One of the most difficult problems to create an effective therapy against cancers, is selectivity; another is multi drug resistance, where drugs are pumped out of cancer cells. I doubt that any cell would get rid of nutrients like amino acids; therefore, a trojan horse should be attempted to fight MDR cancers, especially aggressive tumors, that ought to absorb amino acids faster than surrounding healthy tissues: feed cancer cells with S35 labelled L-cysteine; the isotope of sulphur S35 would be used to assemble proteins, enzymes in cancer cells and at the moment the S35 would undergo beta decay, the transmutation " to the right " in the periodic table, would transform it into stable chlorine; disulfide bonds would be substituted by a HCl molecule that breaks peptide bonds. The energy released by S35 is very weak and it should not penetrate more than three milimeters around the isotopes, the idea is to use the chemical reactions triggered by the substitution of one element placed in a molecule. Other types of isotopes with electron capture transmutation or decay modey could also be attempted, but those have usually a very short half life. Carbon 14 has a half-life that exceeds 5300 years, but after absorbing one single neutron, the resulting isotope carbon 15 has a very short half-life; therefore, a new tool to treat a number of diseases could be possible, if an array of very narrow beams of neutrons could be focused on a tumor that absorbed nutrients labelled with carbon 14.
Fantastic, I really enjoyed this. Brilliant use of organoids. It's kind of like "real life computational neuroscience", where you try to simulate the brain with actual neurons instead of artificial ones.
"neuroscientists' ambitions to model complex brain organization in organoids will require a the lab to significant printed organoidgoBolyrher try to reduce levels Scafföfdng stress. Biomimicry Of "Different groups have Anatomy how they culture organoids in lots of different ways, so the fact that we see these issues across organoids from different laboratories suggests it's probably" 3D printed Biopolymer scaffolding could work to organize brain components into their proper functioning configurations?
Thanks, Dr. Arnold Kriegstein, for sharing knowledge.
Great talk, Dr. Arnold Kriegstein! Thanks for providing the references.
He is so smart and good looking too
One of the most difficult problems to create an effective therapy against cancers, is selectivity; another is multi drug resistance, where drugs are pumped out of cancer cells. I doubt that any cell would get rid of nutrients like amino acids; therefore, a trojan horse should be attempted to fight MDR cancers, especially aggressive tumors, that ought to absorb amino acids faster than surrounding healthy tissues: feed cancer cells with S35 labelled L-cysteine; the isotope of sulphur S35 would be used to assemble proteins, enzymes in cancer cells and at the moment the S35 would undergo beta decay, the transmutation " to the right " in the periodic table, would transform it into stable chlorine; disulfide bonds would be substituted by a HCl molecule that breaks peptide bonds. The energy released by S35 is very weak and it should not penetrate more than three milimeters around the isotopes, the idea is to use the chemical reactions triggered by the substitution of one element placed in a molecule. Other types of isotopes with electron capture transmutation or decay modey could also be attempted, but those have usually a very short half life. Carbon 14 has a half-life that exceeds 5300 years, but after absorbing one single neutron, the resulting isotope carbon 15 has a very short half-life; therefore, a new tool to treat a number of diseases could be possible, if an array of very narrow beams of neutrons could be focused on a tumor that absorbed nutrients labelled with carbon 14.
Fantastic, I really enjoyed this. Brilliant use of organoids. It's kind of like "real life computational neuroscience", where you try to simulate the brain with actual neurons instead of artificial ones.
What is the primary protein sequence of amino acids that makes up MOST of a human's brain?
Is that even a well-defined question?
Thx Sir
fucking Ghost in the shell shit. Amazing
Never knew we had Orgy in our genes!
BIV
"neuroscientists' ambitions to
model complex brain organization in organoids will require a
the lab to
significant printed organoidgoBolyrher try to reduce levels Scafföfdng stress. Biomimicry Of "Different groups have Anatomy how they culture organoids in lots
of different ways, so the fact that
we see these issues across
organoids from different
laboratories suggests it's probably"
3D printed Biopolymer scaffolding could work to organize brain components into their proper functioning configurations?
🌸🌸🌸👏👏👏
First
second
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Imperial Corp™
Always old guys in stem ...