DNA Transcription Processing | Exons, Introns, Splicing, 5' Cap, and 3' Poly A Tail

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  • Опубліковано 1 жов 2024
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    Instructor: Dave Carlson
    DNA Part 14 - The Processing Stage of DNA-RNA Transcription

КОМЕНТАРІ • 110

  • @jennifergibbs7481
    @jennifergibbs7481 6 років тому +67

    ive never understood splicing until hearing you explain it, my MCAT is in 9 days. THANK YOU!!!

  • @nerdbyblood
    @nerdbyblood 4 роки тому +45

    The fact that these videos are so bite-sized while being so informative is what makes me watch these videos so eagerly.

    • @PremedHQ
      @PremedHQ  4 роки тому

      Thank you! Glad they were helpful :)

  • @lowinq
    @lowinq 3 роки тому +7

    I have an AP bio midterm tomorrow, in 10 minutes I've understood 60 slides that will be tested on the exam. Thank you so much!

  • @Sessa107
    @Sessa107 4 роки тому +8

    I don't think I'll ever really finish watching this video. I keep cracking up at 'snurps'!

  • @salvagonzaga5680
    @salvagonzaga5680 2 роки тому +4

    You are so gifted at explaining all the topics in your channel. Thank you so much

  • @tomharrysson8379
    @tomharrysson8379 2 роки тому +3

    Took my lecturer 1 hour to explain this, and I still didn't get it. Thank you so much!

  • @jaimiemckeel3415
    @jaimiemckeel3415 4 роки тому +4

    Great video! Just a note; mRNA processing occurs co-transcriptionally (beginning with the addition of the 5' cap). Also, the PolyA tail is added before splicing occurs.

    • @princesspat5239
      @princesspat5239 4 роки тому

      Hello, i want to make sure if i understood so poly A tail comes first then 5' cap along with splicing?

  • @CB-ut2rf
    @CB-ut2rf 6 років тому +18

    I can’t learn because of your pretty smile >

    • @PremedHQ
      @PremedHQ  4 роки тому +7

      It's all love here!

  • @silva0003
    @silva0003 3 роки тому +1

    Why is it so hard to find a video where someone takes a normal sequence template strand and goes through it in order, identifying exons and introns and showing the mature mRNA?

  • @hannahpedersen3202
    @hannahpedersen3202 3 роки тому +3

    I'm not going to be a medical student, but I'm in my first year of a biology major and with zoom school, the first two weeks I missed everything important. In hs bio, I slept through it completely. It's taken me 11 minutes to learn something that's taken me 3 years to learn. These videos are the best in terms of content. Never too much in depth so I don't understand, but never to the point it's too vague either.

    • @fayeduddin3229
      @fayeduddin3229 3 роки тому +1

      Yup, same here. Those Amoeba sisters' videos only go so far lol 😩

  • @renukaundal5287
    @renukaundal5287 5 років тому +4

    I am from India and tomorrow is my biology 1st term examination. Your video helped me a lot!
    Thank you sir!

    • @PremedHQ
      @PremedHQ  4 роки тому +1

      You're welcome! Best of luck!

  • @ronaldsamontanez8592
    @ronaldsamontanez8592 3 роки тому +2

    The best! I wish I had a teacher with similar talent as you doc, then I get a better grasp of fundamentals and complex principles of Pharmacy in general especially Pharmacology and Therapeutics!

  • @stevendinkha3270
    @stevendinkha3270 4 роки тому +2

    Thank you so much, you achieved what both my associate professor and professor failed to do. Much love from Iraq

  • @t-thevil2256
    @t-thevil2256 4 роки тому +4

    Where was this guy all my life?!?! It's fantastic, I finally could understand this whole process!! Thank you sir!!

    • @PremedHQ
      @PremedHQ  4 роки тому

      We're here now! Glad to hear you've gotten the concept now! You're welcome :)

  • @ferdiefatiga3443
    @ferdiefatiga3443 3 роки тому +1

    Best teacher in youtube! ❤️

  • @salomezhozhadze9071
    @salomezhozhadze9071 2 роки тому +1

    thank you

  • @estherbelog
    @estherbelog 6 років тому +4

    Thank you so much. These are extremely helpful, while being concise.

    • @PremedHQ
      @PremedHQ  4 роки тому

      You're most welcome!

  • @cookingcraze4856
    @cookingcraze4856 Рік тому

    Thank you for this! But I have one question, I don't understand why mRNA needs to be processed before leaving the nucleus? Is it to ensure that it doesn't degrade? I'm not sure...can someone please help

  • @abudialgamdi3872
    @abudialgamdi3872 4 роки тому +2

    You are amazing!!!!!! Thank you sooo much for this very informative content you have.

    • @PremedHQ
      @PremedHQ  4 роки тому

      You are so welcome!

  • @angelitawansa6533
    @angelitawansa6533 2 роки тому

    thank you so much . pls i need an explain for the term degrading. is it like the sequence/strands destroyed or dissolving away or something? 😅

  • @breeromero7668
    @breeromero7668 4 роки тому +1

    Really nice explanation! Thank you 🙂 New sub!

  • @private7285
    @private7285 3 роки тому

    5:20, why are they called EXOnucleases? I thought he was going to say because they begin at the end of EXOns, but he didn't say it.

  • @ndowidar
    @ndowidar 2 роки тому +1

    Such a great speaker. Really appreciate the steady and clear presentation!

  • @sujufan009
    @sujufan009 6 років тому +2

    Thank you very much, I don't know what I'd have done without your videos, well and clearly explained, you made it look like a simple subject, thank you.

    • @PremedHQ
      @PremedHQ  4 роки тому

      Thank you!!! Glad you enjoyed them :)

  • @reophokeng4098
    @reophokeng4098 2 роки тому

    nice vid!! thank you very much. but is it homogenous nuclear rna or heterogenous nuclear rna?

  • @zhangvv1293
    @zhangvv1293 2 роки тому

    SnRNA is the small nuclear RNA instead of the short nuclear RNA

  • @brainbook3035
    @brainbook3035 4 роки тому +2

    small nuclear rna

  • @reallifestories3687
    @reallifestories3687 5 років тому +3

    Thank you sir your videos are too good.

  • @mooshedpotato
    @mooshedpotato Рік тому

    I did not understand this the first time I was taught. thank you thank you

  • @MarianaBaez
    @MarianaBaez Рік тому

    This man just saved me. Thanks

  • @oznur812
    @oznur812 3 роки тому +1

    just explored the channel and loved it

    • @nazlcanguc8541
      @nazlcanguc8541 3 роки тому +1

      and then she recommended this channel to me..I ALSO LOVED IT even though this topic is too hard. Thank you so much!

  • @selaletube7121
    @selaletube7121 2 роки тому

    Teachers are so different! You are the one who is destined to be it!!!!!!!!!!!!!!!!!!!!!!!!!!!!! Every thing of you is perfect! frankly perfect! Amazing bro! please make more vedios.. Views may gradually come.

  • @meryemlahbara2834
    @meryemlahbara2834 Рік тому

    You're Handsom & Smart 🧠🥰

  • @Yankee4ever2
    @Yankee4ever2 Рік тому

    God Bless you, hope you're doing erll

  • @dalaxkid
    @dalaxkid 6 років тому +1

    Saving my ass on a regular basis thank you

  • @maithanhphong4089
    @maithanhphong4089 3 роки тому

    Trọng lú, xem chưa

  • @jelyneustaquio4774
    @jelyneustaquio4774 5 років тому +2

    best mcat video prep I've watched!

    • @PremedHQ
      @PremedHQ  4 роки тому

      Thank you! Please feel free to share them with your school's pre-health group!

  • @jamaluddinahmed2193
    @jamaluddinahmed2193 Рік тому

    I'm a student of class 12th from India and going to attend HS final exam of State Board.....i well understood that topic...Thank u sir

  • @abuharbesh
    @abuharbesh 3 роки тому

    Some basic principles need to be clarified. The direction of translation and transcription 5 to 3. Is every piece of DNA used only in one gene or can be used in more than one gene , I mean example a sequence of DNA (TGATCGCTCATCTC) at site X? of chromosome 1 . Can be part of gene X? and gene Y . Is the anti-sense side of the DNA also used as part of the genes ?

  • @ruththomas5667
    @ruththomas5667 Рік тому

    SUCH. AN. AMAZING. VIDEO. !!!!!!!!

  • @AygulBabayeva-t7d
    @AygulBabayeva-t7d Рік тому

    Splicing was hard to comprehend. Although I watched a lot of videos about it, yours is greatest.

  • @htm5934
    @htm5934 4 роки тому +1

    Im kinda confused my book shows that addition of 5’ cap and poly A tail happens before splicing?

    • @khadidjaesperanza7078
      @khadidjaesperanza7078 4 роки тому

      HT M even me🤔

    • @231mac
      @231mac 4 роки тому

      It would make sense for the splicing to occur first, because what if there is an intron at the beginning or end of the pre-mRNA?

  • @mustafayahia3517
    @mustafayahia3517 2 роки тому

    God bless you

  • @meryemlahbara2834
    @meryemlahbara2834 Рік тому

    I love the trick to memorize ❤❤❤❤

  • @Mars-cs5dp
    @Mars-cs5dp 3 роки тому

    why are you not my professor?

  • @srikarsharma633
    @srikarsharma633 7 років тому +2

    Absolutely understandable.

  • @private7285
    @private7285 3 роки тому

    how does the mRNA leave the nucleus? is the 3' or 5' end the "front-end"? 🤔

  • @numericalcode
    @numericalcode Рік тому

    Really clear explanation

  • @kanekiken-ls5iu
    @kanekiken-ls5iu 2 роки тому

    thank you so much

  • @Epicgustt
    @Epicgustt 2 роки тому

    My final genetics exam is tomorrow and thanks to you for making transcription make sense now!

  • @BaninDiarSukmono
    @BaninDiarSukmono 3 роки тому

    Thank you very much for your explanation 🙏🙏

  • @MohammadAminArji
    @MohammadAminArji Рік тому

    thanks a lot

  • @valentinaalonso3469
    @valentinaalonso3469 3 роки тому

    guys i just wanted you to know that this is stilll happening in the nucleus. dont get confused

  • @armanmarghzar7475
    @armanmarghzar7475 Рік тому

    you're amazing man! mcat in 2 months. you been getting me through content

  • @The-hf7zg
    @The-hf7zg 2 роки тому

    The best video, I've ever seen. Thank you so much.

  • @DanKolis
    @DanKolis 2 роки тому

    tnx

  • @gatwechjohn7786
    @gatwechjohn7786 2 роки тому

    Vitamin

  • @fadelhanoun6121
    @fadelhanoun6121 5 років тому +1

    F Kaplan, this is way better!

  • @رشدالمعمري
    @رشدالمعمري 4 роки тому

    HnRNA stands for heterogenous or homogenous?

  • @ix7666
    @ix7666 3 роки тому

    Thank you I finally understand it.

  • @Angelica-uj7ky
    @Angelica-uj7ky 3 роки тому

    thank you! This is very helpful

  • @melekchellouf3844
    @melekchellouf3844 2 роки тому

    if only my professor explained like this

  • @zahrakhavari623
    @zahrakhavari623 2 роки тому

    Your videos are great. Thank you

  • @roubajay4658
    @roubajay4658 3 роки тому

    Now, I understand gene expression

  • @KyasimireSavious
    @KyasimireSavious Місяць тому

    So exellent

  • @Jere616
    @Jere616 7 років тому +1

    Clearly explained. Good job.

  • @emmavictoria4286
    @emmavictoria4286 2 роки тому

    i love this man , thank you

  • @janiamunoz3933
    @janiamunoz3933 4 роки тому +1

    Wooow thanks!

  • @cto3vkkasyap785
    @cto3vkkasyap785 3 роки тому

    Nice explanation sir

  • @inesgonzalez2246
    @inesgonzalez2246 2 роки тому

    Awesome lecture 👌

  • @sharonbrookes6722
    @sharonbrookes6722 4 роки тому

    .

  • @SandeepGunalan
    @SandeepGunalan 4 роки тому

    2:41 Why introns are preserved throughout its generations?? Can justify that statement sir?

    • @choogwalda
      @choogwalda 4 роки тому

      DNA is passed on to the preceding generations. The DNA that is passed on will determine what RNA is transcribed from that DNA. You never hear about "RNA replication" because DNA contains the instructions for RNA. Conserve DNA, and you conserve the RNA which can be produced from it.

    • @choogwalda
      @choogwalda 4 роки тому

      RNA is not directly passed on to future generations.

    • @choogwalda
      @choogwalda 4 роки тому

      Maybe a better answer to your question is Alternative Splicing. Look that up, I think it is your answer.

  • @youwhat.
    @youwhat. 8 років тому +1

    Good videos!

  • @yaxiu3799
    @yaxiu3799 4 роки тому +2

    This is the best genetics video I have ever found. Excellent explanations!I subscribed right away.

    • @PremedHQ
      @PremedHQ  4 роки тому

      Welcome aboard!

    • @yaxiu3799
      @yaxiu3799 4 роки тому

      @@PremedHQ You are such an elegant and knowledge gentleman, I like you !

    • @PremedHQ
      @PremedHQ  4 роки тому

      @@yaxiu3799 Thank you!