NAFLD and clinical significance of grading fibrosis

NAFLD is associated with increased risk of CVD and liver related clinical events. Hence, it is important to do risk categorization of NAFLD patients. It is the fibrosis in liver which is directly related to major adverse liver events (like cirrhosis, decompensated liver failure, hepatocellular carcinoma, liver transplantation and mortality). Hence, risk categorization has to be done based on grading of fibrosis (F0 to F4). F0 and F1 fibrosis is considered as no or minimal fibrosis and in such NAFLD patients, the risk of liver related event is not high compared to general population. Such F0 to F1 NAFLD patients should be managed for CV risk factors like controlling insulin resistance, diabetes, dyslipidemia (high TG and low HDL), blood pressure, body weight etc. F2 fibrosis category is considered as clinically significant fibrosis and there is increased risk of liver events and mortality. F3 is considered as an advanced fibrosis while F4 is considered as Cirrhosis. The gold standard method to grade the fibrosis in liver is biopsy, however, it has its limitation and disadvantages. Non invasive techniques, like biomarkers or non-invasive imaging technology can be useful tool to risk categorize NAFLD patients. FIB-4 scoring is a calculator based on age, AST, ALT and platelet, it is simple biomarker based test. Vibration controlled transient elastography (VCTE) is a non-invasive simple imaging technique which can also be used for grading the liver stiffness (fibrosis).

[@liverMD]

Great video!

[@debigdogk9563]

You are the best. Thank you for teaching. God bless you for teaching and sharing ❤❤❤

[@ashokjaiswal6470]

Thank you!

[@user-ff3gn4re4g]

Thank you very much Sir

[@arifwaja9577]

Best teacher

[@ashokjaiswal6470]

Thank you

[@adiraj6852]

@@ashokjaiswal6470 Sir my mother's report shows :
Median LSM 9.7 kpa
Median cap 196 db/m
IQR/Median 13%
Valid measurement 10
She is 45 years old and non alcoholic.
In ultrasound it says that she also has a gall stone of nearly 23mm (no pain).
What to do??🙏🙏🙏

[@iqbalbuneri7469]

👍👍👍

[@md.almamun8148]

Sir cap 285 b,,, in this situation how can recover it???

[@user-hw2hu9ku3t]

Is fib4 score method is as reliable for nafld

[@nissansunny1704]

Sir my age is 37 , have hepatitis B kpa is 23
What shell i do

[@user-sl9tc9rs3x]

Fib4 report 0.35 what is my condition sir?

[@minimichael4435]

How to plateletes value change 10 9

[@ashwaniayaananoop6408]

My husband's result CAP 245 kpa 75 will it decrease? Anyone down?

[@NanNan-fw9mr]

Is he all right now? Maam

[@adiraj6852]

Sir my mother's report shows :
Median LSM 9.7 kpa
Median cap 196 db/m
IQR/Median 13%
Valid measurement 10
She is 45 years old and non alcoholic.
In ultrasound it says that she also has a gall stone of nearly 23mm (no pain).
What to do??🙏🙏🙏

[@ashokjaiswal6470]

I would recommend you to consult a liver specialist for further evaluation

[@rasatna]

How much grade ur ultrasound

[@letsgoaxel]

Fib score 1.91 age 45? Can u please describe the situation

[@ashokjaiswal6470]

Fib 4 value of 1.91 is indeterminate. This patient requires further evaluation by Transient elastography like FibroScan.

[@johnmckenna4256]

Doctor, What does a nafld fibrosis blood test score of -2.80 mean? Thank you in advance

[@ashokjaiswal6470]

NAFLD fibrosis score of < - 0.145 indicates absence of significant fibrosis in liver; score > 0.675 is a predictor of presence of significant fibrosis; and score in between is an indeterminate score.

[@johnmckenna4256]

@@ashokjaiswal6470 Thank you Doctor, But what does -2.80 mean? that is the score Quest Diagnostics gave me, and I can't find another score like it anywhere

[@subashdas8558]

Kpa 9.8 and cap 347..is it reversible?

[@enjoywithme1966]

Abhi kaisa hai report

[@swadeshkumar7321]

Sir mai Fibroscan karta hu Jaypee hospital Noida

[@gayaprasad7199]

Sir mera kpa 5.8h pahle 7.4tha ab kam ho gaya h kya mai ab sahi ho hu

[@rasatna]

Uap kitna tha?? Kya mdcn khya,,aur km hone k liye kiya kiya

[@gayaprasad7199]

Mera cap 225se 190ho gaya

[@rasatna]

@@gayaprasad7199 ultrasound me grade kitna tha? Mdcn kiya liya

[@MrSonu808]

Kasy Keya btaoo

[@user-mg2pn8vq6d]

Sir my cap score is 366 and kpa 8.8. Is this a concern or what is my situation?

[@rasatna]

How much grade ur ultrasound fatty liver

[@ssss-xt3dk]

Your situation is dangerous so you have 3rd grade fatty liver and early fibrosis so please consult a good hepatologist

[@enjoywithme1966]

Abhi kaise ho

[@DR.IQTIDARKhan]

Sir mara fatty liver grad 4aw raha hi hepatitis b hi is ke medcin antekawer la raha hn PCR negative aw raha hn mara iqr 0.3 hi kpa 10.2 aw raha hi lft normal hi fitness be take hi

[@gurubhagat1249]

Kpa 14.6 kya matlab

[@PriyaSingh-tv1ov]

hey how are you now

[@supravatbandyopadhyay1957]

My kpa 12 cap 321. Is it reversible?

[@ramasingh6928]

kitna din pahle karwaya tha check

[@supravatbandyopadhyay1957]

@@ramasingh6928 20 days

[@baysick11]

Mine is 11 and 295 I hope mine is reversible too I’m terrified.

[@supravatbandyopadhyay1957]

@@baysick11 how are you now?

[@baysick11]

@@supravatbandyopadhyay1957 I just found out a few weeks ago, but I’m doing low carb diet trying to fix it. How about you? Any improvements?

[@MrTroubleMaker-sb9mq]

Cap score 435 and kpa is 10.2 i am 26 yr old obese

[@ashokjaiswal6470]

I recommend you to have a consultation with a gastro or hepatologist

[@MrTroubleMaker-sb9mq]

@@ashokjaiswal6470 I am using saroglitazar 4 mg od from 6 months can you recommend any good hepatologist in India ?