How does metformin compare to other geroprotective drugs?

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This clip is from episode 300 ‒ Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, & more.
In this clip, they discuss:
- Peter's current thoughts on Metformin
- What percent reduction in all-cause mortality have recent studies shown?
- Why metformin failed the ITP
- And more
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The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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[@robynhope219]

I been on metformin the last two yrs...i think less problematic than rapamycin. I have HPA axis dysfunction discovered seven yrs ago when i suddenly became very fatigued. Thank god i found a functional MD. This regimen i'm on is costing me a small fortune. I am also on a low dose of bio identical DHEA that i would recommend for any senior person bc it boosts your sex hormones, thus making you less fatigued. I would like to know what the good doctor thinks of David Sinclair, PhD. Thanks a lot!

[@ayo9057]

You take metformin and dhea? I’d look for a new doctor.

[@robynhope219]

@@ayo9057 NO WAY...she is helping me. Do your research!

[@stephensheltcoaching]

I love these insights. Looking beyond the abstract at study design is so crucial.

[@bambidragonfire1706]

I've been on metformin for five years and I don't have diabetes. My np idea was to help me not have to work as hard in maintaining my weight.

[@robynhope219]

Problem with met is that it makes me less hungry...i think it would be good for weight-loss...alas, i want to gain a bit. I still think met has less side effects than rapamycin.

[@ayo9057]

Why do you label Metformin as a longevity drug?

[@robynhope219]

It is a senolytic... fights senescence...it is complicated.

[@annettesoss2114]

Great question!

Have you listened to the first 3 minutes?! 🤷

[@robynhope219]

Dr. David Sinclair explains it beautifully...u can always Google.