Links to Videos and Studies for more Details: Personal Fat Threshold: ua-cam.com/video/aSiINYGC-Mw/v-deo.htmlsi=MK81y5fOrqMwuOWi Creatine on Brain: ua-cam.com/video/ufzfqpG9gf8/v-deo.htmlsi=IskQgcs3SiETpjMG Life Extending Factors: ua-cam.com/video/nA9l3mIhmz4/v-deo.htmlsi=v9HhVImWf0mM9pU6 Niacin on Heart Disease: ua-cam.com/video/N17cmKCVxcw/v-deo.htmlsi=gn1IJqonBa5jIgJx Methylene Blue: ua-cam.com/video/zmogXFrx4Ys/v-deo.htmlsi=UVZKGxrqT2Cs9euK
Nic - Thanks for distilling research into actionable insights while providing the RDA of dad jokes. I’ve watched your channel for years. I gave up ultra processed foods. Increased my diet of Omega 3 fatty fish, low fat dairy, healthy fruits (blackberries, avocados, blueberries), nuts (walnuts, pecans, macadamias), seeds (chia, flax), dark leafy greens and cruciferous veggies. You’ve helped teach me to make informed choices. I walk six days a week getting an average of 15,000 steps per day. Reduced my HbA1c from 6.3 to 5.1 while improving my AST and ALT. Dropped 85 pounds. Reversed my NAFLD and pre Diabetes. Did it all without surgery or GLP-1 agonists. My doctor has been impressed. Your insights have truly helped. Thank you. 🙏🏼
@@Physionic Please do. Share if it will help others. I’m still on the journey - it’s not a destination. My doctor gave me options of GLP-1 injections, a gastric procedure or diet/lifestyle. He said that I would need to change diet/lifestyle even with surgery or injections. I chose to not go the medical intervention routes because of the risks and side effects. It has been 2-1/2 years since I started. Now I have normal triglycerides, normal fasting glucose and insulin, and optimal HDL, LDL and VLDL. My blood pressure last night was 111/61 with a pulse of 57. My breakfast this morning was coffee with monk fruit sweetener, smoked wild salmon with avocado on a medium low carb tortilla, and a 1/2 cup of steel cut oatmeal…the traditional stove cooked version, not instant, not sweetened and not flavored. I am still obese but I am 15 pounds from my next goal of merely being overweight. I now have one chin…I think that is the maximum number of chins I’m supposed to have.
If you're thinking about supplementing methylene blue, be sure to avoid "natural" or "wild-caught" sources. These are almost entirely harvested by poaching smurfs in their native Belgian habitat, leaving them critically endangered. However, if you're on the western coast of the US, you can ethically harvest them, since smurfs are actually an invasive species in North America. Thank you for bringing up this critically important issue of methylene blue sourcing. 🙏
I would LOVE to see studies on creatine’s effect on depression, sleep, and brain injuries. For context I’m a 33yr old male, I’ve battled with depression for the last couple decades and had a rather serious TBI in the frontal lobe a couple weeks before my 10th birthday which likely have contributed to it. I went from a star student, top 1% test performer in the state, to not being able to copy the date off the white board because my working memory was wiped, my personality changed over night, and I now have virtually no memory of my childhood prior among a list of other problems. It was rough to put it lightly. Well, cut to the last couple months I decided to start intermittent fasting, low carb/ high protein diet and working out. Sure it helped the mood a little and I saw some mild muscle gains and fairly considerable fat loss. Nice, but for the most part was still my practically emotionally nonexistent self. One day on a whim I decided I’d try creatine to help push a little harder at the gym. That afternoon I remember while playing with my friend’s dog thinking just how nice the moment was with the sky so wildly blue, the grass vividly green, and how nice it felt. I realized I hadn’t felt that relaxed, appreciative happiness in years, possibly decades. That night I slept 9 hours straight and had complex, detailed, full vivid color dreams. I hadn’t dreamt like that since I was a kid. Dreams had always been vague, brief, forgettable, abstract nothingness for as long as I could remember. Now whether it’s a rest day or not I take the stuff. It’s potentially saved me from myself. I get that makes me an odd case but I suspect I’m not the only person this could help. My parents who, I see fairly regularly seemed to immediately pick up on the fact that my energy and mood has been elevated. Obviously the asked if I felt it was all the diet and I explained that I truly felt it was the creatine. Out of curiosity, both of them tried it as well. My mother who struggled with getting restful sleep reported she too dreamt way more vividly and for longer and my father who also battles depression seemed to have alleviated the symptoms (though not quite to the same degree I had). I’m absolutely amazed given how well studied it’s been in the athletic side for decades that there hasn’t been much research on the cognitive effects, as I’m sure I’m not the first to have noticed these benefits.
Thanks for sharing. I feel like I'm along the same path you were. Things are getting better -best shape I've been in in a decade...but still rather emotionally detached. Gonna give this a whirl.
@@LucasWimanI had my first dose today. I will monitor (as best I can because - ADHD & VERY distracted). 70, diagnosed ADHD after 40, medicated for adhd for several years - it was very helpful, but blood pressure got too high. I didn’t want to keep medicating side-effects.
What's heartening about doing the big five is a lot of leeway to start late, Even at 90 some gains, Again in the long video I just sampled , you get increased health span . I started going to the gym beginning of this year as a 59 year old massive gains , front about 1 pull up to over 10 at a time , knees no twinging . Good muscle growth and weight loss . Cycle fast to and from gym , easy to pump it all the way and back . Except Sunday drive and do HIIT first on step and then elliptical . Elliptical is very gentle, no chance to shoot off, no jarring etc , easy to stop
Methylene Blue is discussed in detail on Peter Attia's interview with Francisco Gonzalez Lima of UT Austin and is beyond fascinating. In particular, they discussed the clinical trial from Scotland and the status of research. They go into the full history and nuance of MB.
I am surprised you only have 175k subscribers 😳 some others so called Doctors 😅 don’t know 💩 has 10+ million subscribers. We appreciate your knowledge and spreading awareness about health with facts🙌🏻 not Bullshit
I like the way you deliver the information, with humor, in rapid delivery. Instead of trying to stretch a small amount of information into a longer video. You get right to the point of data analysis. A lot of times I have my UA-cam notifications off, because many of them provoke flight or fight with doomsday headlines, or I'll run out of data and when I get connected to Wi-Fi I have 10 minutes unable to use my phone because of the notifications.. But i made sure to click all notifications for your channel
I have mitochondrial disease dysfunction at complex one I love methylene blue because it just skips the dysfunction and gives the electron to complex for where it is needed :-) LHON
This is thoguht provoking as always, Mr Physionic. I do have a question thought -I've watched all your videos about how to reverse type 2 diabetes in skinny people (with high visceral fat), and I still do not understand its mechanism? I've follow a low restricted diet for many years, exercise daily, eat a good diet, no alcohol and sugar, and low carbs. I am 1,77, 59kg, and I still on the prediabetic range with high LDL. Can you please detail the study 250 on its praticalities for us? It is a powerful study which I seem to still miss what to do to "reverse it".
You mention exercise but not what type. You might need to lift weights to increase muscle mass. Try googling “Muscle mass increases mitochondria”. Lots of Zone 2 (not zones 1,3,4 or 5 or in otherwords) aerobic training can help too (especially in males)
I'm curious about possible positive or negative effects of niacin flushing on skin health in general, and treatment for skin with flaky or rash-like symptoms. I suspect the increased blood flow may have a positive effect.
Love ur channel …. I have some heart issues and I’m on a regiment meds but my cardiologist took me off niacin. Saint is bad for the kidneys. Have you heard that?
Please do a deep dive into hyperhomocystenemia. The narratives too often skip major curiosities. Like, how does homocysteine damage endothelial linings? Why is it mentioned only regarding cardiovascular and stroke outcomes? Aren't all of our arteries of equal thickness and integrity? How does homocysteine affect the liver, pancreas and kidneys, for example? I feel these matters get such little attention paid them. Please, pursue and bring clarity to the ramifications a decades long hyperhomocystenemia. PLEASE?
on the comment about youth, I used to get that a lot in my 20's but I lived through it and tried (probably failed) to not get a chip on my shoulder, by my late 30's that all went away. These days I prefer to not even bring my qualifications to bear and believe that "my arguments should stand on their own"; which I believe. However the combination of "outright dunning kruger" and "the increasing complexity of the basis of the metabolism upon which the arguments rest" can be beyond most people. Heck even Sabine Hossenfelder admits herself that some arguments rest on knowledge that she doesn't have. I'm quite a fan of your channel, and seldom double check your interpretations (because I've got not time to read 250 studies) as I have solid faith in your intentions. Keep it up, and Best Wishes
i feel smarter everyday from your videos and i love it. i notice on myself i store more of my fat subcutaneously as in my younger years i was fatter i think that helped me not develop serious metabolic disease like diabetes type 2.
I'm now at the point where three things are happening regarding your vids, Nic: (1) I click the Like button before I even start to watch because what's the point of waiting when I know I'm going to love it; (2) and speaking of love, every time I click the Like button, I'm reminded how frustrated I am that there's not a Heart button because your vids deserve so much more than mere Likes; and (3) I now have to budget more time when I click on your vids - not just the time allotted to watch the actual video (and often take notes), but nearly the same amount of time reading all the fun comments from your stans and clicking Like for those too. And there goes my break time! But it's okay. Stealing sentiments from another commenter, I'm wiser, more equipped to age well, and I've also had my RDA of dad jokes. Thank you! - Karen (a loyal stan) 🥰
I'd love you to study the effects of red light therapy. I'm also extremely interested to hear your take on the fact that the supposed benefits come from the production of large amounts of ROS from the light as the main driver of positive health outcomes.
Dinetrophenol reduces mitocondrial efficiency leading to hyperthermia and death. Methyline Blue increases mitocondrial efficiency leading to hypothermia and cryosleep? (Chemically induced smurfification)
I have really enjoyed watching your channel grow. Your combination of wit and attention to detail have made it one of my go to channels when learning about health and wellness. I wish you continued success! Cheers
That's Niacin off my list now Was thinking of taking it I've got my blood sugar levels In check but I don't like the thought Of it sneeking up on me When I'm not expecting it.
Methlyne blue has been a God send for my CFS. Took awile to get the dose and dosage timings right but it literally restores my energy and gets rid of my muscle aches. I think it helps make sleep more restoring but I can't be certain.
I have had great results with it. I have had to adjust dosage off and on to find what fits for me, but I will keep taking because it has so helped the quality of my life thus far!
Thank you for making it simple as possible to understand data analysis. I think food got kinda messed up in order to increase production. Some nutrients are not there anymore. It's only speculation. No science as far as i know. But this favors supplementation.
The quitting smoking for longevity point is interesting for those who grew up in smokers homes and couldn’t control proximity to second hand smoke as a child. I’m curious to know if there is a time threshold from the point of “quitting” (or extracting oneself from smoking environments) that determines the longevity effect? Or does the potential of effect just increase as time distances one from the environment?
Can you do a video showing what I can get by subscribing to the insider? I just want to know how is the library structured and what are the content that I would be getting, thank you
Great summaries. Just a reminder creatine only helps with short-term memory not long term because of its mechanism of action (it just increases ATP). It will decrease NREM sleep which can decrease your ability to clear your accumulated neural toxins/waste products at night during deep sleep so take it in small doses if you wish to take it. In youth you have an abundance of creatine and it is not necessary. Although it can be beneficial in older adults especially for those > 60yo, when levels are lower, if you have kidney disease, it can cause issues. It's pretty safe in younger adults, though some older people do have adverse issues especially in men with hair loss through mechanisms that are not properly researched (and most people "speculate" why it happens. Either way it can happen and is not just imagination. It does not affect everyone but a smaller % of men). Higher dose Niacin needs to be paired up with TMG or B12 and Folate to replenish free methyl groups that are used up in the methylation of niacin which also produces homocysteine that causes arterial-occlusive disease that can lead to heart attacks. Also in a 2024 study, high levels of niacin results in higher levels of two breakdown products, 2PY and 4PY, which are associated with inflammation in arteries and other adverse cardiac events. Over 3 years, people were found to have strokes, myocardial infarctions, and death. So please take all these factors into account before engorging in the video-mentioned supplements for "longevity" :D
the fact not smoking is the most important for increasing lifespan is really interesting. Does this mean that someone who follows the other 4 well but smokes is at greater risk of death than someone who doesnt smoke but is overweight, bad nutrition etc or is the effect not that great? Awesome vidya btw i rly enjoy the "i read x studies"
My friend at uni , his brother died from heartattack at the age of 28. He's skinny but living on bacon, salami and sausages. My friend was skinny and living on bacon and sausages as well. After his brother passed away, he changed his diet.
Hey Nick! Thanks for your informative and useful videos. I appreciate the research and sharing in a way that we can understand the pros and cons of different supplements, lifestyles, etc. Would you please consider making a video to compare and contrast the benefits of Glynac versus Creatine for older adults? I currently take Glynac and am wondering if I should add Creatine or if they provide similar benefits and wouldn’t need to take both. Thank you.
I originally started taking methylene blue to fix my crippling caffeine addiction. I take a really low dose though (7-8 drops of the most diluted solution) once a day. I did it twice in one day and it made me super nauseous.
riddle me this, I lost 45lb, I have greatly increased my physical activity and my diet is great, but I noticed that I am now prediabetic. Before the weight loss my fasting glucose was in the 80s now, it hovers in the 100s. When I eat simple carbs, I see a jump and then a drop to 80s then slowly climbs back to 100 showing that my insulin glucose reaction is active and I'm not insulin resistant. So why does my body want to keep my fasting blood glucose so high?
You are funny. Do you have any videos on mental health like depression? Also, if I want to try on Creatine where could I find dosage recomendations? Thank you.
Can we talk more about sleep? Or actually insomnia? My husband is 66 and for most of his adult life he’s not been able to sleep. He has no problem falling asleep but, staying asleep is the big one. He wakes up every hour and some nights, or most, he lays there wide awake. He’s talking magnesium. I’m just wondering if he could have developed some kind of deficiency as a child. Anyway, please, I know he’s not the only one. I too have terrible sleep problems but I’m more concerned about the hubs. Thanks so much! I’m a new sub here so 😉
An Oura Ring, or other sleep monitoring device, could be helpful. I assume you're aware of sleep apnea, if not, a sleep study would be logical. I assume he's tried many sleep aids? Then there are Sleep Hygiene practices.
“Smarter than the average garden toad”” and a helluva lot more tuned in to statistical nuance, impartial data interpretation, and differences between animal and human studies than plenty of long-time PhDs in these spaces. Thank you for prioritizing scientific rigour over confirmation bias and shilling products.
What about niacin and raising NAD+ levels? Isn't there a blood test for measuring whether one will benefiit from this supplementation and tayloring dosage? niacin not just ffor heart disease... Niacin...the tingling/pins-and-needles/itchy feeling...much more than the flushing.
Please could you do a video on any studies showing the amount of calories lost during processing for each of the macros? I'm seeing so many different people saying different things about this... some saying it can be as much as 25% more for protein than carbs / fat. Which would be a massive swing in net calories if you eat much more protein than a carb / fat heavy diet 🤔
WRT reversing diabetes hba1c may not be the best measure. Diabetes is primarily a disease of poor insulin effectiveness so Homa-IR or similar may be a better indicator of healthy metabolism
This video speaks to me - I am definitely the skinny fat guy. Mostly good blood panels but high but still normal red/white counts and A1C creeping up over the years.
Excellent content. Can you look into making a YT video about Interleukin 6 (IL-6) in relation to Heart disease and Osteoporosis. I have checked all of your videos and surprisingly this has never been covered specifically although it has been mentioned in some videos. If levels are elevated consistently IL-6 can increase the activity of osteoclasts causing excess bone loss and have an inflammatory effect on arteries. It plays a role in many other conditions when consistently elevated. A real nasty character! (Coincidentally I do have osteoporosis and heart disease). By chance my recent blood test showed an elevated level of IL-6 but surprisingly normal CRP. There is a lot of "academic" content on line so it would be great if you can explain what it means. From what I can find online IL-6 levels can increase exponentially with exercise but apparently drop rapidly. I am trying to get some professional advice on my result. My family doctor had never heard of IL-6 and worse still could not advise which specialty she could refer me to. Maybe you could interview the relevant specialist (probably in immunology). Thanks, David Barnes
Methylene blue is among other things a neuroleptic from which chlorpromazine was derived. My understanding is that it was widely researched in the premodern era and then the research suddenly stops. It's all a little weird if you ask me.
I tried creatine for its purported benefits and ended up with a gout attack in one knee and one foot simultaneously. It was so bad I had to get a cortisone shot in both. Was it coincidence? I have been told that creatine does NOT engender gout. Does it, or doesn't it?
I train in powerlifting (to compete) and bodybuilding (for fun), and I still could never remember to take Creatine until I discovered pineapple flavor creatine monohydrate gummies on Amazon. I haven't missed a day since. :)
Wow same, I had to stop creatine though I got nasty cramps. I remember I would have to lay on a lax ball for like 10 minutes in between deadlift sets. As soon as I stopped taking it that stopped happening.
I'm not surprised that smoking was the biggest factor. Coming from a family of smokers, I've seen how badly smoking messes people up. I started down that path myself, but was able to kick the habit in 2004. And I never looked back. But I still wonder how many years that took off my life.
My mother-in-law smoked in her youth but quit in her 30s or 40s. She lived to age 96 and remained in pretty good health until the very end. So, maybe you'll do okay too.
I really wish someone would figure out if the Niacin flush is good or bad; or rather the effect of it. I’ve come to find it pleasant, but I’d like to know what it’s actually doing to me.
Glad you know more than common garden toads. I had been consulting common garden toads for health advice, but yes, the uncommon toads are far more knowledgeable! 😁 What is your PHD in?
You can boost Methylen blue together with red light therapy panel. I use it myself and Redlight alone help me a lot..MB is just the Biohacking Cherry on my Tart😄
@@contagiousintelligence5007 I use the Infraredi Max Panel Multiwave+ technology, encompassing the 5x most bioactive wavelengths including 630nm, 660nm, 810nm, 830nm & 850nm
Im still using MB, just an 1/10 solution. Put it in a small spray bottle thats designed for mouth spray (for people that have issues creating saliva), mechanicly its perfect as the solution doesnt go bad becuase of this and you can take it with you as well. MB can absorb trough your mouth quickly and the rest of it trough your stomach. Its great, benefit are very noticable quickly. Big downside, blue tongue. Have to say as well, i had issues with my gums being inflamed, but using 1 or 2 sprays of methelyne blue (which is probadly 2 drops max) i got instant pain relief. It has this ability to enclose any inflametory material. And your body cells dont mind being 'drowned' in the stuff im geussing this is because body cells are part of an chain inside the body, where as any bacteria that stands on its own is being put out of reach of any resources to do further damage. Honoustly can only guess how it works.. but i just have to say it works very well for me. My biological age is 23 according to the fitdays health app, my actual age is 40. Its not an cure all or powerboost, its just noticably good.
It just kills me that I’m doing all of these things right but still struggle with crippling depression. I wish we knew as much about the brain as we do about the body.
Well this is particularly relevant to me as although in my late 40s I still have a six pack and very little fat under my skin also good muscle mass. But I was told i have fatty liver and only just under the pre diabetes range. As I have cut abs etc and keep fit it really surprised me.
This is exactly my reality. It is still not quite clear how to "reverse this visceral fat". I've always been lean, good diet, sports, no sugars etc but I just got on the prediabetic range.
Reduce Fructose. In comparison to glucose, fructose has to be processed by the liver after absorption. Problem is, that fructose easily gets stored in visceral fat around the liver. Being lean while having prediabetic symptoms is something alot of vegans deal with. Thats because you essentially became insulin resistant. Which is one of the key primary anthropological evidence that we in fact evolved to be carnivores. We are adapted to high fat diets. That extra fat is susceptible to be stored in visceral fat, unlike excess calories from Fructose and glucose. So yes, you can be super unhealthy while being active and lean. In fact , being too lean is rather bad for our immune system and especially for our hormone levels. Bodybuilders know this very well when they get close to a show.
@@edjack5on you need to gain some skeletal muscle and get into a healthy bodyfat range of at least 14%. Once you are there focus on reducing load on your pancreas. This means going high fat and low carb to avoid high spikes of insulin and give your pancreas time to repair. If you are Vegan, i would advice eating more coconut milk for the fats ( not avocados, they are FODMAPS and will give you digestive problems). Make sure to get a good vegan bioavailable protein supplement, since the amount of vegetables necessary to get your proteins and calories up just isnt feasible for someone your stature. Add in some intermittent fasting to speed up the process. Im not gonna sugercoat it, but a low carb vegan diet is not the most tasty diet out there. Personally i would just advise you to go for a High fat Meat based diet, but thats usually not something people want to do morally and especially financially.
@@snakeace0 Hi, thank you for the comment, and advice. I am carnivore close, eating high fat and vegetables, avoiding fructose and carbs, and all sorts of sugar. Despite all that, as said, my blood glucose levels and LDL cholesterol are almost at the danger zone.
@@snakeace0 Thanks for your reply appreciate it, I actually only just started re-introducing carbs back in. I was already low carb and then full keto for a long while before my blood test. I actually went full carnivore for about 3-4 months after my blood test. I was loosing body fat by the day on carnivore but felt mentally fatigued and exhausted so after watching the energy balance podcast I have started introducing carbs again from clean sources. Not grains etc. But definitely won't over do the fructose. Been doing weights etc for many years. But suffered a bad back injury that set me back but hopefully sort this out. Lots of great advice and opinions out there so been experimenting to see what works... 👍
Good golly. I have used methylene blue in the lab for about 40 years, never even considered eating any of it. And yes, I was born in the 1950s. So, too late for me.
There was an article off cochrane I read that stated a 20 - 30g dose/distributed dose throughout the day when you are sleep deprived it can maintain your cognitive performance compared to no creatine. Couldn't find it but I also didn't try thoroughly to find it lol
![The Promise of Two Anti-Aging Molecules [10 Studies]](/img/n.gif)
Links to Videos and Studies for more Details:
Personal Fat Threshold: ua-cam.com/video/aSiINYGC-Mw/v-deo.htmlsi=MK81y5fOrqMwuOWi
Creatine on Brain: ua-cam.com/video/ufzfqpG9gf8/v-deo.htmlsi=IskQgcs3SiETpjMG
Life Extending Factors: ua-cam.com/video/nA9l3mIhmz4/v-deo.htmlsi=v9HhVImWf0mM9pU6
Niacin on Heart Disease: ua-cam.com/video/N17cmKCVxcw/v-deo.htmlsi=gn1IJqonBa5jIgJx
Methylene Blue: ua-cam.com/video/zmogXFrx4Ys/v-deo.htmlsi=UVZKGxrqT2Cs9euK
Excellent.
Very impressive presentation and video composition .. . and the wholesome (corny) humor too!
You missed one for the last section. A lot of research has demonstrated that getting 8 hours of quality sleep is extremely important for longevity
Can you have a 'look' at lithium orotate? It seems to have a lot of health benefits for the body and mind.
Nic - Thanks for distilling research into actionable insights while providing the RDA of dad jokes. I’ve watched your channel for years. I gave up ultra processed foods. Increased my diet of Omega 3 fatty fish, low fat dairy, healthy fruits (blackberries, avocados, blueberries), nuts (walnuts, pecans, macadamias), seeds (chia, flax), dark leafy greens and cruciferous veggies. You’ve helped teach me to make informed choices. I walk six days a week getting an average of 15,000 steps per day. Reduced my HbA1c from 6.3 to 5.1 while improving my AST and ALT. Dropped 85 pounds. Reversed my NAFLD and pre Diabetes. Did it all without surgery or GLP-1 agonists. My doctor has been impressed. Your insights have truly helped. Thank you. 🙏🏼
That's really wonderful to hear - thanks for sharing. I may highlight this in my community, if that's okay with you?
@@Physionic Please do. Share if it will help others. I’m still on the journey - it’s not a destination. My doctor gave me options of GLP-1 injections, a gastric procedure or diet/lifestyle. He said that I would need to change diet/lifestyle even with surgery or injections. I chose to not go the medical intervention routes because of the risks and side effects. It has been 2-1/2 years since I started. Now I have normal triglycerides, normal fasting glucose and insulin, and optimal HDL, LDL and VLDL. My blood pressure last night was 111/61 with a pulse of 57.
My breakfast this morning was coffee with monk fruit sweetener, smoked wild salmon with avocado on a medium low carb tortilla, and a 1/2 cup of steel cut oatmeal…the traditional stove cooked version, not instant, not sweetened and not flavored. I am still obese but I am 15 pounds from my next goal of merely being overweight. I now have one chin…I think that is the maximum number of chins I’m supposed to have.
@@OTatime love reading such inspiring comments such as yours! Thank you!🎉
@@jellybeanvinkler4878 Thanks for your comment. I’m in my 60s. It is never too late to make a choice.
15,000 steps a day! Wow! You’re a machine!
If you're thinking about supplementing methylene blue, be sure to avoid "natural" or "wild-caught" sources. These are almost entirely harvested by poaching smurfs in their native Belgian habitat, leaving them critically endangered. However, if you're on the western coast of the US, you can ethically harvest them, since smurfs are actually an invasive species in North America. Thank you for bringing up this critically important issue of methylene blue sourcing. 🙏
I really thought the conclusion was going to include a 6th thing: Watching Physionic videos is the best thing to do for your health
Hehe, thanks :)
Ha, it's certainly not bad for it :)
I regularly sit on the couch, eat Milk Duds, and watch Physionic. And I've lost 28 lbs!!! It's that stimulating.
@@presence5426😂🎉❤
@joshy2joshy - only recently discovered physionics, I second your emotion!
I would LOVE to see studies on creatine’s effect on depression, sleep, and brain injuries. For context I’m a 33yr old male, I’ve battled with depression for the last couple decades and had a rather serious TBI in the frontal lobe a couple weeks before my 10th birthday which likely have contributed to it. I went from a star student, top 1% test performer in the state, to not being able to copy the date off the white board because my working memory was wiped, my personality changed over night, and I now have virtually no memory of my childhood prior among a list of other problems. It was rough to put it lightly.
Well, cut to the last couple months I decided to start intermittent fasting, low carb/ high protein diet and working out. Sure it helped the mood a little and I saw some mild muscle gains and fairly considerable fat loss. Nice, but for the most part was still my practically emotionally nonexistent self. One day on a whim I decided I’d try creatine to help push a little harder at the gym. That afternoon I remember while playing with my friend’s dog thinking just how nice the moment was with the sky so wildly blue, the grass vividly green, and how nice it felt. I realized I hadn’t felt that relaxed, appreciative happiness in years, possibly decades. That night I slept 9 hours straight and had complex, detailed, full vivid color dreams. I hadn’t dreamt like that since I was a kid. Dreams had always been vague, brief, forgettable, abstract nothingness for as long as I could remember.
Now whether it’s a rest day or not I take the stuff. It’s potentially saved me from myself. I get that makes me an odd case but I suspect I’m not the only person this could help. My parents who, I see fairly regularly seemed to immediately pick up on the fact that my energy and mood has been elevated. Obviously the asked if I felt it was all the diet and I explained that I truly felt it was the creatine. Out of curiosity, both of them tried it as well. My mother who struggled with getting restful sleep reported she too dreamt way more vividly and for longer and my father who also battles depression seemed to have alleviated the symptoms (though not quite to the same degree I had).
I’m absolutely amazed given how well studied it’s been in the athletic side for decades that there hasn’t been much research on the cognitive effects, as I’m sure I’m not the first to have noticed these benefits.
Given that it helped with executive function, it would be interesting to see if it benefits ADHD as well.
Thanks for sharing. I feel like I'm along the same path you were. Things are getting better -best shape I've been in in a decade...but still rather emotionally detached. Gonna give this a whirl.
@@LucasWimanI had my first dose today. I will monitor (as best I can because - ADHD & VERY distracted).
70, diagnosed ADHD after 40, medicated for adhd for several years - it was very helpful, but blood pressure got too high. I didn’t want to keep medicating side-effects.
When I read “250 Studies” I thought we were in for a 16-hour video
Hi Nic, I’ve always considered you to be smarter than a “common garden toad”…your content and humor are spot on! Thank you!
Love the self-efacing dry humor too. Keep doing what you do!
As usual, fascinating and great delivery. :)
Thanks!
What an amazing combination of presentation talent, production skills, and intellectual prowess. Bravo!
What's heartening about doing the big five is a lot of leeway to start late, Even at 90 some gains, Again in the long video I just sampled , you get increased health span . I started going to the gym beginning of this year as a 59 year old massive gains , front about 1 pull up to over 10 at a time , knees no twinging . Good muscle growth and weight loss . Cycle fast to and from gym , easy to pump it all the way and back . Except Sunday drive and do HIIT first on step and then elliptical . Elliptical is very gentle, no chance to shoot off, no jarring etc , easy to stop
Methylene Blue is discussed in detail on Peter Attia's interview with Francisco Gonzalez Lima of UT Austin and is beyond fascinating. In particular, they discussed the clinical trial from Scotland and the status of research. They go into the full history and nuance of MB.
I am surprised you only have 175k subscribers 😳 some others so called Doctors 😅 don’t know 💩 has 10+ million subscribers. We appreciate your knowledge and spreading awareness about health with facts🙌🏻 not Bullshit
Who?
Facts versus hyperbole.
Great summary and advises. Science driven and unbiased
Very simple solution - just follow number 5
I like the way you deliver the information, with humor, in rapid delivery. Instead of trying to stretch a small amount of information into a longer video.
You get right to the point of data analysis.
A lot of times I have my UA-cam notifications off, because many of them provoke flight or fight with doomsday headlines, or I'll run out of data and when I get connected to Wi-Fi I have 10 minutes unable to use my phone because of the notifications.. But i made sure to click all notifications for your channel
Methylene blue sounds like something from several episodes of Breaking Bad
It's as good as advertised 😂😂😂
It's actually a stain commonly used in diagnostic laboratories.
I'd like to hear a summary on Benfotiamine and Theanine. Thank you.
You are amazing, thank you. With a bit of corralling I believe I can convince my brothers to watch the entire video.
Adding drama for those who fall asleep, hilarious😅😂. I guess sadly yes but your voice is very resonant, calming and even.
You are very good and doing a very good job.
Thank you! 😃
I have mitochondrial disease dysfunction at complex one I love methylene blue because it just skips the dysfunction and gives the electron to complex for where it is needed :-) LHON
This is thoguht provoking as always, Mr Physionic. I do have a question thought -I've watched all your videos about how to reverse type 2 diabetes in skinny people (with high visceral fat), and I still do not understand its mechanism? I've follow a low restricted diet for many years, exercise daily, eat a good diet, no alcohol and sugar, and low carbs. I am 1,77, 59kg, and I still on the prediabetic range with high LDL. Can you please detail the study 250 on its praticalities for us? It is a powerful study which I seem to still miss what to do to "reverse it".
You mention exercise but not what type. You might need to lift weights to increase muscle mass. Try googling “Muscle mass increases mitochondria”. Lots of Zone 2 (not zones 1,3,4 or 5 or in otherwords) aerobic training can help too (especially in males)
I'm curious about possible positive or negative effects of niacin flushing on skin health in general, and treatment for skin with flaky or rash-like symptoms.
I suspect the increased blood flow may have a positive effect.
Great piece about methylene blue, much apprecitated
Love ur channel …. I have some heart issues and I’m on a regiment meds but my cardiologist took me off niacin. Saint is bad for the kidneys. Have you heard that?
Thank you so much for your always valuable opinion.
Can you please tell us what's your scientific take on Hydrogen water supplement?
Please review PQQ which often is overlooked
Please do a deep dive into hyperhomocystenemia. The narratives too often skip major curiosities. Like, how does homocysteine damage endothelial linings? Why is it mentioned only regarding cardiovascular and stroke outcomes? Aren't all of our arteries of equal thickness and integrity? How does homocysteine affect the liver, pancreas and kidneys, for example? I feel these matters get such little attention paid them. Please, pursue and bring clarity to the ramifications a decades long hyperhomocystenemia. PLEASE?
I have just got methylene blue and will start it soon, I also take niacin and will now add creatine…thanks
on the comment about youth, I used to get that a lot in my 20's but I lived through it and tried (probably failed) to not get a chip on my shoulder, by my late 30's that all went away.
These days I prefer to not even bring my qualifications to bear and believe that "my arguments should stand on their own"; which I believe. However the combination of "outright dunning kruger" and "the increasing complexity of the basis of the metabolism upon which the arguments rest" can be beyond most people. Heck even Sabine Hossenfelder admits herself that some arguments rest on knowledge that she doesn't have.
I'm quite a fan of your channel, and seldom double check your interpretations (because I've got not time to read 250 studies) as I have solid faith in your intentions.
Keep it up, and Best Wishes
The fact that I was actually half-sleeping while listening to this and the “drama” actually woke me up is so funny to me. It was so spot on 😭
Niacin is also great for muscle cramps and aches!
Thanks for keeping it entertaining.
i feel smarter everyday from your videos and i love it. i notice on myself i store more of my fat subcutaneously as in my younger years i was fatter i think that helped me not develop serious metabolic disease like diabetes type 2.
I'm now at the point where three things are happening regarding your vids, Nic: (1) I click the Like button before I even start to watch because what's the point of waiting when I know I'm going to love it; (2) and speaking of love, every time I click the Like button, I'm reminded how frustrated I am that there's not a Heart button because your vids deserve so much more than mere Likes; and (3) I now have to budget more time when I click on your vids - not just the time allotted to watch the actual video (and often take notes), but nearly the same amount of time reading all the fun comments from your stans and clicking Like for those too. And there goes my break time! But it's okay. Stealing sentiments from another commenter, I'm wiser, more equipped to age well, and I've also had my RDA of dad jokes. Thank you! - Karen (a loyal stan) 🥰
I'd love you to study the effects of red light therapy. I'm also extremely interested to hear your take on the fact that the supposed benefits come from the production of large amounts of ROS from the light as the main driver of positive health outcomes.
As usual a greatly informative presentation. No question about your qualifications!
Dinetrophenol reduces mitocondrial efficiency leading to hyperthermia and death.
Methyline Blue increases mitocondrial efficiency leading to hypothermia and cryosleep? (Chemically induced smurfification)
I have really enjoyed watching your channel grow. Your combination of wit and attention to detail have made it one of my go to channels when learning about health and wellness. I wish you continued success! Cheers
That's Niacin off my list now
Was thinking of taking it
I've got my blood sugar levels
In check but I don't like the thought
Of it sneeking up on me
When I'm not expecting it.
Methlyne blue has been a God send for my CFS. Took awile to get the dose and dosage timings right but it literally restores my energy and gets rid of my muscle aches. I think it helps make sleep more restoring but I can't be certain.
I have had great results with it. I have had to adjust dosage off and on to find what fits for me, but I will keep taking because it has so helped the quality of my life thus far!
@@peaceandlove809 @Mr_Penguins_Pet_Human Where do you get it, and what dose works?
Thank you Physionic for doing this great work. Highly appreciated :D Greetings from Germany!
Thank you for making it simple as possible to understand data analysis. I think food got kinda messed up in order to increase production. Some nutrients are not there anymore. It's only speculation. No science as far as i know. But this favors supplementation.
The quitting smoking for longevity point is interesting for those who grew up in smokers homes and couldn’t control proximity to second hand smoke as a child. I’m curious to know if there is a time threshold from the point of “quitting” (or extracting oneself from smoking environments) that determines the longevity effect? Or does the potential of effect just increase as time distances one from the environment?
Can you do a video showing what I can get by subscribing to the insider? I just want to know how is the library structured and what are the content that I would be getting, thank you
Thanks mate.
Chase Hughes' journey finding Methylene Blue through Dr John Lieurance, a great video, life changing stuff.
Thanks again, mate 👍
Great summaries. Just a reminder creatine only helps with short-term memory not long term because of its mechanism of action (it just increases ATP). It will decrease NREM sleep which can decrease your ability to clear your accumulated neural toxins/waste products at night during deep sleep so take it in small doses if you wish to take it. In youth you have an abundance of creatine and it is not necessary. Although it can be beneficial in older adults especially for those > 60yo, when levels are lower, if you have kidney disease, it can cause issues. It's pretty safe in younger adults, though some older people do have adverse issues especially in men with hair loss through mechanisms that are not properly researched (and most people "speculate" why it happens. Either way it can happen and is not just imagination. It does not affect everyone but a smaller % of men).
Higher dose Niacin needs to be paired up with TMG or B12 and Folate to replenish free methyl groups that are used up in the methylation of niacin which also produces homocysteine that causes arterial-occlusive disease that can lead to heart attacks. Also in a 2024 study, high levels of niacin results in higher levels of two breakdown products, 2PY and 4PY, which are associated with inflammation in arteries and other adverse cardiac events. Over 3 years, people were found to have strokes, myocardial infarctions, and death. So please take all these factors into account before engorging in the video-mentioned supplements for "longevity" :D
I believe mitochondrial dysfuntion is related to most of our metabolic issues. And that obesity is more of a symptom than a cause in some cases.
Our physiology is so complex, it's a shame that we don't live longer than we do. Our short lives seem like a waste of our body technology.
Interesting thought. 🤔👍
Biohack.
the fact not smoking is the most important for increasing lifespan is really interesting. Does this mean that someone who follows the other 4 well but smokes is at greater risk of death than someone who doesnt smoke but is overweight, bad nutrition etc or is the effect not that great? Awesome vidya btw i rly enjoy the "i read x studies"
My friend at uni , his brother died from heartattack at the age of 28. He's skinny but living on bacon, salami and sausages. My friend was skinny and living on bacon and sausages as well. After his brother passed away, he changed his diet.
Carnivore diet = 💀
Many thanks for your informative videos. Greatly appreciated.
Whatever spot you have on your wall kept making me think I needed to clean the screen of my phone.
Cool video, do L-Ergothioneine and Triacetyluridine next, maybe even Berberine or Lithium, er Ceramides. All cool stuffs
Hey Nick! Thanks for your informative and useful videos. I appreciate the research and sharing in a way that we can understand the pros and cons of different supplements, lifestyles, etc. Would you please consider making a video to compare and contrast the benefits of Glynac versus Creatine for older adults? I currently take Glynac and am wondering if I should add Creatine or if they provide similar benefits and wouldn’t need to take both. Thank you.
If NOT smoking qualifies as a health intervention, I would also posit the health and longevity benefits of not eating rat poison.
Please tell us about C15 fatty acid, thanks for all the great info
What about the importance of sleep for life expectancy?
I originally started taking methylene blue to fix my crippling caffeine addiction. I take a really low dose though (7-8 drops of the most diluted solution) once a day. I did it twice in one day and it made me super nauseous.
riddle me this, I lost 45lb, I have greatly increased my physical activity and my diet is great, but I noticed that I am now prediabetic. Before the weight loss my fasting glucose was in the 80s now, it hovers in the 100s. When I eat simple carbs, I see a jump and then a drop to 80s then slowly climbs back to 100 showing that my insulin glucose reaction is active and I'm not insulin resistant. So why does my body want to keep my fasting blood glucose so high?
You are funny. Do you have any videos on mental health like depression? Also, if I want to try on Creatine where could I find dosage recomendations? Thank you.
5g/day, with ~20g of simple carbohydrate.
@@presence5426 thank you
Can we talk more about sleep? Or actually insomnia? My husband is 66 and for most of his adult life he’s not been able to sleep. He has no problem falling asleep but, staying asleep is the big one. He wakes up every hour and some nights, or most, he lays there wide awake. He’s talking magnesium.
I’m just wondering if he could have developed some kind of deficiency as a child. Anyway, please, I know he’s not the only one. I too have terrible sleep problems but I’m more concerned about the hubs. Thanks so much! I’m a new sub here so 😉
An Oura Ring, or other sleep monitoring device, could be helpful. I assume you're aware of sleep apnea, if not, a sleep study would be logical. I assume he's tried many sleep aids? Then there are Sleep Hygiene practices.
I've been having the same problem many years. I fall asleep but wake u at 1 or 2 am and can't go back to sleep.
When are you going to share wih us your daily stack ?
MB suppresses NO. Does it act equally on eNOS as iNOS? Hopefully not eNOS.
Hi
Regarding Methylene Blue, what amount is ok, 10 to 30 drops of 1%
A day is ok?
“Smarter than the average garden toad”” and a helluva lot more tuned in to statistical nuance, impartial data interpretation, and differences between animal and human studies than plenty of long-time PhDs in these spaces. Thank you for prioritizing scientific rigour over confirmation bias and shilling products.
Love the sense of humour.
What about niacin and raising NAD+ levels? Isn't there a blood test for measuring whether one will benefiit from this supplementation and tayloring dosage? niacin not just ffor heart disease... Niacin...the tingling/pins-and-needles/itchy feeling...much more than the flushing.
Just curious, does that mean Niacin is as effective as Statins ?
Please could you do a video on any studies showing the amount of calories lost during processing for each of the macros? I'm seeing so many different people saying different things about this... some saying it can be as much as 25% more for protein than carbs / fat. Which would be a massive swing in net calories if you eat much more protein than a carb / fat heavy diet 🤔
Can you please explain why methylene blue causes hemolysis in G6PD deficiency individuals?
Ayo I have this! ❤
WRT reversing diabetes hba1c may not be the best measure. Diabetes is primarily a disease of poor insulin effectiveness so Homa-IR or similar may be a better indicator of healthy metabolism
Any cross reference research on taking creatine with MB?
When you referred methylene blue to an old movie I immediately thought of a movie from the seventies: Soylent Green 🤣
Yes!
But, which tastes better🤔
I was picturing a designer drug from the 1980s, complete with big hair, neon lights, etc.
@@libertycowboy2495I definitely go for methylene blue 🤣
“It’s people!” 🫠
This video speaks to me - I am definitely the skinny fat guy. Mostly good blood panels but high but still normal red/white counts and A1C creeping up over the years.
Does MB down regulate cancer cell ROS ? TY Physionic
Excellent content. Can you look into making a YT video about Interleukin 6 (IL-6) in relation to Heart disease and Osteoporosis.
I have checked all of your videos and surprisingly this has never been covered specifically although it has been mentioned in some videos.
If levels are elevated consistently IL-6 can increase the activity of osteoclasts causing excess bone loss and have an inflammatory effect on arteries. It plays a role in many other conditions when consistently elevated. A real nasty character! (Coincidentally I do have osteoporosis and heart disease).
By chance my recent blood test showed an elevated level of IL-6 but surprisingly normal CRP. There is a lot of "academic" content on line so it would be great if you can explain what it means. From what I can find online IL-6 levels can increase exponentially with exercise but apparently drop rapidly. I am trying to get some professional advice on my result. My family doctor had never heard of IL-6 and worse still could not advise which specialty she could refer me to.
Maybe you could interview the relevant specialist (probably in immunology).
Thanks, David Barnes
Do you have videos on the effects of choline and its efficacy?
Speaking of methylene blue, I'd also be interested in the benefits of Ketracel-white.
Hard to get. Except you happen to live near a Vorta.
@@matthiaspriester2368 lol 👍
Methylene blue is among other things a neuroleptic from which chlorpromazine was derived. My understanding is that it was widely researched in the premodern era and then the research suddenly stops. It's all a little weird if you ask me.
I tried creatine for its purported benefits and ended up with a gout attack in one knee and one foot simultaneously. It was so bad I had to get a cortisone shot in both. Was it coincidence? I have been told that creatine does NOT engender gout. Does it, or doesn't it?
What about the ROS?
Reactive oxygen species? I dont think they exist.
Interesting! Keep them coming.
I train in powerlifting (to compete) and bodybuilding (for fun), and I still could never remember to take Creatine until I discovered pineapple flavor creatine monohydrate gummies on Amazon. I haven't missed a day since. :)
I didn't know that existed... sounds delicious...
Wow same, I had to stop creatine though I got nasty cramps. I remember I would have to lay on a lax ball for like 10 minutes in between deadlift sets. As soon as I stopped taking it that stopped happening.
I'm not surprised that smoking was the biggest factor. Coming from a family of smokers, I've seen how badly smoking messes people up. I started down that path myself, but was able to kick the habit in 2004. And I never looked back. But I still wonder how many years that took off my life.
My mother-in-law smoked in her youth but quit in her 30s or 40s. She lived to age 96 and remained in pretty good health until the very end. So, maybe you'll do okay too.
I really wish someone would figure out if the Niacin flush is good or bad; or rather the effect of it.
I’ve come to find it pleasant, but I’d like to know what it’s actually doing to me.
I remember seeing studies on people who quit smoking and had a longer life expectancy than non smoker's. Probably a lot of confounders
Glad you know more than common garden toads. I had been consulting common garden toads for health advice, but yes, the uncommon toads are far more knowledgeable! 😁 What is your PHD in?
😋
You can boost Methylen blue together with red light therapy panel. I use it myself and Redlight alone help me a lot..MB is just the Biohacking Cherry on my Tart😄
@@contagiousintelligence5007 I use the Infraredi Max Panel
Multiwave+ technology, encompassing the 5x most bioactive wavelengths including 630nm, 660nm, 810nm, 830nm & 850nm
Im still using MB, just an 1/10 solution. Put it in a small spray bottle thats designed for mouth spray (for people that have issues creating saliva), mechanicly its perfect as the solution doesnt go bad becuase of this and you can take it with you as well. MB can absorb trough your mouth quickly and the rest of it trough your stomach. Its great, benefit are very noticable quickly. Big downside, blue tongue.
Have to say as well, i had issues with my gums being inflamed, but using 1 or 2 sprays of methelyne blue (which is probadly 2 drops max) i got instant pain relief. It has this ability to enclose any inflametory material. And your body cells dont mind being 'drowned' in the stuff im geussing this is because body cells are part of an chain inside the body, where as any bacteria that stands on its own is being put out of reach of any resources to do further damage. Honoustly can only guess how it works.. but i just have to say it works very well for me.
My biological age is 23 according to the fitdays health app, my actual age is 40.
Its not an cure all or powerboost, its just noticably good.
There is something to learn about anything fast?
It just kills me that I’m doing all of these things right but still struggle with crippling depression. I wish we knew as much about the brain as we do about the body.
I think depression is often physical. Check everything from gut microflora, activity levels, allergies, diet, lymes disease, long covid etc..
Well this is particularly relevant to me as although in my late 40s I still have a six pack and very little fat under my skin also good muscle mass. But I was told i have fatty liver and only just under the pre diabetes range. As I have cut abs etc and keep fit it really surprised me.
This is exactly my reality. It is still not quite clear how to "reverse this visceral fat". I've always been lean, good diet, sports, no sugars etc but I just got on the prediabetic range.
Reduce Fructose. In comparison to glucose, fructose has to be processed by the liver after absorption. Problem is, that fructose easily gets stored in visceral fat around the liver. Being lean while having prediabetic symptoms is something alot of vegans deal with. Thats because you essentially became insulin resistant. Which is one of the key primary anthropological evidence that we in fact evolved to be carnivores. We are adapted to high fat diets. That extra fat is susceptible to be stored in visceral fat, unlike excess calories from Fructose and glucose.
So yes, you can be super unhealthy while being active and lean. In fact , being too lean is rather bad for our immune system and especially for our hormone levels. Bodybuilders know this very well when they get close to a show.
@@edjack5on you need to gain some skeletal muscle and get into a healthy bodyfat range of at least 14%. Once you are there focus on reducing load on your pancreas. This means going high fat and low carb to avoid high spikes of insulin and give your pancreas time to repair. If you are Vegan, i would advice eating more coconut milk for the fats ( not avocados, they are FODMAPS and will give you digestive problems). Make sure to get a good vegan bioavailable protein supplement, since the amount of vegetables necessary to get your proteins and calories up just isnt feasible for someone your stature.
Add in some intermittent fasting to speed up the process. Im not gonna sugercoat it, but a low carb vegan diet is not the most tasty diet out there. Personally i would just advise you to go for a High fat Meat based diet, but thats usually not something people want to do morally and especially financially.
@@snakeace0 Hi, thank you for the comment, and advice. I am carnivore close, eating high fat and vegetables, avoiding fructose and carbs, and all sorts of sugar. Despite all that, as said, my blood glucose levels and LDL cholesterol are almost at the danger zone.
@@snakeace0 Thanks for your reply appreciate it, I actually only just started re-introducing carbs back in. I was already low carb and then full keto for a long while before my blood test. I actually went full carnivore for about 3-4 months after my blood test. I was loosing body fat by the day on carnivore but felt mentally fatigued and exhausted so after watching the energy balance podcast I have started introducing carbs again from clean sources. Not grains etc. But definitely won't over do the fructose. Been doing weights etc for many years. But suffered a bad back injury that set me back but hopefully sort this out. Lots of great advice and opinions out there so been experimenting to see what works... 👍
How do they know the visceral fat imbalance wasn't caused by lifestyle choices or chronic stress in the first place?
Methylene blue is the power house of the cell 🔋
Great video! My stepdad is very thin so that always boggled my mind, thanks! Are you and Glucose Goddess hooking up?
We like it when you 'annoy' us! 🥰
Good golly. I have used methylene blue in the lab for about 40 years, never even considered eating any of it. And yes, I was born in the 1950s. So, too late for me.
thanks for the good content as always
There was an article off cochrane I read that stated a 20 - 30g dose/distributed dose throughout the day when you are sleep deprived it can maintain your cognitive performance compared to no creatine. Couldn't find it but I also didn't try thoroughly to find it lol