Tissue Healing at the Nano Level

UIC researchers are working to develop a better way to regenerate bone or tissues that have been lost to disease or injury.
Sriram Ravindran, Research Assistant Professor, Oral Biology and Praveen Gajendrareddy, Associate Professor, UIC Periodontics and Diplomate, American Board of Periodontology are co-investigators on a project evaluating the use of engineered exosomes (nano-sized cellular particles) for tissue regeneration.
Current treatments rely on growth factors or chemical agents to stimulate stem cells, which have the ability to grow into any type of cell in the body, to regenerate what has been lost. But this approach has many limitations, like side effects and uncontrolled abnormal growths due to dosing and toxicity.
"We need therapies that better mimic the body's natural processes, so the body is better able to tolerate treatment,” said Sriram Ravindran, co-principal investigator of the project.
Ravindran and Gajendrareddy have received approximately $2 million in funding from the National Institutes of Health for the project. Their lab at UIC College of Dentistry focuses on the synthesis of materials, synthetic systems and tools designed to mimic biological processes.Their hope is to inspire development of new biomimetic tools and clinical therapies that mimic natural biology for tissue regeneration.
With this latest round of funding, they will evaluate and characterize the use of engineered exosomes, which are small vesicles in cells that act as messengers that govern cellular activity. The goal is to develop engineered exosomes designed to trigger regeneration of target tissues, and evaluate this as a safer and more clinically promising alternative to growth factors.

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Is possibile build human skin? Now