Thank you so much! I had to watch this video twice to understand it, but it really opened my eyes to the subject, which was complete darkness for me. I hope you'll continue to post more videos like this one because they explain the subject better than most written literature. Thanks again for taking time from you schedule to make this videos!
Thank you, Dr. Mukhopadhyay, for breaking down a complex topic into such a concise and informative presentation! The clarity of this one-slide explanation is truly remarkable. Looking forward to more insights from your expertise in thoracic pathology!
Thank you Dr. Mukhopadhyay. I am grateful for the time you took to explain this difficult and volatile topic. What is your say in implication of molecular heterogeneity and resistance in lung adeno? How molecular testing adress these challenges?
Thank you so much! There is a great study on so called molecular heterogeneity from Japan that was presented at the USCAP meeting many years ago, which was supposed to dispel this myth. However, the idea persists, I'm not sure why. The reference is: Yatabe Y, et al. J Clin Oncol 2011;29:1-6
Sir in any malignancy with targetable mutation with additional equally pathogenic however non targetable genetic abherration.... Will that targeted gene therapy be of any help? For e.g egfr and rb mutation in a small cell carcinoma... Will anti egfr therapy work?
Hello Tapan, good question! My answer would be no, I have seen no evidence that this would work. For example I have seen no evidence that EGFR-directed therapy works for small cell carcinoma with an EGFR mutation.
@smlungpathguy got it sir. Thank you. I assume the same reason will also apply for high tumour mutational burden ones like squamous cell carcinoma and of a chromosomal abnormality driven tumour as well?
@@tapansaikia5230 Yes. My rule for "targeted therapy" is this: if well designed randomized clinical trials show benefit, then I am more likely to believe it. Otherwise it's just a theory!
Thank you so much! I had to watch this video twice to understand it, but it really opened my eyes to the subject, which was complete darkness for me. I hope you'll continue to post more videos like this one because they explain the subject better than most written literature. Thanks again for taking time from you schedule to make this videos!
Thank you for watching twice! And for your kind feedback :)
Thank you, Dr. Mukhopadhyay, for breaking down a complex topic into such a concise and informative presentation!
The clarity of this one-slide explanation is truly remarkable.
Looking forward to more insights from your expertise in thoracic pathology!
Glad it was helpful! Thank you so much for the feedback!
Thank you!!
Thank you...
You're welcome!
Thank you Dr. Mukhopadhyay. I am grateful for the time you took to explain this difficult and volatile topic.
What is your say in implication of molecular heterogeneity and resistance in lung adeno? How molecular testing adress these challenges?
Thank you so much! There is a great study on so called molecular heterogeneity from Japan that was presented at the USCAP meeting many years ago, which was supposed to dispel this myth. However, the idea persists, I'm not sure why. The reference is: Yatabe Y, et al. J Clin Oncol 2011;29:1-6
Really appreciated thank you@@smlungpathguy
Sir in any malignancy with targetable mutation with additional equally pathogenic however non targetable genetic abherration.... Will that targeted gene therapy be of any help? For e.g egfr and rb mutation in a small cell carcinoma... Will anti egfr therapy work?
Hello Tapan, good question! My answer would be no, I have seen no evidence that this would work. For example I have seen no evidence that EGFR-directed therapy works for small cell carcinoma with an EGFR mutation.
@smlungpathguy got it sir. Thank you. I assume the same reason will also apply for high tumour mutational burden ones like squamous cell carcinoma and of a chromosomal abnormality driven tumour as well?
@@tapansaikia5230 Yes. My rule for "targeted therapy" is this: if well designed randomized clinical trials show benefit, then I am more likely to believe it. Otherwise it's just a theory!