Its more ordered(the water ) *pre/before* hydrophobic effect and aggregation. Afterwards however you have less ordered water molecules. Which is why the less ordered environment of water, is favored because more disorder is more favorable
You're better than my lecturer thank you so much!!!!! I remember hearing that the bonding of hydrophillic ligands to proteins was mainly because that is entropically favourable too becuase the hydrophillic ligands bond to many water molecules and bonding to a protein means more free molecules in solution, but the again I remember hearing the main driving force of binding is the decrease in enthalpy instead, do you have any idea which one the truth is
so the hydrophobic effects decreases the solvation layer of a protein? it makes protein folding make some more sense as to why it's energetically favorable
finally. a short precise explanation that actually makes sense. I think the pictures really helped. I read through jack westin, shem, and reddit and still couldn't understand it as well until I watched this. I knew all of the concepts but I just couldn't make it make sense.
Thanks for explaining this concept clearly. It helped me to understand the forces stabilising self assembly of amphiphiles. For lay person to follow it could have been better if you explained bit more slowly.
OK so the water gets disordered through the aggregation of the non-polar molecules, doesn't the opposite effect occur with the hydrophobic peptides? They go from infinite number of states to a small number of states?
theres a total net increased possible conformations when hydrophobic amino acids aggregate.. so the increased number of conformations of water outweighs the number of possible conformations lost by amino acids
The amount of times he says orderly makes it hard to forget the concept XDD
I really appreciate this method of teaching, sometimes you just gotta beat the concept into your head
ORDERLY
Great concept but.. this video is giving me a stroke.
samee
In an orderly fashion, very orderarily
Lmao!
wait so is it ... orderly?
literally the only thing i take away is that things have been orderly in this video. This video is the very definition of orderly.
Its more ordered(the water ) *pre/before* hydrophobic effect and aggregation. Afterwards however you have less ordered water molecules. Which is why the less ordered environment of water, is favored because more disorder is more favorable
@@tammyclairs166 I read in a biochem book that before the hydrophobic effect happen , the entropy is more favorable… that’s weird
This video should be used as a drinking game!
great job though. thank you man!
I was having such a hard time understanding this concept. Thank you for the clarification! :)
Teachers just said "disorder" but that means nothing unless we see it. You did an excellent job at helping us visualize it.
TL;DR HYDROPHOBIC EFFECT, ENTROPICALLY FAVORED, ORDERLY
drink everytime he says orderly
This is how I explain things when I don't get them for a long time and then suddenly it clicks because i understood a fundamental thing (ORDERLY)
amazing teaching, making my life easier omg tysmmmm, and the video is so comprehensive
Thanks, demonstrating this with the phenylalanine made the concept so much clearer
You're better than my lecturer thank you so much!!!!! I remember hearing that the bonding of hydrophillic ligands to proteins was mainly because that is entropically favourable too becuase the hydrophillic ligands bond to many water molecules and bonding to a protein means more free molecules in solution, but the again I remember hearing the main driving force of binding is the decrease in enthalpy instead, do you have any idea which one the truth is
I couldn’t watch past 49 seconds. Oh lord. My heart
so the hydrophobic effects decreases the solvation layer of a protein? it makes protein folding make some more sense as to why it's energetically favorable
Explained absolutely PERFECTLY, and in such a short video! Thanks so much
The amount of times he said "orderly" makes me cringe but I learned the concept well.
guys i think it’s because the water is orderly
Thank you for your nice explanation. I would ask, why water molecules ordered on the surface of non polar molecules?
I’m wondering the same thing!
Why do u sound like the one from nicki minaj livestream
A lot of passion, man, that's great! Make sure to not have unrelated flashing or moving elements in the video, because it's very distracting.
Passionate orderly
wait, it's all orderly?
Definitely not everything i need to know
Now this... this. Makes sense
O R D E R L Y
couldnt miss the point here
i love you
it was tremendously great explained. Thank you very much!!
I love how everything comes back to physics
Finally, a video that explains it all!!!
Very well explained thank you ❤
Great video. I totally understand this concept now!
take a shot every time he says orderly
Just dropped dead from alcohol poisoning, would recommend
Thank you for making this so simple!
amazing
finally. a short precise explanation that actually makes sense. I think the pictures really helped. I read through jack westin, shem, and reddit and still couldn't understand it as well until I watched this. I knew all of the concepts but I just couldn't make it make sense.
THANK U!!! finally
So what are the new L17 A21 street lights supposed to be? Anything to do with fibril growth?
why you are saying ORDERLY many timessssss
I rarely comment on UA-cam, but I'm really grateful for your clarification!
interesting! is there a non entrophic explaination?
this is the best way I've ever heard this explained. thank you so much!!
Awesome video I really appreciate this, slow down a bit that's my only critique, nice work!
Thank you for this♥️ read the passage in an mcat book, and was a little confused until I saw this
To reduce surface area. That's it.
Great Job bro.. u cleared my doubt. Keep Going as such bro 👍
DAMN SIR STOP YELLING AT MEE💀💀
Amazing thank u I have my exam in two weeks I’m so nervous
Answered my exact question, thanks!
This explanation was magnificent!
this was really freaking good
Thank you for helping me with my biophysics exam, you’re the best!!!!!🙏🙏🙏
You sounds like Morty lol
Thanks for explaining this concept clearly. It helped me to understand the forces stabilising self assembly of amphiphiles. For lay person to follow it could have been better if you explained bit more slowly.
Great didactic, thanks!
u sir... r AMAZING.. THANK U
Very clear explanation. Thank you!
Thank you!
Great Video
OK so the water gets disordered through the aggregation of the non-polar molecules, doesn't the opposite effect occur with the hydrophobic peptides? They go from infinite number of states to a small number of states?
theres a total net increased possible conformations when hydrophobic amino acids aggregate.. so the increased number of conformations of water outweighs the number of possible conformations lost by amino acids
@@sciencesimplified3890 Thanks. A complex problem then.
Great!
Great explanation!
but why WHY
It's a little bit more complex than that, it relates to the number of possibilities.
If any one is interested I would reconsider explaining it
W explanation ty