That is why it is MIT ! professors not just teach , they also inspire and make you feel interested , that is what matters , you can have a thousands books to learn the materials , but where you discover the passion? Thanks MIT for these free materials
i've seen others from MIT courseware, lectures by people who literally have nobel prizes, and they are some of the most boring lectures i've ever seen - I couldn't even get through them. Eric Lander is an amazing lecturer though.
Ah the legend Eric Lander and those marvelous MIT sliding boards with thick stubby chalks so the writing is silky smooth! "DNA is just scaffolding" (chuckle)
This guy's a hell of a teacher. We need more professors like this. That is, we need more professors who are just as passionate about teaching as they are research.
This guy is so great. I usually find it very boring when lecturers talk about history and lab techniques instead of the actual biology of the things, but he found a way to do it really quite interesting. =)
Just one thing: Rosalind Franklin didn't show her photos of DNA's crystal structure to Watson and Crick. Wilkins showed the pictures to the two men without her permission, and her role in discovering DNA's structure wasn't really acknowledged until a while after she died.
Exactly! And this happened because she was a woman. The years showed that people like Watson, despite his brilliant work on DNA, are a shame to science. In my classes I always bring the name of Rosalynd Franklin as one of the real key minds behind the discovery.
That part seemed to me to make no sense. Who cares whether the bases only differ slightly. Any difference is enough to encode information. Boringness shouldn't come into it, I would have thought. What bearing does that have on whether it is the "transforming principle"? Does he mean those scientists were subpar? If so, why not let us know that? I wish Lander had explained what he meant. Edit: Also, so what if (a strange conclusion) "DNA has to be structural, given that it is boring" (or words to that effect)? Even if it were structural it could *also* carry heredity information, just as a load-bearing wall can have writing on it, or could encode information in different color bricks". So Lander seems to be attributing to those WW2 scientists a very strange and absurd line of reasoning.
@@matthewbartsh9167 it was believed to be a solid structure who couldn't do much, so scientists thought it was boring and not really worth of studying then dedicated all their work on proteins.
I love the sdcc skepticism part. I laughed so loud the librarian came over and warned me then I show her. When she laughed her colleague gave her a scornful look.
The was a wonderful presentation. Usually DNA presentations tell me the same old basics. This one told me all sorts of things I had never heard before, all with crystal clarity.
I hope Eric Lander will do more Lectures in Molecular Biology and Genetics. I just love the entire lectures. I keep watching the video since 2014 untill now.🙌
1st: I could listen to Mr/Dr Landen 4ver!!!😃 So inspiring, so clear; I find myself feeling carried away, humbled, and absolutely jaw dropped by the level of clarity, and this genuine, positive approach, that brings a fresh breeze in every lesson that I watched. Simply fantastic. 2nd, I can't still wrap my head around the fact that Franklin's image of the DNA molecule was key to deciphering its structure, but then only the two guys received the 1962 Nobel Prize for their work. I am beginning to wonder whether winning the Nobel Prize in any scientific field is still really relevant, considering how much research they miss out from non-white and non- predominantly male labs around the world. I'm starting to feel quite depressed about it... IDK. I hope I will be able contribute to change this someday. (We got to do something about it, any ideas you geniuses out there?)
What a superb lecture, Professor! I'd like to share a hypothesis for the mechanism of huntington's disease: I believe that the inadvertent methylation of the carbon 5, followed by spontaneous deamination of cytosines in CAGCAG triplet repeats form one or more stop codons TAG and when a certain threshold of the formation of stop codons exceeds the DNA glycosylases capacity to repair errors, truncated proteins will be produced and possibly causing the formation of peptides that could interfere with the nuclear pore complexes so that the truncated proteins would get stuck across and in the vicinity of the nuclear membrane; the same transformation of cytosines into thymines in CGA triplet repeats could produce stop codons in the neurons of Parkinson's patients; maybe this phenomenon is the primordial cause of other neurodegenerative diseases; do you think that ( provided my suppositions are correct) DNA methyltransferase inhibitors, like azacytidine and decitabine, could delay the onset of such diseases?
This is the nice thing about going to a school like MIT "You can ask Meselson down the hall about how he proved the semi-conservative model". You can have a chat about the very thing you learned in class with the guy who actually discovered the thing lol
If you use a radioactive isotope, in the form of a Molecular element, Isn't the bacteria then subject to mono atomic bombardier mutation, altering the Genetic code of symbiote from Origen of Species to Survival of the Fitest?
I just didn’t likeDNA topics just because I thought it wasn’t interesting,and hey I just realized it’s fun.thanks you are not just a best ,I have found a father.❤️
all americans and whole world scientist are required to mix the genome of methane producing bacteria genome mixing with nitrogen fixation bacteria genome mixing with lactobacillus bacteria genome mixing with cellulose digestive enzyme production bacteria genome mixing with cynobactirium genome mixing with yeasts genome mixing with big oil production plants genome mixed so we got more complex compound for fractional distillations and patrol solution forever become possible
Feet up feet down assay is about showing a difference on a macro scale of some obvious change ... in this case dead or alive ... active lethal virus will kill while a non-lethal one wont kill ... ie the animal (rat) is either alive (feet down on the ground going about its life) or Feet up (dead no movement) Could this type of experimentation be used on a cell that has mutated (ie cancer) and find a way to see HOW it has mutated when compared to a healthy cell of similar or identical function?
I have a doubt.... Griffith worked with deadly microbe (during his period) how did he protect himself from pneumonia, there's no antibiotic or vaccine during that time????
genetics always remains amazing and enjoyable but i wish if only we could find out how to being independent about the byproducts, i mean there can be a vast disapproval against what is made up by genetic modulations. anyway thank you. i pay tribute to your attention to the science!!
That is why it is MIT ! professors not just teach , they also inspire and make you feel interested , that is what matters , you can have a thousands books to learn the materials , but where you discover the passion? Thanks MIT for these free materials
i've seen others from MIT courseware, lectures by people who literally have nobel prizes, and they are some of the most boring lectures i've ever seen - I couldn't even get through them. Eric Lander is an amazing lecturer though.
Ah the legend Eric Lander and those marvelous MIT sliding boards with thick stubby chalks so the writing is silky smooth!
"DNA is just scaffolding" (chuckle)
This guy's a hell of a teacher. We need more professors like this. That is, we need more professors who are just as passionate about teaching as they are research.
I love the way this guy lectures
An eminent teacher is someone who has a lot of knowledge, but a Great teacher is the one who knows how to impart that knowledge.
The way he stitches together a beautiful and engaging narrative with such enthusiasm is incredible; I wish I was in his biology class
what a gifted teacher-from an admiring colleague
Wow, this is so dense with information, presented so well your barely realise you're absorbing it. Conversational without a superfluous word.
Were was this guy when I was in College. My word he makes it so interesting that I have no problem following him.
One of the best lectures i've ever heard, explained so well that even i understood most of it.
Watching Dr. Lander is like a therapy. I almost feel like I am watching a documentary.
This guy is so great. I usually find it very boring when lecturers talk about history and lab techniques instead of the actual biology of the things, but he found a way to do it really quite interesting. =)
Just one thing: Rosalind Franklin didn't show her photos of DNA's crystal structure to Watson and Crick. Wilkins showed the pictures to the two men without her permission, and her role in discovering DNA's structure wasn't really acknowledged until a while after she died.
ihavemanyobsessions he corrected that later in another lecture
Exactly! And this happened because she was a woman. The years showed that people like Watson, despite his brilliant work on DNA, are a shame to science. In my classes I always bring the name of Rosalynd Franklin as one of the real key minds behind the discovery.
Leave the shape and color of the tree and focus on getting wood
I always used to think that why MIT is number one in the world. Then I started watching your videos and realized that MIT has Eric lander. 💖💖
I liked his interpretation when he calls DNA a Boring molecule! I will never ever forget that for the rest of my life.
That part seemed to me to make no sense. Who cares whether the bases only differ slightly. Any difference is enough to encode information. Boringness shouldn't come into it, I would have thought. What bearing does that have on whether it is the "transforming principle"?
Does he mean those scientists were subpar? If so, why not let us know that? I wish Lander had explained what he meant.
Edit: Also, so what if (a strange conclusion) "DNA has to be structural, given that it is boring" (or words to that effect)? Even if it were structural it could *also* carry heredity information, just as a load-bearing wall can have writing on it, or could encode information in different color bricks". So Lander seems to be attributing to those WW2 scientists a very strange and absurd line of reasoning.
@@matthewbartsh9167 it was believed to be a solid structure who couldn't do much, so scientists thought it was boring and not really worth of studying then dedicated all their work on proteins.
Just superb! I miss my university days! Professors like him are pure gold!
These videos are timeless and valuable with his lectures of clarity and getting his students actively involved
“Spanish influenza epidemic was the worst flu ever.”
Corona virus: Hold my RNA strands
I love the sdcc skepticism part. I laughed so loud the librarian came over and warned me then I show her. When she laughed her colleague gave her a scornful look.
The was a wonderful presentation. Usually DNA presentations tell me the same old basics. This one told me all sorts of things I had never heard before, all with crystal clarity.
the bestest biology video i have ever seen
I wish I could attend his lecture one day. Thank you sir for an amazing lecture. Unforgettable experience.
Brilliant teacher. These kids are lucky to have this man. I could not find other lecture of his.
Thank you, Dr Lander. An amazing lecture! This has got to be the best way to teach a subject.
I hope Eric Lander will do more Lectures in Molecular Biology and Genetics. I just love the entire lectures. I keep watching the video since 2014 untill now.🙌
Eric lander sir is best in biology the main real information provider
God. If you were my teacher. I would have found the cure for HIV or Cancer. Such passion is contagious and transferable.
These are marvellous lectures with an enthusiastic lecturer. Thank you for the open content
38:20 "That two such pygmies cast such giant shadows shows how late in the day it is." - Erwin Chargaff
это искусство, так лекции проводить, настолько интересно и понятно👏👏
This was just awesome. Humbled by this teacher!
1st: I could listen to Mr/Dr Landen 4ver!!!😃 So inspiring, so clear; I find myself feeling carried away, humbled, and absolutely jaw dropped by the level of clarity, and this genuine, positive approach, that brings a fresh breeze in every lesson that I watched. Simply fantastic.
2nd, I can't still wrap my head around the fact that Franklin's image of the DNA molecule was key to deciphering its structure, but then only the two guys received the 1962 Nobel Prize for their work. I am beginning to wonder whether winning the Nobel Prize in any scientific field is still really relevant, considering how much research they miss out from non-white and non- predominantly male labs around the world.
I'm starting to feel quite depressed about it... IDK. I hope I will be able contribute to change this someday. (We got to do something about it, any ideas you geniuses out there?)
Oh my goodness!!! The best lecture I have heard... Blessed are u students of MIT
What an outstanding teacher. Terrific
I'm very much inspired by you Sir @MIT the way of delivering information is so fantastic that I am feeling it as live.🙏🙏🙏🙏🙏🙏
Happy Teacher's day, sir thank for enlightening us. superb lecture
Eric Lander is the best.
Reminds me of Prof Diamond. Another like Eric Lander. Out of this world!
What a superb lecture, Professor! I'd like to share a hypothesis for the mechanism of huntington's disease: I believe that the inadvertent methylation of the carbon 5, followed by spontaneous deamination of cytosines in CAGCAG triplet repeats form one or more stop codons TAG and when a certain threshold of the formation of stop codons exceeds the DNA glycosylases capacity to repair errors, truncated proteins will be produced and possibly causing the formation of peptides that could interfere with the nuclear pore complexes so that the truncated proteins would get stuck across and in the vicinity of the nuclear membrane; the same transformation of cytosines into thymines in CGA triplet repeats could produce stop codons in the neurons of Parkinson's patients; maybe this phenomenon is the primordial cause of other neurodegenerative diseases; do you think that ( provided my suppositions are correct) DNA methyltransferase inhibitors, like azacytidine and decitabine, could delay the onset of such diseases?
just awesome. Inspiring and motivating,,, World needs teachers like Eric Lander
this is the way science should be taught 👍👍
This man is such a great lecturer! Thanks, MIT!
This is the nice thing about going to a school like MIT "You can ask Meselson down the hall about how he proved the semi-conservative model".
You can have a chat about the very thing you learned in class with the guy who actually discovered the thing lol
Довольно интересная лекция,мне понравилось,спасибо. Препод просто шикарный лектор!
Wow! Phew!! Lander has put so much of himself into the lecture he looked exhausted...
Excellent teaching methodology by Eric lander
He makes me wanna study biochemistry more and more
This lecture is an excellent introduction. Thank you Dr. Lander and MIT
I really wish this full class was available as uncut videos in order, rather than being suplements to a text-based online class.
Wow, what a great lecture. Finally connected the dots of why, for me.
Thank you for these fantastic videos.I keep watching them all, and its flowing.
excellent teacher - vivid & colorful explanations
I from Pakistan but it seems to me that this uncle seriously genius he teach well but I wish could understand 😕 his lectures ❤🇵🇰
Brilliant teaching!
This guy is brilliant!
This is a fun history lesson with a some molecular biology anecdotes :)
I love this Professor
Brilliant. You have passion, and that's all.
If you use a radioactive isotope, in the form of a Molecular element,
Isn't the bacteria then subject to mono atomic bombardier mutation, altering the Genetic code of symbiote from Origen of Species to Survival of the Fitest?
I just didn’t likeDNA topics just because I thought it wasn’t interesting,and hey I just realized it’s fun.thanks you are not just a best ,I have found a father.❤️
he is a good storyteller actually ...!
Just awesome 👏
Such a brilliant teacher....
This guy is awesome!!!!
When wrote thesis work with citations on Eric Landers articles and after looked in Open MIT Lecture :^D
he is an instructional master.
I love this professor.
Excellent lecture
this is very enjoyable !!
all americans and whole world scientist are required to mix the genome of methane producing bacteria genome mixing with nitrogen fixation bacteria genome mixing with lactobacillus bacteria genome mixing with cellulose digestive enzyme production bacteria genome mixing with cynobactirium genome mixing with yeasts genome mixing with big oil production plants genome mixed so we got more complex compound for fractional distillations and patrol solution forever become possible
Amazing! Great teaching style!
Thank you so much mit
This is so beautiful.
Awesome lecture!
Feet up feet down assay is about showing a difference on a macro scale of some obvious change ... in this case dead or alive ... active lethal virus will kill while a non-lethal one wont kill ... ie the animal (rat) is either alive (feet down on the ground going about its life) or Feet up (dead no movement)
Could this type of experimentation be used on a cell that has mutated (ie cancer) and find a way to see HOW it has mutated when compared to a healthy cell of similar or identical function?
Thanks for sharing: extraordinary Teacher!
he is just awesome
This instructor's face really reminds me of professor Mario Lebendiker from the Hebrew University in Israel😊
Brilliant lecture!
He is having fun and jokes... but nobody laughs. Relax, people. Enjoy everything everywhere.
all the world wide scientists are required to mix the genome of oil plants of all types at once which give a tap supply of oil
Mistakenly clicked,ended up watching whole video
I actually watched this entire video instead of doing my biology homework lol.
To which class he is teaching?
39:16 What do you do in England when you make a big discovery?
Anyone knows where to find Brice Huang’s lecture notes?
Gsus!!!! It's absolutely awesome!!!! So cool
ty for you lectures
Thanks! Excellent lecture!
I wish i had studied at MIT
I have a doubt....
Griffith worked with deadly microbe (during his period) how did he protect himself from pneumonia, there's no antibiotic or vaccine during that time????
Look in the NCERT Book
This is awesome!
Thank you so much sir :)
genetics always remains amazing and enjoyable but i wish if only we could find out how to being independent about the byproducts, i mean there can be a vast disapproval against what is made up by genetic modulations. anyway thank you. i pay tribute to your attention to the science!!
I wanna ask something .... did anyone learnt this in high school like I did ?
Amazing !
thanks sir
why dna is antiparallel ?
Awsome ..!
I'm from india ...I'm a PCB student of class 12 .....how can I join MIT .... anyone suggest me plzzzz .....
mitadmissions.org/ Good luck!
why excerpt ??kindly upload the full lecture.....
This is 2 kek . Very nice (y)
does anybody know what he meant by the "feet up feet down assay"?
+Tyler Bernstein
feet down - mouse is still alive
feet up - mouse is dead
excellent explain
excellent explain
excellent explain
Feet up means dead feet down means alive
Okay 2021?
if you were my teacher. im sure i would have scored full on my exam