Renin Angiotensin Aldosterone System (RAAS)

This video contains a visual explanation of the renin-angiotensin-aldosterone system. We also cover hyperaldosteronism and medications that inhibit RAAS, such as ACE inhibitors, angiotensin II receptor blockers and aldosterone antagonists.
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[@teddypopsicle2397]

One thing to note which is not widely reported in common descriptions of RAAS is that, although quantitatively the highest production of ACE is in pulmonary vascular endothelial tissue, it is also expressed in the kidneys themselves. Considering ANG II has a relatively short half-life in circulation, and that it exerts its effect in the kidneys themselves, it logically makes more sense that most functional conversion into ANG-II occurs in the kidneys. Despite literature constantly reporting the highest ACE expression in the lungs, it's likely this doesn't represent the majority of functional ACE in RAAS, and that the system doesn't do an inefficient trip back and forth from the lungs.
My PI loves using this as an example of how mainstream descriptions of physiological processes, which have been around for a long time, can be prematurely consolidated before they are fully fleshed out and proven. Something to keep in the back of your mind whenever you learn really anything that seems well-established :)
great video!

[@Lifesaver_notes]

Very helpful ❤

[@waelfadlallah8939]

Hello, Tom 😊

[@damxgopak457]

Very interesting thank you.

[@neilbeni7744]

Wow, when one learns something new..

[@shaira4637]

U said at the end about diuresis. How about the natriuresis? Thanks