Human Cardiovascular Disease in the Light of Evolution
Вставка
- Опубліковано 30 чер 2024
- Paper: journals.physiology.org/doi/a...
Chapters
0:00 - Introduction
1:07 - Inflammatory Immune Systems, Man vs Chimp
2:52 - Siglecs
2:32 - Caspase 12
4:12 - Neurobiological Stress
5:30 - Relevance and Conclusion
Like my Lean Mass Hyper-Responder #LMHR shirt?
metabolismshirts.myspreadshop... - Наука та технологія
It’s about time someone did an episode about ApeOhBee. 😂
LOL! Nice Pun! I was looking forward specifically to the primate puns in the comments. Yours is the first!
HAHAHA!!! great pun and yes- that'd be a great topic for Dr Nick to cover.
@@nicknorwitzPhD Generating more primate puns may be beyond the *scopes* of my abilities since it's been such a *trial* . However, not making *gorilla* puns would be a *mist* opportunity.
@@nicknorwitzPhD it's only a matter of time before others ape your content, gibbon its high quality.
My first thought is a Keto lifestyle improves many risk factors that medication can’t really fix. Ketosis lowers inflammation reverses metabolic syndrome and decreases mental stress as evidenced by the new field of metabolic psychiatry. Low Carb / Keto for the win!!👍
now look at the arterial endothelial glycocalyx - our shields.
Why would we want our shields down at all times?
@@jamesalles139 why do you think a keto diet removes arterial endothelial glycocalyx?
@@georgemoonman2830 I did not frame that post well. That question should follow the research into the glycocalyx, where one will find that high blood glucose will wipe out our shields. It takes hours to recover, or longer if we are continuously consuming carbohydrates in snacks and sugary drinks 'to keep our blood sugar up'.
A ketogenic diet to preserve our glycocalyx, FTW!
@@jamesalles139 I thought it was hyperglycemia which destroyed the glycocalyx. That and inflammation, which are both lowered on a low carb diet.
@@trail.blazer YES, of course - therefore why would you continue to consume carbohydrates, when they are completely unnecessary, and ketosis works quite well?
Wouldn't have anything to do with the fact that people with PTSD smoke more, drink more, sleep less, take drugs more and eat more unhealthy food?
I had terrible PTSD before going keto I was drunk everyday smoked and didn't eat for days and when I did it was simple food like oats, instant noodles or can tuna. It was to the point I was drinking 10-15 beers a night or two bottles of whisky the straight 700ml bottles. People with PTSD self medicate with alcohol drugs food and many other things that could increase their risk much more then stress alone.
There are direct and indirect effects of stress on the body. Sorry for what you’ve been through
Heart disease was super rare before seed oils and other food crimes started.
90% of supermarket shelves are a food crime.
I think that's too simplistic a claim. We know that there is evidence of atherosclerosis in ancient populations, so presumably there are a whole lot of civilisation-related factors involved, as Nick points out.
@@graememcelligott8874 yea continue eating refined oils and other nonsense.
corporations are so scared that people will become healthy and active, that's why they support these BS channels
@@graememcelligott8874 those isolated examples have often been explained through things like smoke inhalation. It obviously wasnt diet related if they were eating their species specific diet, makes zero sense
What i find more interesting is how chimps and monkeys in captivity get diabetes and rotten teeth from eating human hybrid fruit like bananas. Its the same with our pet dogs when fed commercial doggie fast food. This we have in common with animals fed high starch, sugar diets either from processed grain based dog food and/or hybridized fruit like bananas.
So true for my pooches. Once I got them off the kibble and put them on carnivore, their teeth tarter and breath began to improve pretty dramatically.
I ❤ anecdotes: I started taking Serrapeptase about 12 months ago as it is supposed to reduce inflammation and help clean and renew damaged arteries. The result has been that my blood pressure has been reduced from 200/100 to 99/65 which is telling me that my arteries are starting to be flexible again. My CAC score over a 12 month period reduced from 500 to 295 in the space of 12 months.
I've never heard of this. Is it a supplement or medication?
@@terraflow__bryanburdo4547 I had never heard of that either and read that it is an enzyme supplement from silkworms that supposed to break down proteins and reduce inflammation. But not to be taken with blood thinners. Of course Amazon sells it but I would read up on it before trying.
The time you took to comment that could've been used to type "serrapeptase" into a search bar and get your answer.@@terraflow__bryanburdo4547
@@terraflow__bryanburdo4547Supplement. I get Doctor's Best Natto-Serra but there are others. My CAC was already zero but I realised my previous diet was awful so now take it in the hope it repairs any damage I did do.
So if your cac scan reduced, does that mean you have removed calcium from your arteries? But that’s impossible?
I remember reading a study a couple of decades ago that jibes with this. The chimps lowest in the hierarchy were riddled with arterial sclerosis and plaque while those at the top were squeeky clean. Stress indeed contributes to heart disease.
Thanks Nicholas, another great video, keep up the great work!
Will try!
Blaming cholesterol for heart disease is like blaming cars for drunk driving accidents.
But if you take away the cars then the accidents stop.. so let's do that.
@mrdavester Yes, let's take all the ambulances. Firetrucks, Police cars, The big rigs hauling food to the supermarkets. Let's just take all that off the road and see how fast everything collapses.
@@mrdavester No because those "cars" have vital functions within the body.
It is not even the cars - that is LDL.
It is the baby in the back seat in a car seat.
@g33k37 the cars are ldl and public transit is the harmful pharmaceutical fix.
Excellent video once again, as always. Thank you
My pleasure!
Your thumbnail image is great! Thanks for sharing. This was all new to me.
I'm so glad!
This is a particularly interesting paper and presentation of it. Thanks!
You're welcome :)
I love the topic of mutations that were at one time beneficial, but now have consequences and implications. More please! It complicates the idea I sometimes see people imply, that during some stretch of our evolutionary past, we were living in perfect harmony with nature, and if we just get back to that way of being all our health problems will go away. Seems much more likely that it’s always been an arms race and therefore we’ve always taken the downsides along with the benefits. Stability = predictability = easy prey.
Given what we have gone through in the last few years with Covid, i have been working to prime and strengthen my immune system. At the same time, I have a genetic predisposition to atherosclerosis on my father's side of the family and now in my late 50's i am following suit, with 4 stents already. I enjoy your thought provoking videos nick and this one presents the conunbrum of how to get the best of a strong immune system while keeping inflammation to a minimum.
Hm , chimps got 60% more LDL ? And hypothetically if human were 1000 years ago and without sugar / carbs and we were all in ketosis LMHR we would have been exactly like chimps are now 60 to 100% more?
Maybe this is our natural and primitive cholesterol level ? but big farma decided otherwise? What do you think about that?
Thanks
Humans have been eating sugar and carbs for much longer than 1k years, but I like the point ur making. It's why carnivore makes the most sense to me
Theories that "make sense" require evidence. Even if they are evolutionary arguments---those don't get a free pass. Big pharma didn't decide anything, a ton of independent research groups have established the risk of LDL. Why ignore the evidence?
Nuh uh. That study missed the fact that chimps in the wild have LOWER ldl than the average human. Around 100 mg/dl - a bit less when younger, a bit more when older. So, no. Also,chimps don't live as long as humans, less time to build up plaque, which manifests in a major way in older humans. Not a perfect study, let's say. :)
@@brockashsfrund yeah. We're actually extremely lucky that we don't make decisions based on theories that "make sense" to people. Theories require evidence. Evolutionary claims require evidence.
Another point would be that chimps don't live in ketosis, more the opposite of that if anything. So the human ketosis tribe would NOT be "exactly like chimps. ^_^
LDL as a marker of cardiovascular disease is being phased out. The increase in cardiovascular disease can be linked to the change on diet, the introduction of grains. They stress the liver and degrade the LDL. Its not the quantity but the quality that's important.
Very insightful. Thank you for this post
You're welcome!
Highly informative thankyou from Perth Australia
You’re welcome mate!
what a wonderfull and exciting new insight! Thank you for bringing this up; I 'll have somethng to think about tonight..........
You're very welcome Jande
yes, keep on eating unhealthy, its called natural selection
Good insight here and in your other videos.
Much appreciated
Not “relevant”, I know, but was so very sad to hear of the tragic death (on holiday) of famous BBC TV doc Michael Mosley today on the Greek island of Symi. Just goes to show how fragile life is…often despite our best good efforts.
@@KenJackson_US Don't think we have a cause of death yet. He did suffer health problems over several decades.
Yes he did. Type 2 diabetes, with an inherited predisposition. Hence his efforts to reverse this and help spread the healthy lifestyle message to millions here in Britain.
I was so upset. Such a wonderful man bridging between regular médecine and the low carb world
very intresting, thank you
Glad you enjoyed it
Egyptians got CAD/CVD from eating too much wheat. Carbs, chemicals, and seed oils are the "death knell."
Super interesting!!! I am sharing this with my doctor who is open to these interesting etiological discussions.
Glad you found it interesting :)
I *had* atherosclerosis (well I probably still have it to some extent, but not at a problematic level). I was diagnosed by a doctor who told me I couldn't reverse it and that I would need to take high blood pressure medication for the rest of my life.
I used to have a diastolic of 90 (sometimes even when taking the meds). Since quitting fructose entirely 1 year ago and monitoring my blood pressure and incrementally reducing the medication, I have now been med free for 9 months and ny diastolic is around 70 (was 98/68 yesterday).
By ceasing fructose (and I mean *cease*) my hsCRP is now 0.9mg/L (which is, I think, salient to the point being made in this video).
I've heard that explanation regarding ApoE4... that it helped human earlier in the evolutionary process by creating a more active immune system...
Yep... "antagonistic pleiotropy"
Excellent points. I think this puts into perspective some of the confusion about why high LDL-C or ApoB values signify higher risk for atherosclerosis in modern populations. We know it's the imflammatory response to cholesterol particles in artery walls that leads to the formation of foam cells and consequently the buildup of plaques. If the human inflammatory response is supercharged over other primates then it shows why this happens. And it gives us greater insight into what kinds of interventions can help reduce that risk. Also, it makes good sense that the evolutionary trade-off worked fine in the past but is less desirable today.
Perhaps our ancestors had a greater helminth parasite burden which might have damped down the inflammatory response?
I have an idea for a new video. How to read scientific studies? I want to learn it. And I want to learn it from you, beacuse you are open minded, nice and you don't treat science like a religion.
That’s very kind! People have suggested that before. It’s not a topic that can be properly covered in one video… maybe a course? It’s in the back of my mind to do eventually.
@@nicknorwitzPhD Good idea!
Absolutely love these videos.
Nick is there any chance of touching on Lp(a) in the future? For those of us with very high numbers but are also LMHR (or close to) there appears to be little information.
Treating metabolic dyscrasias should be the focus with symptoms as a guide. Your insights should lead to the causes of these dysfunctional metabolic compensatory mechanisms. The ascension of the physician is before us. Keep asking and answering these questions. :)
For the neurobiological stress, what about that ? I think wars it stressful ? I know smoking is not good, but there are other factors :
Studies in occupied countries like Norway and Finland found a decline in deaths from heart attacks and atherosclerosis (plaque buildup in arteries). This decrease is linked to the wartime shortages that led to:
Less consumption of fat, especially saturated fat found in meat
Reduced smoking due to scarcity
Increased physical activity due to rationing and war efforts
ScienceDaily article: Heart and cardiovascular disease deaths drop dramatically in Norway
It was seen in most occupied countries.
A lot of papers found that stress in not the cause. It is what we do to cope with it...
It should be great to have a clearer answer !
I see improvement in your video editing every time, thanks
I appreciate that
Bad stress number 1 killer but highly subjective , hard to pin down exactly , would be good to find an objective target like a blood chemical /compound that's present when the organism is in stress mode (the bad type)
Best start to a video ever 😂😂
I'll now watch the rest.
Awe... thanks... what made it the best? Was it my monkey impression? I know it was ;)
@nicknorwitzPhD Just brilliant. The rest of the video did not disappoint either.
You are prolific and on the money with your content. Keep up the amazing work!
@@gray45374 Thank you Gray. Means a lot.
Ape Plus video as always Nick! What are your thoughts on grounding/earthing in terms of CVD. Is it a factor you think could be a big contributor? I have read some interesting studies on it in terms of it being able to neutralise ROS and reduce blood viscosity. Regards, Adrian :)
Love the pun! Made me laugh. Not aware of good data linking grounding to CVD risk.
Between Stimulus and Response There Is a Space. In That Space Is Our Power To Choose Our Response. Viktor Frankl.
Great quote! Thanks for sharing!
Nick, which BMR calculation have you found to be most accurate at the bottom end, ie for estimating the minimum calories required for a lean person not lose weight? I know there's a few but I heard heard you mention revised Harris Benedict once.
They all generate similar values… all pretty crappy 😂
I can't find that particular shirt (the one you're wearing) on your store. I can see the #lmhr tee and I see a hoodie, but I would like that particular tee if it is available.
Here you go... metabolismshirts.myspreadshop.com/lean+mass+hyper-responder-A65e470be30fb6e2cbb26a252?productType=812&sellable=9OQarYmwqYukxv4129Re-812-7&appearance=2
@@nicknorwitzPhD thanks , got 2!
Yes, lets make it more even more complicated. Yes, let's make it even more interesting! Before 1900, heart attacks were almost unheard of. High blood sugar, caused by carbohydrates and seed oils, leads to inflammation. Since the 1900s, saturated fat has been gradually removed from our diets, being replaced by highly reactive unsaturated seed oils and carbs. Even the Egyptians experienced cardiovascular disease because they consumed a lot of bread. Bread can be seen as an early form of processed food.
I read about this with my APO E 3/4 status. We needed this to prevent infections from parasites when we dropped from the trees. But in modern society, we must NEVER eat the SAD diet…
“Antagonistic pleiotropy”
@@nicknorwitzPhD Yes. More about this subject, please 👍
The SAD diet is in a mimetic way an infection by the modern food industry, an evolutionarily novel pathogen ,😮
Also, can you share when you have time, for those curious about inflammation, what markers we should test? And what optimal levels are?
I do test hsCRP .
Ptsd leading to higher risk of atherosclerosis is messed up. That part was really interesting
Ikr!?
I was struck by the title of your posting. It reminded me of a chronic booby trap in relation to light frequencies that affect health. The light of evolution - specifically infrared light. Are you familiar with Prof Gerald Pollocks work on EZ water aka the 4th phase of water which lines each side of any cell’s membrane to create an exclusion zone of gel type water impregnable to viruses. If we are not exposed to infra red frequencies and charges from the natural world around us we lack the energy for change and we fall to the vagaries of viruses and the like…. Worth a gander (look). Those little chia seeds also help create this health preserving H2O3 water web. Would be interesting to know if our cousins the chimps have this same phase of water lining their cell membranes.
Funny you mention light... check this out from this AM related to a new Nature Metabolism publication: x.com/nicknorwitz/status/1799768564498378973
Nick, I'm a LMHR. Is there something unique about us where intense exercise causes BG to drop? I rarely have any spikes (>130) after eating. When doing cardio my BG drops to 70-80. Normally about 100.
Thank you Nick! Will you be doing a review of the new Ornish study for Alzheimer's??
I think you would like Benjamin Bickman as his view is insulin resistance causes most CHD
He's a friend :) ... nice guy ... real respectable family man with a good heart
Are you talking about higher LDL in wild or captive chimps?
As a carnivore, my inflammatory markers are very low, as is my insulin. I haven't had a cold in 4 years, I'm the only person I know who hasn't gotten Covid, in the plant based past, I had a URI every year. And asthma, now gone. I think high CHOLESTEROL is antiviral. What's the research show, Nick?
All I'm going to say to this is (1) I'm happy you're feeling healthy and COVID-free (2) 'somehow' I've escaped COVID too... even though my entire family has had COVID and I work in a hospital...
That and 4th phase water that creates exclusion zones either side of cell membranes to prevent viral penetration into the cell, but only if the organism has sufficient access to infrared light and negative charges from the natural word, see the work of Prof Gerald Pollock.
I sure hope you are right as my ldl has simply sky rocketed to near 800! LMHR for sure but this is getting crazy!
@@nicknorwitzPhD and you, too, have "high" cholesterol. Historically, before statins, wasn't "normal cholesterol" 300? I think I heard that from Chaffee, who researched old textbooks.
I eat primarily plants with a little fish. Never had Covid.
Very interesting! Btw, what's your take on the Unified Theory of Cardiovascular disease by Matt Rath and Linus Pauling? from the hypothesis I've been studying this one can potentially explain the aspects that the cholesterol hypothesis can't. Also, I've read an interventional study where the protocol was applied and could reverse the the plaque within 1 year I think, I don't really understand why this isn't applied in more experimental interventions among these patients. Great video, cheers!
that's wild, I just commented on this too. I mentioned the Dr Rath Institute page, and their concept section, specifically: Plasmin-Induced Proteolysis and the Role of Apoprotein(a), Lysine, and Synthetic Lysine Analogs (1992) Rath M, Pauling L. Journal of Orthomolecular Medicine, 7:17-23.
Is there anything unique in that protocol beyond being low-carb? That is, if we're living keto, might that be enough to expect our existing plaque to reverse?
@@KenJackson_US mmm, keto is better in this sense than a high carb diet, but it may not be enough (btw, this theory could also explain why some carnivores develop plaque, but not bc of the cholesterol).They explain that the primary cause of the heart disease is the ascorbate deficiency (vit C and other nutrients) that can make us have a poor quality arterial collagen (sorry if the words are not technically correct, not a native speaker) which ultimately leads to damage within the arterial wall and cause plaque to develop. I've seen some interventions with this protocol that make reverse the plaque in a few months. It includes ascorbic acid, lysine and some other nutrients I don't remember, but for prevention, it is primarily vitamin C.
@@bastianfuentes8335 Wow. Vitamin C. It seems the case for supplementing vitamin C vacillates all over the place. Some say it's worthless, others say it's very beneficial.
@@KenJackson_US their hypothesis is about cardiovascular disease being the outcome of poor nutrition, specifically a sort of pre-scurvy, so no I don't think keto alone is enough unless is somehow provides the vitamin nutrition necessary.
Can someone help me figure out a LP’a’ of 19.5 Nmol/L to Ng/l
Trying to figure out here i stand, I don’t understand why lapcorp did it in NMOL/L
It’s hard tk convert, just trying to figure out if it’s on the lower end or higher end
Very good perspective I appreciate your video but stress. The little stress is always been the killer
Stress can cause inflammation, indirectly. But I agree neurobiological stress is a big factor in health. Point well taken.
Dr. Nick Hi and good morning, inflammation is so crucial in the avoidance of metabolic dysfunctions. Great Thanks
In a word: Yes. Of course, acute inflammation can be helpful... inflammation is not "bad." But like any fire it needs to be controlled.
We should ask ourselves what's the difference in lifestyle and habits in the western world compared to countries in the third world that don't have high blood pressure, arteriosclerosis, diabetes etc
Is it:
- alcohol
- sugar
- salt
- stress
- food additives and preservatives
....or maybe a combination of all those things?
Reduce your stress levels, stop drinking alcohol and cut the crap !
Maybe it's just as simple as that...
Nick Any thoughts on Tmao ?
When Tea 🫖 and LMAO 😂 had a baby.
Are there more pathogens on land vs. in trees?
On the question of Familial Hypercholesterolemia and its association to CVD studies, do we know if those studies are only looking at people who already have CVD and happen to have FH or if those studies are looking a whole population of people with FH and all of them developed CVD? Are there cases of people with FH but never develop CVD?
I have FH. I did not realize I had this condition and I have been either keto or Paleo for the last 20 years. It was not a good fit for me. I went Paleo to cure an auto immune disease and it worked well.
I was very strict. I was not eating sugar or processed foods or oils. Very weston a price of diet.
I've been eating this way since I was in my late 20s and I'm now 54. I think if I had been eating the standard American diet I would've been dead. I'm positive of that.
Once diagnosed, I tried everything in the Paleo/keto realm to get my numbers in check and get arterial. Inflammation down. Things just kept progressing.
I asked myself the question what diets have been proven to reverse heart disease. Essellstyn, Ornish, McDougall.
I'm just not willing to die while I write for more clinical evidence on the ketogenic diet. I decided to follow Essellstyn's diet. I had determined definitively I was not a lien mass hyper responder. My triglycerides were going up with my cholesterol even though I was low-carb and 100% Whole Foods without any processed shit or bad oils.
Drop my LDL from close to 300 to 125 and only six weeks of the diet. Triglycerides also normalized.
People with FH need to be careful. Choosing the wrong diet can be fatal.
I'm going to go with what has been demonstrated to reverse existing severe heart disease and completely prevent heart disease. Not gonna take my chances by continuing to do what I was already doing. I was eating grass fed meats as well. I only ate organic I was exercising 5 to 6 days a week. I was in the sauna. I was not using dangerous chemicals on my body or around my house and I was still not doing well.
I'm doing great now. Feeling 1 million times better.
We are all biologically different. This is why testing is so important. Look at how your body is responding. Don't believe the hype that your LDL doesn't matter. If you're a lean mass hyper responder, your LDL doesn't matter as much. But we haven't really proven that yet.
But if you're not mass hyper responder, you need to pay attention and do what works for you
@@atransformedlife Esselstyn's diet? No meat, no poultry, no fish, no dairy, no eggs, no oil. Aim for 100% Whole Grain products. Gross.
@@atransformedlife Thanks for sharing your experience and I am glad that you managed to find something to help keep your risk in check. I think its irresponsible for anyone to say that high LDL doesn't matter in any case, however context is the key. Your risk of high LDL with FH is perhaps is much more higher than a LMHR or even just a hyper-responder like me, I have LDL running 200-300 for other 7 years, but with no new plaque (score of 9) build up apart from before I went carnivore/keto and I keep my health markers and scans in check regularly. To me FH is not just a single change of gene that causes LDL not to be removed effectively from the system, there are probably many other genetic changes that comes in the total package increasing the risk profiles. My question is not that FH don't have risks but was the studies on FH comprehensive, i.e. did those studies including an entire population of people with FH or only those who exhibited CVD? I think in science its important to be clear of those limitation and look for black swan and try to understand why for some people with FH this risk is magnified and others they don't. To me just pinning on high LDL as the initiation of CVD in people with FH, albeit the high correlation, need much more work towards a clear explanation.
I literally came here just for that out of pocket thumbnail pic
😂 thanks 😂
In the interest of staying curious, what is the explanation in the LDL-C denier camp as to why people with a genetic loss of function of PCSK9 never develop heart disease?
1/ They do. 2/ Do they live longer? If there aren't data showing PCSK9 low live longer as a population... then one may ask why? 3/ Watch my ApoB and All Cause Mortality video.
Beard game is sharp. Real sharp.
Thanks 😉
Do chimps have 60% more LDL cholesterol compared to humans with matching (carnivore) diet?
Meat makes up about 2-3% of chimpanzees' diet.
I doubt that any of this applies to Hunter Gatherer cultures. It sounds like this paper only describes highly developed "western" societies, in which ultra processed food is commonly consumed. Before modern humans moved out of Africa, what was our immune system like?
Ötzi had atherosclerosis.
The magic of climbing and hanging.
If I see a good climbing tree I revert do acting like a 12 year old. MUST CLIMB!
Rock climbing and tree climbing is my therapy, as is running.
Bros chin looks like the batman sign x)
😂😂😂
What is the life expectancy of chimps?
In captivity median is just under 40... but can live to >70y
👍🏼
I raise you a thumb:👍👍
Stress yes, association with inflammation obviously. But the presupposition that atherosclerosis is normal outcome of human aging is flawed. I've notice that those biased to promote ldl theory and plant based diets like to argue that atherosclerosis is an unavoidable concequence of human physiology/ metabolism. This assumption needs to be properly proven. How do chimps go eating grains, seed oils and modern processed foods in a high stress environment? I bet they never do that study for ethical reason. Yet society is doing it on us.
i was not prepared for that intro.
How was my monkey impression?🙉
@@nicknorwitzPhD On par with Joe Rogan's Gorilla Impression. Made me spit my water / 10
@@Nikkattsu Wait... link me to that... I must hear it!
You forgot to mention sun exposure, or lack of sun exposure.
Did I… x.com/nicknorwitz/status/1799768564498378973?s=46&t=Ke3C7fBkUKZ6FwZHnJnEUQ
in the first 40 seconds you basically tell us that LDL is not the cause of heart disease. Thank you. If LDL does not affect other animals then it is not the LDL in humans that causes heart disease.
By all accounts CVD ramped up in the last 100 years and that is was fairly inexistent before. Of course this is fairly difficult to certify, due to medical practices and records, but anecdotally it is still considered to be fairly rare. I think we miss so many dots when trying to create this picture of the cause of atherosclerosis. I believe the only one to get close is Dr Malcom Kendrick. The industrial age had brough massive amounts of stress and environmental toxins not to mention the shittiest diet ever known.
I highly doubt that inflammation caused by an over active for no reason immune system is the cause of atheroslcerosis and that the researchers are still trying to blame ldl. Sorry. Time to move on from that model. Cholesterol and LDL ARE THE IMMUNE SYSTEM (scientifically understood knowledge). So it stands to reason that it is higher in Chimps given your first statement.
Be careful with your words. Your 3rd sentence does not follow logically. You cannot use that to conclude that LDL doesn't cause atherosclerosis in humans.
This is oversimplifying the situation. Just because LDL is not the only factor it does not mean it doesn't have causal responsibility. Technically people are the cause of mass shootings in America, but it doesn't mean we pretend guns have nothing to do with it. High blood pressure is technically the gunman (as far as I know, I'm not a doctor though), and LDL is the gun.
@@dangallagher6176 So it isnt causal in chimps but it is in humans despite it being quite significantly higher in chimps?
A better analogy would be the fireman. You see them at fires but they are not the cause of the fire. If you are insisting it is high blood pressure, then it is the high blood pressure and not the ldl because as much as anything .... ldl isnt the only thing found in plaques.
Basically the men in white coats have created a paradigm and no one wants to give it up.
@@DANGJOS ldl doesnt cause plaques in veins (of humans) why not? If you take a part of a vein and put it in the arterial section of the body, then it will form plaques. Curious. I know (but I dont know why) that you want ldl to be the culprit. I have seen enough studies and followed enough logical paths to be fairly sure ldl isn't the problem.
My concern is my health. If I thought ldl was the culprit based on all I had read and heard then I would accept it. But I am still not buying it. It doesn't make any logical sense.
People with "normal" levels and also with low levels of ldl cholesterol die in the same numbers as those with high.
@@TheCompleteGuitarist What does cause plaque in the veins of humans? Do humans get severe plaque and damage to their veins in general? What is that point supposed to prove? You're saying that you followed enough logical paths to be pretty sure LDL isn't the problem, but I'm not hearing very logical arguments so far. I'm just curious as to what they are.
sugar (fructose) => uric acid => humans lost the enzyme uricase.
uric acid => hyperinsulinaemia and mitochondrial dysfunction => heart disease...
monke norwitz
Oh no oh no
I believe the reason why blue zones exist is because they aren’t stressed in those areas. Staying happy and calm is the key to longevity. Which is why steak and cheese is crucial;) thanks for the video Dr keto wizard
Neurobiological stress. So we humans evolved into cognitive creatures too thin-skinned to social and environmental signals, which favored our survival then, but is working against us now.
I mean... think about you response to social media posts and whether each response is 'adaptive' ... I know I often have maladaptive emotional responses based subjective analyses alone... I wonder how I'd feel if I had a continuous cortisol meter?
Yeah, they are not relatives.
Are you insulting my cousin Fred 🦧
So, something came from nothing?
The possibility that LDL never did have any real significance to CHD is also a possibility.
That might be a bit much of an extrapolation for me… not really what I said… far from it
Anything can be a "possibility". But why ignore such high volumes of evidence and the scientific consensus?
Someone as smart as you should know that the theory of evolution is absolutely absurd.
Thanks for calling me smart
Sorry but I didn't come from a monkey!
I didn't mean to insult your mother... I'm sure she's lovely.
Some things aren't worth arguing en.wikipedia.org/wiki/Evolution
@@themekfrommars No... but we can make light-hearted jokes to bring a smile even if there won't be consensus... hence the "mother" response. I'm sure even Darwin laughed...
then where did your tailbone come from?
a 17 y.o. in India had a 18cm tail. he got his from Hanuman -- The Monkey God.
(Human Tail, PJ Giri, 2019.)
Not FROM a monkey, but WITH some apes 😅