First semester in med school is almost over and this is the first time I was able to arrive to the correct answer with the correct thought process. Thank you for the resources!
Uncouplers of oxidative phosphorylation like 2,4 dinitrophenol (DNP) ==> enhanced metabolism , increased oxygen consumption & heat production WITHOUT essentially disrupting the electron transport chain OR increasing the NADH/NAD ratio . BUT with time ; the increased oxygen consumption can NOT compensate for the increased metabolism & the subsequent surge in the NADH + H levels in the mitochondria ==> eventual increase in NADH/NAD ratio ==> increased Lactate / pyruvate ratio ==> mild LACTIC ACIDOSIS . That MILD lactic acidosis is NOT sufficient to cause a WIDE anion gap metabolic acidosis , but rather a NORMAL anion gap metabolic acidosis . Lord knows best .
First semester in med school is almost over and this is the first time I was able to arrive to the correct answer with the correct thought process. Thank you for the resources!
Great job!
Thank you Sir.
Uncouplers of oxidative phosphorylation like 2,4 dinitrophenol (DNP) ==> enhanced metabolism , increased oxygen consumption & heat production WITHOUT essentially disrupting the electron transport chain OR increasing the NADH/NAD ratio .
BUT with time ; the increased oxygen consumption can NOT compensate for the increased metabolism & the subsequent surge in the NADH + H levels in the mitochondria ==> eventual increase in NADH/NAD ratio ==> increased Lactate / pyruvate ratio ==> mild LACTIC ACIDOSIS .
That MILD lactic acidosis is NOT sufficient to cause a WIDE anion gap metabolic acidosis , but rather a NORMAL anion gap metabolic acidosis .
Lord knows best .
Super
Is this for usmle step 1 or 2
nothing just saying hi dirty ..love u