How can the R group attack from either top or bottom? Because the step before it is an SN2 reaction (i.e. backside attack) of a bulky group, and so surely the back of the molecule (away from the screen) is sterically shielded, forcing the R group to attach from the front?
Hi! This is the Malonic Ester synthesis video. I'm unsure of which other video you're asking for, but the entire series can be found on my site at Leah4sci.com/AminoAcids
Great question! This synthesis can be used to produce any of the alpha amino acids, even though this video works through the one example of synthesizing methionine.
Hmmm... you didn't really explain why EtO- was used other than the fact that there was COOEt for the malonic ester. It's to prevent transesterification?
this actually makes so much sense! thanks leah!
You're very welcome!
Your voice is much easier to listen to than AK LECTURES. But I also love that guy. Keep it up! Subscribed and liked
Welcome aboard!
wow.... all the lectures on amino acids r amazing........ thanx ....keep up the good work mam
thank you
this was so helpful oh my word thank you God bless
You're very much welcome! :)
How can the R group attack from either top or bottom? Because the step before it is an SN2 reaction (i.e. backside attack) of a bulky group, and so surely the back of the molecule (away from the screen) is sterically shielded, forcing the R group to attach from the front?
At which specific point in the video?
hello, Leah! thank you for your work, organic chem seems more approachable now; what app is the one you are writing on?
You're very welcome!
Hi there, could you point me to the malonic ester video you mentioned? I couldn't find the link anywhere. Thanks for the video btw!
Hi! This is the Malonic Ester synthesis video. I'm unsure of which other video you're asking for, but the entire series can be found on my site at Leah4sci.com/AminoAcids
Solid and solution phase synthesis of peptides
I don't understand whether you have a question. If you do, feel free to contact me through my website at Leah4sci.com/contact
Thank you, Leah! I wanted to ask, does this rxn only synthesize methionine or can it be used for all amino acids?
Great question! This synthesis can be used to produce any of the alpha amino acids, even though this video works through the one example of synthesizing methionine.
you are the best , thank you
Thanks and you're welcome! :)
Hmmm... you didn't really explain why EtO- was used other than the fact that there was COOEt for the malonic ester. It's to prevent transesterification?
My enolate Orgo series leah4sci.com/enolate covers this. See the claisen condensation video
But yes, it's to prevent a side reaction which... guess doesn't really matter here because you're turning the ester into a carboxylic acid
Ok thanks!
+Leah4sciMCAT l its same to my research +255654668410
+Leah4sciMCAT l its same to my research +255654668410
I'd use it to make thalidomide analogues!
Cool!
Thank you
You're very welcome!