Timestamps/vocab: Vibrio Fischeri- 3:09 Bioluminescence- 4:09 Quorum sensing- 7:13 Intraspecies communication- 9:18 Interspecies communication- 10:49 Esperanto/ a universal communication molecule- 11:31 A new approach to antibiotics- 13:45 Quorum sensing in bacteria- 14:43 The gang- 17:11
Ms. Bonnie Bassler gives one of the riveting talk about how Bacteria communicate with each, a study that will propel the future of medicine. This is one of the finest studies ever conducted and hats off to the Princeton team of young innovators.
I got excited about this just from listening to Bonnie talk about it. At first I thought she was nervous, but then I realized it was just her and her excitement for her subject. And her down-to-Earth analogies made it incredibly easy to understand. Thanks so much for sharing this presentation. I learned a lot!
Die ganze belebte Welt besteht aus Symbiosen, würden sie sich auflösen, blieben nur noch wenige Einzeller übrig. app.you-publish.com/render/index/guideStaticId/58606d6c62d6789939176d5f/type/pdf?fbclid=IwAR0UbB6irSbNdT7tI_usHAVa9k0Pi-bggaUhKnneavhTj5SRe5sD6kMduss Lesestoff
Thank you for attributing the students who are doing this important work. So often the students who do research as part of a class don’t know that other students are being directed and taught by amazing instructors-some of whom- may not be as diligent about honoring them early on.
I love the conclusion; that the conversation can go both ways. Her team are developing both - away to stop bacteria from talking to each other (protect us from them) and a way to encourage their conversationability (protect them from us) It could so easily have just gone the one way. Nicely done. And much appreciated.
Its the twentieth century and our most breakthrough discoveries are still happening because we saw a light. Excellent research, groundbreaking discovery and I hope what will be the foundation of our medical treatment of the future.
This must be the absolutely most wonderful presentation in TED's history. Dr. Bassler, you are a remarkable human being, and scientist. Thank you, a quadrillion times, for acknowledging the invaluable contributions of every member in your lab. That was an indescribably beautiful gesture. 🧬🔬
They don't always give a standing ovation, everyone chooses as (s)he wants. It's just a testimony of her speaking abilities and the riveting facts she brought forward. You can dislike any speaker and their subject, but for me this format is of so much value.
She adapted the Dazed & Confused quote: "Thats the awesome thing about high school girls; as I get older, they stay the same age". Fantastic speech Ms Bassler!
Everything about this speech was superb. I really enjoyed everything she had to say. Really was one of the most entertaining talks that I actually really liked.
Never thought of other "friendly" bacteria, always thought that "probiotic" stuff, while having an element of validity was blown out of proportion regarding it's benefits. Suppose I should do a little research on it, starting to find this whole immunology and virology quite interesting. Thank you very much for setting me straight.
I really loved this, one of the best TED Talks as Bonnie did such an amazing job of explaining the journey of bacteria so simply so that one one can understand it. Really great!
You know what last night I was reading about quorum sensing and read many kinds of stuff to get know about that but in vain, and yes now I got to know what quorum sensing is exactly. thanks for such a mesmerizing way of your explanation
She doesn't relate to bacteria like "some complex animal". She doesn't say they're more important than animals. She uses expressions like "talk" to put across her message in a more fluid way, and adds some fun...nobody actually thinks bacteria talk or can think at all. She's excited because these are important scientific conclusions, understanding interaction and the game changer that is to manipulate bacteria like this.
+lillazyboi actually, they have the potential to develop resistance - but it would probably (and hopefully) happen only after widespread commercialization and overuse of the QS blocks. Then we would have to discover the next anti-bacterials..
+lillazyboi I don't think in can be countered. Bacteria immunity is the result of non-immune bacteria dying off. The survivors don't develop resistance, they already have it. As she stated in the video, antibiotics select for immune bacteria. What is happening here is that a molecule is blocking the receptor to the quorum sensing molecules. It would have to develop a brand new receptor, and at the exact same time, develop a brand new communication molecule, and that's never going to happen. And, hypothetically, if it did, you'd only need to block that new receptor.
They could by developing mutations that change the type of molecules that control quorum sensing as well as their corresponding receptors. Which is good news since that would require a lot of changes instead of just requiring getting a plasmid or two, which is the case in the resistance mechanism of many current antibiotics.
I love this stuff. Just the idea of giving a person with a fatal bacterial disease time enough to fight it off is amazing. I could be wrong but it also seems possible to allow a person to go on living a normal life while suppressing a disease indefinitely if they couldn't beat it outright.
Realised that there are more bacteria around me, in and on me than my body cells.. and these bacteria interact with the environment, and my cells...hmm where does my "self" begin, and end? Interconnected, inter-dependant, all one organism..?
TEDtalks is the actual organisation that runs all of these lectures. This channel is an editorial of videos that are educational, so people that are interested in specific areas can get related videos. There are loads of different TED channels, but all are fed from TEDtalks.
Another possible mechanism is what Vincent W, very well said, the enzyme production trigger might be associated not only with quantity but also with density.
I did not miss your bigger point. You did mine. I do read books, search the web and watch tons of hour long documentary series and yes there's not nearly as much information on an 18 minute clip. However there's a lot of diferent ways to retain information and/or being able to integrate that information with previous or future acquired knowledge (topic too long). In any case, any thing from this 20 min clip will be more valuable than your next reality show/soap opera can offer.
Wonderful presentation on so many levels. Naturally, the ones i focus on demonstrate the PANACEA system: the idea of independent holons that make up a holarchies, data exchange, cooperation and emergent effects. The sovereignty of bacterial communities is recognized and a NPV index is assigned to them. (Don't envy who has to count them.)
Prof. Bonnie Bassler and team, thanks a lot for your excellent presentation. Is there any evidence or examples of these "communication molecules" in processes (digestion, immunity, vitamin synthesis etc) mediated by the human microbiome? thanks!
Honestly, I clicked like as soon as I saw the Mac. The rest is good enough that I've already seen this content replicated quite a few times across other channels.
Great for a understanding, knowledge on the Bacteria and works good for a basic understanding the most important living beings that bless and trouble you by being around you.
The main thing that scares me about GM and GE foods is that any DNA from them that isn't denatured by our stomach acid (this can be a lot depending on the health of stomach secretions, which tend to be quite unhealthy in an Americanized diet plan) ends up being absorbed by the bacteria that inhabit our intestines. These bacteria are imperative to many processes within us, and are integral to our immune system, vitamin B and K absorption, and many more important processes. It is estimated that these gut flora have around a hundred times as many genes in aggregate as there are in the human genome. This is what you want Monsanto to be experimenting with? :-/
I think there is just a misunderstanding. Yes, if you filled a room with smoke, and everyone started coughing that would not be a great analogy for quorum sensing. However, if your lungs produced smoke, and made other lungs produce smoke, and they made other lungs produce smoke, and this led to some kind of joint activity from all of the lungs, then that is analogous to quorum sensing. That is why she refers to it as a language, because the cells are producing signals that influence other cells
POV: You are watching this video because your connections academy Unit in Health Sciences is telling you to answer 5 questions based on what this Ted Talk.
Great talk in my opinion. I don't think she tried to make bacteria seem more amazing than they are, its just her over-enthousiasm that kicked in along the talk. Dont judge her for this - this is about the amazing discovery she explains about.
i think kary mullis' molecule approach to killing bacteria is the best way to compensate for the demise of antibiotics but this research on how bacteria communicates is amazing and very promising too
First of all, this is not fake knowledge; these talks are here to enlighten us about the frontiers of science. Secondly, TED talks are not meant to teach everything there is about the subject. It's meant to engender an interest to dig deeper. I think they do a pretty good job. You can't really learn something without being interested in it.
In any case that would never happen. Just as some bacteria evolve anti-biotic resistance, there would always be some humans who'd be naturally able to resist that bacteria. So while the "weak" humans would die off, the survivors would thrive and their future generations would be naturally resistant to that bacteria. And the circle of life would continue exactly as if nothing ever happened.
Unfortunatly as a teacher I can testify to the fact that many children have no imagination for science or are kinesthetic learners. So nothing would be less effective than being leactured, even by a speaker as amazing as her.
They are behaving as a colony. They are responding to stimulus but calling that language means she that she can't distinguish communal behavior from communication. Interaction is not communication. If not everything is communication with everything. Like a standing ovation. we clap, more clap, then one guy stands up and when enough stand up everyone else does. Its stimulus not communication. There is a difference
The issue is that it amkes the bacteria sound like they are responding to each other. They are not.They have no connection with each other. Its like saying when you fill a room with smoke, every one agrees to cough. You cough all on your own as a result of the concentration of smoke in your environment. There is no communication with anyone
That was one of the best explained TED talks I've ever heard
I absolutely agree with you! Really great job!
Timestamps/vocab:
Vibrio Fischeri- 3:09
Bioluminescence- 4:09
Quorum sensing- 7:13
Intraspecies communication- 9:18
Interspecies communication- 10:49
Esperanto/ a universal communication molecule- 11:31
A new approach to antibiotics- 13:45
Quorum sensing in bacteria- 14:43
The gang- 17:11
Goat
LETS GOOOOO
The way she speaks about the young researchers is amazing. Genuinely made me tear up! I don't know what I'd do if my PI talked about me like this
I know 🙌🏾
Not just the great information she gave but also how incredible she talked smoothly energetic non-stop in the whole speech.
Ms. Bonnie Bassler gives one of the riveting talk about how Bacteria communicate with each, a study that will propel the future of medicine. This is one of the finest studies ever conducted and hats off to the Princeton team of young innovators.
Doctor Bonnie Bassler........
Prof. Bonnie Bassler
I got excited about this just from listening to Bonnie talk about it. At first I thought she was nervous, but then I realized it was just her and her excitement for her subject. And her down-to-Earth analogies made it incredibly easy to understand. Thanks so much for sharing this presentation. I learned a lot!
i love the way she present the topic, it makes curiosity in learning about that subject.
You should see my movie Osmosis Jones
Man that symbiosis with the squid is just wild!!
Die ganze belebte Welt besteht aus Symbiosen, würden sie sich auflösen, blieben nur noch wenige Einzeller übrig. app.you-publish.com/render/index/guideStaticId/58606d6c62d6789939176d5f/type/pdf?fbclid=IwAR0UbB6irSbNdT7tI_usHAVa9k0Pi-bggaUhKnneavhTj5SRe5sD6kMduss Lesestoff
Thank you for attributing the students who are doing this important work. So often the students who do research as part of a class don’t know that other students are being directed and taught by amazing instructors-some of whom- may not be as diligent about honoring them early on.
I love the conclusion; that the conversation can go both ways. Her team are developing both - away to stop bacteria from talking to each other (protect us from them) and a way to encourage their conversationability (protect them from us) It could so easily have just gone the one way. Nicely done. And much appreciated.
Hello Fellow AP Biology Students
greetings
Helloo
Fascinating subject. Brilliant speaker.
You should see my movie Osmosis Jones
Amazing! A very passionate scientist, an incredible and enthusiastic teacher! A "must see"!
Bonnie Bassler is wonderful.
Its the twentieth century and our most breakthrough discoveries are still happening because we saw a light.
Excellent research, groundbreaking discovery and I hope what will be the foundation of our medical treatment of the future.
21st but yeah
Here I am sitting in micro class, imagining bacteria sharing memes :D
This lovely intelligent lady is definitely in the right career.
Fascinating!
Thank you
This must be the absolutely most wonderful presentation in TED's history. Dr. Bassler, you are a remarkable human being, and scientist. Thank you, a quadrillion times, for acknowledging the invaluable contributions of every member in your lab. That was an indescribably beautiful gesture. 🧬🔬
wow i didn't know bacteria were so complicated
this was a very good talk. I understood it well.
I thought I was watching this at 1.5x speed for a second
She's passionate, and has a TON of info to give in next to no time.
Yes, I thought about how much she must've practised with a stopwatch to get all info in, in time 😀💪💪💕
Wow ... I thought it was perfect timing. Gave me everything and conclusions at each steps to allow me to go on to the next step with her. Nicely done.
I'm watching it on 2x, and it's wonderful, still coming thru clear ❤
They don't always give a standing ovation, everyone chooses as (s)he wants.
It's just a testimony of her speaking abilities and the riveting facts she brought forward.
You can dislike any speaker and their subject, but for me this format is of so much value.
She adapted the Dazed & Confused quote: "Thats the awesome thing about high school girls; as I get older, they stay the same age". Fantastic speech Ms Bassler!
Wow!! What a fantastic presenter and she explains it so clearly. Excellent. Thank you heaps for the upload.
Everything about this speech was superb. I really enjoyed everything she had to say. Really was one of the most entertaining talks that I actually really liked.
I'm really surprised this isn't more famous, it's so cool!!
Never thought of other "friendly" bacteria, always thought that "probiotic" stuff, while having an element of validity was blown out of proportion regarding it's benefits. Suppose I should do a little research on it, starting to find this whole immunology and virology quite interesting.
Thank you very much for setting me straight.
I got so touched at the end when she recognised her brilliant "gangs". People sometimes forget to acknowledge but she didn't.
Absolutely f'ing excellent talk!!!!!!!!!
The best Ted talk ever!
That was the best TED talk I've ever heard
Your lecture is soo energetic. I felt learning something new. Your talk is very informative and it's amazing discovery.
Phenomenal speech! Beautifully explained and riveting! Had me hooked from the intro...
I really loved this, one of the best TED Talks as Bonnie did such an amazing job of explaining the journey of bacteria so simply so that one one can understand it. Really great!
I've seen Prof. Bassler on another You Tube channel....she's brilliant.
You know what last night I was reading about quorum sensing and read many kinds of stuff to get know about that but in vain, and yes now I got to know what quorum sensing is exactly. thanks for such a mesmerizing way of your explanation
9:36 Species specifities! My favorite moment in any Ted Talk!
Fascinating how Bonnie can initiate such excitement and curiosity about cellular structure and their existence. Makes me hungry for more.
She doesn't relate to bacteria like "some complex animal". She doesn't say they're more important than animals. She uses expressions like "talk" to put across her message in a more fluid way, and adds some fun...nobody actually thinks bacteria talk or can think at all.
She's excited because these are important scientific conclusions, understanding interaction and the game changer that is to manipulate bacteria like this.
My question is: Just like how bacteria can build resistance to antibiotics, can they also counter the quorum sensing block?
Bacteria are very smart
+lillazyboi actually, they have the potential to develop resistance - but it would probably (and hopefully) happen only after widespread commercialization and overuse of the QS blocks. Then we would have to discover the next anti-bacterials..
Thanks!
+lillazyboi I don't think in can be countered. Bacteria immunity is the result of non-immune bacteria dying off. The survivors don't develop resistance, they already have it. As she stated in the video, antibiotics select for immune bacteria. What is happening here is that a molecule is blocking the receptor to the quorum sensing molecules. It would have to develop a brand new receptor, and at the exact same time, develop a brand new communication molecule, and that's never going to happen. And, hypothetically, if it did, you'd only need to block that new receptor.
They could by developing mutations that change the type of molecules that control quorum sensing as well as their corresponding receptors. Which is good news since that would require a lot of changes instead of just requiring getting a plasmid or two, which is the case in the resistance mechanism of many current antibiotics.
Good question.
Fantastic video!! I love the way bonnie describes things.
I love this stuff. Just the idea of giving a person with a fatal bacterial disease time enough to fight it off is amazing. I could be wrong but it also seems possible to allow a person to go on living a normal life while suppressing a disease indefinitely if they couldn't beat it outright.
for how excited and passionate she was throughout the entirety of her talk, her outro was pretty meek. Thats us science nerds for ya
Wow. I am a few years late to this video but this was one of the most interesting videos Ive come across on youtube. She is fantastic.
great talk enjoyed her enthusiasm and the valuable information and the advancements they achieved
I have to do an essay on bacterial biofilms and communication plays a big part of it. This video is great at helping me!
Realised that there are more bacteria around me, in and on me than my body cells.. and these bacteria interact with the environment, and my cells...hmm where does my "self" begin, and end? Interconnected, inter-dependant, all one organism..?
I think it is the best explanation of Quorum sending i have ever seen thunks a lot
TEDtalks is the actual organisation that runs all of these lectures. This channel is an editorial of videos that are educational, so people that are interested in specific areas can get related videos. There are loads of different TED channels, but all are fed from TEDtalks.
Lady, you are brilliant and charming...you explained so graciously a fascinating and profound aspect of life!
So if we tamper with inter-species communication, would that affect beneficial bacteria also?
The best Ted talk ever 👏
Soo many interesting facets of this talk. Love it
I am currently learning this in my Microbial Biotechnology class. She made this topic more interesting for me to understand!
One of the best Ted's. Good job!
Another possible mechanism is what Vincent W, very well said, the enzyme production trigger might be associated not only with quantity but also with density.
Bassler will definitely win a Nobel prize one day
If half of the teachers in this country were like her, I have no doubt that we wouldn't be falling behind on our education scores.
Amazing! Well done Bonnie and well done Bonnie's gang at Princeton.
I did not miss your bigger point. You did mine.
I do read books, search the web and watch tons of hour long documentary series and yes there's not nearly as much information on an 18 minute clip. However there's a lot of diferent ways to retain information and/or being able to integrate that information with previous or future acquired knowledge (topic too long).
In any case, any thing from this 20 min clip will be more valuable than your next reality show/soap opera can offer.
Wonderful presentation on so many levels. Naturally, the ones i focus on demonstrate the PANACEA system: the idea of independent holons that make up a holarchies, data exchange, cooperation and emergent effects. The sovereignty of bacterial communities is recognized and a NPV index is assigned to them. (Don't envy who has to count them.)
A super excellent talk Bonnie, thank you
Great talk , best Ted-ed i have seen .And they are all pretty amazing.
Prof. Bonnie Bassler and team, thanks a lot for your excellent presentation.
Is there any evidence or examples of these "communication molecules" in processes (digestion, immunity, vitamin synthesis etc) mediated by the human microbiome? thanks!
This assignment was very balls, I love balls.
Mind is blown love this stuff!
A small update on the fact about the resident microbes and the human cells- It's more like 1:1 ratio between them not 1:10.
+Jānis Galdkājis True. My microbio professor just told us this lol.
1.3:1
Honestly, I clicked like as soon as I saw the Mac. The rest is good enough that I've already seen this content replicated quite a few times across other channels.
Ms. Bonnie Bassler.....this is one of the best talks ever....well explained as well as interesting...Thank you so much
We as humans could take a lesson from these primitive organisms.😊
16:38
beautifully articulated and amazing persona !! thank you for doing what you do.
She is so passionate! Love it!
Respect from BANGLADESH. Thank you for such explanation.
Her passion is so inspiring!!!
She seemed so surprised when everyone stood up for her!
Very interesting and such an articulate speaker
This fantastic presentation was around 6 yrs ago but still nowhere near new line of antibiotics. Why ?
I'm sorry to say but it has its reasons that anything that involves human trials and such take a really really long time 10, 20 or more years
Great for a understanding, knowledge on the Bacteria and works good for a basic understanding the most important living beings that bless and trouble you by being around you.
What an excellent explanation
Excellent explains..congratulations
Really interesting talk! Excellent speaker as well. Would love her to be one of my microbio professors.
The main thing that scares me about GM and GE foods is that any DNA from them that isn't denatured by our stomach acid (this can be a lot depending on the health of stomach secretions, which tend to be quite unhealthy in an Americanized diet plan) ends up being absorbed by the bacteria that inhabit our intestines. These bacteria are imperative to many processes within us, and are integral to our immune system, vitamin B and K absorption, and many more important processes. It is estimated that these gut flora have around a hundred times as many genes in aggregate as there are in the human genome. This is what you want Monsanto to be experimenting with? :-/
Einstein chose Princeton. Dr. Bonnie Bassler chose Princeton. Total geniuses.
Really awesome talk
I think there is just a misunderstanding. Yes, if you filled a room with smoke, and everyone started coughing that would not be a great analogy for quorum sensing. However, if your lungs produced smoke, and made other lungs produce smoke, and they made other lungs produce smoke, and this led to some kind of joint activity from all of the lungs, then that is analogous to quorum sensing.
That is why she refers to it as a language, because the cells are producing signals that influence other cells
POV: You are watching this video because your connections academy Unit in Health Sciences is telling you to answer 5 questions based on what this Ted Talk.
Great talk in my opinion. I don't think she tried to make bacteria seem more amazing than they are, its just her over-enthousiasm that kicked in along the talk. Dont judge her for this - this is about the amazing discovery she explains about.
Wonderful, mind expanding talk.
Amazing talk
attentive to the end.. awesome speaking! well done
i think kary mullis' molecule approach to killing bacteria is the best way to compensate for the demise of antibiotics but this research on how bacteria communicates is amazing and very promising too
Impressive how a minute stuff takes on a host million times its size
First of all, this is not fake knowledge; these talks are here to enlighten us about the frontiers of science.
Secondly, TED talks are not meant to teach everything there is about the subject. It's meant to engender an interest to dig deeper. I think they do a pretty good job. You can't really learn something without being interested in it.
Just when I was beginning to think anti biotic resistance would wipe us out.
In any case that would never happen. Just as some bacteria evolve anti-biotic resistance, there would always be some humans who'd be naturally able to resist that bacteria.
So while the "weak" humans would die off, the survivors would thrive and their future generations would be naturally resistant to that bacteria. And the circle of life would continue exactly as if nothing ever happened.
Incredible, 18 mins passed sooooo quickly. So interesting!
The key to our humanness
Unfortunatly as a teacher I can testify to the fact that many children have no imagination for science or are kinesthetic learners. So nothing would be less effective than being leactured, even by a speaker as amazing as her.
Excellent video 👍👍
You can tell she's an experienced lecturer.
They are behaving as a colony. They are responding to stimulus but calling that language means she that she can't distinguish communal behavior from communication. Interaction is not communication. If not everything is communication with everything. Like a standing ovation. we clap, more clap, then one guy stands up and when enough stand up everyone else does. Its stimulus not communication. There is a difference
The issue is that it amkes the bacteria sound like they are responding to each other. They are not.They have no connection with each other. Its like saying when you fill a room with smoke, every one agrees to cough. You cough all on your own as a result of the concentration of smoke in your environment. There is no communication with anyone
I would love to see a culture of bacteria flash mob