The Efficacy and Safety of Creatine for High Homocysteine
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- Опубліковано 21 лип 2024
- Those on a healthy plant-based diet with elevated homocysteine levels despite taking sufficient vitamin B12 may want to consider taking a gram a day of contaminant-free creatine.
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This concludes my series on stroke risk. If you missed any of the videos here they are:
• What to Eat for Stroke Prevention (nutritionfacts.org/video/what-...)
• What Not to Eat for Stroke Prevention (nutritionfacts.org/video/what-...)
• Do Vegetarians Really Have Higher Stroke Risk? (nutritionfacts.org/video/do-ve...)
• Vegetarians and Stroke Risk Factors-Vitamin D? (nutritionfacts.org/video/veget...)
• Vegetarians and Stroke Risk Factors-Omega 3s? (nutritionfacts.org/video/veget...)
• Vegetarians and Stroke Risk Factors-Vegan Junk Food? (nutritionfacts.org/video/veget...)
• Vegetarians and Stroke Risk Factors-Saturated Fat? (nutritionfacts.org/video/veget...)
• Vegetarians and Stroke Risk Factors-Animal Protein? (nutritionfacts.org/video/veget...)
• Vegetarians and Stroke Risk Factors-Vitamin B12 & Homocysteine? (nutritionfacts.org/video/veget...)
• How to Test for Functional Vitamin B12 Deficiency (nutritionfacts.org/video/how-t...)
• Should Vegetarians Take Creatine to Normalize Homocysteine? (nutritionfacts.org/video/shoul...)
• The Efficacy and Safety of Creatine for High Homocysteine (nutritionfacts.org/video/the-e...)
Now I’m assuming that nearly everyone who’s taking their B12 will have normal homocysteine levels, so these last two videos are just for the rare person that doesn’t, but those on a healthy plant-based diet with elevated homocysteine levels despite taking sufficient vitamin B12 should consider taking a gram a day of contaminant-free creatine (which would be about a quarter teaspoon).
OK, so where do you get contaminant-free creatine? You can’t rely on supplement manufacturers no matter what they say, since the regulation is so lax, so I would recommend going directly to the chemical suppliers that sell it to laboratories and guarantee a certain purity. Here are some examples from some of the largest companies in alphabetical order where you can get unadulterated creatine:
• Alfa Aesar (www.alfa.com/en/catalog/B25009/)
• Fisher Scientific (www.fishersci.com/shop/produc...)
• Sigma-Aldrich (www.sigmaaldrich.com/catalog/...)
• TCI America (www.tcichemicals.com/eshop/en...)
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Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution!
-Michael Greger, MD FACLM
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All of the videos in this series can be found on the playlist: ua-cam.com/video/G1E7Upc2lPQ/v-deo.html. My new series on B12 recommendations will be coming out in a few weeks, but if you want them all now, you can also get those in a digital download here: drgreger.org/collections/videos/products/b12-recommendations-digital
I have heard that B12 absoption is limited to about a days worth every 5 hours, so taking a larger dose once a weak would not help. Is this fake news? If I remember correctly the person stating this was Chris Masterjohn who has Phd in nutrition I believe and he suggests taking a dose with every meal to fill up storages that can then hold years worth of B12 if filled correctly.
I thought I should share my experience, after seeing this video I had my homocysteine levels and B12 levels checked. My b12 was fine, but my homocysteine levels were high. Also my blood pressure was elevated. I started creatine about 2 weeks ago as of Wednesday my blood pressure seems to have normalized.
I hope to hear more from you. If you ever take your homocysteine/ blood pressure again, share the results here, please
@@ahgcomegaguardian5575 I am currently taking more b12 to see if that helps. As of yet the Creatine is not helping. I will test again in a few months
@@asloan193 Creatine can take some time to make a difference (months). 2000 micrograms a week of B12 should be enough if you're under 50 and an average person. Obviously, the older and bigger you are, the more you need. Older people can need at least 2000 micro grams a day
You changed my life sir. You deserve multiple medals.
I take creatine. Glad to hear it may help with homocysteine levels, but that's definitely not my swole reason for taking it. Or even the main reason. To be honest, I was swolely unaware of those benefits....untiiil now.
Man that makes swole much sense
😂
Which one you take
@@IsmaelDiazIAGoupeFinancier Just a random creatine monohydrate, that stuff has a ton of research behind efficacy and safety. Only take it off season when I lift a lot, it does cause very slight weight gain (water retention), barely noticeable, but I don't need it when racing.
Excellent series. I'm kinda sad because it's over, but I'm looking forward to the next one!
I remember a video from years ago where Dr Gregor trashed creatine supplements and as someone who had been taking it for years I felt worried BUT I did not stop taking it because I also know he has a hate for bodybuilding. Now I he has reversed his position. Crazy how things work.
note he still only recommends trying it for a specific group to address a specific problem, not recommended for everyone
@@TheOnlyHalfline I am 40 and been taking it non stop since I was 24. Had my blood work done 2 months ago and all levels are outstanding. So anecdotally I can say its great stuff and has not caused a problem for me.
@Laszlo Vegh monohydrate for the first 5 years at 5 grams a day. Then I switched over to KreAlkalyn at 3 grams a day.
Thank you for sharing always useful information with us ❤️
Thank you Dr. greger and team!!
As always, great videos.
What can 8 take for nerve pain following a Cortisone injection in my neck?
Dizziness, pain etc
You're a blessing in my life, thanks for all your work.
Thanks Doctor, I'm definitely gonna stop huffing whippets, starting on monday
Good for you.
Too late for me
Nah I'm on the Whippet diet. Surprisingly high in dead braincells.
Thank you so much for this series ❤
RED FLAG! As a WFPB for 10 years I was happy to hear that Creatine could lower my homocysteine levels. On the 3rd day of taking a gram of creatine a day, I had a GOUT flareup. I have never had gout before. I thought Vegans didn't have to worry about gout. It's very painful. You don't want it. Creatine is high in purines, and so is nutritional yeast, one of my favorite foods. Body builders complain of creatine triggering gout attacks. I have stopped taking these supplements. Just giving you a heads up.
Thanks for this info. Being b12 deficiant for a long time now, and an almost vegan except for goats milk, and reacting to all types of b12 quite horribly, i was just about to order some creatine, but spotted your post. I also have gout, which i suppress quite well with tart cherry extract.
I take 6 grams of creatine a day and eat meat. I also regularly drink alcohol and have never had gout. I am 50. Everyone is different and creatine specifically causing gout isn't something widely reported in studies on creatine.
My homocysteine is 10 and stays there (I get quarterly blood tests and my last 6 it is 10 on every test). 10 isn't great but considering I am homozygous for MTHFR it's not terrible.
Thank you for your post. I wonder if your creative levels were already high and maybe taking supplements triggered gout
Do you eat a lot of sugar and simple carbs? purines are created by the breakdown of fructose leading to production of uric acid.
I've taken creatine every day for a year on WFPB diet, haven't had the issue yet, maybe it takes longer
Great series! Glad to watch it to the end. When researching for potential side effects of B12 I found some studies that reported higher incidence of pulmonary cancer in men taking high doses of this vitamin.
Could you adress this issue in a future video please?
Thanks for all the content in here and elsewhere, it's been life changing for me.
Greetings from Portugal
Yes, in smokers!
Interesting! Yes, pls do a video on that Dr. Greger
Post on the site otherwise you don’t get a response probably not even a view.
Check what Dr. Greger says here about this
ua-cam.com/video/hNZLB0JawNg/v-deo.html
Like always thx for the information =) It`s always good to learn something new/ more. ;)
I was one of the vegans neglecting B12 supplementation... I am utterly ashamed! I really thought that it would be stored better and the amount found in plant milks and such would be enough, and I also was a bit scared of cyanocobalamin as I thought there was a risk it would convert to cyanide... I have learned my lesson and now take 1000 mcg of B12 3-4 times a week. I never want to become deficient again. I haven't tested my homocysteine level but it can't hurt to use half a teaspoon of my bf's creatine powder a couple of times a week!
Dr G you are amazing! Thank you!❤️🙌
Very nice !
Excellent content. Excellent video. Excellent ending to this series ;)
hyped for next series
The thought has occurred to me that if you are already suffering the effects of too much meat consumption, then eliminating meats or drastically reducing them and then taking a creatine supplement might be beneficial. I have been taking the buffered kind by EFX. And it makes a major difference in my strength levels. I even read something that said creatine can help fight cancer by fueling immune cells.
I love this channel!
Hello, Doc. Wondering if that moringa video is being considered? Thanks.
😊 Thank you Dr. Greger.
So Wfpb diet + B12 + Creatine.
Another one! Thanks
Thanks so much.
I've been watching different videos on strokes. Dr. Greger says that you have to take a proper B12 supplement to prevent strokes. Having had 3 strokes, I'm concerned with what is considered to be a proper B12 supplement. Can you answer this Dr. Greger? I don't eat foods supplemented with B12 but I take some liquid B12 most days.
What about trimethylglycine?
I would wonder whether these vegetarian populations with elevated homocysteine levels were consistently engaged in resistance training? I'm still learning about this but it seems to be that there is less methylation available, due to excessive methylation during creatine synthesis, and couple this with B-vitamin(s) deficiency, and we have a higher likelihood of homocysteine levels. Interestingly, resistance training has been shown to potentially upregulate endogenous creatine synthesis yet reduce homocysteine levels. Also, betaine, found in whole grains and beets has been shown to act as a methyl donor and sustain adequate methylation to ensure normal homocysteine levels. So it appears to me we have a two-fold issue: A low compliance or adherence to a steady resistance training program and inconsistent vitamin B12 supplementation as well as perhaps holes in one's diet (not all plants are created equal via nutrient density). For example, refined grains have substantially lower levels of betaine compared to whole grains, thus we have less methyl donors available, and this is even more important in a vegetarian population due to increased metabolic burden of creatine synthesis as you put in the video.
Dr Greger we need some studies on how TMG ie tri methyl glycine also called betaine, helps lowering homocysteine also. Thanks
Would supplements from other countries be safer for those of us int the USA?
Would Canada, for example, have higher standards for supplement quality and purity?
Please tell us about taurine
What’s a good brand for cyanocobalamin B12? I usually cycle between nature’s made, nature’s bounty, or doctor’s best
Lol that last comment at the end got me😂 I used to work in a cafe years ago where the bored staff used to do that 😂
how do you check for homocysteine levels?
It's a blood test that vegans should take when getting their b-12 checked
In another video he says that methylokobalamine is better. Which one it is? I'm confused.
i wonder what your recommended inebriant is doc (i know know it's not weed and whippits)
Some people have the mthfr gene mutation, either from one parent or a double mutation, one from each parent. This can lead to high homocysteine and a host of other problems. Folks with these gene issues should see their physician as they may need more help. They may need more help getting homocysteine levels down and investigation into other problems that may arise from the mutation. People can find out if they have this mutation through 23andme or similar gene testing if they want to.
Aaauntill now! Love it!
Is it alright for someone who is lifting weights and is plant-based to take creatine, which boosts athletic performance? Or are there any potential drawbacks that one should be considered about regarding creatine supplementation?
Sure it's one of the most researched and recommended fitness supplements. It is very safe as long as you buy high quality. I recommend you look for the Creapure logo - it's made in Germany to the highest standards. Vitacost and Jarrow are two of the brands using it in their product.
It's the most recommended supplement.
@Leon Schuring did it thicken again after you stopped
@Leon Schuring I think you're just going naturally bald brother
Also those are rather high doses
Dr Greger, why don't use use the seemingly more bioavailable methycobalamine instead?
Thanks for all the great information! I have a question. Is taking 500 mcg of Methylcobalamin oral spray once a day too much? Thanks!
Likely not a problem. Methylcobalamin B12 is always in higher doses because it is a ''natural'' but unstable form. The body can absorb it more readily, but some is always lost, so exactly how much is absorbed is hard to say, therefore the dosage is higher to make sure you're getting enough. The tiny amount of cyanide in cyanocobalamin B12 (which is what Dr. Greger recommends, with the exception of smokers) makes it a more stable form which has also been thoroughly tested, so there is more assurance as to the amount absorbed by the body, hence the lower dosage.
@@MrDannyboy898 OK, thanks for your reply!
i wouldnt worry either, i take a mix of methy and adrenosol 1000 a day, i might skip a day or two since some take it once a week
@@gabrielahimsa4387 OK, good to know. Thanks!
@@MrDannyboy898 Thank you for the information. I was looking for the recommended B12 (Sublingual Methylated / Cyanonobalamin) :)
buying directly from the chemical suppliers? I'm not sure what shape that would be in when you got it.
Most likely more pure
.... until now 😎😎😎😎 We need Nutrition Fact T Shirts/ Hats/ mugs/ key rings with Dr McGregor’s top sayings, like if you agree 😅
R1 R5
THIS...but I believe it does not happen because he, rightly, wants to be able to say he makes no profit
Put it to the test!
If cynocobalamin is water soluble and cannot be stored in the body, wouldn't consuming 1000mcg in one sitting lead to us peeing out the excess?
Thanks for the video! First time ever to be the first comment!
Talk about FRESH (or freshly frozen) Spirulina!
🌱
Nitrous oxide for the win. Gotta love them nangs bro.
Can we take creatine anyway even we don't have problems with homocysteine?
he said in the video, no. the reason is risk of contamination is too high
@@TheOnlyHalfline Thanks!
@@TheOnlyHalfline Do you know anything about Black seeds having anticancer benefits?
@@ginodumitru2529 i dont recall hearing that, but dr.g recommends black seeds for weight loss in how not to diet. soy beans have anti breast cancer and prostate cancer benefits. soluble fiber anti colon cancer benefits. cutting out salt and pickled foods lowers stomach cancer risk
Taking creatine has a bunch of benefits, especially if you do any form of strength or power training. There are also cognitive and cardiovascular benefits. It’s one of the few micronutrients you cants get from plants, and it is incredibly well studied and proven safe. Just choose a manufacturer with well known third party testing, as you should with any vitamin or supplement.
Hmm, I developed symptoms of renal failure while taking 1.5 g of creatine daily over a couple of years. Symptoms went away when I stopped the creo. When I had my kidneys checked later there was no sign of any underlying disease. So I think the common belief that renal failure on creatine only happens to people with an underlying kidney disease is dubious. Of course it might have been caused by contamination of the creo I was using.¯\_(ツ)_/¯
Nootropics depot is the only supplement company I will ever buy from. They do all their own third party testing themselves, in-house. They have creatine and b12 supplements among so many others.
What the hell is this? Tell me about the broccoli yo
B12 in the form of Methylcobalamin not cyanocobalamin
Creatine supplementation somehow makes my prostate hurts :/
5:14
5:34
6:09
lol whipcream
I have yet to find a B12 supplement of cyanocabalamin that is sublingual, or chewable, that doesn't have added questionable ingredients. I have viewed all your B12 videos and haven't heard you mention any concerns about the added compounds -- but I would rather not take them! Nature Made has one, but it has about 10 questionable ingredients! And it has the USP Stamp? I completely lost faith in that USP stamp now!
Have you tried Superior Source sublinguals? They are very tiny dots and the only other listed ingredients besides B-12 are lactose (milk) and acacia gum. That's it. I've never had any problem with them.
@@wilsclanmom No, I haven't tried that, or even heard of it. But I'll look into it! Thanks
so much for taking the time to share!
Does it increase male pattern baldness though? 🙂🙂🙂
joe rogan is that you? asmongold?
No
I use Hydroxocobalamine. It has a depot effect because it binds better to protein than Cyanocobalamine. 1 Shot (1000-1500mcg) every 6 months
@Michael Carney So we would do better on a standard (SAD) diet? I don't think so.
@Michael Carney Majority of B12 supplements are used in animal agriculture.
Nonvegans use more than vegans.
@Michael Carney The animals are supplemented B12.
Michael Carney do you even know where the B12 comes from in ur patty?
Worst case the cow gets a B12 supplement itself, best case it eats fresh grass and gets it from their.
🔔 .... 🌱 🦠
Or, adopt a whole food 80% plant diet. With 20% from animal sources. This might be enough to get us enough B12 and creatine, and get them from natural sources, rather than unregulated supplements. Cut down on animal products, but don’t cut them out altogether.
Cyanocobalamin is like sipping cyanide for my MTHFR mutation.....just sayin'. There are reasons why homocysteine in high that regular medicine has made pronouncements about that will harm some of us. The CDC still recommends folic acid when some of us can not tolerate (do not have the ability to transform it into useable form) and the result blocks our pathways even further and causes high homocysteine and general unwellness.
This is great. Can you do videos addressing some of the claims Miley Cyrus made about stopping being vegan.
💗💗💗
I eat everything that moves so got no problem
Take B12 on an empty stomach?
yes. because it's hard to absorb it
Taken 1 B12
The Jeff Goldblum of Scientists
I take creatine anyways because I lift weights and practice martial arts.
If i have to slap a p*ssy a$$ n*gga imma make it look sexy
Русских субтитров нет(((
Dr Greger looking strong in his latest pictures: i.redd.it/99852f46aij51.jpg
Finally the season finale. If your're giving a creatine supplementation a try. You can use Creapure.
nutritional nihilism haha that's great
I get it that strength training isn’t Greger’s thing, but he’s way too cautious with creatine. It’s the best studied and safest supplement on record, and high quality manufacturers are easy to find. Just look for GMP certification and a well known third party testing certificate like informed sport and informed choice. Also the correct dosage is .045 grams per kilogram of body weight.
This dude is waisting away … keep listening to him
I have taken it for bodybuilding, it makes your hair fall out.
Lies
Whoa... Clickbate title!
How so
Any diet that humans evolved to eat should not require supplementation. The science is pretty clear that we should be eating mainly fruit and veg, and that well over 95% of our calories should be plants. Probably it's closer to 99%. But 100%? I'm not convinced.
Why not? What are we missing from that 1% that we can't get from plant-sources? Explain the amino acids, vitamins, and minerals that are missing. Keep in mind that there hundreds of thousands of vegans that have been vegan since birth. I know 25 personally that are in the '80s.
@@DrReginaldFinleySr B12 and creatine. Did you even watch the video?
Also, I said WITHOUT supplementation, did you even read my comment?
Vegans tend to be low on omega 3, zinc, iodine, and vit D. We are able to get omega 3 and zinc from plant sources, but it's a very limited selection of plants. Doesn't make sense to me that we would have found adequate supply of these historically when there wasn't a globalized economy with pan-oceanic trade like we have today. So unless there are some herbs with these nutrients now lost to history, I don't think we evolved to only eat plants. Incidentally, fish and certain seafoods contain tons of B12, omega 3, zinc, iodine, and creatine. So my hypothesis at the moment is that we evolved to eat plants and occasionally fish. Just a theory, feel free to make a better case (provided you actually read my comment properly this time).
Reginald Finley well where to start... B12, iodine, EPA, DHA, creatine, sufficient amounts of leucine and calcium. I eat plant based and take supplements, but if I could not take supplements then I would eat animals.
Animals are fed B12 in their food, that is why you might get some B12 by eating animal products; but it's still through supplementation. Also milk is fortified with vitD, and cereals are fortified with B vitamins. In fact, most over-the-counter supplements are sold to meat eaters.
@@flabio7074 Thank you for adding to the discussion. My understanding is that leucine activates TOR and is therefore problematic in large amounts, and the body synthesizes adequate amounts from the amino acids in our plant diet? And that sufficient calcium can be reached by eating lots of leafy greens? Agree about the B12, iodine, and omega 3 however.
Конечно,английский язык хороший, но я им не владею!!! Голосовой перевод, необходим!!!
THIS GUY IS BORING TO LISTEN TO
Vital information ruined by lack of communication skills on this channel always
He has a weird tone and unique speech delivery style, that’s for sure
Ahhhahah healthy plant based? Just eat some meat so you get your b12😃
Unless you are hunting for your meat, the meat you are eating is from feedlot animals that had their feed supplemented with B12. Vegans just eliminate that animal in the middle and take the supplement directly.
Animals do not make B12, it’s only made by bacteria.
@@broddr so you ok with the enslavement of bacteria?
Breaking House, ha ha. Yes, I am totally OK with the enslavement of bacteria (and yeast, too).
@@broddr your nothing but a speicist😂
goodmorning1221 - interesting, so you _never_ eat at McDonald’s or any other fast food chain? You _never_ buy meat from a supermarket? If so, you eat differently from 99.9% of Americans. And you eat in a way that is not possible for those 99.9%, because there is not enough arable land to support that many wild and pasture raised animals.
Will this help against forced vaccinations by bill gates.
There wasn't a study for this, until now!
Hopefully this is a joke and you’re just making fun of antivaxers
Isn’t cyanocobalamin poisonous?