Factors Modifying Drug Action | General Mechanism of Drug Action & Factors Affecting Drug Action

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Drug effect refers to the normal spectrum of biological response evoked by a drug when used at a recommended dose.
Various factors are-
(1)- Species- Absolute dose of a drug varies with species as different species are of different sizes, and the amount of drug has to be in proportion to the size of the target species.
(2)- Age- Very young (neonatal) and very old (geriatric) human and animals require low dosage
Compared to those required by adults. This is predominantly related to liver and kidney function impairments in newborns and geriatric animals. Neonates have under-developed and inefficient hepatic microsomal enzyme systems (oxidation, reduction and glucuronidation processes inefficient); the capacity approaches the adult level in most species in a month.
(3)- gender- gender is not usually a major factor in altering drug effect or drug dosage. Males and females behave, most often, similarly to drug effects. Gender influences have been largely studied in rats ; (males tend to metabolize drugs faster than females) hexobarbital is more effective in females, red-squill is more toxic to females (twice), and contrarily schradan and oxy-de-mention-methyl pesticides are more toxic to males.
(4)- Circadian (Latin: circa = about; Diem = day) rhythms occur in many physiological and many biochemical functions that alter drug dosage and drug effect. This includes variations in hepatic drug-metabolizing enzymes, altered neuronal activity, altered drug distribution or even changes in hormonal profiles and in central receptor density
(5)- genetic factor- Genetic factors or pertinently intra-species genetic variations are responsible for alterations in drug dosage and/or drug effect. These may be related to gene-related alterations in drug metabolism or alterations in tissue/receptor sensitivity. These variations can lead to genetic tolerance, intolerance or idiosyncratic-reactions in susceptible individuals.
(6)- pathological factors- Several pathological states particularly those affecting liver, kidney or altering body fluid pH and electrolytes are known to affect drug, effects and drug dosage. Organic or systemic alterations can markedly alter the pharmacokinetics and/or pharmacodynamics of a drug in affected species. Liver disorders affect mainly disposition and thereby altering effective drug concentration and drug effect
(7) Route of administration
(8) Tolerance
(9) Cumulative effects etc.
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[@soumyaagrawal2023]

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[@dollyprajapati6]

Really sir thank u so much beoz mere ko to smjh ni a rha th k pharma kesy paduu pr those vedio ..fantastic also B.PT student ....👏👏

[@abhitiwari2506]

Sir awesome channel.... 👌very helpful for me to understand the topic... Nice work sir😊

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Thanks for your help

[@pharmaboy6762]

Sir Your Lecture Is Very Helpfull For Pharmacy and Mbbs Student
And Especially for those person who are from Hindi medium
Thanks A Lot Sir ❤❤
I Am B. Pharma Student Of 4rt Semester
Locdown me Aapki Video Bahut Helpfull Hai
Thanks Again 😊😊

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[@pharmaboy6762]

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[@solutionpharmacy]

Most welcome

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[@walia3523]

sir please make videos in ''digestive system drug''...
1]drug that affect appetite...
2]drug that affect salivary gland function...
3]used for treatment ...
4]gastroprotectors...
5]gastric mobelity....
and other all topic of digestive system....drugs and mecanism
request a lot....................................please make video as soon as posssible

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im hearing impaired can we get subtitles for this presentation, or is there a way to get the transcript of this video?

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In class i didn't understood anything..

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Sir, if I follow all your lectures and study KDT book thoroughly, then is it enough to get specialized control over pharmacology?

[@solutionpharmacy]

Yes if you follow my lecture then after any of book (KDT is recommended) then you will clear all concept.

[@the_encephalonaire]

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Placibo is medicinally certified term or just as assume
If we take wrong drug so how should it work in a right way... 🤔🤔🤔

[@vandanasharma8027]

Sir super video for better understanding 👍❤️ but I have a request to you sir ... Plzz sir thoda dere dere bola kijiye kuki kbi kbi smjh m ni ata h jb aap jldi jldi bolte h .....😔

[@solutionpharmacy]

Thank you. Sorry for my speed. It was our initial videos. Trying to be slow

[@dakshu_042]

You can manage your playback speed of video 0.75X or 0.05X.😊 Hope it's helpful for you!

[@SachinKumar-qw8dy]

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[@ashuhooda1012]

any suggestion for dentistry drugs channel plzz

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[@shraddhapushpakar7793]

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Sir kya ye d.pharmacy level k lie bhi (chalega) thik hai kya ?????

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Esic exam ka preparation ka ek video upload kijeye sir please

[@mravinder8057]

English version available?

[@PrinceKumar-tj3ce]

Sir please explain the basic of biopharmaceutics which are given initially in brahmankar

[@solutionpharmacy]

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Please sir ANS drug ke liye video upload kar dijiye plz sir

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Pankaj Sen Uploaded

[@dvijenjagirdar9841]

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Welcome

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Where can i get pdf of this lecture

[@girishyt8207]

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[@solutionpharmacy]

Thank you. From chhattisgarh

[@yoganand7273]

factors affecting in new drug development ke question me isko likh sakte hai kya

[@solutionpharmacy]

Nhi

[@yoganand7273]

@@solutionpharmacy ias topics me bhi video banaiyena 25 ko MEDICINAL CHEMISTRY ka semester exam hai mera

[@kavyasree5539]

Suggest how to prepare for gpat sir

[@sumitsingh-wi1rw]

Sir, Plasma expanders itself increases plasma volume in vessels or by drawing fluid from intestine and through osmosis

[@solutionpharmacy]

Somtime both. But mostly 1 one as you have said.

[@sumitsingh-wi1rw]

Solution- Pharmacy Sir, is 1 means 1st optn. i.e. plasma expanders itself
and Sir is there any pdf on plasma expanders

[@solutionpharmacy]

Yes that means 1st option. Really sorry we dont have notes for it.

[@ankitapure1651]

Sir please antagonism seprately teach

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Sir p.engineering ki v video banaoo...please..

[@abdulrahman2654]

Thanku sir

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My pleasure

[@abdulrahman2654]

God bless you Sir

[@solutionpharmacy]

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[@Pharmacy3154]

Sir ji how to calculate average adult dose and adult dose in parenteral doses form please tell me 🙏🙏🙏

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Please search dose calculation in our channel

[@akashshelokar3400]

Sir,Black and mongle se q fark padega drugs pr?

[@ferojpatel1195]

Sir PJ ki schedule ki video upload kijiye

[@sumitsingh-wi1rw]

Sir, please ek baar thoda side ho jaaya kare jisse hum screenshots lesaake. please don't mind sir

[@solutionpharmacy]

Ha ab se hum ye karne lage hain. Ab aapko har vidoe ke lst me screenshot ke liye time milega. Aur isme mind karne wali koi baat nahi hai dear.

[@vishakanegi3538]

What did mongols mean????x

[@shubhali9655]

sir what are the types of cumulation ?

[@MONK47K]

Hello sir, i think there is a word psychological factor instead of physiological !

[@solutionpharmacy]

Both are there

[@shwethap1534]

Sir one doubt ...placebo comes under psychological factor or physiological factor ??

[@solutionpharmacy]

Physcho

[@shwethap1534]

Tq u sir 🙏

[@bachelorparty8387]

Sir if there is an emergency, a person eat poison and there is no time to run market to bring activated charcoal,
Can we use powder of wooden coal ??

[@solutionpharmacy]

No that may cause problem

[@gautamitirpude8555]

Sir can u plz make a video on placebo effect???

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Visit pharmacy dictionary. Our 2 channel

[@FarhanKhan-ri6wh]

Sir gastric emptying time jyada Hoga to drug jyada time rhegi body m Uska effect jyada Hona chahiye n

[@solutionpharmacy]

Gastric represent stomach and if stomach is taking time for being empty how it will absorb by small intestine

[@saranyasachibalasubramania714]

Sir do you have the same lectures in English?

[@solutionpharmacy]

Yes

[@medicalscience1528]

Sir , placebo drug diya ho kyu jata he jab k iska koi affect nhi he ? Plz clear make it clear.

[@solutionpharmacy]

Us drug ka effect nahi hota but ye baat sirf dr. Ko pata hoti hai. Patient ko lagta hai ki ye best dawa hai to wo mentally sochta hsi ki ye kaam achha karega aur wo kam karne lagta hai. Jaise kuch log ye mante hai ki wo beemar hsi jabki wo hote hi nhi hai to dr unko satisfied karnr ke liye placebo deta hai. Jaise hum ye nahi jante ki Bhoot hain ki nahi but hum maan ke dar jate hai aur bhagwaan ko man kar dar door ho jata hai

[@roshan4579]

Sir B.pharm 8th sem ke objective notes available ho skte h

[@muzahidshaikh8760]

esic ke exam ke liye b helpful hoge na sir

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Muzahid Shaikh ha bulkul

[@saqlainbasit9358]

Plz upload video about volume of distribution and adverse drug reaction

[@solutionpharmacy]

ADR is uploaded

[@saqlainbasit9358]

@@solutionpharmacy plz make short video about volume of distribution

[@solutionpharmacy]

Saqlain Basit That topic has passed. Will do it sometime

[@vraj_.18]

SIR,
FACTORS AFFECT ACTION OF DRUG !
OR ,
FACTOR MODIFY ACTION OF DRUG !!
DONO SAME QUE HAI ?

[@solutionpharmacy]

Ha

[@priyakundelwal2764]

Point 7 m even ke baad kya likha hua hai sir?????

[@solutionpharmacy]

That is evening

[@ashuhooda1012]

sir plzz upload emergency dental drugs
out whole batch is waiting for a good lesson

[@solutionpharmacy]

Sorry cant teach dental exclusive

[@ashuhooda1012]

ok thanku sir😊

[@ilyasahmad8153]

Sir! Please jo PDF notes hey wo proper sequence mey karday...

[@solutionpharmacy]

Please check deacription box

[@kaustavbasak4054]

How do I search pdf in selective topics in facebook...

[@solutionpharmacy]

Kaustav Basak We do not provide topic wise PDF.

[@AnkitSharma-qx9fd]

fb pr notes kaise dwnld karne hai sir

[@solutionpharmacy]

How to Download PDF from Solution Pharmacy Facebook Group Using Mobile
ua-cam.com/video/ntzXKi2pA5U/v-deo.html
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[@drxrahulburman5505]

Sir factors affecting drug metabolism on video

[@solutionpharmacy]

Already uploaded aa enzyme inducer and enzyme inhibitors. Please find in our video list. Thank you

[@arsalanzaidi15]

Sir ap kis college me lectureship krte hai.

[@solutionpharmacy]

Svits bilaspur

[@ankitgopala9002]

sir if u don't mind but sir thoda writing... thik kijye vese thik hai but hlki c kahi smjh ni aati.....q k m screenshot leta hu or unse ek note tyar krta hu...or sir board se ek bar dur ho jaya kro...taki ache se screenshot le ske..... don't mind sir aapke lecture bahuuttt ache...hai...and helpful...thnx a lot....

[@solutionpharmacy]

Mind karne wali koi baat nahi hai dear. Aapke suggestion ko bilkul dhyan me rakhunga. Ha meri hand writing thodi bekar hai jise maine abhi ke videos me improve kia hai. Aur ab video ke last me screenshot lene ke liye option dena bhi suru kia hai. Thanks for suggestion.

[@deepakchanderchandel3233]

I WANT GIVE YOU SUGGESTION. HUMBLE REQUEST PLS ARRANGE THE NOTES IN A SUBJECT WISE ON FACEBOOK. PLS PLS PLS PLS PLS SIR.

[@solutionpharmacy]

I will love to do so. But 2 things - we provide videos only. Notes are not our priority. And its technically facebook fault that we can not arrange it in semester wise. You have idea then let us know

[@pratibhasahu4550]

👌👌👌👌👌👌👌👌😎

[@yusraakhtarali3238]

sir i have a question... very confusing and challenging it is...
Factors modify the bioavailability of the drug / Factors modify the drug action
Are these both terms same or are they different?????
plzz reply soon

[@solutionpharmacy]

Both are different but many factors affect bioavailability so it looks like both are same. (But both are slightly diff)

[@solutionpharmacy]

It was a good question

[@yusraakhtarali3238]

@@solutionpharmacy so sir can we write these factors which you discuss in this video under question of the factors modify drug bioavailability....or some additional factors are required..??

[@yusraakhtarali3238]

@@solutionpharmacy and if some additional factors are required could you please let me know which would be they..??

[@solutionpharmacy]

@@yusraakhtarali3238 please watch factor affecting BA video

[@AdityaYadav-td7kq]

Sir ap padhate acha hai lekin clear kam shikh rha hai

[@solutionpharmacy]

Setting me hd set kariye youtube ke

[@basavarajhadapad4132]

sir plz tell in kannada

[@RxDharmendra22]

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[@brendonmoyo3228]

you started well and then you went on speaking in tongues, may you please stick to English always

[@solutionpharmacy]

Our pharmacology lectures in English (Started From 01/12/2020). Link- Complete Pharmacology Topics (English)
ua-cam.com/play/PLOsge3l7t_CTpZW0qDKEHoYyYBTYPozex.html
Channel list - ua-cam.com/users/PharmacyDictionaryBySolutionPharmacy

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Dont you know english y dont you talk english

[@solutionpharmacy]

Dont you know hindi ? Why dont you learn. You have no right to point out our language. Watch this link to check my english (Although i dont need to clarify you) Please visit our new channel for pharmacology lectures in English (Started From 01/12/2020). Link- ua-cam.com/users/PharmacyDictionaryBySolutionPharmacy

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Ritika Chouhan welcome

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Sir Facebook group se PDF kha se download kre..

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Welcome

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Thank you