The Cerebellum

An introduction to the cerebellum and an overview of the main models of cerebellar function.

[@jpark7636]

This guy just went through all of my week7 lectures in 10 min. Well actually 6mins bc last my uni did not cover last 4 mins

[@xiaoxiaoxiao686]

This is the field I want to study. I was thinking about going for neurology or studying electrical engineering. This is a wonderfully tasting cocktail of the two!

[@RoadkillbunnyUK]

This was so useful, I have just had changes to my cerebellum found in MRI and this has helped me understand how those problems link into my physical symptoms.

[@ammerrstf838]

A 2nd yr med student from Karolinska Institute thanks you

[@rnbbexyjlobt]

Great video! I love your clear drawings and concise narration.
Can I suggest you leave the each drawing up in silence for like 1 additional second before transitioning, so we have more time to process what you just said?
In addition, if you ever feel like upping your production quality, you might want to look into transitions between drawings to put the each drawing into context with the next (moving to a different part of the brain and in which direction vs zooming out/in, etc). The conclusions are great and have the same effect, but then we are a bit confused for longer until it is put into perspective at the end of the section.
Great work though, keep it up! :)

[@Nordic_Scandinavia]

Spot on!

[@thedeadman8361]

Great channel! Has really helped me revise for my Biological Psychology exam

[@ayeshaabbasi4220]

This the best i could find so far.Really helpful.great job ✅ done

[@Saphira6666]

Thank you so much, what a nice relaxing voice and amazing tutoring ty

[@supertramp6833]

EXCELLENT AND BETTER THEN ALL THE TEXTBOOKS ! THANK YOU

[@cupofkoa]

Excellent videos! Looking forward to the next one!

[@prajuxo_1405]

This topic was so confusing before. Thanks to this video. Explained very well. 😌👍

[@XwitterEye]

Why was this such a fantastic explanation?

[@jphb95]

comprehensive and brilliant review. Thanks!!

[@ladymusiclover]

BEST VIDEO ON THIS!! THANK YOU!!

[@joeyransdell133]

Nice video! I do take issue with the notion that parallel fibers excitatory input is what is responsible for Purkinje neuron firing. This is not true. In the absence of synaptic drive Purkinje neurons continue to fire repetitively and at high rates. Instead, it seems parallel fiber input modulate Purkinje neuron firing rates and may also modulate the degree of synchrony across adjacent Purkinje neurons which has implications for the pauses in firing in DCN neurons caused by Purkinje neuron inhibition. The capacity of Purkinje neurons to fire in the absence of synaptic drive was well-understood even in the 1960's

[@walidaouiz9608]

thx

[@cherry-ks9yb]

Saving me before my exam 🙏🙏🙏

[@robinhoman8594]

Beautiful video. Im excited to see if you will make a similar video discussing output of the vestibular system.

[@Brainisnotacomputer]

Excellent concise lecture!

[@maxcuzak2805]

thanks for making such a great video 😀

[@chinyamakazombo192]

A really splendid explanation. Thank you very much. On 5:12 , how does the body know that it has made a motor error?

[@hamzaafridihuzaifa9115]

this is the best channel and deserves a sub :)............... you earned a subscribe

[@oscarsolaresdelaguila8711]

Thank you so much, clarified it very well.

[@rsharma449]

please add more videos explaning other portions of CNS...very useful.!!!!!!

[@jeyananthannavaratnam7055]

Very speedy explanation

[@niemand7938]

this is such a good video, thank you!

[@bonnieprobably]

Thank you! 🙏🏽

[@KellenVu]

amazing video !!

[@monilvalia9425]

thankyou saviour

[@pavarinodu]

OMG! Thanks for explaining this subject! Medical students praise you haha

[@Lola_Wilson64738]

thanks very much very helpful

[@kshitijb.3682]

Thank you !

[@charlotte9777]

this video is the best!!

[@dr.jageth9306]

Its just awesome dude🔥

[@omnesomnibus2845]

Fantastic!

[@NguyenTastic]

very interesting, thank you

[@AliceInGymLand]

Hi, such a helpful video! One question - if the purkinjie cells are the only output from the cortex to the deep nuclei, what does the direct input from the mossy fibre to the nuclei do?

[@BrainsExplained]

That's a great question!
The mossy fibres provide excitatory input to deep cerebellar nuclei, this connection has been much less studied that the purkinje cell synapse, but there is some evidence that synaptic plasticity (LTD) at the mossy fibre - deep nuclei synapse is also involved in motor learning.
As I mentioned in the previous comment, after the inhibition of the deep nuclei by the purkinje cells, there is rebound excitation where the cells of the deep nuclei increasing their firing rate
In order for the synaptic plasticity to take place at the mossy fibre - deep nuclei synapse, the mossy fibres have to stimulate the deep nuclei at the same time as this rebound excitation.
To sum up: If the mossy fibres excite the deep nuclei, just after they have been inhibited by the purkinje cells, synaptic plasticity occurs in the deep nuclei, which also stores information necessary for motor learning.

[@AliceInGymLand]

Ahh right, thanks for the explanation! Your videos have saved a couple of 3rd year undergrads' lives btw!

[@ivakamie3568]

amazing..

[@dr.ranjusreemandal2512]

thankuuù so so much🙏 life saving video

[@rgudduu]

Need revisits to understand

[@vsavchik]

Maybe if mention spinocerebellum, cerebrocerebellum and vestibulocerebellum and consider their circuits separately, it would be more simple to explain what happens, in contrast to attempt to explain combined circuit. You will surprisingly find that all parts have the same climbing input - from IO, i.e. from muscle proprioception, but mossy fibers go from layers of execution cortex hierarchy.
Btw, one serious mistake - thalamus does not project to spinal cord.

[@giorgosgranitsiotis]

thank you so much sir

[@giorgosgranitsiotis]

and im not indian

[@sharedivinelove]

Very precise and well explained.

[@ONE_ONENESS]

_BE BLESSED WITH A BENEVOLENT CEREBELLUM.

[@thatzinged9305]

Good one

[@krautbonbon]

life saver

[@danielschefte2987]

Thank you for this video, really high quality in this one. I do have a question tho: What does stimulation of purkinje cells when fine tuning a movement actually lead to? Because it is an inhibitory neuron it should lead to less activity of the deep cerebellar nuclei which leads to less motor activity? How does this make sense?

[@BrainsExplained]

Thanks! and well noticed, If things were just as simple as shown in the video you would be right, however this doesn't happen because of something I did not have time include known as "rebound excitation".
Essentially when the deep cerebellar nuclei are inhibited by Purkinje cells, after the initial inhibition they can actually show an increase in firing rate, which is known as rebound excitation. This isn't fully understood but it's thought that the inhibition probably activates specific calcium channels which allows positive charge to flow into the deep cerebellar neurones, allowing them to depolarise.

[@danielschefte2987]

Thank you so much! I've watched all your videos and it has really helped me alot. You deserve so many more subscribers :)

[@vsavchik]

In case of most clear spinocerebellum dcn just inhibits red nucleus (the only input to motoneurons, except motocortex) and hence stops cortex command to motoneurons, therefore cerebellum as a whole weakens irrelevant activity or stops irrelevant automatic movements.
More interesting that red nucleus projects to flexors while vestibular nucleus and reticular nuclei to extensors. It means that cerebellum makes proper balance between flexors and extensors/

[@freckletonj]

At ua-cam.com/video/QUkwqAaSrUg/v-deo.html, doesn't motor cortex project directly down the spine (and never the thalamus)? I assume it's a typo. (amazing amazing videos btw, thank you)

[@walidaouiz9608]

ua-cam.com/video/zKA8iaxfEww/v-deo.html
just watch this and you'll get it , it is more complex

[@walidaouiz9608]

yes you are right

[@queennix8947]

Here to learn what's happening to my partner who has cerebellum ataxia

[@Jasim_Basheer]

Woah bro I got mind fucked

[@nadagamal5615]

subhanallah .. thank you for this illustartion

[@mmse6251]

nice video, but you are talking way too fast..

[@SumitSharma-cs3gu]

Sexy content... Keep it up

[@Hudamk99]

You are so fast,

[@marwa5834]

this is soo fast

[@walidaouiz9608]

this video does not explain well the function of cerebullum , go to ninja nerd science video of cerebeullum if you want to get it

[@pamelaramona3925]

please create a better video where you speak slow and coherently. I just cant catch up to the speed. Thanks!

[@soumyasami]

reduce the speed to .75x

[@SilvaMorasten]

PLEEAAASE can you pronounce Purkinje cells as PURKINIE instead of PURKINJEE!!!! your video is excellent and it is very helpful for me, but the pronunciation of the czech name is really disturbing

[@swetasinha9493]

It is purkinjee as written in all the books I studied so far

[@anandsingh4071]

Too fast man