The fact that this video covered all of diuretics in an easy way to understand is amazing compared to 4 hours of lecture time that made no sense. Much appreciated video.
I teach pharm and I really like the amount of time you obviously spend on organizing the information visually. When I cover diuretics I emphasize the hypokalemia/hyperkalemia effects of the drug classes a bit more and mention aquaporins, but I love the level of detail you've got here in each section. You've organized it in such a way as to not be overwhelming to the beginning student. You should consider making a book! :-)
TaiChiKnees None of this is on the PTCB exam- just help me pass that. I am researching this because I was taking lisinopril due to having natural high bloodpressure 140 over 95 with a 101 pulse rate and I want everyone to know that lisinopril: ACE inhibitor/duretic made me pass out twice, so I was switched to metoprolol: Beta Blocker..... With my personal self research: I'd like to say that I believe Beta Blockers should be taken strictly on a prn basis since the prolonged use can cause a stroke once you wing off.... I'd like to understand why my doctor believes I should take this for the rest of my life causing a death sentence? When it should be a prn drug? And another thing. Why did a pharmacy tell my insurance company that I was taking a generic brand named drug whenever I was scripted the brand name? The PTCB exam has hospital software questions--- That should be considered when teaching because they want Technicians to know what Nurses should know.
+TaiChiKnees I am responding to your comment eventhough it wasn't written to me but since you teach pharm i can't pass by and not bring this up to you. Bassically it's about diuretics efficacy in managment of decompensate heart failure, there is no doubt they are effective in treating few acute states and CHF to some extent. However treating decompensated HF is going to do nothing, fluids will accumulate in the body no matter what, the amount you excrete is just going to get back to circulatory system from instersticium and if you stop drinking fluids you're gonna die from dehydration. What my question is, can it be said that they are ineffective in treating decompensated heart failure in the long run?
This was great, thanks, I been tryin to find out about "thyroid wellness for dogs" for a while now, and I think this has helped. You ever tried - Yannabarn Vanish Thyroid - (Have a quick look on google cant remember the place now ) ? Ive heard some extraordinary things about it and my mate got excellent success with it.
To be honest i wont be surprised if other textbooks use either of these cells as the major site of aldosterone function. What I learnt from my lecture was that aldosterone elicits its function on the intercalated cells, but than again its probably both.
You are right i could've made this video better by adding the K and H pumps in. I just felt that I wanted to get the point through, how these diuretics aim to decrease BP. Ill add those comments on the video soon, but worried it might confuse some people. cheers
Awesome stuff armando. I used these videos since the beginning of my nursing journey, the pre-requisites, and have used them throughout. Now I am an ER RN. With these videos and the mobile app Nclex Nursing Tools, I have rocked pharm. Thanks again brother, cheers.
I've been a nurse 11 years and had stumbled upon these videos on one of my late "need to refresh myself since i'm awake" nights. This information is extremely helpful especially when you are working with patients who ask a ton of questions about why, what and the need for their "water pills". Thank you.
One way to remember things is to Visualize them. That's what happened here. Every bit is clearly explained and organised. Recommend watching. Thank you Armando Hasudungan :) Thumbs!
That "WHAT!" at 14:43 sounded like either 1) Armando just made a mistake and is extremely pissed with himself 2) Armando is amazed at the abilities of spironolactone
Hey Armando, I'm a student Paramedic at Sheffield Hallam University UK. I wanted you to know just how much I swear by your videos. Some of this stuff is really difficult for me to understand and text books drive me crazy. Great work. Right now I am looking at thiazide diuretics and the implications on left ventricular failure. Thanks to you I think doing relatively well.
Thank you so much! The best point in your explanation that you never get sick of repeating what is normally happening and THEN telling us what happens diffrently, it keeps reminding us and allowing us to compare the difference between the abnormal(in case of diseases) Or the pharmacological effect If our doctors would bother to spare a couple of minutes to reminds of the normal during their explanation rather than "trusting" that the other (physiology/anatomy/histology) has done it before them, i won't be half as lost as i usually am, and my circulating problem is that when i get lost i lose interest and i tend to zone out the rest of the lecture.... Thus I am extremely thankful for your videos, Thank you!
A great video!, but just one thing, at 14:10 you are stating that spironolactone (aldosterone inhibitors) are working on intercalated cells, but in fact spironolactone (aldosterone inhibitors) - their target cells are Principle cells, as well as aldosterone - his main target cells are as well Principle cells, but again, a great video thank you!
Actually after watching all these videos i don't really understand why do you guys hitting unlike button ................. even if u don't like these videos ,,,, why can't i just leave ????? please don't do this and learn to encourage them ..................
I also learned that ADH and Aldosterone both work on principal cells. But I do know that Aldosterone DOES stimulate the H+ ATPASE on alpha intercalated cells. (alpha = secrete H+, beta = secrete HCO3-) I was surprised I didn't see the K+/H+ antiport and the H+ ATPase in the alpha-intercalated cells. Considering that renal distal tubular acidosis causes hypokalemia as well. Using diuretics with that would just worsen it considering loop and thiazide diuretics are K+ wasting.
At 11:17 you talk about HCTZ increasing urea reabsorption in PCT which causes increased plasma uric acid (and gout)... did you mean increased uric acid reabsorption in PCT or are uric acid and urea reabsorption related somehow?
Hey, I don't know whether this has been pointed out before, but urea has nothing to do with uric acid (urea cannot convert into urate/uric acid). Therefore, the information regarding the thiazide diuretics isn't strictly true, as thiazides promote the reabsorption of urate (not urea) at the distal convoluted tubule and so you end up with hyperuricaemia which can then lead to gout. I just wanted to point this out as it can lead to confusion. Otherwise an excellent video for learning the different classes and MOAs of diuretic drugs.
these compounds are used commonly in my sport, and I now have an incredible understanding of their actions------thank you so much for sharing what must have been years of study
Raissa Canales he didn't mention that in thiazide it will cause hypocalcemia he only mentioned that calcium will be not be reabsorbed in which it won't be excreted in the urine causing increase in ca in plasma. replay the video.
Hi I really like your simple and precise way of explaining concepts! Please continue making such beautiful and helpful videos. P.S."Symptomer" @ 2:42 should be corrected to "symporter"
love...u love...u love u....love your way of teaching....thank you for this video ...its like you made my life easy plzzzz.....make "n "numbers of video like this...thank u sooo....much....😁😁😁😁😁😁😄😄😄😄😘
Thanks for all of the hard work you are doing, it is greatly appreciated by everyone. I believe you should make this artwork into a PDF document and post it on a website for students to download. While the video is great, the notes would help us study for exams, etc. without having to be at a computer. Thanks again.
for Thiazide, I think it is not so much that the Thiazides inhibits the excretion of Calcium, but rather, while inhibiting the NaCl cotransport, it reduces the intracellular Sodium concentration, promoting the NaCa2 transporter (on the blood side) to give to the cell sodium in exchange for Ca2. Therefore, calcium in the lumen will enter the cell and exit via the NaCa2 transporter into the blood.
Although CA inhibitors are small and weak diuretics, they used for prevention of acute mountain sickness. Of course if you already got it you have to take furosemide, but I'm just saying because I had to take acetazolamide before because of AMS :)
VictorNeb8135 loop diuretics as well causing hyperuricaemia, they have mostly the same side effects as thiazides, that's why we have to be careful giving them together, they increasing each other's effect. :)
📌MAKE THIS LECTURE STICK: FREE PRACTICE QUESTIONS HERE! 🎓
youmakr.ai/test-playground/questionnaire/673d4d0e859b9c170836f188
Im a pharmacy student and this was 1000x more helpful than any of the classes or lectures I've been to. Truly grateful THANK YOU!!
ua-cam.com/video/YubDzhN5IRE/v-deo.html
The fact that this video covered all of diuretics in an easy way to understand is amazing compared to 4 hours of lecture time that made no sense. Much appreciated video.
I'm a third year medical student and always use your videos to scrub up on the basics before starting a new firm, you do an excellent job, thank you!
any updates doc
I teach pharm and I really like the amount of time you obviously spend on organizing the information visually. When I cover diuretics I emphasize the hypokalemia/hyperkalemia effects of the drug classes a bit more and mention aquaporins, but I love the level of detail you've got here in each section. You've organized it in such a way as to not be overwhelming to the beginning student. You should consider making a book! :-)
TaiChiKnees thanks!
TaiChiKnees None of this is on the PTCB exam- just help me pass that. I am researching this because I was taking lisinopril due to having natural high bloodpressure 140 over 95 with a 101 pulse rate and I want everyone to know that lisinopril: ACE inhibitor/duretic made me pass out twice, so I was switched to metoprolol: Beta Blocker.....
With my personal self research: I'd like to say that I believe Beta Blockers should be taken strictly on a prn basis since the prolonged use can cause a stroke once you wing off....
I'd like to understand why my doctor believes I should take this for the rest of my life causing a death sentence? When it should be a prn drug? And another thing. Why did a pharmacy tell my insurance company that I was taking a generic brand named drug whenever I was scripted the brand name?
The PTCB exam has hospital software questions--- That should be considered when teaching because they want Technicians to know what Nurses should know.
+TaiChiKnees I am responding to your comment eventhough it wasn't written to me but since you teach pharm i can't pass by and not bring this up to you.
Bassically it's about diuretics efficacy in managment of decompensate heart failure, there is no doubt they are effective in treating few acute states and CHF to some extent. However treating decompensated HF is going to do nothing, fluids will accumulate in the body no matter what, the amount you excrete is just going to get back to circulatory system from instersticium and if you stop drinking fluids you're gonna die from dehydration. What my question is, can it be said that they are ineffective in treating decompensated heart failure in the long run?
This was great, thanks, I been tryin to find out about "thyroid wellness for dogs" for a while now, and I think this has helped. You ever tried - Yannabarn Vanish Thyroid - (Have a quick look on google cant remember the place now ) ? Ive heard some extraordinary things about it and my mate got excellent success with it.
TaiChiKnees i
To be honest i wont be surprised if other textbooks use either of these cells as the major site of aldosterone function.
What I learnt from my lecture was that aldosterone elicits its function on the intercalated cells, but than again its probably both.
I LITERALLY SHOULD PAY YOU TO BE MY PROFESSOR, CAUSE THE ONES I HAVE, ARENT CUTTING IT
ua-cam.com/video/_cV_6deVJSk/v-deo.html
you always save my life when it comes to studying for tests! thanks a lot!!
ua-cam.com/video/YubDzhN5IRE/v-deo.html
you consume lots of time to help us beautifully understanding various medical basics in short time ! & saving our time
A huge Thanks !
You are right i could've made this video better by adding the K and H pumps in. I just felt that I wanted to get the point through, how these diuretics aim to decrease BP. Ill add those comments on the video soon, but worried it might confuse some people.
cheers
Awesome stuff armando. I used these videos since the beginning of my nursing journey, the pre-requisites, and have used them throughout. Now I am an ER RN. With these videos and the mobile app Nclex Nursing Tools, I have rocked pharm. Thanks again brother, cheers.
If you keep doing these videos all medical disciplines then YOU are the future of medical education !
great explanation SIR 👍👍
ua-cam.com/video/YubDzhN5IRE/v-deo.html
@@drnajeebali425ua-cam.com/video/YubDzhN5IRE/v-deo.html
I've been a nurse 11 years and had stumbled upon these videos on one of my late "need to refresh myself since i'm awake" nights. This information is extremely helpful especially when you are working with patients who ask a ton of questions about why, what and the need for their "water pills". Thank you.
ua-cam.com/video/YubDzhN5IRE/v-deo.html
ua-cam.com/video/YubDzhN5IRE/v-deo.html
One way to remember things is to Visualize them. That's what happened here. Every bit is clearly explained and organised. Recommend watching. Thank you Armando Hasudungan :) Thumbs!
I wish I can see the map as a whole in the end so I can memorize it easily like a (mind map) thank you
Rawan its linked in the discretion box
That "WHAT!" at 14:43 sounded like either
1) Armando just made a mistake and is extremely pissed with himself
2) Armando is amazed at the abilities of spironolactone
THANK YOU SO MUCH! I was struggling to understand how osmotic diuretics worked and i couldn't find the mechanism anywhere until now! Very helpful!
ua-cam.com/video/YubDzhN5IRE/v-deo.html
Your drawings are awesome! You are so talented!
Thanks for your illustrated video. FYI you misspoke at 11:05 - thiazides increase absorption of urate not urea. Hence gout as a side effect.
No it is urea itself
Urea combines with sodium to form sodium urate which precipitates to form tophi or gout
I love your video I pass my exam because of you thank you
Thank you very much for your clear explanation. I used some of your video to prepare for the NCLEX RN exam and I enjoyed watching it. And....I passed!
congratsssssss!!!!!!
I can't express how great and detailed this video is
ur a legend for my exam tomrow ur ideal
Hey Armando, I'm a student Paramedic at Sheffield Hallam University UK. I wanted you to know just how much I swear by your videos. Some of this stuff is really difficult for me to understand and text books drive me crazy. Great work. Right now I am looking at thiazide diuretics and the implications on left ventricular failure. Thanks to you I think doing relatively well.
I'm so impressed with how smart people have to be to know this stuff well. I see why people that know this stuff get paid. It's inspiring!
Thanks for this video. It's amazing. Also, whoever is drawing is a really good artist. Not sure if that's you or not.
FASCINATING... I was merely trying to better understand what diuretics like coffee were & how they worked, but I got a whole lesson!! Loved it!!
seriously your way of teaching is too good... i really liked your video.
6 years after , still the best videos that explain diuretics
This was so helpful! Love that you posted a link to the full photo. Just printed it off to help study. Thank you!!
I am also a pharmacology teacher but still love the way u teach.....just love each and every video of urs
I watched your video when i was in last year of med school and it still helps me a lot❤
Your video is better than all over online class.
thanx bro ur video took me to top 🔝 in my college
Thank you so much!
The best point in your explanation that you never get sick of repeating what is normally happening and THEN telling us what happens diffrently, it keeps reminding us and allowing us to compare the difference between the abnormal(in case of diseases) Or the pharmacological effect
If our doctors would bother to spare a couple of minutes to reminds of the normal during their explanation rather than "trusting" that the other (physiology/anatomy/histology) has done it before them, i won't be half as lost as i usually am, and my circulating problem is that when i get lost i lose interest and i tend to zone out the rest of the lecture....
Thus I am extremely thankful for your videos, Thank you!
I'm a visual learner... Your videos help big time! Thank you so much...
my life would have been easier if those videos came out before i finished my studies -.-
but thanks man we can still learn :) keep it up!
Really I like such oversimplified lectures which are making my life end proffession very simple and enjoyable.
Thank you so much for this amazing video! It helped me to understand everything about diuretics now. Greetings from Germany 🇩🇪
A great video!, but just one thing, at 14:10 you are stating that spironolactone (aldosterone inhibitors) are working on intercalated cells, but in fact spironolactone (aldosterone inhibitors) - their target cells are Principle cells, as well as aldosterone - his main target cells are as well Principle cells, but again, a great video thank you!
Really good video to explain how Diuretics work, thanks a lot ...
I love your handwriting!
Actually after watching all these videos i don't really understand why do you guys hitting unlike button ................. even if u don't like these videos ,,,, why can't i just leave ????? please don't do this and learn to encourage them ..................
The best diuretic video ever! Excellent
I also learned that ADH and Aldosterone both work on principal cells. But I do know that Aldosterone DOES stimulate the H+ ATPASE on alpha intercalated cells. (alpha = secrete H+, beta = secrete HCO3-)
I was surprised I didn't see the K+/H+ antiport and the H+ ATPase in the alpha-intercalated cells. Considering that renal distal tubular acidosis causes hypokalemia as well. Using diuretics with that would just worsen it considering loop and thiazide diuretics are K+ wasting.
At 11:17 you talk about HCTZ increasing urea reabsorption in PCT which causes increased plasma uric acid (and gout)... did you mean increased uric acid reabsorption in PCT or are uric acid and urea reabsorption related somehow?
I'm a visual learner and your videos definitely help me. Thank you!
Hey, I don't know whether this has been pointed out before, but urea has nothing to do with uric acid (urea cannot convert into urate/uric acid). Therefore, the information regarding the thiazide diuretics isn't strictly true, as thiazides promote the reabsorption of urate (not urea) at the distal convoluted tubule and so you end up with hyperuricaemia which can then lead to gout. I just wanted to point this out as it can lead to confusion. Otherwise an excellent video for learning the different classes and MOAs of diuretic drugs.
Loved it! Thank you so much... Is it possible to find this whole drawing as a poster ? I'd love to print it out
you can get it from his official website...
Thank you sooo much!!! I love you for dedicating your time to make Pharmacology fun and easy. ❤❤❤❤❤
these compounds are used commonly in my sport, and I now have an incredible understanding of their actions------thank you so much for sharing what must have been years of study
Excellent video! Did you mean symporter rather than symptomer?
WOW! You hope me to understand pharm and now it's simple :) Great job!
Accidentally slept through a test. So starts my waiting period binge-watching this while waiting for the next scheduled one!
This is incredibly helpful. Thank you so much for posting this video.
Your explanation is amazing😍
How can I get the whole picture please? The description box aks for access
awesome... thank you so much sir.
in thiazide diuretics na/ca exchange increase, and gives you hypercalcemia not hypo.
Raissa Canales he didn't mention that in thiazide it will cause hypocalcemia he only mentioned that calcium will be not be reabsorbed in which it won't be excreted in the urine causing increase in ca in plasma. replay the video.
Hi I really like your simple and precise way of explaining concepts! Please continue making such beautiful and helpful videos. P.S."Symptomer" @ 2:42 should be corrected to "symporter"
kept on making me think of maths.
Hey, does your poster thing that you have drawn, Come in like a pdf or something like that?
Thank you so much. Your explanation are so grate and useful👌👌👌
Very simple and concept clearing....hatts off sir
Excellent explanation and illustration sir.....thank so much for making these videos🥺
Thanks so much. I'm taking Pharm right now and your video makes so much sense. Why can't you be my professor? ☺️
love...u love...u love u....love your way of teaching....thank you for this video ...its like you made my life easy plzzzz.....make "n "numbers of video like this...thank u sooo....much....😁😁😁😁😁😁😄😄😄😄😘
Very detailed and informative! Thank you!!
great videos! can you please do some about electrolytes? Na, K, Ca, etc. Hyper and Hypo?
You are amazing!!!!!THANK YOU SO MUCH for offering me this! I love what you're doing
Nice and beautiful way of explanation.
Thank you for this video, word for word from my veterinary pharmocology class but perfect for a visual learner like me!
Man seriously u r a great teacher
Thank u for such easy explanation
hey ur doing a really good job... please keep posting videos like this.. helped me for my finals... thank u so much...;-)
The video was very easy to follow. Thanks.
12:08 shouldn't it be increase in excretion of sodium?
Thanks for all of the hard work you are doing, it is greatly appreciated by everyone. I believe you should make this artwork into a PDF document and post it on a website for students to download. While the video is great, the notes would help us study for exams, etc. without having to be at a computer. Thanks again.
This is Awesome! Thank you Armando, you are now my new study buddy :)
Hands down men. You are absolutely awesome.
Thank you somuch for the video. Hope you stay happy and healthy and richhhh
Such a helpful video!! Your channel is saving me right now!
Thanks for the great work 💕💕💕
Thank you, Armando. What an amazing video.
very clear n simple explanation... thanks
Clearly described, spoken, highly recommend this lesson, thank you
Armando, great work. Thanks.
I would love to have this artwork in PDF form. Would be a terrific study/reference guide.
Stephen Stevens there is a link in the description box
Armando you are supergenous,, finally i understand pharmacology 👍👍
14 and cramming for the Science Olympiad, very helpful thanks!!!
FINALLY someone I can understand. Thank you so much! #nursingstudent #visuallearner
Good videos for beginners .. great effort
you are so Creative ... keep learning us .
for Thiazide,
I think it is not so much that the Thiazides inhibits the excretion of Calcium, but rather, while inhibiting the NaCl cotransport, it reduces the intracellular Sodium concentration, promoting the NaCa2 transporter (on the blood side) to give to the cell sodium in exchange for Ca2. Therefore, calcium in the lumen will enter the cell and exit via the NaCa2 transporter into the blood.
also,
Aldosterone does not only promote the synthesis of NaK-ATPase, it also increases the production of regular old Na+ channel~
Thankyou so much🥺❤️
Although CA inhibitors are small and weak diuretics, they used for prevention of acute mountain sickness. Of course if you already got it you have to take furosemide, but I'm just saying because I had to take acetazolamide before because of AMS :)
a true legend, thank you.
Very nice and fruitful lecture.
you are very good at teaching.
beautiful lecture....thank you..respect👌
This was very helpful! Clear and easy to understand! Thank you
VictorNeb8135 loop diuretics as well causing hyperuricaemia, they have mostly the same side effects as thiazides, that's why we have to be careful giving them together, they increasing each other's effect. :)
wonderful..I keep looking for your videos and they are really helpful ..keep on 💪