Chapter 7.2: Making a Bio-Filler presented by Dr. Richard Miron
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- Опубліковано 7 лют 2025
- In this video, an explanation for how to make biological fillers (AKA Bio-Filler) using White/Blue Top Tubes is presented. Noteworthy, by remixing the buffy coat zone, the denatured albumin gel is re-infiltrated with many platelets, leukocytes and growth factors to further assist in the generation process, all while maintaining longer stability when compared to standard PRF. The Albumin gel + liquid PRF (Alb-PRF) mixture (often referred to as extended-PRF or e-PRF) has been shown to last 4-6 months instead of 2-3 weeks found in standard PRF.
Understanding Platelet-Rich Fibrin Full Textbook is available for purchase at www.prfedu.com...
For research articles on Alb-PRF, please read:
bio-prf.com/re...
For info regarding ordering tubes or the Bio-PRF system, please visit www.bio-prf.com
Full textbook and Hands-on courses are available at www.prfedu.com/
Please leave comments below.
Excellent teaching
So it’s an amazing filler , bio compatible , gel consistency , what would you do to break down or dissolve this filler if there was a problem , Vascular or arterial occlusion , or intravenous injection how could you break it down fast if needed in an emergancy
Use TPA or an anticoagulant.
Thank you so much for these instructions. I don’t have a bio-cooler, can you please tell me what temperature the bio-cooler is set to and is it possible to achieve the same cooling results with a sterile bowl of cold water monitored by a thermostat?
What should the ratio of albumin heated to liquid be, 2 to 1 for total of 3? Is it important to get the bubbles out before mixing? Thank you, its an excellent video.
What is the maximum quantity recommended for one session for someone who is wanting a larger volume such as a body area?
Dear Dr how cold is the bio cool?? Thankyou
Dr. Marion I was wondering why did you choose to centrifuge 700g for 8 min instead of 2000g for 8 min?
This is also something I wish he answered because now im wondering if I should be spinning all my injectables at 700g. Very confusing.
Any news on the exact difference? The UA-cam video's, articles published and the book PRF in facial aesthetics don't give me a clear answer. Also where does the 300RCF/5minutes protocol comes in and when 2.000RCF/8 minutes vs 2.000RCF/5 minutes? In the book PRF in facial aesthetics they also talk about 2.200RCF/8 minutes for albumin gel. So really getting confused.
A study conducted by Durgillon et.al reported that the number of platelets is not always proportional to the growth factors quantity and proved TGF beta 1 nd platelet conc.are proportionally related to the centrifugation forces when the forces r less than 800g.
TGF b1 becomes inversely related to the centrifugal force when centrifugal forces r above 800g
Yes I would do 2000 for 8 min if you are just doing Bio-Fillers. That's correct. If we do microneedling and papule injections as well, we typically spin at 700g for 8 min.
Dear Dr, how many RPM IS 700 RCF? PLEASE EDUCATE US THANKYOU I LOVE UR VIDEOS VERY CLEAR
How long this Bio filler last o body? Can this replace normal HA filler.? Can I use bio filler for lip augmentation..?
Am I able to use regular syringes or do I need specific syringes?
What is inside this gel? Isn't that just like a synthesized Halluronic acid?
No, it's 100% biological made from your own blood. No HA
Thank you for your videos! My Bio-Cooler arrived yesterday and my heater. I would like to know where to order the blue caps or can I use a similar cap device ?
You can order those also from www.bio-prf.com!
What happened to the Tubes which were first placed in the bio cool after drawing up the 2 cc of ppp. Because in the video , I noticed the PPP from the bio heat was mixed with the 2 tubes on the rack snd not in the bio cool
Those were pulled out of the Bio-Cool and those are the 2 tubes you see in the video which are then mixed with the heated albumin gel.
3' 52" ?
How long does biofiller last in the body? Also does the cooler make the albumin same as body temperature?
Typically 4-6 months. Very similar half-life to Botox
Is it ok to transfuse the remaining of the blood back to the patients after separating prf, IF the tubes were kept in the biocool device after the spin?
I would definitely recommend that NOT be done.
That is a big NO NO NO!
can we use A prf as a biofiller instead
No, A-PRF will not act as a Bio-Filler. That is an older technology for the early 2010s but doesn't last long in the body (1-2 weeks).