I've Got A Big Problem In My Oral Microbiome (Serratia marcescens), But Also A Plan To Reduce It
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- Опубліковано 14 жов 2024
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Papers referenced in the video:
Association between periodontal pathogens and systemic disease
pubmed.ncbi.nl...
Serratia marcescens antibiotic resistance mechanisms of an opportunistic pathogen: a literature review
pubmed.ncbi.nl...
Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens
www.ncbi.nlm.n...
Hydrogen peroxide-mediated antagonism against serratia marcescens by Streptococcus mitis
pubmed.ncbi.nl...
Seriously the best reality TV show ever! Every episode is a cliffhanger!! Can we have a season recap as a NYE special? Please!!
Thanks @LandonPark!
Ha, it's a 73y+ cliffhanger-can I science my way to breaking the longevity record?
Stay tuned to find out, lol!
OMG, right?
My favorite series of videos ☺. So informative and well conveyed. Thanks Mike
Thanks Brian!
Mike -- The first thing is your community is clearly not robust against changes and that is a tricky situation. Its a shame bristle doesn't report overall abundance too.
This could be community dynamics where the species are oscillating. I put your numbers through a period analyser and its suggesting there could be fundamental periods with decreasing certainty of 27-28 days, 48 days, 3-4 days, 21 days, 31 days. To rule this out what you need to do is test on different intervals than before, which fits nicely into the current approach. If the levels are oscillating, then using a 30 day average is not the best approach because it wont capture what's starting the reversal in the dynamics.
I'd also look at deviations in your trends in the blood testing to see if there are any hints in the immune markers.
I think your current approach is definitely worth trying. Community dynamics can be quite complex and unpredictable, don't be surprised to see it go from 100 to 0 with a small change though...that's how these things work.
If mushrooms as a whole food are helping your blood markers you'll have to live with the reduction, but if its ergothioneine, then there are other options to get more of that.
Thanks James. No deviation in the blood biomarkers for all these tests, except maybe #7, but that's probably a B3 story. In terms of mushrooms, it may be a matter of scale-would 220g/d be as potentially good for biomarkers as 275g/d? We'll find out...
Oil of oregano diluted in water and used as a mouth rinse may reduce serratia marcescens. It is very powerful, so only a few drops are needed. Sugar-free rosemary tea may also reduce oral bacteria.
Hey @Icarianbrother, I've already tried topical oregano oil to the corner of my mouth where Serratia likely lives, no luck.
Sorry to hear that. Raw garlic was used as an antiseptic to treat wounds. It might reduce oral bacteria, but if you use it make sure to eat a lot of parsley to neutralize the smell. @@conqueragingordietrying123
@@Icarianbrother Garlic (and parsley) are parts of my diet-I had some today, but garlic is not significantly correlated with any of the bacteria in the video...
I am sure that you will find something that works. I am looking forward to hearing about it. @@conqueragingordietrying123
The taste of death.
I have been struggling with Serratia marcescens for a very long time. Confirmed twice with oral bristle test 70%+. Started after taking antibiotics and berberine. So far, what has helped has been matcha teas. This microbe seems impossible to kill and needs other oral bacteria to out compete it.
Interesting, thanks for that @ayotundeogunye. I drink green tea every day, so that isn't a factor for me. i'm determined to solve this as fast as possible, and without antibiotics, if I can, as having antibiotic-resistant S. marcescens would be even worse.
@@conqueragingordietrying123 I hope it goes great for you. You are spot on I believe with the streptococcus mitis inhibiting it. I also had hydrogen sulfide sibo and whenever the sibo flared, there was a positive correlation with increased S. marcescens on my bristle test. I saw several studies showing lactic acid bacteria are sensitive to hydrogen sulfide, so it seems sensible to believe h2s = inhibits s.mitis than low lactic acid bacteria = s.marcescens overgrowth. I will say low sulfur has shown a decrease when in s.marcescens when I took another test. I would definitely recommend trying to lower you sulfur in take for a bit if possible.
How was your experience with the antibiotics? My Bristle exam showed I suffer from this as well.
Antibiotics made everything worse. Not one antibiotic helped and actually they made it even worse. I think it was coming from my gut. I did a FMT for an unrelated reason and my new bristle test showed it was not present after being 90% of my oral
flora@@sduwop4434
A) I question the true accuracy of any of these tests measuring bacteria (oral or gut). Would love to see a second lab do the same analysis. B) They make a Xylitol gum. As a side note, Rhonda Patrick mentioned on the Joe Rogan podcast a while back that she resolved a cavity by chewing Xylitol gum.
If it was a Bristle issue, we'd expect to see Serratia more widespread in their cohort, but it's almost never in others (99% with < 1%), but consistently in mine.
Are there other oral microbiome companies?
In the paper cited in the video, 10% xylitol wasn't better than 5%, so I don't think xylitol fixes the problem.
Cardamom seems beneficial for Rothia [11:51]. Do you use Dr Tung's floss (infused with cardamom)? Would it be possible for you to check for S. marcescens in saliva yourself with a microscope? @@conqueragingordietrying123
She didn't. That is total nonsense. I don't know who Rhonda Patrick is, but xylitol is not directly involved in remineralisation and it is only inhibitory against s.mutans. a cavity would suggest gram negative biofilm formation somewhere in the oral cavity and getting s.mutans under check would not inverse the switching on of the STATH gene that prevents PLP(proline like protein)being released in saliva which can potentially cause new dentin formation which is what you would need to fill a cavity. There is no known pathway currently available in the science that does this, so i know for certain they are talking out of their arse
Tom's mouthwash has xylitol.
As you know it is a competitive environment. You are approaching it prebioticly. What about probiotic pressure. Due to stomach acid it is way harder to populate lower down. The mouth should be many magnitudes easier. Try buying or making your own fermented vege and yoghurt. I do so from time to time and have been able to find and buy most beneficial species and their cultivation parameters. It is way quicker to set up a batch than to cook a meal. You would only need to eat a spoon of it after a meal and or mouth wash.
In terms of probiotic pressure, none of the 8 bacteria that are inversely correlated with Serratia are sold as probiotics...
Super interesting. I have one question, and maybe you've already thought of that:
We know that stress levels can impact the microbiome in our mouth and gut. I know that personally my diet will be affected by my mood. When I'm low in energy and stressed I tend to eat differently to when I'm energized and feel good. Could this be affecting your results so that the changes you see in your microbiome is primarily affected by your mood that also affects your diet?
If you wear a health tracker it would be pretty easy to see if there is a correlation between your microbiome and for instance sleep quality or maybe HRV.
Thanks @bogrunberger. I do track HRV and RHR, which are great stress indicators. Both have improved since 2018, so it's not a stress-related issue. More specifically, I also track the average daily HR, which from previous experience is sensitive to emotional and other types of stress (work), besides movement. The ADHR isn't different year-over-year...
My diet is remarkably constant over time-there are many videos on the channel that demonstrate that...
You're a machine! 😄
Again: Very interesting video. Look forward to the follow up!
Thanks@@bogrunberger!
In general, i am curious about the impact of red cabbage on bio markers due to the compounds that are in the pigments. Wondering if you have tried that or would be open to trying it.
I haven't tried that, but I like red cabbage, and could include it at some point.
However, it would be best to know if any of those compounds have been shown to have efficacy against Serratia, as a first step...
@@conqueragingordietrying123 meant for just the regular biomarker updates done in other videos, not for oral microbiome. But awesome topic of an area that likely plays a role in health but doesnt get as much attention.
Amazing detail and thoughts on biome and diet combined impact.
Another thought was perhaps its worth finding out what bacterial strain is in your yogurt and investigate other options. Maybe even changing the meal timing so mushrooms and yogurt coincide at meals?
Hmmm, if I had a lab to do this full time, that could be a project. I'm not sure that meal timing would have an effect, as I took the average intake over a 30d-period.
@@conqueragingordietrying123 with meal timing, I was thinking organisation during the day itself may be important. I assume your testing the oral microbiome in the morning after fasting? If so, the last thing your eating the day before may be having an effect on the oral microbiome, and the effect could get larger each day because of your diet consistency.
@@jamesgilmore8192 Only a 2hr fast, but after eating most of the day's intake (~80%) in the morning. Testing under the same conditions for each test, at the same time of day (9-10AM), after brushing at 9AM.
The morning diet and prior day could have the most impact, but it's debatable how far back to go for the impact of diet on the oral microbiome...
What an interesting way of pronouncing it 😀
Have you considered using hydrogen peroxide and water as a mouthwash to kill it off which might then allow other strains to grow?
I have-I've used it a few times topically in an area of my mouth that may be harboring Serratia. Unfortunately, no effect (in my case) on improvements...
hm i know its tempting to assume that using "the last 30 days of nutrient intake before a test" is a tempting approach, because its seemingly pretty "broadband" and catches everything that happened in that period
however, in my subjective n=1 experiments, its very clear that (only really noticeable if u go from one crazy experiment to another experiment) that ur microbiome can switch within very few days - what im trying to say is: instead of finding associations between the bacteria "within the last 30 days" it might actually be better to look into "what happened the last 3-7-ish days"
if i had to guess id say from 1 diet extreme to the next (until its settled and ur digestion/breath doesnt change much anymore...and subsequently ur sleep quality...) takes around 4 days in my experience (and its just "the same" from then on out)...despite what the weird keto ppl with their "u gotta do it for 2 months!" (until u wont be able to remember what a carb deficiency feels like anymore xD) will try to tell ya
I'm not sure that a 7-day window is best either-I can see the argument both ways, i.e. for longer vs shorter
@@conqueragingordietrying123 yea what i meant isnt that what i said was true - but (if its not too much work) maybe look into the half to 1 week range (of intakes of things before the tests) and see if there r any associations that r different from the ones u presented in the video - they might shine another light onto the data which could give further insights
@@conqueragingordietrying123 Mike if you redo the correlations on a (3? &) 7, 14 and 30 day windows and you have the same foods showing up across timescales, you could at least disfavour community dynamics, and have more certainty in the foods that are repeating.
Funny how similar we maybe… are you perhaps both italin and Greek origin? My self decode and 23and me shows highest risk in Alzheimer’s disease. I test my micronutrient panel with heavy metals which shows high aluminum cadmium levels both lead to Alzheimer’s as well as low levels of silica. So I changed to increase silica via Fiji water + green beans which may reduce heavy metal load in body if silica rises. Can’t wait for second video.
I drank Fiji water too for the silica until I got a bottle that smelled and tasted like diesel! I found out the bottles come from China. I switched to Biosil and I'm glad I did. Saves a lot of plastic too!
@@jpintero6330 wow that’s aweful! Good to hear that! I see biosil is a smart move! They sell them on Amazon in little collagen drops? Pretty smart! I’m also wary of supplements usually I have not so great reaction to supplements so I try to get it from foods. I was considering non alcoholic beer as an alternative
Maybe you have too much Serratia in your environment? Do you use a Brita filter? Have you checked the inside of your drains, etc? Pomegranate has some effect against Serratia marcescens.
Hey @jpintero6330, I doubt that's true-I've had bad breath issues for a very long time, independent of living in different cities. The difference is, now I'm actively quantifying the oral microbiome. Can you please post a link for pomegranate vs Serratia? I haven't seen that data.
@@conqueragingordietrying123 Joshi C, Patel P, Godatwar P, Sharma S, Kothari V. Identifying the Molecular Targets of an Anti-pathogenic Hydroalcoholic Extract of Punica granatum Peel Against Multidrug-resistant Serratia marcescens. Curr Drug Discov Technol. 2021;18(3):391-404. doi: 10.2174/1568009620666200421083120. PMID: 32316896. --- (Some papers indirectly related) Prasad D, Kunnaiah R. Punica granatum: A review on its potential role in treating periodontal disease. J Indian Soc Periodontol. 2014 Jul;18(4):428-32. doi: 10.4103/0972-124X.138678. PMID: 25210254; PMCID: PMC4158581. ---- Bhadbhade SJ, Acharya AB, Rodrigues SV, Thakur SL. The antiplaque efficacy of pomegranate mouthrinse. Quintessence Int. 2011 Jan;42(1):29-36. PMID: 21206931.
this might or might not be helpful but I managed to get rid of my persistent gingivitis that I couldn't get rid of even with dental gum cleaning, tea tree oil, flossing, xylitol erythritol baking soda mouthwash mix after every meal, gum gel, brushing several times a day and reducing processed sugars to near zero. I healed my infected gum by adding a drop of iodine in my water tank of my waterpik device. I noticed a big reduction in redness after just a few days and now it seems to be gone. I don't have access or funds to test for the bacteria though. I believe a waterpik of any kind is better than thread flossing because it can reach far deeper into the pocket.
the two things that was recommended for gingivitis was hydrogen peroxide and tea tree oil. I found both to have no effect on my gum infection after months of usage.
Yep, thanks for that, @kae2678-none of that has worked for me.
Fascinating stuff , tks
I've started having problems too since I put braces.
Sorry to hear that!
Oh dear! Have you tested your microbiome? What type of braces do you wear?
@@jpintero6330 I think they are ceramic, I will test the microbiom next week.
I take an lactobacillus salivare.
Have you ever heard of brushing with a DMSO solution? I use a 50% and it is a completely different experience than on skin. No burning at all. My NO production is great, I check with strips. I read about it in a book, gave a try. I'm so curious I'm about to do bristle.
I'm open to anything, but with a proposed mechanism, or previously published evidence demonstrating efficacy against Serratia. i haven't seen that data-if it's published, please post!
Do you still have your tonsils, and if so, any issues with tonsil stones? I noticed you said you had breath issues in a reply, that could be a part of the problem.
Unfortunately not, removed as an infant. I agree, that could be a part of the problem, but I've got to work around it...
if a probiotic food such as yoghurt, which is high lactobacillus, helps, but higher amounts of it r sus'd in ur blood-data (other than RBC iirc), u may wanna consider making no-salted sauerkraut or kimchi from scratch, they may also help to alter ur microbiome(s) without messing with ur animal products/protein intake too much 🤔
I don't think you can prove any correlation with a low sample size n=7, though the test is not enough powerful. It's probably better to use multiple ANOVA / F-test with n=7.
Thanks for the insightful videos
It's not about proving correlations, that is what the data currently shows...
@@conqueragingordietrying123
I meant the data cannot prove correlation or no correlation. The sample size is too low, hence the test is not powerful enough. It's worth trying the multiple ANOVA to compare and probably focus on the elements/variables with pvalue
Do you have any video/article on you oral hygiene practice?
This playlist covers that evolution:
ua-cam.com/video/EnkJqACCEE4/v-deo.html
Those are only percentage or also there is a hint to the total amount of bacteria? Because a 90% ratio tends to neutralize the importance of other bacteria present.
To put it simple: can it be that there is something killing the other bacteria and not that one? One test could also have lower amount of that bug while a higher percentage.
Yes, I think Serratia-when it's high, it limits the others. But somehow, when the others are not suppressed, Serratia is low.
First of all. Thank you for the video. ☺️
I have a question(maybe slightly off topic) but do you know of a service for sequencing ones blood virome? 🤔
Thanks @dariusszablowski5474. Karius offers it, but I'm not sure if it's commercially available in the US. In Europe, there might be some companies doing that, though...
@@conqueragingordietrying123 Okay, thanks a lot for the information. I will look into that. I am from Europe. I thought looking at a metagenomics based service so it might be able to capture anything not narrowed down by a panel.
:)
Have you tried getting your tap water tested?
I haven't, but if it was that, Serratia would be high for every test. That it's not suggests something else
Hi Doc, you didn't specify how specifically you made a mouthwash, you mentioned just water and xylitol. I would not consider this a mouthwash at all. Mouthwash should have active ingredients which actively fight ALL mouth bacteria (alcohol, triclosan, cetylpyridinium chloride or even a little of peroxide for example) and also include several additional ingredients that specifically target individual species. So a metaphorical wide range napalm strike upon the jungle immediately followed with targeted sweeps by choppers over the remains. Please note that induvidual ingredients of this kind of mouthwash have compound, additive effects. If nothing else works, use a commercial mouth wash with some xylitol added. I would also add erythritol and arginine for more precise p. gingivalis and s. mutans targeting.Also, I most recently added magnesium carbonate powder into the mouthwash - it's super fine and easy to shake if it is settled on the bottom. This should remain on teeth after the wash and serve as a kind of buffer to neutralize some of the acid that is generated by remaining bacteria. Also, if you increase arginine or citrulline intake, you will get more arginine content in your own saliva, which also serves to neutralize acids and s.mutans biofilms. Water + xylitol was a nice hack but it didn't work, so I suggest: go big or go home.
Hi @derghiarrinde, based on prior experience, I disagree. In the oral microbiome playlist, you'll see that I've experimented with peppermint oil, sodium bicarbonate, clove oil, berberine,xylitol, nitrate, etc in a homemade mouthwash. It's probably better to "do no harm" and stick with my current approach, using water after meals, plus flossing, water pik, and tongue cleaning, while selectively trying to get rid of Serratia.
@@conqueragingordietrying123 Hmm, I would do all of these super targeted approaches while also including a super killer that does the clean sweep of the area. The bicarbonate comes close but not close enough to this wide-range bactericide. Ethanol would be my choice, with an additional one as an adjunct.
@@derghiarrinde Have you measured your oral microbiome?
@@conqueragingordietrying123 No, but I continue to have excellent results with exogenous arginine taken orally almost daily, along with K2 and D3 supplementation, with my custom mouthwashes. I take several exogenous substances I mentioned before on this channel (taurine, creatine, ALA, GlyNAC, arginine, glutamine, etc) and rate their effectivness based on overal look and feel. You're on a completely different level though.
Please don't take too much risk with this bug. Perhaps this goes beyond choice of food?
You are probably familiar with the expression "paralysis by analysis". It looks like you are in that area now.
S.M. forms biofilms and thus becomes less sensitive to attacks.
Your mechanical approach may include 2 mm brush, combined with sodium citrate 5% or stronger to break biofilm.
Perhaps this is the time for an antibiotic? Anyway, this probably goes beyond choice of food...
Hey @rredding, with objective analysis, it took a few months to figure out what to do with these results, so there was some paralysis there, but not anymore, as I have a plan!
Put H2O2 in a Water Pik to make sure you get it under the gumline. Use Na bicarb to change the oral pH to being basic.
Bicarb was in the original approach (homemade mouthwash), so it's not an oral alkalinization issue. Topically applied H2O2 (3%) to the area of my mouth where Serratia may live hasn't worked, either, nor has topically applied essential oils (peppermint, oregano, lemongrass, clove).
@@conqueragingordietrying123 Perhaps through a water jet, you may be able to hit occult bacterial pockets. That's what the device is designed for. Just a thought.
Do you use chlorinated water without filtering it out? Seems like your microbiome is being regularly nuked by something (like chlorinated water) and this is the lone survivor.
My filter removes chloride, so that's not likely an issue
@@conqueragingordietrying123 It still looks to me like it’s being nuked by something. Even if you have a lot of this bacteria, it shouldn’t be the only thing in your mouth. Makes me think you’re exerting some anti-biotic selection pressure and this is the sole survivor.
I haven’t read any papers on how fluoride affects the microbiome, but it would be interesting to see as well. Could also be any other type of assault that you would be able to better identify in your life than I could speculate.
The water filter (Big Berkey) also removes fluoride @@mime454
@@conqueragingordietrying123 sorry I meant in toothpaste.
Big Berkey is a long lived filter, right? Any chance it could be contaminated? @@conqueragingordietrying123
How about a whole home UV LIGHT TO KILL BACTERIA
would you do a video on severe halitosis and what to do about it? I'm desperately looking for solutions. 😰
The lowest hanging fruit are:
Tongue scraping
Daily flossing (at least 1x)
Cut out processed foods
Eat a high nitrate diet (beets, greens)
Outside of that it gets individualized based on which microbes are in the mouth..
@@conqueragingordietrying123 thank you! already doing that. chocolate is still hard for me. would you say chocolate or sugar in general need to be cut out strictly for the bad bacteria to die and not give them any supply/food that they can feed on? is it more abut starving and refeeding or actually killing (using harsh mouthwash which kills the good bacteria too). Bristle couldnt recommend anything. They are trying to expand but who knows when :´( others said they healed their severe halitosis by doing the carnivore diet. I wish we could un-taboo the oral microbiome just we are our stool and digestive system. so much unnecessary shame about it. what are the bad guys who are feeding on the bad breath bacteria feeding on and how can I reduce them?
What's your current recipe for your mouthwash?
In the most recent video for this series, I outlined going back to the original formulation:
ua-cam.com/video/DkOceKds2a8/v-deo.html
Then, I added salt to that formulation for another test (4% sodium vs 1% in the original formulation).
I'm currently waiting for results from both tests (#10 and 11), but I've since cut the sodium level of the mouthwash to 2%, to see what (if anything), that can do (test #12).
Why not try 100% xylitol instead of 5%. Just swish the powder in your mouth and it will melt in about 15 seconds to a liquid.
In the paper in the video, 10% xylitol wasn't better than 5%, so I'm not sure that 100% would make a dent...
@@conqueragingordietrying123 Maybe it would make a dent, maybe not. I suspect the petri dish environment is a sustained xylitol environment, and I would guess that xylitol quickly dissipates orall.y with a mouth wash. Long duration candy or gum might be more effective than a quick hit mouthwash. Alternatively, high percentage concentration may make up for short oral duration. Or maybe xylitol just does not work in vivo for you as you suspect. It's hard to know without testing different parameters.
Is there a video where once he’s done all these tests, where he states, after all these experiments - THESE are best ingredients to use and that are the most effective? Or this does not exist ?
The most recent video in this series is here:
ua-cam.com/video/DkOceKds2a8/v-deo.html
Update video (Tests 10, 11, 12) coming this week (Wednesday)
Have you considered nitric oxide? Oral microbiome can have quite an effect. The benefit of reducing serratia, or other OM components could impact NO levels
I eat > 200g of raw beets every day, so nitrate (and NO) shouldn't be an issue. I've also used potassium nitrate in a homemade mouthwash for 2 tests, with no luck on reducing Serratia (or increasing nitrate-reducing bacteria levels).
Danke!
Thanks for the support, @xenofontzaras2741!
I would suggest that your food is not the problem. Rather I would guess that your frequent mouthwash is the problem. Probably the mouthwash is more effective at killing the good bacteria than the bad bacteria, or the bad bacteria is better able to recover in an environment where the good bacteria has been destroyed.
I stopped using the homemade mouthwash a few tests ago. Please see the oral microbiome playlist, I've never used conventional mouthwash.
I presume you dont sleep with your mouth open
love the diet insights thou
I don't, dry mouth in the morning is generally not an issue, and thanks!
How about testing LF yogurt before bed time, after brushing teeth?
ideally, I'd test under the same conditions, at the same time as the rest of the tests, which is ~10 AM, fasted for ~2h, ~1hr after brushing.
I guess if it applies kissing ones partner needs to be looked at as a test confounder. It would be helpful to also have the quantites of these as well as relative figures. Are these in a private access group ? As there will be a point that the quantities are within what the immune system and microglia can easily deal with. Also be interesting to see what difference the high pressure waterpik flosser made on quantities of bacteria.
Definitely, but I'm currently single, so that hasn't been a confounder for a while. While my immune system is likely dealing with it locally (only in the mouth), that may not always be the case-systemic Serratia infections are nasty and hard to treat.
No difference using the water pik, unfortunately, as that was used for the last test, and Serratia was higher than ever, 96%.
@@conqueragingordietrying123 sorry wasnt trying to be intrusive personally, I would have guessed you picked that factor up already. Just a general comment for anybody else on here doing their oral microbiome to remember,
So h2o2 did not work, nor xylitol. I assume rinsing with ivermectin would be the same, followed by rinsing with the right fermented solution. Could it be an environment situation? Like you are hanging around the wrong people?
I'm open to trying anything, but with published data as a starting point-is there data for ivermectin impacting Serratia?
I don't think it's an other people issue, ha, my social life isn't that active
would imply not only hanging, nut more like exchange of oral microbiome :)
@@conqueragingordietrying123 I did some Google Scholar searching and could find nothing on ivermectin impacting Serratia. But I do use a small amount of ivermectin in a water pik any time I get some gum infection. It works far faster than h2o2 or xylitol, both of which do work. I have no way to know what microbe causes my gum infections. And doing this literature search told me why this topic is so complex. But I am convinced that ivermectin subdues at least one oral pathogen.
Oil pulling might be worth trying
There's no evidence that it works against Serratia. If it did, I'd use it
@@conqueragingordietrying123 You can generate your own evidence
Ask and you shall receive: why low fat (vs. high fat) yogurt?
For whatever reason, high-fat dairy products (cheese, too) are significantly correlated with more blood biomarkerks going in the wrong direction than right. Problem mostly solved with the switch to low fat/complete removal (cheese, or at least once in a while as opposed to more often).
On the mushrooms correlation. Could vitamin D2 play a role here?
Perhaps, but more mushrooms (i.e. D2) may negatively impact the bacteria that I want to reduce Serratia (if the correlations are causative)...
@@conqueragingordietrying123 They contain various types of sterols, including ergosterol. Some of these might just interfere with quorum sensing and related secretions. Bit of a stretch but could be.
I chew xylitol gum nearly every day. It's good for the teeth, at least.
Unfortunately, as mentioned in the video, it didn't reduce Serratia, and I had it at lower doses (1%) for oral microbiome tests #1 and 2.
@@conqueragingordietrying123 Yeah, that's why I said "it's good for the teeth, at least." Consolation prize.
Your lucky to be alive with all that serratia....lol...have you ever tried biocidin?
Serratia is nasty, especially bloodstream infections. I haven't-why would you expect that to impact Serratia?
Try to take a long mouthwash with a small spoon of coconut oil
I prefere a more directed mechanistic approach, i.e. stuff in that mouthwash that's been shown to kill off Serratia. otherwise, I may be doing more harm than good, as evidenced my a video in this series using berberine in the mouthwash.
this bacteria is on black pepper and on other nasty staff
Interesting about black pepper-got a link? I eat that every day, so it could be the source.
I made mistake and after I almost cleared all my sinus bacteria I had a stupid ideea to buy eco black pepper from a uk known supermarket and smell it. And now is almost one month and half that I tried everything to conquer it. It's like a fire. Sugar and heat it exacerbates it. My immunity doesn't work well and I struggle daily. Xylitol is a sugar, will not help. Slowly with good bacteria will replace it. Nothing kills this bacteria despite the fact we live in 21 century
Probiorinse is discontinued. That bacteria acted like a healing protection of mucosa blocking all nasty bacteria. I don't know if will work for this nasty bacteria.
I made mistake and after I almost cleared all my sinus bacteria I had a stupid ideea to buy eco black pepper from a uk known supermarket and smell it. And now is almost one month and half that I tried everything to conquer it. It's like a fire. Sugar and heat it exacerbates it. My immunity doesn't work well and I struggle daily. Xylitol is a sugar, will not help. Slowly with good bacteria will replace it. Nothing kills this bacteria despite the fact we live in 21 century.
I think Bruce Willis has this bacteria. And I think this bacteria is the reason a lot of people going bald, because of reactive peroxid in the mucosa tissue
Bleach
I might need something that strong-for example, zinc chloride/chlorine dioxide are potentially on the list
I have recently (3 weeks) started using:
Chlorine dioxide (Closys unflavored) as a pre-rinse, brush, rinse with original Listerine. I have experienced significant changes in my gum health.
Also after meals, put 1/4 tsp xylitol crystals directly in my mouth, swish, spit.