Inadvertent methylation followed by spontaneous deamination of cytosines, transform cytosines into thymine; I believe the resulting stop codon TAG is the very first cause of numerous diseases where there are more errors in CAG repeat triplets than DNA glycosylases can repair. If I'm right, perhaps inhibitors of DNA methyltransferases, like Decitabin, might delay or even prevent the onset of Huntington's disease.
And the inadvertent methylation of cytosines in codons CGA, ( after spontaneous deamination of the methylated cytosine, would result in the second possible stop codon, TGA) may be one first step among other causes of Parkinson's disease. Just google DNA genetic code table and compare the stop codons with the codons CAG and CGA then think of the transformation of cytosine into a thymine in one of those codons; stop codons arrest protein synthesis and may explain truncated proteins that gain access to the cell nucleus of neurons...
you sir are awesome. Thank you for all that you do!
thank you, awesome
would be cooler if you show what causes the trinucleotide repeats, backwards slippage
This was great! Thanks!
Awesome! One question tho isn't gene affected for myotonic dystrophy DMPK?
you really saved my day sir, you are very helpful, thank you.
Great work! Thank you, dude!
Inadvertent methylation followed by spontaneous deamination of cytosines, transform cytosines into thymine; I believe the resulting stop codon TAG is the very first cause of numerous diseases where there are more errors in CAG repeat triplets than DNA glycosylases can repair. If I'm right, perhaps inhibitors of DNA methyltransferases, like Decitabin, might delay or even prevent the onset of Huntington's disease.
And the inadvertent methylation of cytosines in codons CGA, ( after spontaneous deamination of the methylated cytosine, would result in the second possible stop codon, TGA) may be one first step among other causes of Parkinson's disease. Just google DNA genetic code table and compare the stop codons with the codons CAG and CGA then think of the transformation of cytosine into a thymine in one of those codons; stop codons arrest protein synthesis and may explain truncated proteins that gain access to the cell nucleus of neurons...
Really a high yield video!🤩
good job :) loved it. thank you so much!
Thank you
Thanks for this educative video, I subscribed!
awesome doctor
thank u alot of this amazing explination
thank you
Very helpful thx.
thanks
thanks d000d