Options for testing your microbiome | Peter Attia & Colleen Cutcliffe

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This clip is from 283 ‒ Gut health & the microbiome: improving and maintaining the microbiome, probiotics, & more with Colleen Cutcliffe, Ph.D.
In this clip, Peter and Colleen discuss:
- How to measure your microbiome
- The added complexity of the microbiome with the human genome sequence
- How to determine the health of the function of the gut microbiome
- And more
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About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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[@dallas1love]

Digoxin was also used " in ancient times" to slow down the AV ventricular rate in rapid atrial fibrillation. So yes, it was part of the armamentarium of controlling the heart rate in atrial arrythmias. Now it has been relegated to low dose usage in systolic dysfunction( low EF), congestive heart failure( if used at all).

[@carrievanderhoff]

I began taking Metabolic Daily probiotics by Pendulum a few days ago. So far it seems I am not overeating anymore! Not sure if placebo effect or not, time will tell.

[@Eysc]

🎯 Key Takeaways for quick navigation:
00:00 🧬 *Microbiome Testing Overview*
- Importance of longitudinal microbiome data.
- Comparison between whole-genome sequencing and targeted tests.
- Shotgun sequencing for the microbiome and its complexities.
01:38 🧬 *Shotgun Sequencing Explained*
- Different methods: short-read and long-read sequencing.
- Short-read sequencing's accuracy and assembly process.
- Long-read sequencing's trade-off between fidelity and full sequence.
03:02 🧬 *Microbiome Impact on Drug Metabolism*
- Microbial impact on drug efficacy and dosage.
- Influence of gut microbes on drug metabolism.
- Significance of microbial gene variations in drug effectiveness.
04:44 🧬 *Microbial Gene Variations*
- Significance of microbial gene count in drug metabolism.
- Understanding variability in drug metabolism beyond human genome variations.
- Importance of gut microbes in oral drug effectiveness.
06:21 🧬 *Sequencing Methodologies*
- Challenges in cataloging and identifying bacterial strains.
- Quantitative PCR for precise strain quantification.
- Longitudinal data necessity due to microbial replication and mutations.
08:02 🧬 *Functional Assays in Microbiome Analysis*
- Importance of functional assays beyond genomic data.
- Focus on carbohydrate metabolism and short-chain fatty acid production.
- Analyzing enzymatic reactions to understand microbial function.
09:53 🧬 *Understanding Gut Microbiome Processes*
- Challenges in sampling and understanding gut microbiome processes.
- Difficulties in assessing gut microbiome composition accurately.
- Limitations and contamination risks in sampling methodologies.

[@whatthefunction9140]

Thanks. I learned nothing

[@puzz88]

Lmao I know what ur saying but usually these snippets are more exploratory conversation about the topic and not quite an educational tutorial themselves

[@dopamine-87]

The guest might as well have been talking chinese, perhaps i would've understood more 🤦‍♂️

[@yoyoschmo1]

Omg stop interrupting her so I can actually piece together what she is saying. Just when I think I’m getting it you interrupt her