NG+

This is not WR anymore. Check speedrun.com/mec for the current world record.
White Screens Removed: 51:58
In Game Time: 52:50.27
Real Time: 1:01:03.87
If you want to skip the mission loads, here are some timestamps:
Release - 0:28
Old Friends - 5:59
Be Like Water - 8:00
Back in the Game - 9:14
Savant Extraordinaire - 15:05
Benefactor - 16:16
Fly Trap - 20:35
Sanctuary - 27:10
Encroachment - 29:26
Vive la Resistance - 31:26
Prisoner X - 36:04
Thy Kindom Come - 42:03
Family Matters - 47:12
Tickets Please - 51:15
The Shard - 54:40