Metformin: The First Anti-Ageing Drug? | The Future of Ageing | WIRED
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- Опубліковано 8 гру 2021
- "Average life expectancy is now in the 80's in most developed countries, so we are losing out on 15-20 years of life for most people".
In episode two of Wired UK's four-part documentary series, we head to New York City to talk to Dr. Nir Barzilai and Dr. Ana Maria Cuervo, directors at the Institute for Ageing Research at the Albert Einstein College of Medicine, about their extensive and detailed work on the biological, physiological and functional processes of ageing. We also discuss the institute's exploration into what genes are resilient to the negative aspects of ageing, as well as what impact the so-called 'miracle drug' Metformin could potentially have.
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![ANTI-AGING EFFECTS OF METFORMIN | Drugs For Longevity [2020]](http://i.ytimg.com/vi/gCIBZKEAXNs/mqdefault.jpg)
![ANTI-AGING EFFECTS OF METFORMIN | Drugs For Longevity [2020]](/img/tr.png)
Great video! Love it when wired uk put one up.
Also my first time seeing James after listening to him for years on the podcast, not at all what I imagined you looked like mate 😂
you may want to get the genetic components of my 90yo father, eats everything , doesn't exercise (but keeps busy working on stuffs), only has one maintenance pill (for hypertension), got delta covid but survived just on home care, mind works perfectly, body naturally a bit battered but he is still very much mobile on his own
my dad didnt survive covid even on hospital care, you're really lucky he's still around
That's impressive. My wife's grandmother is 89 and still lives on her own and does her own errands and shopping and flies here every year to visit for Christmas. I find it amazing how some can be like them, then other people are 65 and are far less healthy mentally or physically.
Actually, you’re just unlucky. Virtually no on under 80 dies from Covid. Even the elderly survive by a large margin (90%+).
@@booyabooya5162 this is simply untrue. There are many young people dying from Covid and having their lives completely changed. I know SEVERAL and even know a 45 yo woman who died. Another 50 ish year old guy I know had to get a lung transplant and likely only has a year of life left. A 20-some year old girl I know from college can barely walk into class without passing out. Please stop acting like this doesn’t affect people. I have seen it first hand. If 100 million people get something and only 1% of them die, that is still 1 million people. Just keep that in mind.
@@metalheadzaki i’m so sorry for your loss…
This is great
Interesting because Metformin is a 'standard' treatment for Type 2 diabetes so here in the UK where almost 10% of drug expenditure is directed towards Diabetes, there will be a lot of people already on this medication.
In India as well ❤️❤️❤️
Yeap! 25 on recall list!
I also made a comment saying: "I also heard hyperbaric oxygen chamber therapy reveres aging. What if you also installed metformin into the gas? seriously!" The drug has potential agreeing with your statement that it will be more widely used.
Yoo what medication should I take?
@@Mehdi-jo6uj The medication your doctor prescribes! Or more specifically ask them about Metformin.
*Needs to be taken with Vitamin B12
Why ?
metformin, I'm 50, has given me a new life.
I can't explain enough what it has done for me
Can u try to elaborate? It’s an intriguing topic
@@Jasmine-se7bs exatly Jasmine tell us what secrets you keep
@@meruem6995ujjoooo fine keep your secrets
me too. Im 65 started when I was 52, I feel amazing. Since first month I became a year younger and so much more... now going to hikes daily like im 23
Me too I started it a few months ago and I feel amazing I have more energy. I sleep better. I am a much happier person my skin is looking better it’s just amazing and I’ve had no side effects. I love it
Thank you for being the dedicated, thoughtful, and compassionate doctor that you are, you are more honest than I imagined, thank you so much Dr Igudia UA-cam channel for curing my type 2 diabetes, you are amazing
when you hit the market pleas inform us.....
I was prescribed metformin for PCOS because I can gain weight easily and it suppresses my appetite.
Same!
same here, i dont feel like overeating now.
Have you lost weight?
I was 270 when I started it and now I'm in the upper 240s three-and-a-half months later I think it works, I'm just satisfied now eating half of the amounts that I used to
@@tjmnsthey put me on metformin for my pre-diabetes and when I started 3 weeks ago I was 270, right now I'm at 263. Help me diet, lose weight, control my sugar and start my journey to healthy life. I used to be 285 ish. Lost a little bit of weight when compared to other but it was all me doing the work, I was really depressed when younger so I just ate and ate. Figured if I filled my stomach it would fill the void in my soul so I gained weight and had no interest in losing weight, now I am in a different path in life and I look and feel much better 💪🏼🤲🏻👌🏼
Sounds intersting!
I see the benefits of taking metformin.. I take it every other day.. and I feel good.. more confidence.. I really feel much healthier..
Whats your dosage ?
My husband Bern on this for about 6 months and has been having mood swings
Time for a new husband
Wow Im almosy sixty & thats one of the first things they say . Just started metformin just now .
Sir please work on urethral stricture deases treatment which is hard ball injury or tissues reconstruction process
Does it work
Everyone’s question that
I've been taking metformin for over 25 years for type 2 diabetes, 2X1000mg, daily with no side effects. I believe the average male life span in America is 78, with diabetics having a shorter average life span....so, maybe metformin for me has already helped my longevity?
@@robertstancliffsr9575 Interesting. How old are you?
@@mouse6210 I'll be 80 in August of 2023.........
So bummed. I've read David Sinclair's book and a bunch of other literature on anti-aging and Metformin, but becuase I'm currently healthy, and not pre-diabetic, I can't get a prescription for Metformin to try this. Wanted to try a low dose, ~500mg, on off days. Very frustrated with the medical establishment.
You can't ask your doctor anyways? Assuming that you have not yet.
@@blacdiamond2334 the uk isnt like the US where you can just ask for a drug because you want it. You have to meet specific criteria or you cant have them
I would recommend going to a private GP and asking for an off label prescription, bring some research papers and say why you want it. Alternatively go to mexico where you can buy your years supply over the counter.
My GP is clueless on these subjects. I pay out of pocket for a functional MD who also prescribes hormones. My fasting glucose was slightly elevated. Hopefully this will put me into the “optimal” range. I’ve only been on it a week so will retest in 6 months.
@@deborahstensvaag2033 just go to a country like greece and buy bunch otc
Go science!
I almost bought Metformin but became aware about the side effects as problems with gaining muscle and better cardio when you work out…???So I am still concidering….
I wouldn't risk my pancreas becoming insencitive by taking metformine, i mean what dosage would you need to get the beneficial results?
You can take the lowest dose 2-3x a week on days that you don’t work out and get amazing results.
@@StunningTransformationslike what?
how do you know it is bad for the pancrease? I like to know
Cool
Some people cannot tolerate metformin. I could not function. Had to just sit around or sleep. Too much fatigue. After a year I gave up. Feel fine without it. Dr claimed not possible. But I have read about others on internet.
If you read it on the internet...case closed.......
@@robertstancliffsr9575 she had an experience
Honestly that shouldn't happen but be careful with all meds.
what are you taking for your diabetes if not metformin. something very expensive? like those new injectables.
I saw a YT video about the toxicity of Metformin. I think it was a 60 Minutes segment, but not sure? After years & years of taking it, I felt like I was indeed being poisoned by it. I stopped taking it for a couple of years. Now I’m back on it. Idk if it has anti-aging benefits, but I take it to help control my Type 2 diabetes. If there are bonus effects to taking it “Great!”, if not, than so be it. To be honest, I don’t really feel any better/younger while taking it, but maybe it works on a more cellular level to help slow the aging process, idk?
I have heard of doctors prescribing it to those with Syndrome X. HBP, high cholesterol, & borderline diabetes. They say it can help prevent full blown diabetes if taken early along with diet modification. I’ve also heard that women with fertility issues have taken it to help them conceive a child. I think it helps with fertility when the woman has PCOS which are small cysts on the ovaries. Insulin signaling along with other hormones, plays a very important role in the ability to conceive. Best wishes to all those facing these auto immune conditions, that can be so detrimental to one’s overall health!🙏”Health is your wealth!” as they say.
Americans really need to adjust their portion sizes and slow their roll on the processed food. I’ve noticed that the less I eat and the less often I eat, the better I feel. Makes one wonder wtf they are doing to our “food”. I also notice that my overweight friends are addicted to the food. God forbid they miss a freakin meal, they act like they’re going to eat your soul.
Blie zones people experience different things ?
Better living thru chemistry .....what could go wrong ....
You think the food you eat doesn't have chemistry?
@@RNCHFND no ...better living thru chemistry was an advertising slogan.... in many ways was supposed to be a sign of great things for a fancy new future ...but instead has actually brought in horrors as money making edges out long term safty concerns
I would want to know funded the studies.
there is no money to be made on metformin, it cost me $20.00 for qty 180 1 gram pills.
This is a very cheap drug in the US. The drug company has no incentive to sell more of it. So curious as well about the studies.
I make the elixir of life ❤
Isn’t metformin cytotoxic? I believe this drug can cause pancreatitis with chronic use…
The connection was seem on someone who chronically exceeded the recommended dosage.
Why can't we just bind the young healthy cells (forcing them from breaking off) together permanently?
They will die regardless due to accumilation of damage
Thats what they should focus on. Reparing dna cells everytime they break inmidiately. We would be 25 permanently. And choose when to die. We could have multiple careers and increible knowledge. We could make the world advance 1000 years in 10 years with all our knowledge combined. We could make the world a better place and go on a mission to bring the best of humanity to space and other habitable planets.
Will you use cryogenics to preserve your body after death?
Should be over the counter
You can get it online.
@@StumpyComedyAct where can I buy it?
It also holds cardio vascular effects from working out by 50% another thing to think about before taking this if you exercise a lot
People look at it bad but to live longer is not bad it open new door think if all the innocent people wrongly convicted of jail time that they didn’t do imagine you do time and come him and don’t even miss a beat or your youth and have a extra 100 years to live
Metformin can have some side effects you don't want to deal with.
Yes! It nearly killed my grandmother!
Such as what please?
Metformin can cause diarrhea and nausea. But there's also a Metformin ER - extended release that can reduce or eliminate these symptoms.
2 59
Metformin is not proven by anyone to slow down aging! It's just an assumption so far. Метформин - для замедления старения не доказано ни кем! Это пока всего лишь предположение.
This is to make it more expensive, and not attainable for people who actually need Metformin, like the drug Ozempic that is now the new weight loss drug Being used by celebrities and influencers and it's now out of stock
That's not true. Metformin has been available as a generic for 20+ years.
I also heard hyperbaric oxygen chamber therapy reveres aging. What if you also installed metformin into the gas? seriously!
That doesnt make sense. Metformin needs to be eaten and metabolised through the liver. Thats like saying instead of drinking water go and sit in a steam bath for hydration.
@@MegaPoliyo Oh ok I understand better now, I made a assumption that metformin could seep into the bloodstream if it was released topically throughout the entire body as a gas.
I want a psychiatrist with 20+ experience question this guy wether this guy takes it or not.
There is one thing that bothers me: the only ways to be healthy in the old age are also ways which cause the longer life. I don't want no bloody longer life! I'm so old already! I want to be healthy, yes. But what would I do with another 20, 30, 40 (if people can become 120) years? What's the point of that?
The point is to be healthy to a very old age. A long healthy life
Ok, clearly you hate life and you don't have to have this if you don't want. But that's not a reason to prevent other people from having it who love life.
One can't simply die from natural causes while at the same time being "healthy". Also what is the point in becoming 10,20,30,40?
what is the point of it all ? and why does the average lifespan of around 80 years sounds so appealing to you?
And why should we take that into consideration when assessing our chances of living longer? If you don't to live longer, by all means don't! Euthanasia is a thing.
To each their own mate.
@@Ahmad-ww4ue There's obviously no reason for you to do that as long as these treatments are not one-shot irreversible alterations - and it doesn't look like they will be. If anything, the people who this could be addressed to would be the scientists in the field. It's obviously illusory that they will take this into consideration or that there's even a viable research path to what I'm proposing, but the alternative I would - personally - like would be to stay physically and mentally, say, 20-30 until the end of a normal lifespan. "Euthanasia" doesn't exactly help with that and is a facetious supposition in the first place, because suicide is a far more onerous option than letting life run its course. It does sound good as a theoretical argument on paper though, which tells me that you are probably in your late teens or early 20s.
Didnt this drug just get pulled for cancer with a black box warning?
It was a recall
Recall, extended release version only.....
It is low for cancer. Although every drug has potential for cancer because they all alter our chemical reaction in cells
Just bring back doctor evil
And he will research it in year
" When you're 60 you get your first chronic disease you get your Diabetes " What rubbish! I got Diabetes before I turned 40. Some are born Diabetic & have Type 1 Diabetes and some develop Type 2 Diabetes like I did through Obesity and/or Genetics. My Father & His Mother both had Type 2. So maybe there's further generations going back that had it. It's ridiculous for any medical professional or medical scientist to make such a incorrect misleading statement. This gentleman needs to get his facts straight.
My 4-month trial of Metformin (1.5g) proved me right: For all the wonderful health and longevity-enhancing benefits, I' experienced a 36% drop in total testosterone since starting which I knew about and several studies have shown.. I was already low normal (high 400s) which was not optimal, now am at 318 which is basically hypogonadal. Have been contemplating TRT for years but was concerned mainly over issues with moderate hypertension, and past blood clots. This seems like it will push me over the edge to have embark on TRT.
To be honest, high 400s is not great to begin with. Do you exercise? More specifically, are you performing compound lifts with reasonable weight? How’s your diet?
I’ll read more info on meteor in affecting test, but I think you are right that TRT would benefit you heavily.
No brainer if you ask me if your natty levels are sub 500 and you are over 35
@@henrymahon train five times a week, cardio three times a week. Diet is on point. 5-7 62 y/o 180lbs 2000kcals/day 150-180g pro/75g carbs/100g fats.
I experienced the opposite, my total testosterone almost doubled in a year from mid 400s to low 800s. Cholesterol dropped 68 points.
@@generalmgr7729 62 years old is your answer for those levels. Try Enclomiphene monotherapy
I am contemplating that but any thoughts on Kisspeptin-10?
So all the poor people will get old looking and all the rich people will stay looking young. Sounds fair. 😢
Yup. Seems like this is what they're promoting. Yet another wedge that expands the gap of the 'haves and have nots.'
You just need to give it enough time, so cost will come down. New drugs take up a lot of capital to keep on going at the start.
Fighting against old age and therefore against death must be the primary task of modern science
We must demand a total mobilization of humanity for the extension of life in good health.
Declare biology a priority science and train biologists massively.
Build laboratories to declare war on death.
Matt
So we can die of overpopulation?
25 different recalls on Metformin!
For reasons not pertinent to metformin as a whole.
Metformin 750 er zero sides
Thankfully mine have not been recalled. Been taking metformin for 25 years for type 2 diabetes and I'm 78 now. I"m.hoping it proves to be an anti-aging drug.. also......
@@robertstancliffsr9575 lots of people with t2dm have been on metformin for years and years. I am 75 and has been on 2 grams since 1987. They could use people like you and me in a study. They would have lots of subjects vs those people who never took it. There is no need to start a study from ground zero.
@@robertstancliffsr9575 if it turns out this drug is anti aging, there will be a run on metformin and people like you and me won't be able to get it and we need it. so I don't really care if people think it is fake and phony and that drug companies want to make money.
Sponsored by drug companies
why? the drug been around for 60 years and is very cheap.
I am disqusted.
why?
I’m thinking a lot of this is hype, sponsored by the drug company. It’s possible, but metformin is not a super drug.
the drug is so cheap, been around 60+ years. the drug companies won't make any money. That's the problem. Any thing that works people believe has to cost lots of money. People take all kinds of vitamins and not has ever proven anything about them. Read the vitamin bottles.
and you know this, how?
I didn't know research was "hype". At what point was it said in this video that they have the cure. They have a hypothesis, as in a scientific question to be answered.
If we lived any longer we would have an overpopulation problem
too late.
we dont have an over population problem we have a resource allocation problem
No really, because if people lived longer,they would have kids later
Elon Musk says the greatest risk is population COLLAPSE.
No Covid was the solution to that problem
we'll find the cure to ageing but that will only cause more problems.
Metformin is bad. I wouldn't take it. It caused me stomach issues. Thank God I stopped.
Extended release version does away with this side effect
Robert Stancliff, SR
I've been taking metformin for over 25 years for type 2 diabetes, 2X1000mg daily, with no side effects. I believe the average male life span in America is 78, my current age, with diabetics having a shorter average life span....so, maybe metformin for me has already helped my longevity? I believe metformin is one of the safest and most useful drugs ever invented......
@@robertstancliffsr9575 are you also getting strength and energy like young people?
@@trijit96 No, but I do at least 30 pushups daily. Often 60 in two sets of 30. Helps keep my arms from looking flabby......getting strength and energy like young people isn't going to happen. I'm busy most of the time and feel good, but, yes I have chronic back problems that I take an occasional meloxicam to help relieve. I do feel certain 25 years of metformin has not harmed me in any way, in fact it has helped me eat more of what I like and still maintain a normal for a non-diabetic A1C......
I do take fiber. Non GMO Artichoke inulin fiber.
im 32 dont want be any older then 36 please make it stop
Medical model. Biochemistry only. Lifestyle factors, such as individual & social stress do not exist in humans? Used to work in medical (physiology) research. Then I moved to social work. Humans are not laboratory rats.
When it comes to biology we are actually mouses.
Social stress & lifestyle factors are literally biochemistry buddy. Everything is.
And laboratory rats expierence more stress & trauma than most humans.
@@andrxmeda97 Especially when there is a big hungry cat around.
Utter nonsense 🤣
The earth is round was utter nonsense at one time also. We all agree it's not flat. Let these people test it. Right now millions of t2DM are taking it for many years. People are spending billion$$ on vitamins today, where is the proof they work?
This technology has been suppressed for 2500 years
Well anti aging technology
Give me only 500 year please