Awesome... You're doing great.... I love Electronics but...I've never been this much interested in the fusion of Physics and Biology..... You're really a great thinker and achiever.....All the very best for all your ongoing research works.....✌🏻
I've always wondered if we could slowly replace parts of the brain, piece by piece, with biologically compatible electronics capable of storing the electrical neurological structure of the brain in a format similar to a hard drive, couldn't we effectively gain some form of immortality as a species? It keeps me up night after night knowing that one day my biological "ram" that is my brain is going to degrade and eventually become non-functioning when I die, effectively destroying my consciousness and everything that I have stored in my brain that makes me who I am. I love life and I want to be able to see what the future has to hold, I want to live long enough to explore this entire planet and planets beyond our own, yet I am limited by my biology. From what reading I have done on what happens to brain cells after we die, brain cells lack particular proteins that keep the brain tissue alive even after a person no longer has a pulse. This is why they decay so quickly after death from what I have read. As an engineer myself, I want to fix this major flaw in my biology, I want to have a fault resistant brain that can keep a "backup" of parts of myself even after other parts of my body stop functioning. I don't want everything that I am and everything I even could be to just disappear in an instant. I hope that you continue your research and bring us all closer to transcending these amazing, yet faulty bodies of ours, to giving each person a chance to make their mark on the universe.
great talk !! you really need to meet Dr G tononi or better with prof max tegmark at MIT. Would be a great work towards designing a qualiascope to capture consciousness. Getting connected with Dr Xerxes Archiwalla would also be great.
What will be the cost of fabricating such devices ? What will be their characteristics ? Power consumption, modes of operation, power up, bootup, FoTa Upgrades, sleep/idle, shutdown...et al..what kind of interface shall be used to communicate...i see a whole standard has to be drawn up, unlike SPI/I2C CAN UART I2S Serial Parallel standard IC communication methods we have today....I don't see it is impossible...but shall need a lot of leaps and standardization before it comes up on commercial scale....
I am pretty much sure that the project you are working on will be a huge contribution to mankind.The most complicated element of nature is brain itself, if you could decipher it, it would be possible to implement most of the theoretical quantum physics concepts which are not yet proved practically.Thank you mam, I would like to follow your footprints.Keep up the good work and make the nation proud. :)
Very nice and imaginative talk, thanks a lot !! I just have a few comments: 1) How do you envision embedding such device in each and every neuron and what is the ratio of area between the device and the neuron?! 2) Let's say that you successfully embedded the device; aren't you concerned that it may disrupt the original functionality of the neurons - e.g., it may affect surface area available for chemical reactions, etc...? 3) Let's assume that it is now embedded and causes no harm to the neurons, for the readout, you need super-ultra sensitive machines to collect the signals, and just imaging the potential overlap and noise output is insane, do you have anything in mind? ....... I have many comments actually :)
hi Ahmed, 1> It is possible to coat the device is special polymers which will enable the uptake to the devices by the neurons without being destroyed by the neurons. These polymer coated devices can be attached to specialized cells called monocytes which can effectively navigate our vasculature system and deliver the devices to the brain. The volume of the devices will be less than 0.1% of the neuron volume. 2>the volume occupied by any particles is less than 1% of the neuron volume, is the standard for acceptable value for cell intrusiveness. in that case cell response is negligible. The devices will have biocompatible coating as well. 3> this is actually the easiest part. the signal change when the neuron becomes active is pretty high and can be easily detected by atomically thin materials that I mentioned in the talk. Sure, let me know ur other comments as well!
The electronic devices will be attached to cells called moocytes which can navigate through the vasculature system and enter the brain by crossing the blood brain barrier. After reaching the brain, the electronic devices will be released. The devices will have special coating which will allow them to enter the neuron.
Hi Deblina, Great talk !! Does the device coating has some chemical functionality which allows it to interact with neuron or there is some type of electromagnetic interaction between the chip coating and neuron? Also, what will be the effect of water on the coating and on the chip (if water penetrate/diffuse through coating, I guess it's not hydrophobic coating)? Thanks !!
Nice talk. Great initiative! I was just curious about your proposal on inserting small device in neuron. What might be the response of brain cells to the foreign object such as electronic device. If it goes wrong, it will be a catastrophe for a patient. Long way to go... Best Luck.
Hi Maximus, thanks for your comment. We will definitely not put these into the brain of patients to start with. Extensive validation will be first done in cultured cells and then in animal models and the devices will be optimized accordingly. Experiments have shown that neurons with particles in it can be healthy for several days. The idea with these devices is that they will be used to record brain activity for a period of time and these devices will be retrieved. These devices will be coated with a biological layer such as lipids so that in that disguise, the cell does not identify it as a foreign body. Also, the volume occupied by these electronic devices will be less than 1% of the neuron volume, which is the standard for acceptable value for cell intrusiveness. In present recording methods, we make a hole in the brain and put in a large electrode inside brain damaging several neurons and blood vessels. I think this technology will be much less invasive than that. We will do detailed characterization and analysis, and only when it satisfies the safety benchmark, will they be used in patients. And, I absolutely agree with you that its indeed a long way to go.
Good concepts.. But not sure about these 2D TMD materials like Mos2 (which she had shown). What about bio-compatibility and environmental stability (oxidation!!) for these transistor that you are showing. Can we make 100 transistor with these materials that could show similar properties.. ? Silicon is Silicon. There is no match. Make 'Silicon' great again !!!!! :) Anyways Nice PPT !!
Well articulated. nice application of your research in biological science. As I have seen the semiconductor industry little closely, we can be there where you are proposing however the it's a long road ahead. It means we need to start Now. Have you thought over or researched on how brain/neuron functions while accepting foreign bodies in its regular functioning? I understand with body implantations becoming order of the day, the scenarios would brighten to encourage more pragmatic research in this area..
Thanks for your nice comment. We need to do a few things to make sure that the technology is least invasive and causes least disruption to the brain normal functioning. First, the devices will be coated with a biological layer such as lipids so that in that disguise, the cell does not identify it as a foreign body. Second, the volume occupied by these electronic devices shud be less than 1% of the neuron volume, which is the standard for acceptable value for cell intrusiveness. Third, brain activity will be recorder for a period of time and these devices will be retrieved. Neurons with particles in it have generally been shown to be viable for several days. In present recording methods, we make a hole in the brain and put in a large electrode inside brain damaging several neurons and blood vessels. I think this technology will be much less invasive than that.
Awesome... You're doing great....
I love Electronics but...I've never been this much interested in the fusion of Physics and Biology.....
You're really a great thinker and achiever.....All the very best for all your ongoing research works.....✌🏻
Wonderful presentation Deblina
Excellent presentation Mam.Thanks for this amazing explanation. You are really one of my inspirations.
You have explained a complex subject so well ! Great talk Deblina !
thanks Sudeshna! I am happy that you liked it.
A Step forward in the right direction! Superb thinking!!
Outstanding Deblina! Your speech took me to the new world of imagination - A new world of humans with super brains. Good Luck for your research.
thanks Srikar!
Deblina, you are inspiring !! Loved this talk !!
thanks Jamal!
Awesome work. Looking forward to more great stuff coming out of your brain, Deblina. There is so much potential.
thanks Stringybark! yah..lotz going on in my brain now, impatient to come out :)
One of the best Ted talks I have ever heard. She is an inspiration for us.
Right
Wonderful Talk Mam. My gosh you are trying to make this possible in today's time. Best wishes Mam.
So great ..... What a vision? Glad to hear ur talk... ..actually, I was looking ur profile on LinkedIn & landed to your TED talk ..stay blessed..
Simplified explanation of complex concepts - Enjoyed it. Thanks!
thanks Saurabh!
Very interesting tropic and well presented by you madam.
I've always wondered if we could slowly replace parts of the brain, piece by piece, with biologically compatible electronics capable of storing the electrical neurological structure of the brain in a format similar to a hard drive, couldn't we effectively gain some form of immortality as a species?
It keeps me up night after night knowing that one day my biological "ram" that is my brain is going to degrade and eventually become non-functioning when I die, effectively destroying my consciousness and everything that I have stored in my brain that makes me who I am. I love life and I want to be able to see what the future has to hold, I want to live long enough to explore this entire planet and planets beyond our own, yet I am limited by my biology.
From what reading I have done on what happens to brain cells after we die, brain cells lack particular proteins that keep the brain tissue alive even after a person no longer has a pulse. This is why they decay so quickly after death from what I have read. As an engineer myself, I want to fix this major flaw in my biology, I want to have a fault resistant brain that can keep a "backup" of parts of myself even after other parts of my body stop functioning. I don't want everything that I am and everything I even could be to just disappear in an instant.
I hope that you continue your research and bring us all closer to transcending these amazing, yet faulty bodies of ours, to giving each person a chance to make their mark on the universe.
Awesome presentation Deblina! Out of the world!!
thanks Rini!
Deblina, Nice work this can solve many severe problems.
Thanks Sunil. hopefully yes!
Interesting...opening a wide gate of opportunities it seems. Kudos Debolina, congrats on ur success n all the very best!!
thanks Deepak!
Amazing super work👏
Awesome talk! cant wait to see how these small electronics will be implemented into the brain!
thanks Danielesta! yeah..I am now in the process of designing these devices for the brain.
Absolutely very interesting and hopefully we see such device in near future.
Thanks Vishal! Activity recorder from each and every neuron will be realized sooner than the augmentation device.
Ma'am U are awesome. All the best for the future.
Excellent talk!
we are very much proud of you,congrats to you
great talk !! you really need to meet Dr G tononi or better with prof max tegmark at MIT. Would be a great work towards designing a qualiascope to capture consciousness. Getting connected with Dr Xerxes Archiwalla would also be great.
very nice mam..your talk and your study profile motivates me to go for research.
thanks Rahul!
Inspiring
Thanks fr all the info😁
Just one word for the professor, WOW
What will be the cost of fabricating such devices ? What will be their characteristics ? Power consumption, modes of operation, power up, bootup, FoTa Upgrades, sleep/idle, shutdown...et al..what kind of interface shall be used to communicate...i see a whole standard has to be drawn up, unlike SPI/I2C CAN UART I2S Serial Parallel standard IC communication methods we have today....I don't see it is impossible...but shall need a lot of leaps and standardization before it comes up on commercial scale....
I am pretty much sure that the project you are working on will be a huge contribution to mankind.The most complicated element of nature is brain itself, if you could decipher it, it would be possible to implement most of the theoretical quantum physics concepts which are not yet proved practically.Thank you mam, I would like to follow your footprints.Keep up the good work and make the nation proud. :)
thanks Shikhar! yeah brain is arguably the most complicated system we can think of.
Its a brilliant talk. Hope you make a working prototype soon.
thanks Aditya! yes...working on the components now.
Very nice and imaginative talk, thanks a lot !!
I just have a few comments:
1) How do you envision embedding such device in each and every neuron and what is the ratio of area between the device and the neuron?!
2) Let's say that you successfully embedded the device; aren't you concerned that it may disrupt the original functionality of the neurons - e.g., it may affect surface area available for chemical reactions, etc...?
3) Let's assume that it is now embedded and causes no harm to the neurons, for the readout, you need super-ultra sensitive machines to collect the signals, and just imaging the potential overlap and noise output is insane, do you have anything in mind?
.......
I have many comments actually :)
hi Ahmed,
1> It is possible to coat the device is special polymers which will enable the uptake to the devices by the neurons without being destroyed by the neurons. These polymer coated devices can be attached to specialized cells called monocytes which can effectively navigate our vasculature system and deliver the devices to the brain. The volume of the devices will be less than 0.1% of the neuron volume.
2>the volume occupied by any particles is less than 1% of the neuron volume, is the standard for acceptable value for cell intrusiveness. in that case cell response is negligible. The devices will have biocompatible coating as well.
3> this is actually the easiest part. the signal change when the neuron becomes active is pretty high and can be easily detected by atomically thin materials that I mentioned in the talk.
Sure, let me know ur other comments as well!
Inspiring
superb dear.god is with u my friend
Excellent one mam...!!
thanks Awanit!
Very interesting and nice talk......
thanks Sumit!
Just curious as how to reach each neurons individually and record how they function? What's the idea and technology behind it?
The electronic devices will be attached to cells called moocytes which can navigate through the vasculature system and enter the brain by crossing the blood brain barrier. After reaching the brain, the electronic devices will be released. The devices will have special coating which will allow them to enter the neuron.
Hi Deblina, Great talk !! Does the device coating has some chemical functionality which allows it to interact with neuron or there is some type of electromagnetic interaction between the chip coating and neuron? Also, what will be the effect of water on the coating and on the chip (if water penetrate/diffuse through coating, I guess it's not hydrophobic coating)? Thanks !!
very interesting knowledge has been shared
thanks Bishodev!
Nice talk. Great initiative!
I was just curious about your proposal on inserting small device in neuron. What might be the response of brain cells to the foreign object such as electronic device. If it goes wrong, it will be a catastrophe for a patient.
Long way to go...
Best Luck.
Hi Maximus, thanks for your comment. We will definitely not put these into the brain of patients to start with. Extensive validation will be first done in cultured cells and then in animal models and the devices will be optimized accordingly. Experiments have shown that neurons with particles in it can be healthy for several days. The idea with these devices is that they will be used to record brain activity for a period of time and these devices will be retrieved. These devices will be coated with a biological layer such as lipids so that in that disguise, the cell does not identify it as a foreign body. Also, the volume occupied by these electronic devices will be less than 1% of the neuron volume, which is the standard for acceptable value for cell intrusiveness. In present recording methods, we make a hole in the brain and put in a large electrode inside brain damaging several neurons and blood vessels. I think this technology will be much less invasive than that. We will do detailed characterization and analysis, and only when it satisfies the safety benchmark, will they be used in patients. And, I absolutely agree with you that its indeed a long way to go.
Yes you are right. You already had innovated so much in such a small age. We are definitely hopeful about your future innovation. Thanks!
@@dsarkar33 Wonderful research you are doing!
Amazing!
Thanks for the nice talk.
great job deblina...
thank you, Manish!
Good concepts.. But not sure about these 2D TMD materials like Mos2 (which she had shown). What about bio-compatibility and environmental stability (oxidation!!) for these transistor that you are showing. Can we make 100 transistor with these materials that could show similar properties.. ? Silicon is Silicon. There is no match. Make 'Silicon' great again !!!!! :) Anyways Nice PPT !!
This is how real "women empowerment" looks like
Smart and cool lady
Well articulated. nice application of your research in biological science. As I have seen the semiconductor industry little closely, we can be there where you are proposing however the it's a long road ahead. It means we need to start Now. Have you thought over or researched on how brain/neuron functions while accepting foreign bodies in its regular functioning? I understand with body implantations becoming order of the day, the scenarios would brighten to encourage more pragmatic research in this area..
Thanks for your nice comment. We need to do a few things to make sure that the technology is least invasive and causes least disruption to the brain normal functioning. First, the devices will be coated with a biological layer such as lipids so that in that disguise, the cell does not identify it as a foreign body. Second, the volume occupied by these electronic devices shud be less than 1% of the neuron volume, which is the standard for acceptable value for cell intrusiveness. Third, brain activity will be recorder for a period of time and these devices will be retrieved. Neurons with particles in it have generally been shown to be viable for several days. In present recording methods, we make a hole in the brain and put in a large electrode inside brain damaging several neurons and blood vessels. I think this technology will be much less invasive than that.
just woww :)
Ex(Com)ponential..