Thanks for an excellent explanation! I'll add a suggestion based on my experience with this syndrome. In the early 1980s I was working nights on a pediatric Hem-Onc unit. A boy of about eight was admitted having leukemia (ALL) with an exceptional high blast count and a low platelet count (70,000). We moved even quicker than usual. As his chemo was wrapping up, he developed a nose bleed. Every other remedy failed, so the resident decided to pack his nose with cotton. As he did so, I became worried. A half hour before the boy had been obviously miserable as his nose bleed triggered vomiting. Now and without being given anything to reduce the pain, he was oblivious to what had to be a painful procedure. Something is wrong, I thought. There was already an order for a CBC to monitor those low platelets. I persuaded the resident to add a blood chemistry. The latter came back with all alarms ringing and the boy went (briefly) to our ICU. Now for the clincher. Because of that incident, a few days later the national protocol for treating childhood leukemia was altered to prevent that from happening again. My suggestion? Our brains are sensitive to changes in our blood. Watch patients who're getting chemotherapy. If they seem to be losing an awareness of their surroundings, get a blood chemistry run pronto.
Andrew Wolf, Thanks for the video. I just wanted to let you know that with Chronic Myeloid Leukemia (I haven't confirmed AML, yet) the uric acid increases well before chemotherapy ever begins. The increased uric acid levels are attributed to high turn-over rate of cells. -Source: Fundamentals of Pathology: Pathoma. 2011. - I have also seen a case of CML that presented, at least initially, with only hyperuricemia and none of the other TLS's. I am not sure if that is typical or not, and I'm wondering your take on that.
tumor lysis syndrome is complication of chemotherapy. due ko chemo many cell dies and releases toxins which increases level for potassium,phosphate ,uric acid levels but decreases calcium level. this leads to AKI to kidney.
I believe it's due to the presence of phosphate in the sugar-phosphate backbone in DNA. Thus when the cell lyses phosphate is released into the bloodstream.
very nice , and realy thank you , in fact I am RN working in emergency ,dep , and i get from you brief nice way about TLS , but what i KNOW ALSO inside the emergency unite i observe the Drs they manage the hyperkalemia with k oxilator , woulg give me your maagment inside the emergency unite to do shifting of abnormal electrolytes to be normal and i saw them giving insuline and calecium , plz i am waiting your responce
Thanks for an excellent explanation! I'll add a suggestion based on my experience with this syndrome. In the early 1980s I was working nights on a pediatric Hem-Onc unit. A boy of about eight was admitted having leukemia (ALL) with an exceptional high blast count and a low platelet count (70,000). We moved even quicker than usual. As his chemo was wrapping up, he developed a nose bleed. Every other remedy failed, so the resident decided to pack his nose with cotton. As he did so, I became worried. A half hour before the boy had been obviously miserable as his nose bleed triggered vomiting. Now and without being given anything to reduce the pain, he was oblivious to what had to be a painful procedure. Something is wrong, I thought. There was already an order for a CBC to monitor those low platelets. I persuaded the resident to add a blood chemistry. The latter came back with all alarms ringing and the boy went (briefly) to our ICU. Now for the clincher. Because of that incident, a few days later the national protocol for treating childhood leukemia was altered to prevent that from happening again. My suggestion? Our brains are sensitive to changes in our blood. Watch patients who're getting chemotherapy. If they seem to be losing an awareness of their surroundings, get a blood chemistry run pronto.
Awesome input Michael! We appreciate you sharing :)
Awesome video! One of those syndromes where the findings and treatment fit the pathology perfectly! Cheers.
Thanks for tuning in DOC
You are an awesome teacher!
Thank you so much!
Andrew Wolf, Thanks for the video. I just wanted to let you know that with Chronic Myeloid Leukemia (I haven't confirmed AML, yet) the uric acid increases well before chemotherapy ever begins. The increased uric acid levels are attributed to high turn-over rate of cells.
-Source: Fundamentals of Pathology: Pathoma. 2011.
- I have also seen a case of CML that presented, at least initially, with only hyperuricemia and none of the other TLS's. I am not sure if that is typical or not, and I'm wondering your take on that.
Thank you this was way helpful!!!! im a nursing student and this makes way more sense then the textbook!
same with me! specifically for pharmacology
Thank you for the "easy to understand" explanation
Of course:). Thank you for tuning in.
Very insightful ! Many thx for sharing knowledge :)
the drawing look so confusing at the end but its SO well explained and completely understood thank you!
Thank you Megan:)
Excelente! Y muy creativo... Gracias! por dedicar tiempo a compartir conocimiento y de una manera tan creativa!
Thank you!
Thank you so much! You're a god sent!
Thanks so much Tara!
tumor lysis syndrome is complication of chemotherapy. due ko chemo many cell dies and releases toxins which increases level for potassium,phosphate ,uric acid levels but decreases calcium level. this leads to AKI to kidney.
Thanks Suman for your input!
thanks--great video! much appreciated.
Thanks so much!
Great lecture!! Thanks 🙏🏻☺️
Thanks Katrina! More lessons to come:)
thank you so much
Thank you so much for watching!
hi andrew! thank you so much'! you made it so easy!!!!can you make a video for oncologic emergencies--icp?
Thanks so much for the input. New videos coming weekly.
Awesome video thanks a ton! "
Could someone please tell me what's the reason for hyperphosphaetemia is tumor lysis synd?
I believe it's due to the presence of phosphate in the sugar-phosphate backbone in DNA. Thus when the cell lyses phosphate is released into the bloodstream.
@@sars2509 oh yes that makes sense. Thank you :)
Thanks for the feedback Sarvesh:)
Great, thanks a lot
very helpful! keep it up!
Thank you Matthew!
Thanks
Thank you for tuning in!
Thank you this was way helpful
Glad it helped!
thank you!
Thanks for watching!
Tumor lysis syndrome more common in ALL not AML
Thx for you
Thanks for taking the time to comment and watch. Appreciate the input!
very nice , and realy thank you , in fact I am RN working in emergency ,dep , and i get from you brief nice way about TLS , but what i KNOW ALSO inside the emergency unite i observe the Drs they manage the hyperkalemia with k oxilator , woulg give me your maagment inside the emergency unite to do shifting of abnormal electrolytes to be normal and i saw them giving insuline and calecium , plz i am waiting your responce
Thank you so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
Why is there hyperphosphatemia in tumor lying associated nephropathy!
Thank you so much for your inquiry. We have passed this question on to our medical review team. Thanks again for watching!
sooo slooow
Thanks for the feedback Rania! We will work to speed things up in the future:)