Introduction to Neuroscience 2: Lecture 15: appetite

In this lecture, we learn about brain and hormonal mechanisms that regulate appetite and feeding. We learn about the two competing feelings, hunger and satiety. I then discuss the role of the hypothalamus in regulating these feelings, with focus on four hormones: ghrelin, leptin, PYY, and orexin. I present the two types of neurons found in the arcuate nucleus and how the counterbalance each other to regulate satiety and hunger. We also learn how the body creates these hormones and how they affect activity in the arcuate. Then we discuss clinical conditions related to feeding, and finish with a discussion of role of genetics and obesity.

[@mvsoma]

Just stumbled upon your channel. I really like the way you present, your words are filled with clarity. You're a great professor! Thanks for the solid lecture!

[@eduardboiko7219]

Very cool lectures, thanks! I didn't understood does the leisures in hypothalamus makes you starve to death and at last here's an answer - along with lot of other useful stuff.

[@DragesoresX]

Thank you so much this was a great video and the visuals and clear explanations helped me so much!

[@curlybaburlly]

Great lecture! Thank you alot for uploading this!

[@zes3813]

wrr, no such thing as impx or not

[@BHBalast]

Thank you, this information helps me choose my diet. :)

[@Dr.ChrisThompson]

I'm glad I could help!

[@angelogarcia1918]

It seems that Leptin function is not inhibiting appetite in obese individuals. It seems like there might be something akin to insulin resistance, leptin resistance. It also seems based on early in the talk that ghrelin differential signaling is also not functioning in obese individuals. The question I guess that remains is how to restore these signaling systems in overweight individuals.
I am curious about the status of reward pathways as they relate to food consumption. Is there such a thing as food addiction that also influence food intake? Is this an active area of research?

[@Dr.ChrisThompson]

Thanks for the question. You are 100% correct that leptin doesn't seem to inhibit appetite in obese individuals. This is known as "Leptin resistance". It's still kind of a mystery, but here is a recent review on then phenomenon.
www.mdpi.com/2072-6643/11/11/2704

[@aysegulyorulmazlar5212]

Thanks for your video. I loved it. How can I learn if my leptin receptors are working correctly. How can I get tested? I do have no satiety since my childhood. I can continuously eat but it gives me psychological pressure not being able to control myself. Thanks

[@Dr.ChrisThompson]

Thanks for the comment. I'm not sure if doctors regularly test for mutations like this. They aren't particularly common, but as I made clear in the video, there are people that do have these mutations and that they can have huge effects on their weight. But it does sound like you could have some kind of misregulation. Also, leptin is not the only player; control over satiety is very complex and includes many genes and many hormones.

[@aysegulyorulmazlar5212]

It is so hard to get into the real problem as you suggested. I am doing research everywhere to find a solution to my problem and what actually it is. It is with my brain for sure. I can not stay away from eating even when I have physical satiety😌