As someone interested in the topic but not having the background in this field it would be a lot easier to understand just by adding some natural retorical pauses (as we normally do when we talk) 😀 It is better better to speed up the video pase than to slow it down since the quality differs. Just a tip! Thanks for making this information available! (even though I only grasp half of it just because some retorical details 😉)
But is it necessarily a bad thing that SIRT1 gets degraded within a cell that is already senescent? It would be important to know if autophagy degrades SIRT1 in a normal cell which would be bad. My takeaway is that activating/upregulating SIRT1 with resveratrol etc may prevent the onset of senescence, but once senescence has set in, I don't see how rescuing SIRT1 in those senescent cells helps with anything at all.
Please help me answer this .., why would Sirt1 have a higher expression in high fat diet than in mice fed with NMN ? Would really appreciate your response Thankyou
Hello, so it has always been stated that deacetylation of p53 reduced its dna binding ability, so short answer yes. But, i am certain the situation is a lot more complex and given that p53 has >300 PTMs i doubt it would be that simple!! This question bugs me a lot!
You are quickly becomming my favorite PhD health youtuber. You and FMF.
I just discovered your channel and I really like it. It seems sincere. Looking forward to watching more of it!
I studied this in the book "Lifespan" by Dr.David Sinclair....Love from India....❤
this one is important...full attention...
looks like the induction of a mechanism to clear out senescent cells via autophagy.
As someone interested in the topic but not having the background in this field it would be a lot easier to understand just by adding some natural retorical pauses (as we normally do when we talk) 😀 It is better better to speed up the video pase than to slow it down since the quality differs. Just a tip!
Thanks for making this information available! (even though I only grasp half of it just because some retorical details 😉)
Awesome. Thanks for that insightful lecture
phenomenal and clear explanation, really good teacher thank you sm
Very nice video! Help me a lot in some doubts I had int sirt expression!
Great video! With the least meaningful thing I could add: sirtuins are named after SIR2, so should probably be pronounced closer to "sir two ins" :)
What anti aging Supplements are you taking currently?
But is it necessarily a bad thing that SIRT1 gets degraded within a cell that is already senescent? It would be important to know if autophagy degrades SIRT1 in a normal cell which would be bad. My takeaway is that activating/upregulating SIRT1 with resveratrol etc may prevent the onset of senescence, but once senescence has set in, I don't see how rescuing SIRT1 in those senescent cells helps with anything at all.
a recent paper shows that RVS is not a direct activator of SIRT1...
Can I have the source to paper for cross reference? Thank you.
As far as I remember, David Sinclair proves otherwise regarding RVS to SIRT1
Would love to have a look at the papers that you read
Please help me answer this .., why would Sirt1 have a higher expression in high fat diet than in mice fed with NMN ? Would really appreciate your response Thankyou
We want to activate a autophagy, but it is going to degrade the sirt1?
Hey! Quick question, isnt deacetylation of p53 a bad thing?
Hello, so it has always been stated that deacetylation of p53 reduced its dna binding ability, so short answer yes. But, i am certain the situation is a lot more complex and given that p53 has >300 PTMs i doubt it would be that simple!! This question bugs me a lot!
Maca can do this..check it out..