I am type 1 diabetic myself for over 23 years. This is such an excellent video about the history of diabetes I really appreciate your work professor Dave
@@jetpond7904 If you have a clean and new needle on the insulin pen, you literally won't feel anything when you inject the needle. However, the needle is very soft metal and structurally weak, so it will dull after a couple of uses and it may start to hurt a little. Also, if the amount of injected insulin is large, it may hurt as it forms a small pocket of liquid stretching surrounding skin and fat tissue and might pinch some nerves. The third way it can hurt is just bad luck. I'm not sure what causes this, but I speculate that if the needle happens to hit directly to a nerve, it stings. What ever the case is causing the pain, it is very rarely even as bad as a mosquito bite, even more rarely worse than that. Telling this also with 23 years of experience.
As a type 1, do you do low carb eating to lessen your need of insulin? Some Physicians are now curing type 2(a disorder of too much insulin and insulin resistance) by doing low carb, as the need of insulin reduces, which lessens the resistance over time. Long term they can improve their metabolic health, and thus carbohydrate tolerance, by reductions in the omega-6 fat Linoleic Acid, but this takes time.
Usually not, but you can accidentally discover some...glorious types of pain haha. Aside from the stretching or a dull needle, it's entirely possible to hit a nerve, puncture a blood vessel, or inject directly into a vessel. All of which are their own very unique and indescribably painful sensations. Usually it's painless or close to it though, but if you're doing multiple shots a day as a Type I, usually can mean you get a nasty surprise multiple times a week.
Thank you for all you do Dave! As someone who uses a glargine insulin, it's hard to convey just how life-changing it was/is to have a single injection daily. I'm a ketosis-prone type 2, and one of the weird cases where, at 28, after feeling awful for months, a smart nurse actually suggested I may be diabetic. I wasn't in bad health otherwise, never been overweight, always a skinny kid, and sudden;y, diabeetus ::in Wilford Brimley's voice:: It's bizarre, but my grandmother had almost the same circumstance. Around 50 years old, with no other health issues, type 2 diabetes. I followed her example, learned all I could, tried some non-insulin treatments (my endo tried, not me lol), but eventually, I just started insulin. SO MUCH EASIER! I have so much gratitude for every scientist, doctor, researcher, etc. who contributed to this amazing story . . . . . 'cause i'd be fu*king dead without their hard work!! . . . . and OF COURSE dipsh!t Kennedy & his merry band of Luddites were there, trying to screw it up for everyone 🙄. To all of the flerfs and other assorted geniuses trying to 'make ::insert country name here:: great again', take note, If you're one of these science-denying clowns, it's past time for y'all to get smart, like WAYYY past time. EVERYTHING you people say and believe is a lie and/or a distortion, and y'all think you're smarter than any and all experts (scientists, researchers, doctors, etc.), REGARDLESS OF THE FIELD, and tick tock, times up. One day soon, y'all are gonna push just a bit further, and nobody wants that, ESPECIALLY y'all. Believe that. So knock it off please. Thanks! 🙄 Thanks again for all you do Dave!! 🐧🙂
Docs never tell the truth to patients. They deny the science as they are beholden to drug reps. Eating carbs and treating the high blood glucose they cause with more insulin causes weight gain. Diabetics cannot use the insulin they make as it is. Food companies influence the ADA, AHA, and medical schools, they have diabetics eating "heart healthy" whole grains and fruits that raise trigycerides and create high sugars and fatty livers. Low carb diets should be the first line of treatment. Your rant about politicians is misplaced, the slow steady rise in diabetes has been happening since the 70s. Influence peddling by food companies has been a huge part of that.
@@mrooz9065 Not really. Keto diets can help in managing blood sugars, but in general you can eat whatever you want as long as you keep your sugars in check.
@@coloradoing9172 this is probably the most uneducated comment people make about diabetes. so many diabetics think you can eat whatever you want and just increase your insulin dosage to compensate. that is a terrible strategy.
Great video. I am a Type 1 diabetic. I wish that you hadn't said that diabetes was caused by poor food. Type 1 is an autoimmune disease. I know that we are a minority of patients but it makes it sound like it is our fault.
I'm only about halfway through the video, but he hasn't said that so far... only that diet was important to treatment. He also specifically called out type 1 diabetes as autoimmune. Ed: found it, "seems to be, at least in part, due to an unhealthy lifestyle" right at the start, yeah, agree that could be more explicit about the nature of that "in part"
Diabetes 2 is definitely caused by BAD food choices. Once a Diabetic 2 person kills off all their Pancreatic Beta Cells, due to Glucose Toxicity, they will become a Diabetic 1.
the whole video was pretty much all about type 2. type 1 diabetes mellitus, diabetes insipidus, are both diseases that are called "diabetes" that are completely unrelated to t2dm
I just started (3 months) working in a diabetes research lab at Vandy with a background in microbiology. So this is interesting to see Dave make a new video on this stuff!
My fairly fast and steady decline in health over the last 10 years. At 50, I was a pilot Class 1 medical "highest." Injured my 15/s1 vertebrae requiring 3 surgeries failed. Gained 50 pounds to inactivity, side effects and became type 2 diabetic. Stayed that way a few years and then a massive DVT clot developed leg, removed "3.5 feet" and two pulmonary embolisms. This hobbled me further, gained more weight "240 pounds", and now on pain meds. Began insulin A1C1 is TEN!! Morning sugars are 250 to 300!! Now my body has rejected insulin "Soliqua" and will not come down. Now the effects of a damaged spine, cut sciatic nerve with diabetic neuropathy, poor vein drainage has all but finished me at 60.
My father in his late 20s became seriously ill with a virtual infection and as a result it killed his pancreatic islet cells. I never found out what virus did this. He unfortunately passed away in his sleep 5 years ago. I wish they had a cure for type 1. He took injections 3 x a day was constantly doing the finger stick 6 plus x a day. He became increasingly unstable. He never had the gadgets and used two different types of insulin clear and cloudy. Anyway thanks for educating people.
Latent Autoimmune Diabetes in Adults LADA. I'm grateful for all the technology I have "glued" to my body everday, without them I'd be a yoyo. An insulin pump controlled from a mobile phone would have probably sounded like science fiction when your Pop was first diagnosed, unfortunately some diabetics still have to do finger pricks like this is the dark ages. If all diabetics had access to CGM's I believe the disease could be so much easier to control and so much less stressful. Its not cheap with insurance and that is a shame, every one deserves a chance to be hopeful about life and not set on a road where one day you'll be such a bad diabetic that you'll have to feel ashamed about daily injections. Sorry your Pop didn't have that option, IDK your Dad but I know less time finger pricking is more time he could have spent doing what he wanted to do with the ones he loved.
I am a type 1 diabetic and have been since I was 7 years old I'm 32 now but also have diabetic retinopathy and diabetic neuropathy I have a complete retinal detachment in my right eye and dehydration on my left I was taking insulin before the pumps and pens came out and we came a long way even since I was a kid I knew some of this stuff but learning a lot just from this video alone and thank u for teaching me some of this I really enjoy ur content and love ur debunk videos I appreciate the time and research u do to educate people on this
I planned to release today but I got a copyright claim for a bit I used, I’m trying to work around it, it’s really annoying. Hopefully I can get it sorted out in a day or so.
I know it wasn't intentional but "seems to be, at least in part, the product of an unhealthy lifestyle" makes it sound as though IDDM is a condition that is brought on by laziness and over indulgence rather than an autoimmune disease.
Dave, I have been watching your programs, for what seems like a quadrillion eons, and this was one of the most excellent episodes yet. Thank you very much for your exceptional contribution to education. 🔬
This video is informative, but missing some important distinctions. Type 1 and type 2 diabetes are so different that they should really be distinguished from each other. Type 1 diabetes is an auto-immune disease and (almost) never caused by “lifestyle”. Type 2 is mostly reversible and treatable with diet, exercise, and some medications that help your body utilize the insulin it produces more efficiently. A type 1 diabetic is insulin dependent, produces almost no insulin themselves, and will go into ketoacidosic shock within days without external insulin regardless of diet or exercise. I understand that they are similar in some ways, but i think few people know the differences and it creates misunderstanding, stigma, and stereotypes that hinder both type 1s and type 2s from being heard/understood/helped. Thanks for the vids dave!
I've been watching professor Dave's debunks for years, and i finally realised what else he makes. Im extremely happy that im here now, this was super interesting!
You would think all those people that get debunked would look at his other stuff and maybe actually learn some real science. Dunning Kruger at its finest.
I've just discovered this series and it looks awesome, I can't wait to watch more. Now I am even more glad I supported you last year by buying your book :)
Believers often point at the beauty of nature as proof of God! Well than, God also gave us that child “before” picture at 6:27, science gave us the “after” picture. I instead, get more emotional when I see the incredible benefit to the human condition and suffering, brought by the scientific method and genius of few gifted individuals.
Prof Dave great video as always but as others have pointed out in the comments please remove the opening statement that Diabetes is caused by unhealthy lifestyle. As a type 1 D this might be true of T2 but T1 is a autoimmune genetic disease. I am 160 pounds 5,9 and when i was diagnosed 27 and could run 10k a week. It’s misinformation like this that causes shame amongst diabetics. Please edit the video. Thanks chief
You are right that lifestyle does not always influence onset and progression of the disease, but 95% of patients worldwide have type 2, so this cautious generalization is not unrealistic. Poor diet and exercise are truly the main drivers of this diabetes epidemic.
Read the comments bud. Notice how almost everyone commenting who is diabetic is a T1D? Maybe that 95% is T2 is true but they are millions of us T1Ds and lumping us together is still factually wrong and hurtful. So no i disagree it’s not realistic just all Dave had to do was talk about the two consisting separately. No need to generalize
Very well presented information. Thank you. I would ad though the failures of pancreatic transplant failures and the theories of what causes type 1 disease.
Prof Dave, an excellent video of course. Could I ask you to make a distinction early on, between Type I and Type II? Type I does not seem to be lifestyle related. Also is the diagnosis a death sentence, or is it the disease itself?
if you are sentenced to death by hanging the sentence is a death sentence. the rope is the death cause. the diagnosis is the sentence. the disease is the cause.
Finding out you had diabetes meant you would die soon. Not finding out meant you would still die soon and not know why. Obviously a doc telling you you have a disease doesn’t kill you in itself, but the diagnosis is the point when you learn that your death will be sooner than you may have otherwise expected.
Good eveninf from France dear Professor, I have been watching your video for nearly 2 years and these like delicious sweets for my intellect. Could you make a video on ulcerative colitis or Crohn disease. I'm asking because I personnaly suffer from ulcerative colitis since June 2016 and I am since always searching for any information to explain why I developped this disease.
I would love to see you make a video on how modern and upcoming science may offer pathways to treat and cure autoimmune diseases in the future, or how realistic hopes are, that we might be able to regrow organs or replacement teeth in the (not to distant) future. Although I'll certainly be long dead before I could ever possibly benefit from either.
Great informative video! I'm glad you're not just constantly debunking flat Earthers, those get tiresome. Just one minor quibble, your pronunciation of the name McLeod, it's not Mac-lay-od, it's Mac-Cloud. Looking forward to the rest of your series on diabetes, I'm on insulin myself, and also Ozempic and the other drugs from time to time. I want to know how they work.
Great video as always! I was diagnosed with type 2 in 2017 along with polycythemia vera. I also just lost a friend to type 1 a couple of weeks ago. This is definitely not a disease to handle lightly but yeah, it's absolutely one that modern medicine has made many people think is just a minor issue. I think it presents an interesting psychological problem... modern medicine has made so many things completely survivable that they become trivial, and that I think leads to all sorts of new problems that no one seems to be too concerned with. I can only hope that videos like this have some kind of effect in countering that phenomenon.
I think it's absolutely disgusting how people are so against genetic engineering even today given how time proven and well understood it is and how many millions of lives it benefits. We could virtually eliminate so many diseases in humans if there wasn't so much pushback.
You are the second to comment on Paulescu. You must be Romanian, and I assume you learned this in school. School systems tend to be patriotic and always assign inventions to local scientists. However, the Nobel committee articulated in great detail why the isolation of insulin belongs to Macleod and Banting and NOT to Paulescu. There were other people who actively worked in the area, including Paulescu, too many to mention. Like many Nobel Prize decisions, this one was full of controversy, but the decision stood and this is what history now tells, maybe with the exception of Romanian textbooks. Some say Paulescu was dismissed in part due to his rabid antisemitism and racism.
@@vittoriof4871 yes I am Romanian, but he's insulin research was credited later, saw this in some documentaries done by people outside Romania, so it's no just school. :D .
Fantastic video! Small nit pick, but insulin is considered a monomer (not a heterodimer) because the two chains originate from the same gene and are covalently attached.
Most sources identify it as a heterodimer. There are two separate peptide chains, held together by disulfide bonds. I fail to see how structurally this can be defined a monomer. The fact that they originate from the same gene does not change the structural evidence of TWO separate peptide chains.
@@vittoriof4871 Like I said, it is a nit pick for an otherwise great video. Structurally if it is covalently attached it is a single polymer (the chemist point of view). What are your sources if I may ask? Wikipedia? not many folks I come across in the field calls it a heterodimer and I am a prof in Biochemistry. Just out of curiosity what is IgG1 antibody then? a tetramer? It has 2 copies of the heavy and light chains. Part of the problem is how these things are defined by physiologist and medics vs a pure structural view that you have taken (which I am fine with btw). In addition, a single insulin can further oligomerize. Typically we call these dimers and so on... but always treating the original unit of insulin as a monomer. Same rule applies for antibodies (IgG1). Typically we refer to it as a monomer. I hope that clarifies things.
@@MrOmid1955 Indeed Wikipedia calls insulin a heterodimer. Since insulin is stored as a hexamer, when it dissociates in the plasma it is called "monomer", but the structure itself is a heterodimer consisting of two separate chains. I checked a few papers I had, like Org. Biomol. Chem., 2019,17, 1703-1708, and here as usual the structure is referred to as a "heterodimer". Medical dictionaries I use, like the Lexicon der Medizinischen Laboratoriumsdiagnostik, also define the structure as heterodimer.
@@vittoriof4871 I am going to end up repeating myself. In chemistry we define a polymer a repeated unit that is covalently bound. Thus insulin would be a single polypeptide chain! We don't bother teaching undergraduates these subtleties because students like simple rules. Just look at the original paper. Not even Dorothy Hodgkin called it a heterodimer. Or better yet look at the 1969 paper in Nature: "Structure of Rhombohedral 2 Zinc Insulin Crystals" These are structural biologists.
@@MrOmid1955 Look, I do not really want to make a big deal out of this, but I showed you that, to some scientists at least, insulin and insulin derivatives are heterodimers. If I accept a common definition (Merriam-Webster Medical) of heterodimer as "a protein composed of two polypeptide chains differing in composition in the order, number, or kind of their amino acid residues", I just fail to see how you can argue that insulin is not a heterodimer. But I wish to stop here: obviously some scientists refer to a construct like insulin as a heterodimer, others do not. It would not be the first case in science where some nomenclatures are used by some but disliked by others. In organic chemistry we have many such issues.
My god, my doctor didn't even give me a reasonable description of the action of Lantus as is in this video. This was very valuable. I know as a type II I should feel guilty about using insulin, but after trying different drugs for years with a gradual loss of control over the condition, but with Lantus its finally under positive control. Ozempic, my former drug, was a bear for side effects and was getting impossible to find due to TikTok (thanks). I am glad not to use it now.
Good series, and accurate as always. Except that as the number of diabetics globally rises, there is no cure, and the huge complications that still present themselves I'd argue that diabetes is abso,ureky NOT considered " a minor ailment " .. ive been diabetic for 35 years.. its a life altering disease, you always have to think about what you eat, when, what are you doing, level of activity.. how many carbs will I burn vs how many have I eaten, do I have enough sugar to counter a low sugar, what if my bike breaks and I'm walking some distance.. do I need more ?? I guess so, I'll die otherwise , small cut can equal gangrene.. no joke. Respectfully intended, I love ya Dave.. but not a minor ailment, a hang nail.. thats a relatively minor ailment.. :) I've said my entire life that every person should just once experience a low low blood sugar.. its the feeling of dying, your body shutting down.. if that were the only side effects of this disease, I'd still have to feel death upon me at least a few times a week, low blood sugars can kill you in an hour, and when they happen it always feels like they just might this time.. again respectfully intended :)
I work in the field of pharmacy at the lowest level. We learn about insulin of course, but only so far as brand and generic names and duration. This was illuminating, thank you!
Did you mention Charles Best, a graduate student with Banting? Best was so involved with the discovery that Banting shared his Nobel Prize money with him. Apparently, because he was a graduate student he was not part of the award for the Nobel prize.
That was an awesome video on the history of diabetes medical treatment. Had no idea they had people who tasted urine and that it was called honey urine. But also the chemistry of insulin was fascinating. You said diabetes was due to lifestyle but could it also be epigenetic?
So my doctor tested my urine and said to me, "Mr. Allen, your urine is 43% alcohol." I said to him, "so what?" He raised my urine sample and said, "so cheers."
@@derekallen4568 When the body metabolizes alcohol, it is broken down into acetaldehyde, before it is eventually eliminated from the body as water and carbon dioxide through the lungs, kidneys and sweat. If you are unable to metabolize the alcohol you consume, then you are either drinking too much alcohol or your body is unable to produce the enzyme responsible for metabolizing alcohol which is called alcohol dehydrogenase (ADH) and so your urine will intoxicate your doctor. But it is better to have an intoxicating effect on people without consuming alcohol.
He’s lying or at least being overly (way overly) generous with the term “cure” I am a T1D myself and there is no cure for it. It’s hell and i wish other diabetics wouldn’t spread such misinformation. If cinnamon can cure your T1D why haven’t you cured yours yet buddy??? Huh? What’s that? … 😏
@@crazycatlady2744 Not a study like the kind Dave uses for his videos, but a lot of people have told me how helpful cinnamon treatments have been for them. It's pretty hard for a lot of patients to do. For full efffect, they have to take a full spoonfull of it without water, and hold it down. Rationale is that diluting it makes it ineffective.
Hey, Professor Dave, my grandpa has been diabetic for 30+ years, until, for some reason, he stopped needing insulin. His blood sugar is stable now, and he’s not even considered diabetic; i didn’t think that was possible, so could you try and explain it?
Was he diagnosed as Type 1 or Type 2? Type 2 is insulin resistance and can be reversed sometimes via diet/exercise and probably other general normal metabolic changes. Type 1 is where a person has lost the ability to produce insulin. They will not get that back short of a transplant of the relevant cells (which like any trnasplact has all sorts of other complications/risks)
Type 1 for 63 years and still kicking. Humalog KwikPen and Lantus Vial insulin, kept me going, however the more recent continuous glucose monitoring (Dexcom) discovery has done wonders for my A1C levels, something I never achieved with insulin alone. May live to actually see a cure, which has been promised by the industry for 50 years but alludes us diabetics. To many think it's just a nuisance disease and that insulin was a cure.
Hey dave i got a question for you if you can spare the time. I may be incorrect in this but the pancreas produces insulin in the beta cell islets and glucagon in the alpha cell islets. Has any research been done into or treatments of diabetes involving these cells being performed, or is there a reason why this is not looked into? Or am i incorrect in saying this? Great video btw
As a possible mechanism for the Ebers papyrus' treatment on type 2 diabetes, gut fermentation syndrome from beer swill inoculation of S. Cervisiae could forcibly moderate sugar intake. The combination sounds torturous, but might be more survivable if you otherwise had to live on a large proportion of cereals and fruit in a time before [intentional medical delivery of] insulin.
The mention of the anti-science hindrance to insulin research is very appropriate. We have a new, financial hindrance for diabetics now, however. Certain "investors" and companies that have bought the necessary means to control the production of insulin and are now charging massively higher prices for an essential medication.
Apologies. I wasn’t clear. I was referring to the skyrocketing cost of insulin in the United States, quite unlike every other western democracy where prices for insulin are reasonable, and where diabetics don’t have to make hard decisions between insulin and eating.
Very thorough. My only issue here is that I don't think you addressed that diabetes mellitus covers two VERY different conditions with Type I and Type II. The first being an autoimmune disease and the second being thought to be caused by poor diet and genetic predisposition.
Very common, correct observation, but perhaps it is not clear to you that this video is part of the series "History of Drugs", and attempts to tell the story of how treatments came about, and is not a pharmacology series.
Back to this relaxing series :) I should say that it's fascinating how far science has evolved to the point that we are able to engineer a specific compound such as insulin on a defined molecular scale!
9:52 This was bad insulin for me (Humulin N) , doctor swapped it with Lantus. I am still using Humalog after meals. 20+ diabetic. I am thankful for existance of the medicine.
So this is hopefully the type of field my education is taking me and I have to say a big thanks to you Dave. You helped a lot with my orgo studies and I remember your arenes and aromaticity video was so good it just have me a whole aha moment on the important go resonances and how it works. I remember how well you went over ortho/para vs Meta directors and it just helped me so much to now I feel like organic chemistry is one of my best subjects
Very interesting. I live across the street from a dialysis center and I've been inside it a few times and it was depressing. Plus the smell is something you will never forget and not in a good way.
McLeod and Best sold their patent for one dollar, in the hopes of making it affordable to all humanity. But today, in Canada, insulin costs much more than it did in the 1930’s. But in the United States insulin has been made so expensive it is unaffordable, and patients die.
excellent video, you should also talk about the new drug that has come out that is curing half the patients if caught in the early stages of Type 1 diabetics. The need for screening is a must now if we are to cure Type 1. Also most people have no clue that their glucose is not in range because the way they check your glucose using the a1c only tells you your average over several weeks so you were probably very high and low but the a1c looks normal. CGM's need to be given to any diabetic if they are to stay within range. Also they have pumps now and you no longer need long acting insulin, with the pump you can use fast acting and coupled with a CGM is almost a pancreas replacement
What part of the video had this? " you also talk about the new drug that has come out that is curing half the patients if caught in the early stages of Type 1 diabetics"
@@rembrandt972ify Yeah, I guess what I meant to say was that we need to screen for Type 1 diabetics now because there is a drug that cures half of those diagnosed if caught early enough before the immune system has taken out the pancreas. So would an a1c be the best way to screen or just informing the public about excessive urination or sticky pee, or maybe just peeing in a cup and setting it by an ant hill to see if the ants like it. Pretty sad people are getting Type 1 diabetes when we have a drug for it, seems like we should be doing something.
What drug is curing diabetes? I’ve never heard of this and am a T1D myself. Please tell us the name and more details. I’m curious but also very doubtful. T1D cannot be cured. And there is no early stages of T1D. I just happens with zero warning. No way this is true but please explain.
Indeed diabetes death sentence had been given to me. Thanks for valuable indepth insights about the real historical background of the silent sweet poisoning subliminal disease triggered by sedantary lifestyle. 😊❤
The Nobel committee articulated in great detail why the isolation of insulin belongs to Macleod and Banting. There were other people who actively worked in the area, including Paulescu, too many to mention. Like many Nobel prize decisions, this one was full of controversy, but the decision stood and this is what history now tells.
I have type 2 diabetes for 10 years now and need 100 units of insulin a day along with metformin & januvia. So can someone tell me why insulin is $2000 dollars a 30 day supply!
I am type 1 diabetic myself for over 23 years. This is such an excellent video about the history of diabetes I really appreciate your work professor Dave
Type 1 myself, first took insulin in 1987.
@@jetpond7904 Mostly not, sometimes it does hurt.
@@jetpond7904 If you have a clean and new needle on the insulin pen, you literally won't feel anything when you inject the needle.
However, the needle is very soft metal and structurally weak, so it will dull after a couple of uses and it may start to hurt a little. Also, if the amount of injected insulin is large, it may hurt as it forms a small pocket of liquid stretching surrounding skin and fat tissue and might pinch some nerves. The third way it can hurt is just bad luck. I'm not sure what causes this, but I speculate that if the needle happens to hit directly to a nerve, it stings.
What ever the case is causing the pain, it is very rarely even as bad as a mosquito bite, even more rarely worse than that.
Telling this also with 23 years of experience.
As a type 1, do you do low carb eating to lessen your need of insulin?
Some Physicians are now curing type 2(a disorder of too much insulin and insulin resistance) by doing low carb, as the need of insulin reduces, which lessens the resistance over time.
Long term they can improve their metabolic health, and thus carbohydrate tolerance, by reductions in the omega-6 fat Linoleic Acid, but this takes time.
Usually not, but you can accidentally discover some...glorious types of pain haha. Aside from the stretching or a dull needle, it's entirely possible to hit a nerve, puncture a blood vessel, or inject directly into a vessel. All of which are their own very unique and indescribably painful sensations. Usually it's painless or close to it though, but if you're doing multiple shots a day as a Type I, usually can mean you get a nasty surprise multiple times a week.
Never seen a video covering so much of diabetes history, as a type 1 diabetic for 26 years there's always something new to learn about it thank you.
Thank you for all you do Dave! As someone who uses a glargine insulin, it's hard to convey just how life-changing it was/is to have a single injection daily. I'm a ketosis-prone type 2, and one of the weird cases where, at 28, after feeling awful for months, a smart nurse actually suggested I may be diabetic. I wasn't in bad health otherwise, never been overweight, always a skinny kid, and sudden;y, diabeetus ::in Wilford Brimley's voice::
It's bizarre, but my grandmother had almost the same circumstance. Around 50 years old, with no other health issues, type 2 diabetes. I followed her example, learned all I could, tried some non-insulin treatments (my endo tried, not me lol), but eventually, I just started insulin. SO MUCH EASIER!
I have so much gratitude for every scientist, doctor, researcher, etc. who contributed to this amazing story . . . . . 'cause i'd be fu*king dead without their hard work!!
. . . . and OF COURSE dipsh!t Kennedy & his merry band of Luddites were there, trying to screw it up for everyone 🙄. To all of the flerfs and other assorted geniuses trying to 'make ::insert country name here:: great again', take note, If you're one of these science-denying clowns, it's past time for y'all to get smart, like WAYYY past time. EVERYTHING you people say and believe is a lie and/or a distortion, and y'all think you're smarter than any and all experts (scientists, researchers, doctors, etc.), REGARDLESS OF THE FIELD, and tick tock, times up. One day soon, y'all are gonna push just a bit further, and nobody wants that, ESPECIALLY y'all. Believe that. So knock it off please. Thanks! 🙄
Thanks again for all you do Dave!!
🐧🙂
I got it from being on a certain medication for a prolonged period of time.
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Docs never tell the truth to patients. They deny the science as they are beholden to drug reps. Eating carbs and treating the high blood glucose they cause with more insulin causes weight gain. Diabetics cannot use the insulin they make as it is. Food companies influence the ADA, AHA, and medical schools, they have diabetics eating "heart healthy" whole grains and fruits that raise trigycerides and create high sugars and fatty livers. Low carb diets should be the first line of treatment. Your rant about politicians is misplaced, the slow steady rise in diabetes has been happening since the 70s. Influence peddling by food companies has been a huge part of that.
Fantastic video! The only slight improvement might be to clarify that type 1 diabetes is NEVER due to poor lifestyle choices.
It seems to be due to bad luck.
Yeah, that’s type II. Much easier to deal with, even reversible by diet, type one is not.
Even with type I you still need to watch your diet albeit diet does not lead to it.
@@mrooz9065 Not really. Keto diets can help in managing blood sugars, but in general you can eat whatever you want as long as you keep your sugars in check.
@@coloradoing9172 this is probably the most uneducated comment people make about diabetes. so many diabetics think you can eat whatever you want and just increase your insulin dosage to compensate. that is a terrible strategy.
Great video. I am a Type 1 diabetic. I wish that you hadn't said that diabetes was caused by poor food. Type 1 is an autoimmune disease. I know that we are a minority of patients but it makes it sound like it is our fault.
I'm only about halfway through the video, but he hasn't said that so far... only that diet was important to treatment. He also specifically called out type 1 diabetes as autoimmune.
Ed: found it, "seems to be, at least in part, due to an unhealthy lifestyle" right at the start, yeah, agree that could be more explicit about the nature of that "in part"
Diabetes 2 is definitely caused by BAD food choices. Once a Diabetic 2 person kills off all their Pancreatic Beta Cells, due to Glucose Toxicity, they will become a Diabetic 1.
the whole video was pretty much all about type 2. type 1 diabetes mellitus, diabetes insipidus, are both diseases that are called "diabetes" that are completely unrelated to t2dm
This is fantastic. Please keep this series going. I would love to see other chronic diseases covered as you alluded to
I just started (3 months) working in a diabetes research lab at Vandy with a background in microbiology. So this is interesting to see Dave make a new video on this stuff!
My dear sir, are you from USA ?
How close are we to finding a cure?
My fairly fast and steady decline in health over the last 10 years. At 50, I was a pilot Class 1 medical "highest." Injured my 15/s1 vertebrae requiring 3 surgeries failed. Gained 50 pounds to inactivity, side effects and became type 2 diabetic. Stayed that way a few years and then a massive DVT clot developed leg, removed "3.5 feet" and two pulmonary embolisms. This hobbled me further, gained more weight "240 pounds", and now on pain meds. Began insulin A1C1 is TEN!! Morning sugars are 250 to 300!! Now my body has rejected insulin "Soliqua" and will not come down. Now the effects of a damaged spine, cut sciatic nerve with diabetic neuropathy, poor vein drainage has all but finished me at 60.
Look into a Low Carb high fat diet, KETO,. Type two is result of excess glucose , caused by eating carbs..Hope this helps.
My favorite defender and teacher of science. Dave is the man! ❤
My father in his late 20s became seriously ill with a virtual infection and as a result it killed his pancreatic islet cells. I never found out what virus did this. He unfortunately passed away in his sleep 5 years ago. I wish they had a cure for type 1. He took injections 3 x a day was constantly doing the finger stick 6 plus x a day. He became increasingly unstable. He never had the gadgets and used two different types of insulin clear and cloudy. Anyway thanks for educating people.
Latent Autoimmune Diabetes in Adults LADA. I'm grateful for all the technology I have "glued" to my body everday, without them I'd be a yoyo. An insulin pump controlled from a mobile phone would have probably sounded like science fiction when your Pop was first diagnosed, unfortunately some diabetics still have to do finger pricks like this is the dark ages. If all diabetics had access to CGM's I believe the disease could be so much easier to control and so much less stressful. Its not cheap with insurance and that is a shame, every one deserves a chance to be hopeful about life and not set on a road where one day you'll be such a bad diabetic that you'll have to feel ashamed about daily injections. Sorry your Pop didn't have that option, IDK your Dad but I know less time finger pricking is more time he could have spent doing what he wanted to do with the ones he loved.
I am a type 1 diabetic and have been since I was 7 years old I'm 32 now but also have diabetic retinopathy and diabetic neuropathy I have a complete retinal detachment in my right eye and dehydration on my left I was taking insulin before the pumps and pens came out and we came a long way even since I was a kid I knew some of this stuff but learning a lot just from this video alone and thank u for teaching me some of this I really enjoy ur content and love ur debunk videos I appreciate the time and research u do to educate people on this
This isn't part 3 of the James Tour debunk, but of course I'm interested nevertheless, refreshing my diabetes knowledge from nursing school.
I planned to release today but I got a copyright claim for a bit I used, I’m trying to work around it, it’s really annoying. Hopefully I can get it sorted out in a day or so.
@@ProfessorDaveExplains Fingers crossed 🤞 Once again I can't overstate how impactful your work is.
I know it wasn't intentional but "seems to be, at least in part, the product of an unhealthy lifestyle" makes it sound as though IDDM is a condition that is brought on by laziness and over indulgence rather than an autoimmune disease.
Dave, I have been watching your programs, for what seems like a quadrillion eons, and this was one of the most excellent episodes yet. Thank you very much for your exceptional contribution to education. 🔬
Thank you for saying, "preventive," rather than, "preventative." 😊
This video is informative, but missing some important distinctions. Type 1 and type 2 diabetes are so different that they should really be distinguished from each other. Type 1 diabetes is an auto-immune disease and (almost) never caused by “lifestyle”. Type 2 is mostly reversible and treatable with diet, exercise, and some medications that help your body utilize the insulin it produces more efficiently. A type 1 diabetic is insulin dependent, produces almost no insulin themselves, and will go into ketoacidosic shock within days without external insulin regardless of diet or exercise. I understand that they are similar in some ways, but i think few people know the differences and it creates misunderstanding, stigma, and stereotypes that hinder both type 1s and type 2s from being heard/understood/helped. Thanks for the vids dave!
Did i go into biotech because of professor Dave? No. Am I staying and keeping my interest alive because of him? Probably yeah!
I've been watching professor Dave's debunks for years, and i finally realised what else he makes. Im extremely happy that im here now, this was super interesting!
You would think all those people that get debunked would look at his other stuff and maybe actually learn some real science. Dunning Kruger at its finest.
Your videos are always so interesting.
Excellent presentation. You now have another subscriber and I have hit the bell to get all your videos. Thank you
nice work on the animation! they look pretty good
I've just discovered this series and it looks awesome, I can't wait to watch more. Now I am even more glad I supported you last year by buying your book :)
Outstanding presentation!!!
Believers often point at the beauty of nature as proof of God! Well than, God also gave us that child “before” picture at 6:27, science gave us the “after” picture. I instead, get more emotional when I see the incredible benefit to the human condition and suffering, brought by the scientific method and genius of few gifted individuals.
Great content!
Great video! Congratulations on your work.
Keep up the great work ♥️
Prof Dave great video as always but as others have pointed out in the comments please remove the opening statement that Diabetes is caused by unhealthy lifestyle. As a type 1 D this might be true of T2 but T1 is a autoimmune genetic disease. I am 160 pounds 5,9 and when i was diagnosed 27 and could run 10k a week. It’s misinformation like this that causes shame amongst diabetics. Please edit the video. Thanks chief
You are right that lifestyle does not always influence onset and progression of the disease, but 95% of patients worldwide have type 2, so this cautious generalization is not unrealistic. Poor diet and exercise are truly the main drivers of this diabetes epidemic.
Read the comments bud. Notice how almost everyone commenting who is diabetic is a T1D? Maybe that 95% is T2 is true but they are millions of us T1Ds and lumping us together is still factually wrong and hurtful. So no i disagree it’s not realistic just all Dave had to do was talk about the two consisting separately. No need to generalize
Amazing science. Unfortunately, until open source insulin in available, it is quite costly.
非常棒的视频，这个系列终于更新了，期待再次更新
Very well presented information. Thank you.
I would ad though the failures of pancreatic transplant failures and the theories of what causes type 1 disease.
Prof Dave, an excellent video of course. Could I ask you to make a distinction early on, between Type I and Type II? Type I does not seem to be lifestyle related. Also is the diagnosis a death sentence, or is it the disease itself?
if you are sentenced to death by hanging the sentence is a death sentence. the rope is the death cause.
the diagnosis is the sentence. the disease is the cause.
The diagnosis was a death sentence, while the disease was the eager executioner.
Finding out you had diabetes meant you would die soon. Not finding out meant you would still die soon and not know why. Obviously a doc telling you you have a disease doesn’t kill you in itself, but the diagnosis is the point when you learn that your death will be sooner than you may have otherwise expected.
Excellent Video.
Good eveninf from France dear Professor, I have been watching your video for nearly 2 years and these like delicious sweets for my intellect. Could you make a video on ulcerative colitis or Crohn disease. I'm asking because I personnaly suffer from ulcerative colitis since June 2016 and I am since always searching for any information to explain why I developped this disease.
Excellent video
mcleod is pronounced mcloud. and thanks for this.
Super clear, thank you!
A wonderful lecture. Thanks a lot.
I would love to see you make a video on how modern and upcoming science may offer pathways to treat and cure autoimmune diseases in the future, or how realistic hopes are, that we might be able to regrow organs or replacement teeth in the (not to distant) future.
Although I'll certainly be long dead before I could ever possibly benefit from either.
One correction Dave, MacLeod is pronounced ma-cloud, it is a Scottish name.
This is a great topic. Thanks so much for covering this.
08:01 how do I know that for certain though?
Great informative video! I'm glad you're not just constantly debunking flat Earthers, those get tiresome. Just one minor quibble, your pronunciation of the name McLeod, it's not Mac-lay-od, it's Mac-Cloud. Looking forward to the rest of your series on diabetes, I'm on insulin myself, and also Ozempic and the other drugs from time to time. I want to know how they work.
Are there more videos for The History of Drugs that didn't get added to this playlist?
No this is the most recent one, #14 in the works right now.
@@ProfessorDaveExplains Thanks for this information.
Oscar Minkowski wasn't German physiologist. He was Lithuanian, born and raised there in Kaunas city. Please stop referring to Lithuanians as Germans.
Great video as always! I was diagnosed with type 2 in 2017 along with polycythemia vera. I also just lost a friend to type 1 a couple of weeks ago. This is definitely not a disease to handle lightly but yeah, it's absolutely one that modern medicine has made many people think is just a minor issue. I think it presents an interesting psychological problem... modern medicine has made so many things completely survivable that they become trivial, and that I think leads to all sorts of new problems that no one seems to be too concerned with. I can only hope that videos like this have some kind of effect in countering that phenomenon.
amazing video
Excellent!!
very very interesting. I would also like to know... HOW does Diabetes kill you when left untreated and why?
Very interesting.
I think it's absolutely disgusting how people are so against genetic engineering even today given how time proven and well understood it is and how many millions of lives it benefits. We could virtually eliminate so many diseases in humans if there wasn't so much pushback.
Luddites... pure and simple
Nice clip, you forgot to mention Nicolae Paulescu. Regarding he's insulin research.
You are the second to comment on Paulescu. You must be Romanian, and I assume you learned this in school. School systems tend to be patriotic and always assign inventions to local scientists. However, the Nobel committee articulated in great detail why the isolation of insulin belongs to Macleod and Banting and NOT to Paulescu. There were other people who actively worked in the area, including Paulescu, too many to mention. Like many Nobel Prize decisions, this one was full of controversy, but the decision stood and this is what history now tells, maybe with the exception of Romanian textbooks. Some say Paulescu was dismissed in part due to his rabid antisemitism and racism.
@@vittoriof4871 yes I am Romanian, but he's insulin research was credited later, saw this in some documentaries done by people outside Romania, so it's no just school. :D .
Great job as always👌Would you mind discussing MODY Maturity-onset diabetes of the young
?
Didn't mention Mr. BEST at all!!!!
This is wonderful.
Type 1 diabetes is genetic, not the result of an unhealthy lifestyle.
Absolutely brilliant 👏🏿, you know have a new sub and 👍🏿,from me.
This guy knows a lot about the science stuff
Fantastic video! Small nit pick, but insulin is considered a monomer (not a heterodimer) because the two chains originate from the same gene and are covalently attached.
Most sources identify it as a heterodimer. There are two separate peptide chains, held together by disulfide bonds. I fail to see how structurally this can be defined a monomer. The fact that they originate from the same gene does not change the structural evidence of TWO separate peptide chains.
@@vittoriof4871 Like I said, it is a nit pick for an otherwise great video. Structurally if it is covalently attached it is a single polymer (the chemist point of view). What are your sources if I may ask? Wikipedia? not many folks I come across in the field calls it a heterodimer and I am a prof in Biochemistry. Just out of curiosity what is IgG1 antibody then? a tetramer? It has 2 copies of the heavy and light chains.
Part of the problem is how these things are defined by physiologist and medics vs a pure structural view that you have taken (which I am fine with btw). In addition, a single insulin can further oligomerize. Typically we call these dimers and so on... but always treating the original unit of insulin as a monomer. Same rule applies for antibodies (IgG1). Typically we refer to it as a monomer. I hope that clarifies things.
@@MrOmid1955 Indeed Wikipedia calls insulin a heterodimer. Since insulin is stored as a hexamer, when it dissociates in the plasma it is called "monomer", but the structure itself is a heterodimer consisting of two separate chains. I checked a few papers I had, like Org. Biomol. Chem., 2019,17, 1703-1708, and here as usual the structure is referred to as a "heterodimer". Medical dictionaries I use, like the Lexicon der Medizinischen Laboratoriumsdiagnostik, also define the structure as heterodimer.
@@vittoriof4871 I am going to end up repeating myself. In chemistry we define a polymer a repeated unit that is covalently bound. Thus insulin would be a single polypeptide chain!
We don't bother teaching undergraduates these subtleties because students like simple rules.
Just look at the original paper. Not even Dorothy Hodgkin called it a heterodimer.
Or better yet look at the 1969 paper in Nature:
"Structure of Rhombohedral 2 Zinc Insulin Crystals"
These are structural biologists.
@@MrOmid1955 Look, I do not really want to make a big deal out of this, but I showed you that, to some scientists at least, insulin and insulin derivatives are heterodimers. If I accept a common definition (Merriam-Webster Medical) of heterodimer as "a protein composed of two polypeptide chains differing in composition in the order, number, or kind of their amino acid residues", I just fail to see how you can argue that insulin is not a heterodimer. But I wish to stop here: obviously some scientists refer to a construct like insulin as a heterodimer, others do not. It would not be the first case in science where some nomenclatures are used by some but disliked by others. In organic chemistry we have many such issues.
This is one of the best series of videos from your channel! Thank you Dave, well done!
So this was interesting, thanks
Did you make your intro?
Yeah with a buddy
My god, my doctor didn't even give me a reasonable description of the action of Lantus as is in this video. This was very valuable. I know as a type II I should feel guilty about using insulin, but after trying different drugs for years with a gradual loss of control over the condition, but with Lantus its finally under positive control. Ozempic, my former drug, was a bear for side effects and was getting impossible to find due to TikTok (thanks). I am glad not to use it now.
Good series, and accurate as always. Except that as the number of diabetics globally rises, there is no cure, and the huge complications that still present themselves I'd argue that diabetes is abso,ureky NOT considered " a minor ailment " .. ive been diabetic for 35 years.. its a life altering disease, you always have to think about what you eat, when, what are you doing, level of activity.. how many carbs will I burn vs how many have I eaten, do I have enough sugar to counter a low sugar, what if my bike breaks and I'm walking some distance.. do I need more ?? I guess so, I'll die otherwise , small cut can equal gangrene.. no joke. Respectfully intended, I love ya Dave.. but not a minor ailment, a hang nail.. thats a relatively minor ailment.. :)
I've said my entire life that every person should just once experience a low low blood sugar.. its the feeling of dying, your body shutting down.. if that were the only side effects of this disease, I'd still have to feel death upon me at least a few times a week, low blood sugars can kill you in an hour, and when they happen it always feels like they just might this time.. again respectfully intended :)
I work in the field of pharmacy at the lowest level. We learn about insulin of course, but only so far as brand and generic names and duration. This was illuminating, thank you!
Did you mention Charles Best, a graduate student with Banting? Best was so involved with the discovery that Banting shared his Nobel Prize money with him. Apparently, because he was a graduate student he was not part of the award for the Nobel prize.
This video is a geme.
That was an awesome video on the history of diabetes medical treatment. Had no idea they had people who tasted urine and that it was called honey urine. But also the chemistry of insulin was fascinating. You said diabetes was due to lifestyle but could it also be epigenetic?
type 2 has multiple causes the most common are age and lifestyle. type 1 is a genetics being acted upon by an environmental factor
So my doctor tested my urine and said to me, "Mr. Allen, your urine is 43% alcohol." I said to him, "so what?" He raised my urine sample and said, "so cheers."
@@derekallen4568 When the body metabolizes alcohol, it is broken down into acetaldehyde, before it is eventually eliminated from the body as water and carbon dioxide through the lungs, kidneys and sweat. If you are unable to metabolize the alcohol you consume, then you are either drinking too much alcohol or your body is unable to produce the enzyme responsible for metabolizing alcohol which is called alcohol dehydrogenase (ADH) and so your urine will intoxicate your doctor.
But it is better to have an intoxicating effect on people without consuming alcohol.
@@oidbio2565 😆
T1D here. Excellent breakdown of this. Only critique is that you didn't mention how cinnamon can be used to reverse and even cure folks of their T1D.
That sounds interesting, do you have a study on that?
He’s lying or at least being overly (way overly) generous with the term “cure” I am a T1D myself and there is no cure for it. It’s hell and i wish other diabetics wouldn’t spread such misinformation. If cinnamon can cure your T1D why haven’t you cured yours yet buddy??? Huh? What’s that? … 😏
@@crazycatlady2744 Not a study like the kind Dave uses for his videos, but a lot of people have told me how helpful cinnamon treatments have been for them. It's pretty hard for a lot of patients to do. For full efffect, they have to take a full spoonfull of it without water, and hold it down. Rationale is that diluting it makes it ineffective.
As a parent of a T1D I'm laughing so hard at this. Whenever someone mentions this I just shake my head in despair.
@@shaunmoore681 People subscribe to some truly stupid ideas. Hearing this one made me sad for us as a species.
Im currently writing a big assignment on diabetes, and this came just in time. Thank you professor!
complication number 1 in Europe is a mix of nerve damage and arteriosclerosis that leads to amputations (toes and eventually feet)
Hey, Professor Dave, my grandpa has been diabetic for 30+ years, until, for some reason, he stopped needing insulin. His blood sugar is stable now, and he’s not even considered diabetic; i didn’t think that was possible, so could you try and explain it?
Was he diagnosed as Type 1 or Type 2?
Type 2 is insulin resistance and can be reversed sometimes via diet/exercise and probably other general normal metabolic changes.
Type 1 is where a person has lost the ability to produce insulin. They will not get that back short of a transplant of the relevant cells (which like any trnasplact has all sorts of other complications/risks)
@@vctrsigma I’m not certain but i’d presume its type two judging by your description; I’ll ask him later.
He's Type II. This is the one thing I think Dave didn't cover properly here.
@@vctrsigma yeah he was type two, thanks.
Type 1 for 63 years and still kicking. Humalog KwikPen and Lantus Vial insulin, kept me going, however the more recent continuous glucose monitoring (Dexcom) discovery has done wonders for my A1C levels, something I never achieved with insulin alone. May live to actually see a cure, which has been promised by the industry for 50 years but alludes us diabetics. To many think it's just a nuisance disease and that insulin was a cure.
Hey dave i got a question for you if you can spare the time. I may be incorrect in this but the pancreas produces insulin in the beta cell islets and glucagon in the alpha cell islets. Has any research been done into or treatments of diabetes involving these cells being performed, or is there a reason why this is not looked into? Or am i incorrect in saying this? Great video btw
The name of Roumanian scientist Nicolae Paulescu is worth to be mentioned in relation to insulin discovery.
As a possible mechanism for the Ebers papyrus' treatment on type 2 diabetes, gut fermentation syndrome from beer swill inoculation of S. Cervisiae could forcibly moderate sugar intake. The combination sounds torturous, but might be more survivable if you otherwise had to live on a large proportion of cereals and fruit in a time before [intentional medical delivery of] insulin.
The mention of the anti-science hindrance to insulin research is very appropriate. We have a new, financial hindrance for diabetics now, however. Certain "investors" and companies that have bought the necessary means to control the production of insulin and are now charging massively higher prices for an essential medication.
Minor nitpick - Macleod is usually pronounced "Mac-loud".
Greed and out of control scientists are to blame, not science.
To blame for what?
Apologies. I wasn’t clear. I was referring to the skyrocketing cost of insulin in the United States, quite unlike every other western democracy where prices for insulin are reasonable, and where diabetics don’t have to make hard decisions between insulin and eating.
Very thorough. My only issue here is that I don't think you addressed that diabetes mellitus covers two VERY different conditions with Type I and Type II. The first being an autoimmune disease and the second being thought to be caused by poor diet and genetic predisposition.
Very common, correct observation, but perhaps it is not clear to you that this video is part of the series "History of Drugs", and attempts to tell the story of how treatments came about, and is not a pharmacology series.
Back to this relaxing series :)
I should say that it's fascinating how far science has evolved to the point that we are able to engineer a specific compound such as insulin on a defined molecular scale!
9:52 This was bad insulin for me (Humulin N) , doctor swapped it with Lantus. I am still using Humalog after meals.
20+ diabetic. I am thankful for existance of the medicine.
So this is hopefully the type of field my education is taking me and I have to say a big thanks to you Dave. You helped a lot with my orgo studies and I remember your arenes and aromaticity video was so good it just have me a whole aha moment on the important go resonances and how it works. I remember how well you went over ortho/para vs Meta directors and it just helped me so much to now I feel like organic chemistry is one of my best subjects
اللهم بلغنا رمضان وصل اللهم على سيدنا محمد وعلى اله وصحبه وسلم 💕💯
Very interesting. I live across the street from a dialysis center and I've been inside it a few times and it was depressing. Plus the smell is something you will never forget and not in a good way.
McLeod and Best sold their patent for one dollar, in the hopes of making it affordable to all humanity. But today, in Canada, insulin costs much more than it did in the 1930’s. But in the United States insulin has been made so expensive it is unaffordable, and patients die.
Does rDNA in insulin change your DNA?
Oh wow, using ants to diagnose diabetes sounds a lot more pleasant than tasting the urine
excellent video, you should also talk about the new drug that has come out that is curing half the patients if caught in the early stages of Type 1 diabetics. The need for screening is a must now if we are to cure Type 1. Also most people have no clue that their glucose is not in range because the way they check your glucose using the a1c only tells you your average over several weeks so you were probably very high and low but the a1c looks normal. CGM's need to be given to any diabetic if they are to stay within range. Also they have pumps now and you no longer need long acting insulin, with the pump you can use fast acting and coupled with a CGM is almost a pancreas replacement
A type 1 a1c will never look normal. I've never heard of testing a1c in non-diabetics, but I guess it could happen.
What part of the video had this?
" you also talk about the new drug that has come out that is curing half the patients if caught in the early stages of Type 1 diabetics"
@@vctrsigma sorry, it should have said you "should" also, and I just edited it so it does now
@@rembrandt972ify Yeah, I guess what I meant to say was that we need to screen for Type 1 diabetics now because there is a drug that cures half of those diagnosed if caught early enough before the immune system has taken out the pancreas. So would an a1c be the best way to screen or just informing the public about excessive urination or sticky pee, or maybe just peeing in a cup and setting it by an ant hill to see if the ants like it. Pretty sad people are getting Type 1 diabetes when we have a drug for it, seems like we should be doing something.
What drug is curing diabetes? I’ve never heard of this and am a T1D myself. Please tell us the name and more details. I’m curious but also very doubtful. T1D cannot be cured. And there is no early stages of T1D. I just happens with zero warning. No way this is true but please explain.
Outstanding work!!
I dont like school but i like learning
Indeed diabetes death sentence had been given to me. Thanks for valuable indepth insights about the real historical background of the silent sweet poisoning subliminal disease triggered by sedantary lifestyle. 😊❤
*Macleod - "Mac Cloud"
Nicolae Paulescu, the first man to discover insulin. Why don't you say anything about him?? He is the first Romanian man who discovered insulin!!
The Nobel committee articulated in great detail why the isolation of insulin belongs to Macleod and Banting. There were other people who actively worked in the area, including Paulescu, too many to mention. Like many Nobel prize decisions, this one was full of controversy, but the decision stood and this is what history now tells.
Thanks, Dave. This was an excellent presentation, which I'll have to watch several times. Much appreciated.
So where are all the armies of YEC presupp nutcases shouting angrily that Dave "doesn't know anything about science"?
that's knowledge
I have type 2 diabetes for 10 years now and need 100 units of insulin a day along with metformin & januvia. So can someone tell me why insulin is $2000 dollars a 30 day supply!
There's cheap insulin (like $35) but it's not quite as good and safe as the insulin insurance usually pays for.
very informtive, as always great work professor
excellent.
Allah bless u.