Epigenetics| DNA methylation | Histone Modifications| Bisulfite sequencing| Genetics for beginners
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- Опубліковано 16 чер 2024
- This video lecture explains
1. What is epigenetics?
2. What are different factors and processes affecting epigenetics?
3. What is DNA methylation?
4. How DNA methylation regulates gene expression?
5. What is bisulfite sequencing?
6. What are histones?
7. What is histone modification?
8. How histone modification regulates gene expression?
9. What are the end points of epigenetics?
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0:00 Epigenetics: Epi+ Genetics Literally means "above" or "on top of" genetics
3:01 DNA methylation, the addition of a methyl group, or a chemical cap, to part of the DNA molecule, which prevents certain genes from being expressed.
7:30 (Without histones, DNA would be too long to fit inside cells.) If histones squeeze DNA tightly, the DNA cannot be "read" by the cell. Modifications that relax the histones can make the DNA accessible to proteins that "read" genes.
Thank you so much for this very clear explanation. 💯
you are most welcome. Wish you all the best
very clear and simple, thank you
Thank you very much 😊
Very good explanation!
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Thanks sir for making it understandable
You are most welcome
Excellent explanation. Keep rocking.
Thank you, I will
thank you so much for this very useful and clear lecture💯
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I feel like i have got my dronacharya to learn genetics... Sir thankyou so much sir . Keep uploading about genetics,, there's a list of genetic test and etc etc things listed in harvard online courses kindly explain those not everyone is affordable to learn there. Please sir please. And please explain about base editing expt undergoing in Japan for genetic disease treatment
Thank you very much for the kind words. Please also visit the following playlists
Molecular and cell biology methods
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Genetics
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For nucleotide therapy, please visit the following links
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@@BiologyLectures yes daily am doing notes from your videos.. blessed to have such teacher.. thankyou sir thankyou so much🙏🙏🙏🙏🙏
@@seema.sankeshwari you are most welcome.🙂
Keep continue cover genetics at higher level
We will certainly cover more topics on advanced topics. Please feel free to suggest some if you have any. Thank you.
Perfectly put!!!
thank you.
Very helpful
Thank you sir
You are most welcome.
thankyou so much
You are so welcome!
Very helpful lecture plz make more such videos 😍😍
thank you. We will
Excellent lecture 😃
welcome
Thank you
You're welcome
Very well explained. Thanks a lot sir 😊
Most welcome
Thank you sir ❤️❤️❤️
Most welcome
very good
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thankyou so much sir,
You are most welcome 😊
Thank you so much 🙏🏼
You’re welcome 😊
One thing to add is that not only tails but also histone cores are modified.
You should redo your lecture with better acoustics. And a bit slower
Superb
Thank you.
Question..... can anyone explain or give clarity on the following ... does any change to typical Purine & Pyrimidine, folate, B6 or B12 pathways during pre or early post natal periods result in heritable genetics that could be passed from that baby should they procreate in later life?
The level of the complexity of the body just went through the roof. Finding therapies and new drugs for diseases just became very very very difficult if genes are being turned on and off by almost any external factor.
thanks for the great explaination ..... I just wanna ask about the resources you used plz as I want to go into further details ?
Thank you. We used multiple resources . Please find the link below for one of the sources used w3.biosci.utexas.edu/atkinson/Epigenetics2014/Epigenetics2014/Readings_files/Ch%201%20Overview.pdf
Hello Sir, does epigenetic changes are reverseible?
Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence
Epigenetics and methylation same? Thanks for clarification
In addition to methylation, epigenetics also contains histone modification.
Can you explain the causes of epigenetics....🙏
Environmental Factors: Environmental exposures, such as diet, stress, pollutants, and lifestyle choices
Developmental Processes: Epigenetic changes are crucial during development and can result from the sequential activation or inactivation of specific genes
Disease and Pathological Conditions: Epigenetic alterations are implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.
Does DNA methylation only prevent certain genes from being expressed ?
Not all genes are active at all times. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression.
I have a question that is making me sick. I thought that methylation should always be interpreted as a repressive mark. So, how is it that H3K4me3, H3K36me, and H3K79me for example could lead to gene expression}? thank you
DNA methylation is a fundamental epigenetic event associated with physiologic and pathologic conditions, including cancer. Hypermethylation of CpG islands at active gene promoters leads to transcriptional repression, whereas hypomethylation is associated with gene overexpression.
Reference: pubmed.ncbi.nlm.nih.gov/21692051/#:~:text=Background%3A%20DNA%20methylation%20is%20a%20fundamental%20epigenetic%20event,repression%2C%20whereas%20hypomethylation%20is%20associated%20with%20gene%20overexpression.
@@BiologyLectures thank you very much! I will check out the paper. So, there are histone's methylations that are repressive (like H3K9me3 or H3K27me3) and methylations that are permissive, right? Maybe it depends on context, signals, or that are made in different aminoacids? I will read the paper btw. Thanks again!
Very hard to understand.
Please watch and rewatch again. Hopefully you will understand
Thank you
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