TWiV 1134: Clinical update with Dr. Daniel Griffin
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- Опубліковано 7 вер 2024
- In his weekly clinical update, Dr. Griffin discusses Merck’s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.
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I’m Vincent Racaniello, Earth’s Virology Professor, and I believe that education should be free.
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#microbe #viruses #coronavirus #pandemic
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_UA-cam timestamps by Les_
00:35 Bow Tie There is fungus among us
01:50 Quotation (T Edison)
02:42 *RSV*
monoclonal ab
04:13 *CoViD update*
Insights from an N3C RECOVER EHR-based cohort study characterizing
SARS-CoV-2 reinfections and Long COVID
12:35 Testing
Cost-effectiveness of COVID rapid diagnostic tests for patients with
severe/critical illness in low- and middle-income countries:
A modeling study
journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004429
15:56 Durability of protection against COVID-19 Through
the Delta Surge for the NVX-CoV2373 Vaccine
academic.oup.com/cid/article/79/1/78/7610213
18:41 Combined Protection of vaccination and Nirmatrelvir-Ritonavir Against
Hospitalization in Adults With COVID-19
academic.oup.com/cid/article/79/1/108/7614681
21:51 *Early Phase*
22:24 Week 2
22:54 Long CoViD
Tracking cognitive trajectories in older survivors of COVID-19
up to 2.5 years post-infection
www.nature.com/articles/s43587-024-00667-3
26:15 How to donate
26:39 *Dr D answers your Qs*
see microbe.tv/twiv/twiv-1134-letters
26:47 David
28:19 Tony
30:14 Janet
33:13 Jay
_Audio podcast timestamps by Jolene_
Thank you, gents! I look forward to this every week.
I'm thinking some contributors to the summer increase in covid cases could be:
- the prior fall's vaccination has waned (or the protection one gets from a winter infection has waned) by late July/August.
- Folks move indoors to be in the air conditioning
- Vacation travel (planes/cruises)
- It's summer music festival season featuring audiences crammed together cheering/singing. Even if the shows are outside, people are still packed shoulder to shoulder;
- Anecdotally, I know of several folks who got sick after attending one of Taylor Swift's tour dates.
- Couple all these activities with the new highly-transmissie FLiRT/FLuQE variants that seem to be good at evading prior immunity, and you've got a recipe for a summer wave.
(I'm just spitballing here.)
Anyway, Dr. Griffin, I hope your race was fabulous!
Thanks for the time stamps
Love you Daniel- that's where good ppe management pays off!!!!!
It’s definitely vacation and travel. Almost everyone I know that’s had COVID recently has flown.
Agreed. Pretty much all of my friends who've traveled had at least one family member who came back with covid. (Anecdotally, my friend's daughter always wears a mask and she's the only one in the family who didn't get it.)
I'll never not mask on a plane. Pre-Covid, I knew I'd always get sick when I took a plane trip. Post-Covid, I'm still NoVid (unless asymptomatic and had no reason to test). 4x vax'd.
Not preventing reinfections will be a deal breaker with long term health. It's not a cold you can try and treat it the same but, it will be a disappointment all the same. Deaths have been consistent since the beginning.
Given that COVID 19 has responded to behaviour (lockdowns, working from home, avoiding travel, masking, etc.) more than to seasonality in the past, is this growth rate not simply down to the fact that almost everyone has now abandoned every precaution because most people believe "the pandemic is over" and life should go back to normal?
It's crazy COVID is not over
Yes. I'm reminded of Peter Gabriel's song: We do as we're told (repeat). I persist in ignoring advice to not mask, to behave as if covid is behind us. It's lunacy, and I'm not doing it.
@@Starclimber I still mask inside in all public spaces. People who come into my tiny apartment are asked to mask. I keep N95s on hand for guests and people who come to do maintenance in case they don't have one. It just seems sensible to me.
People are Traveling without Mask on planes. I believe the plane ride is the issue. There was some studies that short flight is less at risk verse long flights.
In 2024, US airlines are expected to carry a record 271 million passengers worldwide from June 1 to August 31, which is a 6.3% increase from the previous summer.
I know airplanes have the air filters but they have gone back to their old practices. 1. They don't run the air conditioning (filters) while people are boarding/deplaning which is the most vulnerable time where people are stressed breathing trying to get situated. 2. The planes are packed with maybe ~ 5% wearing masks. (8/175 passengers). Overall people are trying to return to Normal so they are gathering more often. Co-worker w went to church function (20/100) caught COVID. This is anecdotal but we know length of exposure time can increase your chances of getting COVID. Events and plane trips lock people near them for extended periods of time.
Yes, people are no longer masking on planes, on public transport, in movie theatres... etc..
The plane ride is the same as any situation where you are in enclosed spaces with spreaders. In fact ventilation on the plane is better than in many other situations but it can’t overcome the risk if you’re sitting in proximity with sneezing, coughing Inconsiderates or next to someone who is incubating infection and talking etc. Treat all of these situations like defensive driving. Wear an N95 or equivalent from the moment you start to line up or sooner.
I read your whole comment and agree with you. But add the airport and the taxi ride too, right now that we’re in a summer surge
Thank you Daniel ❤
"There's chlamydia. There's spores." That cracked me up. Happy sailing.
Thanks so much for continuing to give these updates. It is very much appreciated.
Many places experiencing heatwaves over last month. More people staying indoors in AC systems running non stop. Contributing factor to spike in cases?
I would suspect so, especially if the AC systems are not serviced regularly by a competent person and installed correctly. HEPA filters can help to reduce viral load, sadly good indoor air quality doesn't seem to be a priority in many settings.
I also wonder about these air tight energy efficient biuldings and ac.
thanks Daniel and Vincent
That's great 👍 . Thank you 🙏 very much
Thank you & good luck with race.
Thanks!
My son in Maryland just had Covid. He is in his 30’s, no underlying health issues and had three vaccinations in the past. He thinks he had Covid at least once before.
Fortunately he had a mild case and is back to normal.
@@karenkaren3189 Glad to hear he's well. Paul Offit's been saying for a long time that three shots + prior infection + good health = good prognosis.
@@Logotic that's crazy how does he know that. They have no idea how this virus and pandemic will play out or what it's capable of. It's not a cold or flu. Don't put your faith in these people
Can the increase in long Covid with more recent Omicron variants be explained from fewer and fewer people getting the booster? The veteran study suggests that a recent booster reduces the risk of long Covid by around 50%.
Could the hot weather have contributed to an increase in COVID ? More people are inside taking advantage of air conditioning.
@@jonnash5196 more variants spreading and people living like no one is at risk. Bad things are coming
Increase in the UK and everyone's outdoors 😢
I've gotten too lazy to wear a mask anymore .
@@jonnash5196 Seriously?! It's that difficult for you? 5 seconds of effort to pull one out and stretch those elastic straps around your noggin?! OK, you got me. Thought you were serious.
Your right I should . I know several people in different states who just caught COVID . An ounce of prevention is worth a kind of cure .
The summer peak happens because we aren't vaccinating often enough and because we aren't updating vaccines often enough.
8:35 some buried good news on reinfection from the paper: while reinfection was 6.9%, almost nobody had more than one reinfection until now, so maybe that's significant
@@Rene-uz3eb that's crazy some our on their 4 and 5th infection most likely LC at that point. There are over 30 million people with LC
There is no real reason for covid to be seasonal or go away. Reasons for this are numerous. First of all, it's incredibly infectious, possibly one of the 1 or 2 most infectious diseases of all time. So it has absolutely no problem spreading in the summer, as any air sharing is enough. Secondly, it replicates very quickly, so immune memory isn't enough to stop it before symptoms and damage start - only antibodies to the same strain are enough, and those last a few months - much less than a year. If people behave as they did before the pandemic, it is guaranteed that you will get infected 2-3 times per year, every year, until you finally lose the russian roulette of long covid or death.
@Simon-fg8iz false information about antibodies mine are sky high 2 years later and yes you can catch it 2 or more times but everyone is different we can't live our lives scared of covid the country wouldn't survive financially
Well, yes, it is 100% guaranteed that we will all lose the race against death. But the odds of that being due to covid were never objectively high on a percentage basis and have been falling ever since the first omicron wave, even though most of us have long since been behaving as we did before the pandemic.
@@Logotic More people died from Omicron than from the previous variants, because it infected more people.
More people are being infected, being hospitalized and dying now compared with the same time last year.
This pandemic is far from over.
@@christopherrobinson7541Well, we certainly don't have much rigorous data about infections or hospitalizations lately, but there's a link in the show notes to CDC numbers showing that the death rate right now is two-thirds what it was in 2023 and under 20% of what it was in 2022. We're moving in the right direction.
@@LogoticI don't know if we're totally moving in the right direction.. sometimes there are things worse than death.
Start reading the latest papers out there on multiple infections with Covid - vascular disorders, long covid, loss of IQ, etc.
What will this world look like in 20 years? 😢
Then look at Puerto Rico .. why are >8% dying of Covid right now? 😮
Relative or absolute efficacy?
Good , relevant update, thx,
My wife and daughter got covid. My wifes fever went away 3 days before meeting up with family for a vacation. My daughter stopped having a fever 1 day before we went. My grandma got sick 2 days after we got there, but no one else got sick until 3 days after and 6 days after. My grandma was always the firthest away from us at the house. Why did no one else get sick first that held and kissed my daughter, but my grandma did? Does it make more sense that my grandma got covid from someone else when we were out on the boardwalk or that she got it from my daughter first because she's more vulnerable?
There was a placebo given to newborn infants?? What??😮
💜💜💜
Have either one of you listened to Dr. Phillip Macmillan from Vejon health explain his STORM theory about why COVID cases are increasing right now? You are saying you are mystified. He has predicted exactly this quite a while earlier, for very specific reasons.
@ Daniel Griffin, I have a friend and my godmother who has caught Covid. She’s 82 my friend 64! has kidney disease. They went to the doctors and they will not prescribe paxlovid they said people are committing suicide on it and I told her I would check to see if there’s any studies out there ! I was wondering if you could help. I’m very concerned for them. I’ve taken Paxlovid twice it twice and it’s a great help.
'Twill be interesting to see how many snide remarks I get from posting this along with a pic of the chart about outcomes of subsequent infections...
So I’m charging and challenging the argument not the person how could Covid be “annoying” when you talking about increase severity with increased reinfection
I'm getting boosted again today with the current Spikevax. Is it ok to get vaxed again in 2 months with the new vaccine?
July 25th was the hottest day ever recorded. I suggest that because of the heat arriving sooner this summer than in years past, the Covid increase makes sense as people crowed indoors to stay cool.
Dr. Griffin is looking quite pale. Hope he is doing well.
Maybe can decrease risk of blood spread of liposomes with mRNA If after lent strict intramuscular injection, injected muscle are not used some hours after ?
I see there was the study you were going over about reduced hazard ratio for number of shots of vaccine and then also for using Paxil Covid.
Are those reductions relative or absolute reductions? I would like to see the same chart with absolute reduction percentages.
Maybe some crossreact IgM antibody occur after reinfections,and act like cryoglobuline ?
If cryoglobuline level increase, must avoid to decrease lung temperature by using low temperature oxigen mix.
12:36
Gentlemen, why don’t you talk about what is happening to the doctors, hospitals, care givers in Gaza, and spread of different diseases, including Cholera, Polio, Measles, and more? Even Israel is vaccinating their soldiers.
Are you afraid of the power of Israeli Lobby AIPAK at Colombia University?
Quit scaring people
@actyrrel the variants now are not worse than in the beginning look at the views on this video no one is watching or talking about it anymore yes covid is here to stay but getting a shot every 6 months is more dangerous than covid at this point and I had covid that gave me bloodclots in my lungs in 2020 and my antibodies are still sky high I'm unvaccinated I will never take that shot but I just happened to see this video scrolling it has some good information but saying you might die from covid now is possible but very rare
@@shawnlennen7871 Only those at risk, including those 75+ are offered vaccines every 6 months and for those 65+ every 6 months. This is because as we age our immune response becomes less robust than it was when we were young. For those under 65 who have had 3 doses of vaccine further vaccinations are probably not required.
@@shawnlennen7871 👈 TROLL
Where can I buy these cute twiv mugs ?
www.cafepress.com/shop/twiv
then select "drinkware"
Thanks so much for continuing to give these updates. It is very much appreciated.