Ep:352 WHAT DOES METABOLIC HEALTH LOOK LIKE? - with Isabella Cooper
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- Опубліковано 2 лют 2024
- ISABELLA COOPER - SCIENTIST EXTRAORDINAIRE NERDS OUT WITH DR CYWES in a 4 part series. We discuss her group’s recent BRILLIANT publication: Ketosis suppression and Aging (ketoSage): the effects of suppressing ketosis in Long-term Keto-adapted Non-athletic females. Cooper, I, et al. Int. J. Mol. Sci. 2023, 24, 15621. doi.org/10.3390/ijms242115621 In my opinion this is one of the best papers ever written in the #KETOGENIC SPACE. It is a REVERSE STUDY taking fat adapted ketogenic young women and PUTTING THEM ON THE #EATWELL UK EQUIVALENT OF THE STANDARD AMERICAN DIET AND TRACKING THEIR BIOCHEMISTRY. Isabella is poised and fabulous with her knowledge and patience while Dr Cywes is awful as an excited interviewer -a lot to learn!
EVERY SENTENCE HAS A PEARL. #METABOLICHEALTH IS NOT JUST WHAT YOU EAT, BUT CHANGING THE #RELATIONSHIP AND YOUR BEHAVIOR PATTERNS. Please leave comments.
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Sincere advise, Please let Isabella Cooper talk more, we lost the track of her hypotheses. It is easier for the audience. We are the follower of you Dr Cywes
Im 45 minutes in and honestly have no idea what the study revealed at all.
@@Robinhood179 It should be continued:)
Very impressive and brave is this Isabella, PHD candidate. Very nice to see her and an upcoming generation challenge the collective understanding and standard of care regarding metabolic pathways in a very thoughtful way. The veteran Keto community of doctors and scientists benefit from the work of the doctors of tomorrow.
Brilliant paper and author! 🧠 I thank God for passionate young minds that are curious and have beautiful smiles! 🤩
I wish Isabella was able to speak at least 95 % of the time vs 5% . I really was lost with so many interuptions 😮😮😮
he has apologised in comments about his over zealous excitment and interrupting lol
Isabella was really good… for the 3 minutes she was allowed to speak 😂
Classic Cywes 😂
hes like that with every guest ive seen him with, he certainly likes the sound of his own voice
Correction: 3 nano seconds😂😂😂😂😂
He is The Carb Addiction Doc ! 😂
I was really interested to hear Isabella speak. I was disappointed in this interview because it seemed like all that mattered was your opinions.
Great subject matter and great extra questions. Looking forward to part 2.
Dr Cywes, "curb your enthusiasm " and you'll do great! I felt like i was watching a professor make his student defend her thesis...and this is not meant as a slam against you! It brought out a lot more information back and forth. As with most of your videos, ive got to watch it at least once more.
Her approach to an ethical study was outstanding and a great way to beat the vegan drumbeat!!
Wow so rudely interrupted her so many times, I will hope to watch her on a podcast/ video where SHE can speak!
Just like the Oreo vs statin experiment, it's great to see people thinking outside the box. A big thank you to the ladies who took part in this.
I cannot appreciate this enough! Like being a fly on the wall in a hall of learned investigators hearing how all the complex variables impact outcome. THIS is “science” fueled by curiosity, intellect and integrity. BEST comprehensive discourse on metabolic heath EVER.
Gee, I really like the study criteria…it’s pleasantly refreshing.
Love this video. Not only is Isabella extremely intelligent, she is beautiful as well 😍
And I'm very handsome😅
@@robertcywes2966 agreed Dr. Rob 😂
Beautiful name to go with her heart, mind, and face.
She is 👌🏼❤️
An awesome study!! So glad we are seeing this level of science proving what those of us know is a very healthy livable way to eat! Thanks
Refreshing that so much was covered that gives me hope the next generation of health professionals will actually study how different diets affect different people in a natural way. Wouldn't it be great to employ full time an Isabella Cooper and a supporting team in every country with sufficient funding?
I am so sad that I was so excited I was an awful overspeaking interviewer. Please bear with me as you listen to this discussion. Apologies.
No need to apologise. There's nothing wrong with being excited over a brilliant publication. Thank you for all your much needed advice that you so generously give on your UA-cam channel. From a fellow South African. 😊
💯 fellow Saffie here
Now you know how we feel when we finally get to talk to you as a patient for the first time!
I enjoyed listening to you!
Hi doc. Indeed :) you know yourself well. Would be great to redo this interview and allow her to speak thru, stay on point and avoid so many side tracks. It was a great conversation between two great and excited minds but hard to make the point across the line . I fear many will give up a quarter way thru and the study deserves proper attention. So much information and a fascinating 2 way conversation, but if Isabella would be so kind would be great to do a take 2 and do this interview again. 🙏🙌✌️
Keep up the good work doc.
Can’t wait for the subsequent continuations! Great information and very exciting.
very interesting and informative
I really appreciate the information here. Funny, though, I think I’d have to watch 3 more times to grasp all the nuances they go back and forth on. I think I need a tutorial or resource to follow the processes being discussed.
Dr. Cywes, could we have a written summary of the main points/findings covered. I found it hard to follow in places and lost the thread at times. Great conversation though. Thank you.
This is one of the best videos you've ever done.
Thanks. She s brilliant. I'm embarrassed by my poor skills
Thank you, both, for a fascinating discussion. I will have to read the paper and watch the rest of this series.
Human physiology is so variable and there is so much noise in the nutrition space, that we are constantly pushed and pulled by competing interests and ideologies. It is refreshing to find some sane, scientific discussion.
As per some of the other comments on here: you are both clearly passionate about science, and the discussion raised some really important points about metabolic processes. However, you might need a moderator, or to agree some ground rules, to allow each other to finish a point, before cutting in.
This is such an important topic and I enjoyed hearing both of you speak ao eloquently, if not both at the same time.
I look forward to reading the paper and to hearing more discussion of the details and conclusions.
Thank you so much for providing this broadcast. Fascinating!
Like the new shirts, Doc!
FIRST....FASCINATING
Beyond that...
* I was always lead to believe you had to be strict Carnivore to be in ketosis. 🤔 untrue then
* I'm glad you brought up genetic thinness. My Mom was always very thin. Only when I ate ice cream & pasta did I have noticeable fat residue.
* On Carnivore, I went from (@68 & 5'4") & 120 down to 100...101 stabilized on Carnivore. At 3 months Carnivore my A1C went from 5.1 to 5.5 and HDL went down slightly & Trigs & LDL went up. I was number-wise better on the Keto side, but FEEL better as a Carnivore. Weird.
I can't wait for my yearly, as the NP I see is intrigued and willing to learn. I even got the guy who takes patients' blood to start Carnivore! 😊
* I'm going to pass this WONDERFUL video on to her... along with the TBC 2nd half.
💥Soooo interesting!!!
Great Job Ms/Dr? Cooper!!!!
Plus.... how you handled that long of a day and finished with this exchange w/Dr Cywes ... nothing short of amazing! You MUST be Carnivore 😊
Thanks for the great discussion. Look forward to other parts.
Assuming they were in Calorie deficit ? Maybe not maybe some of the weight gain was MUSCLE?? Did anyone check.
Great study. Don't interrupt her so much!
Brilliant!!
Great podcast, great study
Great stuff.
In light of this....I think my call to do a ketogenic study of those (like me) with heart disease with those who are already stable ketogenic makes even more sense.
As far as LMHR...they are those who simply process fat well whether via good metabolic health (low BMI an example) or by being active. I have been LMHR on and off for more than 30 years. Don't get the confusion like it is new.
"Science progresses one funeral at a time."
Who kicks the bucket to make room for this wonderful woman?
Love that you mentioned the shirt. 6 nations just began
:)
Love to have your comments on tucker Carlson podcast on ozempic.
Nothing to say....he is a broadcaster not a scientist
I need to hear more about hyper insulinemia. Or, maybe it doesn’t matter the fix for is the same. Keto diet.
Yeah you are right 😅 a lot was also not discussed, i think. I didnt understand a lot.
Dr C. what can you tell us about out remnant cholesterol? Thank you.
Food for the liver....or testosterone estrogen and progesterone
I fast forward to only here her
Uhh, i recognize her face… is she the same person whom partnered up with a phd student that had a brain tumor and was managing it with a ketovore diet, to work on a study about brain tumors and ketosis? I’ll have to look up her name . Might be wrong. Anyhow, Look forward to this development
I believe that is true you will see in one of the future segments she talks about glioblastomer
She’s a brilliant scientist. I have to be as frank with you Dr. Cywess as you were with her. You sound like someone who is looking for more clients, by proving her insufficient or wrong and yourself knowledgeable by frequent mostly wrong interruptions, and teaching her with your poorly understood concepts that she could explain better than you but you did not allow her.
You mentioned glucagon is the main glucose regulator! I want to mention that there are 3 hormones that raise glucose, but it’s only insulin that lowers it.
You coined the term insulin suppression. I believe she rightly mention it as carb intolerance. Since it’s not much suppressed. It’s more like a misuse atrophy. As you rightly said: “homeostasis is a complex and intricate state” not pathway! But you don’t act like it is. She was very polite, and tries to divert your successive attacks by trying to laugh.
You mentioned everyone can go into ketosis by drinking a bottle of olive oil. Which is not correct in my opinion. Ketosis happens when body cannot burn glucose and burns fat.
What you said about insulin effect on gaining weight, you learned from Ben Hickman. It would have been appropriate to quote him instead of teaching it as if you discovered it.
Even if she was your student, it would have been inappropriate to put her to successive questions on youtube. It would have been more appropriate to write to her beforehand the questions you had, so that she would prepare the answers. Then you could let her talk more!
Please accept my criticism as constructive feedback and do not take it personal.
All the best
I hope this study is done again, but over a longer period of time. At least 6 months or even a year seems better to me, because the even more interesting information would come from the body adapting to the high carb diet, and back again to no carb diet.
Especially with women, it would be interesting to also see the hormone cycle response on the standard diet that is being forced on the population.
I addition, I would also like to see such a study done with women having PCOS and dysmenorrhoea. I am 60 meanwhile, but I was told to eat the standard diet to regulate these symptoms, which of course never happened. I wonder how much pain would have been prevented by simply getting Vitamin D and Vitamin K2, and by going all carnivore with zero carbs. 😮
curious why my husband’s showing subclinical hypothyroid
I believe it’s measuring around 5.8 6.3 range, last two blood tests Tsh?)
He has 5.3 A 1C and 11.0 fasting Insulin. Can keto do this? His PCP says so… he is 60 yrs old
only started doing this after he changed to a keto diet
It would have been nice if Dr Cywes would have shut up long enough for her to give the result of her study. He did big phrama a service today
Irrelevant to this topic, but could you please talk about why the trajectories of women vs. men are often so different on ketogenic diets; that is, based on what we observe anecdotally even, looking at those who have been documenting their carnivore journeys online, men seem to generally have more success with staying on track, weight loss, etc. Thanks!
Disagree in long term. It's a rabbit tortoise issue. Women are more likely to sustain journey lifelong
Thats so true! Just we need more info if we need carbs or not , how much really fat we need to improve our metabolic heallth:)
Go Bokke!!
Are the results of yhe study ever mentionef?
What do you say about how many grams of protein/fat a senior woman needs a day to lose weight and have optimal health?
Need to see ur bloodwork to know
But it depends on your energetic needs.
While so often insulin is depicted as a villain in the world of low carb, Dr Bikman talks a bit but very little as well, of the importance and role of insulin in the body, and why it’s important to have a natural and healthy curve Of insulin. Doc could you talk more about the importance and dangers of becoming insulin suppressant (too low insulin all the time in LMHR). As a LMHR I can testify, My insulin is stuck at 2 at all times. I have been forcing myself to eat more carbs but hard to do that without becoming constipated again or gaining bloating and uncomfortable gas again. So haven’t been able to test yet a blood draw and see that ldl go down. I generally prefer to stay at 95% zero carb. But trying to allow insulin to spike once a day as well. Anyway would be great to understand the other roles of insulin.
Insulin is the Tom Brady of the human body the quarterback
Wow, that's me in a nutshell! My blood glucose stays up 3-4 hrs with any type of carb. I have increased fat but protein keeps riding along with the fat so I know that my Bun and creatinine stays too high. I guess I just have to stop paying attention to my blood sugar spikes and long time to lower.
Dr C you have to take into consideration that not all calories are ABSORBED the same for utilization. Example, 160 kcal of almonds only allows the body to absorb 130 of those 160 kcal. The other 30 are pushed to the jejunum coated by soluable and non soluble fiber and kept out of the portal pathway. Hence the bacteria residing in the jejunum then eats and absorbs the other 30 kcal for their function. So not all kcals are created, absorbed or used equally. So the weight gain is conditional on WHAT the participants actually ate and how those kcal were parsed out inside the gut. To make a conclusion regarding weight gain is a variable not controlled for and would have to be to understand in total, the reason for the weight gain. There are other variabkes to this but I'm out of space.
With all due respect I am not sure where you get your information from but the human body does not work that way. The body prioritizes energy and nutrition in variable ways at various times and there is no human being it can calculate that biommathematical formula that is why tooth even used the word calories is irrational
With all due respect, as one colleague to another, it does. Dr Robert Lustig has given several lectures on this exact physiology and how calories are actually processsd in the gut. AND with over 50 years of family practice and curing countless type 2 diabetics and metabolic syndrome with FOOD, not drugs, I KNOW physiology better than most. So I suggest you consider you may not know how the body actually uses calories and why a calorie isn't just a calorie.
Where I could get more info about digestion physiology? Books, textbooks? Please...So much different info that makes us confused? Thank you :)
The information you were giving was so interesting. While I thought she was delightful.. I wish she didn’t cut you off in the middle of your explanations. 😊
Ha. I'm the guy in green and gol. The cut off king
@@robertcywes2966 no, youre just somebody pretending to be him
I can't eat meat my bowels get so inflamed if I do and takes days to calm down
Wow, that is sad.😢 I wonder why. Is this with every and all type of animal?
Some meat is ore inflammatory than others. You might want to try out those that are not so inflammatory. I recently saw videos by the Steak and Butter Gal, and also by Anthony Chaffee, diving into this topic deeper. Dr. Ken Berry and Dr. Eric Westman are also a good source on this topic.
I generally like your channel, but if you have people on you need to let them speak, you spent the entire time trying to show how smart you are and didn't let her explain her study. poor job.
Had to tune out. We know Cywes loves to talk but man he was talking all over his guest. Let her speak and finish sentences for gods sake!
Sorry I had to stop listening half way through after really trying. The interruptions blocked any meaninful input from Isabella. I watched Dr Ken Berry's interview with Isabella and brilliant.
You talk to much!!!
OMG! 🤣 You will just not shut up. I gave this advice to Dr Rhonda Patrick early on in her channel: nobody is tuning in to listen to you talk to the smartest people in the world. People are tuning in to listen to the smartest people talk. Ha! Though I do find your enthusiasm infectious, you could do a lot better.
Jesus Christ is resuming Carnivore Diet
Ketosis had a little to do with carnivore... More with fasting i would say? Not with a lot of protein. Carnivore diet is a new thing in modern world, ketosis not.
Too much giggling
You know, doc.You are much harder to follow than she is. You're kind of all over the place, and you don't finish a thought. The contrast is quite striking. You almost look like you're not listening to her and are concentrating more on... OK, well, I do like your videos anyway...
PS, Holy crap doc... Off on another tangent for 5 minutes? 39:33
PSS, Okay doc you've lost it. I gotta go. 40:07
You were very rude and overbearing. Border line combative. Would have enjoyed it more if you would have let her finish a thought.
Too embarrassing to listen to!!!