Thomas Seyfried, PhD -- Cancer as a Mitochondrial Metabolic Disease
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- Опубліковано 14 лип 2016
- Thomas Seyfried, PhD
Professor of Biology
Department of Biology, Boston College
Thomas N. Seyfried is Professor of Biology at Boston College. He received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He did his undergraduate work at the University of New England where he recently received the distinguished Alumni Achievement Award. He also holds a Master’s degree in genetics from Illinois State University, Normal, IL. Thomas Seyfried served with distinction in the United States Army’s First Cavalry Division during the Vietnam War, and received numerous medals and commendations. He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine, and then served on the faculty as an Assistant Professor in Neurology. Other awards and honors have come from such diverse organizations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, and the Ketogenic Diet Special Interest Group of the American Epilepsy Society. Dr. Seyfried previously served as Chair, Scientific Advisory Committee for the National Tay-Sachs and Allied Diseases Association and presently serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, the Journal of Lipid Research, and ASN Neuro. Dr. Seyfried has over 170 peer-reviewed publications and is author of the book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley Press). His full list of peer-reviewed publications can be found on PubMed (www.ncbi.nlm.nih.gov/pubmed). The link to his professional web page follows (www.bc.edu/schools/cas/biology....
Give this guy a Nobel Prize!
I love Seyfried if nothing else than speaking his mind. Hard to find genuine people these days.
God bless all those dealing with a cancer diagnosis. I have been keto for 23 years since diagnosed with type 2 diabetes. In preparation for any future cancer, I am now going to seek out cancer doctors who understand this and may use it if any exist.
Thank you, Professor Seyfried! What an enlightening lecture!
Professor Seyfried, you are an amazing person. Thank you for all you do!!
Best I ever heard, you are an Angel, this is what make some Americans the elite in humanity
I pray you get more and more funding this is so important, big Pharma is sure not going to help you but hopefully private organizations will.
Why so few people know about this? Most doctors tell it's a genetic disease. First time seeing someone explaining it as a completely different condition then what others thought of. Nice video!!
I thank God for Dr Thomas Seyfried, and all the associated researchers involved in this revolutionary approach to cancer therapy and management.
Wow, thanks so much for putting this lecture on internet!
The best thing you can do is knock refined sugar out of your diet. Completely.
And resistant starch and add more fibre
@@worm5175 evidence is pointing towards high Polyunsaturated fats being worse than these, and a major player in obesity, diabetes, cancer, and many more diseases, from the detrimental effects on mitochondrial structure and function, causing energy dysregulation.
Something to keep an eye on for sure. More research is needed, but I'm convinced by the data so far.
Thank you for your studies Thomas.
This really puts a lot of pieces together for me, and I'm sure I am not alone. Thanks for posting and thanks to the Dr. for giving this talk - really outstanding.
I read his book. A lot of biochemistry but the takeaway is #ImpairedRespiration and #Fermentation instead of #OxidativePhosphorylation
What a great lecture. Thanks for uploading.
sure wish I could get a copy of the slides for this lecture, fantastic work by Dr. Seyfried, as usual!!
Here it is, enjoy =) dose-response.org/wp-content/uploads/2015/05/Seyfried.pdf
Great lecture, excellent process. Detractors can poke holes in anything, especially sitting in front of their PCs in their underwear while those fighting the fight put their work on the line. Is Seyfried's work the end all? Probably not, but at least he's out there cutting a new path with structured and repeatable methodologies while others keep beating the proverbial dead horse. If you think you can do better, go get your PhD and government grants and get to work.
Very nice presentation. Please next time get the venue to provide you with a lapel microphone or something similar. It was hard to hear because you were turning away from the microphone so much.
Incredible, magnificent, Gratitude Thomas Seyfried, Success always
Very useful information - many thanks be successful.
Very useful information - many thanks
You can do Wim Hof breathing excercises as an effective stand in for hyperbaric o2.
Same Dogma surrounding cholesterol. The only hope is that scientists with integrity like Thomas Seyfried continue to pursue the truth in science so that individuals who care about knowing themselves, can help themselves instead of relying on the medical industry to serve up some medication and costly care.
You apparently have no idea how much "alternative' cancer treatments cost. Cash, up front. You're thinking all those naturopaths, chiropractors and rogue allopaths are NOT making huge amounts of money? Bahahahahahahahahaha
Big pharma: how will we make our billions with a diet?
Could Diazoxide effect on mitochondria prevent cancer? Excellent lecture
Thank you Professor 👏🏻👏🏻👏🏻👏🏻
The reason why is because they are making money hand over fist! As soon as they can figure out how to make money from the true cure and they will not be held liable for all the deaths that they have caused, they will jump on board. I think that means when he’ll freezes over! My sister has angiosarcoma stage 4😔
Fasting down-regulates anabolic mTOR and up-regulates catabolic AMPK that activates autophagia....do mitochondrial damaged cancer cells, like other junk proteins and damaged organelles get recycled when in AMPK (fasting mode)?
It's very relevant to me. My mom had breast cancer (52 yrs after starting an active lifestyle - from sedentary) and actually died of brain glioblastoma (60). I had breast cancer (45 yrs, after I started to train for a 1/2 marathon). No "genetic" link. You keep speaking about cell respiratory affect on cell, but I'm not sure I get it. After Bx I needed up with lung MAC. I was told by Dr's that they don't know why I got MAC. Both of us had and no "risk" factors and not genetic. WTF is going on? Would love to understand what you are proposing.
Jannell G My oncologist, Vincent Ortolano's prostate cancer prognosis of last September of 6 weeks seems to have been affected by the several water fasts I have done since. July 10th and fasting once more and infinitely less dead than Vinnie imagined.
Age itself is a risk factor in cancer.
Metabolic management is a starting point but light can do a lot more for both glucose and glutamate control within a cell because of EZ water and sunlight.
Let say that this theory is viabal, then there is the main question - what is the rison of metabolic mistake of mitochondria (why fermentation )? If we know the answer we know how to cure. I have not found one.
Ultimately the causes are spiritual, emotional, energetic.
Others have said its lack of oxygen that causes the switch. Not a complete answer I know but you're asking the right question. Dont stop with that line of inquiry!
Damage to the mitochondria. Probably the same factors that damage the nucleus, toxins, age, radiation, etc
Call these cell self-degradation or cell regression rather than cell mutations.
The embryo development have selective propriety for the blasto cells. Mytochondria and cel metabolism have linked feedback. The problem may be is not conspiration theory, but more than one or two evidences. If you remove a mytochondria of a cel, is probable that new one replace it, hierarchy. Some proteines used for mytochondria is from traduction of nucleous gens.
If you have any alteration on mytochondial metabolism, then you can induce the result on experiment that you trasnsplant a mytochondria on normal cell. But the gen of mytochondia have so many less gens to fail on a replication. To the basics, mathematics.
Of course, any alteration on cell organel can be otrential oncogenic factor on cel metabolism, if cells grow factors have any issue, especialy.
Oncogenic cells have havy needs of energy.
Pharma is happy to look at the figure that is going up.
Imagine your mitochondria get filled with bubble gum , slowed way down. Cleaning the bubble gum out is required. Not just external ph manipulation
Summarizing where he goes wrong I think I’m still on the same page:
23:00 the cells don’t go to a ‘more primitive state’ when they run out of oxygen. Hypoxia is a controlled state just like any other state human cells have seen before in evolution, and hypoxia or Ros is certainly nothing new, rather it is extremely common in old people. Sure you get a different phenotype, but you are just as wrong as the genetic people because you assume it’s not controlled by the body.
He recognizes that the phenotype is an indirect result of mitochondrial energy bottlenecks, which obviously points to one should address what causes the energy deficit, NOT try to further put the freaking cells into even more energy reduced state by cutting off glucose (cancer still uses energy from the mitochondria so that’s futile from the start anyway)
Ok so I think the metabolic solution ( no pun intended ) is hydrogen. It reacts with ROS in the mitochondria producing energy and water . Hopefully revitalizing and detoxifying. Hydrogen is the metabolic solution
❤❤❤❤❤❤❤❤
One point I agree with is all cancer is mitochondrial based tied to % heteroplasmy.
Who cares that you agree or not? Please reply with a link to your research.
@@newunderthesun7353 Who cares what you don't care about?
A house hold eating the same, same life style........well, is it genetic? Or life style.
What? Specific gene mutations are known to be associated with specific cancers.
None ... what is implied is Epigenetics and Polymorphisms Cancer is a metabolic disease,70 Going ON 100
that's the point ... none, it's not about the genes.Those mutations are secondary not cause
Did you watch the video?
Correct, specific gene mutations are known to be associated with specific cancers...as secondary downstream epiphenomena not as a direct consequences of the gene mutations.
restricted Keto diet....or "Fasting" would imply the best results
Fasting is great, but when you are eating and its not keto, aren't you taking in carbs that will fuel the cancer?
Professor gives Ben Shapiro a run for his money on speed talking...
Since fermentation is key and the common ground of all cancers, yet Ketogenic diet advocates fermented food, such as pickles and sauerkraut. Thank you so much
Margaret Garcia. Two very different things
Fermented foods are healthy, but that really has almost nothing whatever to do with a ketogenic diet, which is about restricting carbohydrate the body has no use for and subsequently needs to be handled by the immune system (as a toxin).
When he called the body a bomb calorimeter in the Q & A this showed his dogma. Bad idea since the human body is a dissipative structure and open thermodynamically.
Oh, please. Learn how to understand context. He was talking about calorie restriction as a variable in rat studies. He was only saying that you had to have two mice of the same size to have a valid comparison. He is all about keto. He is hardly someone you can attack as being a CICO dogmatist.
He’s arguing against that. What’s your level of comprehension? I think you need some keytones, bc you appear to have brain fog.
I think you overestimate the Jewish peoples apatite to take their own medicine. Take what you want ! Let them take what they want . And then move into their houses and sell the stuff they left behind.
Sackler family
@@virtualpilgrim8645 every pedophile judge / millionaire military oath breaker. They had real responsibilities that they didn't/ couldn't do .
@@virtualpilgrim8645 they die with no honor. And whore government issued wives
You're not talkin about the cure for cancer... which is going vegan ".... doctor"
Going vegan is not the total answer. Eating organic in season veg and no sugar to include certain fruits in the diet is key and eating organic no hormone free range chicken, beef and wild salmon is key to improving health when diagnosed with cancer . Eliminating fast food, junk food to include processed breads, chips and sugared cereals. Intermittent fasting also promotes death in cancer cells and everything green and calciferous vegetables not a favorable environment for cancer cells to multiply. Chemo and surgery is not the entire answer in killing the reproduction of cancer cells. Eat clean and illuminate alcohol. Illuminate stress and negative thinking. Be grateful everyday for something. Yes to the invention of a drug that does not harm good cells!
Yes illuminate standard of care!
Vegetables >>>sugar! No good
Fasting down-regulates anabolic mTOR and up-regulates catabolic AMPK that activates autophagia....do mitochondrial damaged cancer cells, like other junk proteins and damaged organelles get recycled when in AMPK (fasting mode)?
Great question. He mentioned something about the process stimulating apoptosis in these cells.
i think autophagy isnt quite emphasized in the lecture, but he mentioned that cancers cannot really survive in a ketone body because cancer cant metabolize fat to convert into energy like normal cells. That causes cancer to starve and die by itself. As for autophagy, I think it also plays a part but the emphasis is on the metabolic hijack.