These images are brilliant
🗽We have this 3CL-protease inhibitor (IVM), and it is cheap... when will the political actors understand that ???
.
Excellent Excellent Excellent
Sir simply you are the great..🌹
Thanks
Good discussion, however, we know there are plenty of safe and effective treatments available already that are very CHEAP.
One of them, Ivermectin is also 3CL protease inhibitor.
@@sbossan Shhhh 🤫
isnt ivermectin created for treating parasites
@@sbossan morons…
I paid exactly $0 dollars and $0 cents with $6.09 covered by insurance. Hmmmm sounds affordable to me.
Great explanation. Makes so much sense of something that is so complex. Do they know what the side effects are. Are they different from the BIG I
Thanks!
What about emergency use of drugs that we have data for! One of them was a ensential NOBEL prize winning! Was it for horses???
It is also FDA approved for human use, just not use regarding Covid-19. (Shhh. Called Ivermectin) It is wonderful at decreasing inflammation in blood vessels which was much needed in Delta...my doctor prescribed it, India has it in their Covid kits, Japan has used it for the benefits. Extremely cheap. Dr. Been caught some flake more than a few times for discussing it. YT gets ridiculous because they are so so closed minded and not willing to consider alternative treatments. You know those which US pharmaceutical companies won't financially benefit from...blah, blah...on and on.
@@Mimi4UEyesNotBlue would it be useful for omicron I wonder? Haven’t heard yet have you?
@@lisaleed7615I haven't heard either. Omicron is so short lived. Like a cold, just gargle, take a pain reducer if needed. It's usually over in 72 hours.
Thank you for the informative presentation! I will be starting my 5 day course of Paxlovid tonight. I am not one to take medicine willy-nilly, but after day 5 of feeling dreadful I'm going for it!
@Gus D - I could only take three days of it. The terrible metallic taste in my mouth was too much to bear. So I have two days of it set aside for my next dance with da'Rona. I did feel better though. My covid was the "headache" version and it seemed to knock the headache down to 'bearable' levels. Best of luck to you!
How did you go?
@@jackiestahl7827 were you vaccinated
@@jackiestahl7827 silly
Great presentation & info. Since my second pfizer vaccine negative reactions in my body, I follow your videos, very educative. I wish you could make another video of vaccine injury treatment s in related to blood type, besides the supplements. And also why certain blood type like mine(A-) are severly attacked by the vaccine. It is really weird how my entire body parts & organs reacted. I believe there are more people like me.
I had terrible reaction after my 2nd shoot of phijzer Im also looking forward to alternatives but knowing our goverments they dont care and will mandate vaccines
TT M I don’t know, but it may not have anything to do with your blood type, but more to do with the needle /syringe not being aspirated. Perhaps the drug went into a blood vessel and not muscle as suppose to be. Just a consideration.
@@Grace-Upon-Grace Ya, I learnt that from Dr. John Campell videos. But if two people got it with the same method from the same nurse but different body reaction, raises a question mark. The doctors refusal to give a proper treatment after injury tells there is more into the matter than method of injecting.
I second the comment below--your illustrations make it so clear. But my question is why cant our Proteases block virus 3cl-pro?? and if so why not supercharge our natural Proteases
Fear not Delta & it’s type when your trust the Alpha & Omega.
“Peace I leave with you, my peace I give unto you: not as the world giveth, give I unto you. Let not your heart be troubled, neither let it be afraid.” John 14:27 kjv
Praise Almighty God who created DNA, RNA & our powerful Immune system.
He created ALL Life!
“For thou hast possessed my reins: thou hast covered me in my mother's womb.
14 I will praise thee; for I am fearfully and wonderfully made: marvellous are thy works; and that my soul knoweth right well.
15 My substance was not hid from thee, when I was made in secret, and curiously wrought in the lowest parts of the earth.
16 Thine eyes did see my substance, yet being unperfect; and in thy book all my members were written, which in continuance were fashioned, when as yet there was none of them.
17 How precious also are thy thoughts unto me, O God! how great is the sum of them.”
Psalm 139:13-17 kjv
Amazing drawings. I have a question, I know from testing that i am an ultrarapid metaboliser, particularly 2d6.. i dont think i was tested for 34a (if im remembering name right).. i already have POTS and asthma. Have covid right now and am taking paxlovid but worried that my ultra rapid metabolizer status will make it less helpful for me, and possibly suggest a longer course or more frequent dosing would be advisable, is my thinking logical hére ? Thanks for this amazing video..
So same as IVM?
No, not the same at all. Paxlovid costs 1,000 times more than IVM...😉
Probably no where near as good too lol
No not same at all. Apparently Pfizer drug is very toxic compare ritanovir to ivm side effects 😬😱
Just started Paxlovir.....ty for clear wonderful presentation for general public. It's nice to know exactly what meds are doing as cutaneous t-cell lymphoma long time sufferer I was so glad they okd my request for Paxlovir but was confused when it came as two medications. You should write a laymans cartoon book on this and other subjects. Something kids can understand like this.❤
Covid brain. *Paxlovid
Is the Paxlovid working?
what impact could an acceptance of IVM as treatment of Covid have for FDA to give authorization for emergency use (EUA)for Paxlovid? Criteria for issuing an EUA include:
“• There is no adequate, approved, and available alternative to the product for diagnosing, preventing, or treating the serious or life-threatening disease or condition.”
And could you use both at the same time? Or ivermectin only on when you take the daytime part of the Paxlovid?
I have a question. How many viruses do we know that behaves like Covid-19 and can be ”asymptomatic” but still spread? Thanks for a great channel of inlightment!👍😀
Thanks for ur lucid enlightenment!
20:19
Which drug is that I wonder???
I prefer your paintings in the olld software.
Doctor, For the sake of we who respect you and want to hear you but cannot devote a half hour per day. Could we please get an 'executive summary' at the beginning of each video and those (including myself) who have the time can then get into the details?
Thank you for explaining this! I love your drawings and am now able to think of it as a strategy of attack. It makes sense now!
And when will this be readily available?
And do you have to test to get it.....or will drs let you have it on hand.
But they just sent letters warning Doctors against off label use. Meanwhile over here we are gonna prescribe a drug for off label use. I'm done with humans.
😁
What do you think about the 🐍💉🧬🦠 theory? And how would you treat it knowing that?
Can you compare ivermectin and this product seem to have similar mechanisms
he was threatened by Screwtoob filter police last november for it. It's over on odysee i think
Nice drawings
The problem with Paxlovid is that you can't get it from your doctor. I looked into it and they said that it is only being given out at hospitals for high risk patients. This doesn't make sense as it is supposed to be taken early in Covid to prevent hospitalization. Does anyone know why this is the case and why they aren't offering this to anyone who wants it?
Yeah that's dumb! All I know is that there aren't enough available and apparently it's "hard to produce them" so that's why they're only being offered to high risk patients
Not true. I got mine from my primary physician
I got it from a doctor online visit
What is the implication of inhibiting/destroying the enzyme that destroys the protease inhibitor? It obviously exists for a reason to help/protect the cell.
Given the positive effects shown by the “other” drug without suppressing the enzyme, is it really necessary to mess with the enzyme? Are we causing more issues than needed?
Protease inhibitors we're shown to cause cancer in children tested in the 80s under Dr. Faucis experiment
If you don't inhibit the protease, the antiviral compound gets metabolized and eliminated quicker and it would have less of an effect. Ritonavir is specifically used for that when treating HIV, giving the active compounds more time to react.
You could technically use just the second drug, but you'd have to get a higher dose in order to achieve the same effect and that can lead to worse side effects
Does this medication potentiate the Gaba receptors and increases Gaba activity like Ivermectin does or is it safe to take with other meds that can cause respiratory depression like Benzodiazepines? I can't take Ivermectin due to it's interaction with my benzo (no judgement please...doc never told me how awful these meds are). I want to know if this will be safe for me to take if I come down with the virus. Do you mind doing a video on its side effects and interactions and contraindications?
I didn't know IVM was contraindicated when you take benzos...thanks for sharing and no judgement from me. I take one as needed for some issues too.
@@milenalm5288 thank you! You are lucky to only have to take one when needed. I take a low dose daily and have been for 23 years. I have actually been harmed by it, no doubt by now. have tried to get off and failed. The suffering can be inhumane. Why I have a hard time trusting doctors and Big Pharma. And after these past 2 years, I have lost all trust. I have to do lots of research before putting anything into my body. So that's when I saw an article about Benzos with Ivermectin then Dr. Mobeen said so in one of his previous videos. I think you'd be okay taking Ivermectin tho if you didn't take the benzo at the same time. I can't go 5 days without mine as it puts me in some serious withdrawals. Blessings to you!
You should mind the ritonavir:
Ritonavir is an FDA-approved drug that has been used for more than 2 decades as a pharmacologic boosting agent for certain anti-HIV medications; therefore, there is a large body of literature describing its use with other drugs and its potential for serious and sometimes life-threatening drug-drug interactions.
Waaaay to confusing with no reference to the infamous remdisiVIR. DO YOU RECOMEND PROVAXIL????
Can you get a vet to talk about how ivemetrin works on animals!
Dr Geert Vanden Bossche from Belgium
Great talk. In the “Mattrix” they asked if you wanted to take the red or blue pill. Correct answer is BOTH!
PS Day 2 of Paxlovid.
@@chrishvs how are you so far? Any rebound? I am on day 2 and on the fence about continuing
Do protease enzymes work like inhibitors? I understand that they breakdown proteins but can’t decipher if they inhibit or enhance a virus or do nothing.
@@dougpenhall thank you. I am trying to understand how the protease enzymes that I take in supplement form fit in. If they act as inhibitors or play no
Role at all.
There is information that covid come back soon after finish Paxlovid. What to do to
prevent that?
Supposedly less than 2% of cases rebound but it also happens in unvaccinated.
If anyone that definitely understands could reply to my comment I'd appreciate it ,, am I to understand that vitamin I and the d3 k2 C zinc quecertin melatonin flccc deal is still good for omicron , in OZZI it's still 3 out of 4 delta but omicron is rapidly rising , I'm unvacced and had close shaves with son in law getting delta and two other daughters boyfriends having I assume delta ,but it's getting close to me now
Also green tea. Look into health benefits of mushrooms. I recall some had protease inhibiting effect. Be well down there. 🥰
We took all the supps for 2 years and still got omicron and took hydroxycloroquine as soon as we knew we were exposed/getting sick. Still took us a week to get over it but no big issues. Mostly fever and sinus issues. I wish we had gotten some ivermectin as I couldn’t really know for sure the hydroxycloroquine was doing anything. Omicron is supposedly just a “ cold” but we had fever for days. Also we are unvaxxed.
@@dianasimplifies it's possible that you had delta.
@@milenalm5288 my nurse sister gave it to us and she verified her test said omicron. She gave it to our entire family on Christmas. Several of us had fever, body chills etc.
So 3CL protease inhibitors like Paxlovid and Ivermectin work. Great. So let‘s buy the one that costs 100 times more 😅
Also buy the one with unknown long term safety data instead of 40 years safety history.
Not necessarily. Let's hope, one doesn't need any of them🤔
Maybe working better with Panax ginseng?
They don’t have the same mechanism of action and paxlovid is targeted whereas ivermectin has broad range of “off target effects” unlike this new pill
Paxlovid is working and only 6buks I just got the first dose with a severe covid infection. I’ve tried (human) ivermectin it made my stomach hurts like hell…
You look tired. Thanks for bringing us the facts
Mine was free, paid by the gov't
In Russia, currently, several drugs should be distinguished that can be used in the treatment of COVID-19: favipiravir, molnupiravir, remdesivir, synthetic small interfering ribonucleic acid (siRNA) [double-stranded], umifenovir and interferon-alpha. Paxlovir not recommended, but may be recommended as ""off label" nirmatrelvir + ritonovir (it's our latest melodic recommendations by 27.12.2021). But before they have published I know that in severe covid often use Actemra. Not only it, but really often. And always Decametazone in hospital, that not good I thought, but write to prevent cito kine storm. Very interesting what is in your countries!!!! What is your experience?
It is beyond my American attention span to totally grasp/ memorize this wealth of information, but I feel like I'm doing "something" rather than nothing.. about the education this plandemic will provide.. thank you for your gentle approach..
Why Paxlovid should be taken only for 5 days? What if the virus starts to replicate after the 5 days period when I stopped taking Paxlovid?
Somebody please reply, i am a Covid patient and i am taking Paxlovid at home.
Should i continue taking it for another week or so?
How long you take for im on day 3
Did you have any rebound?
I wonder is the Paxlovid does anything for Omicron... Since it was designed for the old virus...
The good thing about protease inhibitors is that they target an enzyme in cytoplasm rather than the spike protein on the surface of the virus. Therefore is doesn't matter how many mutations the S-protein has (in other words, which variant of the virus we're dealing with) - the 3CL-protease will be the same in all of those variants. That's because any significant mutations to the protease gene would likely cause the enzyme to no longer function. Therefore the drug should affect the enzyme, no matter which virus variant.
For me, the main concern is what would happen if paxlovid ends up inhibiting human proteases (e.g. our own chymotrypsin) in addition to the viral ones. Nobody has answered that question for me yet.
Does Paxlovid reduce the symptoms or length of covid illness in Pfizer vaccinated people?
Practicing Dentist and great job making this easy for those without our science background to comprehend..the medication is very effacatious
Anyone have a bad experience with the paxlovid?
Could have made it a lot shorter. Other wise a good video.
Don't Look In.
🗽 WHO tells the virus to replicate ??? Waht is the driving force? For me that looks like a miracle.
Dr. Mobeen, please explain.
.
The virus just abuses the way our cells are programmed: The cell's ribosomes essentially "have to" translate any and each strand of m-RNA that they encounter. If they see a messenger that encodes a protein, the ribosomes will produce that protein.
Normally, an uninfected cell will regulate which proteins should be synthetized, so that not all cells produce all possible proteins: This is done inside the cell's nucleus by determining which genes get transcribed from DNA into m-RNA. Once that m-RNA leaves the nucleus and passes into the cytoplasm, it's up for grabs by any ribosome.
And because the virus injects its own m-RNA directly into the cytoplasm, a ribosome will just grab it and translate it, because that's the only thing the ribosome can do. Once the protein (specifically, the pp1a or pp1b polyproteins, as shown in Dr. Been's video) has been synthesised, that's where the 3-CL protease comes in and cleaves it into the smaller, functional proteins that will eventually from themselves into new viral particles.
@@slavecek Thank you, it is really astonishing, how the cell produces the complete virus. It is not only a protein, it's a whole structure! And I cannot imagine what is a ribosome, what is the molecular structure of this biliogical machine. Who builds it? Who builds the machine which builds everything in the cell ??
Dr. Been, can you include a drawing of a one armed midget chick wearing a teddy in at least one of your illustrations?
Will do!
May 💜God 💚Be 💛With 💙You Always ❤Much 💚Love 💙Blessings 💚Always ✌ 💯 🌈 🎇 🌐 💜💜💜💚💚💚💛💛💛💛💛💛
Drug contradictions- inhibitor of cytochrome cyp3a
How it Works? Mostly with a lot of Profit
LOL
Panax ginseng
plus ivermectin?
Why does it taste so bad? I qualified for it but the taste made me so sick I couldn’t get past the first dosage. I was dry heaving trying to throw up. 🤢🤮
@Michelleisabel - that was your imagination ramping up. It tastes bad but it works well.
I’ll stick to loofymectin
Apparently it doesn’t work…
@songmom8 - why are you lying? It works well.
This does not work. Remdesivir doesnt work either. For the price you pay, I would consider both treatments pure scam.
@hectormadobar - you're lying. It does work and it works well.
@@teressastuckey if you think need two vaccine doses, four boosters and an oral antiviral to get rid of a respiratory virus...this means you are the perfect victim for scamd and frauds..
@@teressastuckey If you think you need two vaccine doses, four boosters , a n N95 mask and an oral antiviral to contain a respiratory virus, this makes you the perfect victim for a scam. But glad you defeated the virus then. It will come back , because its a seasonal virus like flu and the common cold.
@@teressastuckey There are no oral antivirals for the common cold and no oral antivirals for the flu. But this people make you pay 500 bucks for something that has a huge percentage of rebound.