Це відео не доступне.
Перепрошуємо.
URIC ACID & GOUT - यूरिक एसिड और गठिया - یورک ایسڈ اور گاؤٹ
Вставка
- Опубліковано 20 лют 2024
- Uric acid is a product of the metabolic breakdown of #purine #nucleotides & it is a normal component of #urine . High blood concentrations of #uric_acid #uricacid can lead to #gout & are associated with other medical conditions, including #diabetes & the formation of ammonium acid #urate #kidneystone #kidneystoneproblems
The #water solubility of uric acid is rather low. All these salts exhibit greater solubility in hot water than cold, allowing for easy recrystallization. This low solubility is significant for the etiology of gout. Solubility of urate salts (grams of water per gram of compound)
Compound Cold water Boiling water
Uric acid 15,000 2,000
In #humans uric acid is the final #oxidation (breakdown) product of purine metabolism & is excreted in urine, whereas in most other #mammals the enzyme uricase further oxidizes uric acid to #allantoin . The loss of #uricase in higher primates parallels the similar loss of the ability to synthesize #ascorbicacid , leading to the suggestion that urate may partially substitute for ascorbate in such species. Both uric acid and ascorbic acid are strong reducing agents (electron donors) & potent #antioxidants . In humans, over half the antioxidant capacity of blood plasma comes from hydrogen urate ion.
The normal concentration #range of uric acid in human blood is 2.5 mg to 6.5 mg in females & 3.5 mg to 7.5 mg in males. A person can have serum values as high as 10 mg/dL & not have gout. In humans, about 70% of daily uric acid disposal occurs via the kidneys, and in 5-25% of humans, impaired renal (kidney) excretion leads to #hyperuricemia
The #dalmatiandog has a genetic defect in uric acid uptake by the #liver & #kidney resulting in decreased conversion to allantoin, so this breed excretes uric acid, and not allantoin, in the urine. In birds and reptiles, & in some desert-dwelling mammals (such as the kangaroo rat), uric acid also is the end product of purine metabolism, but it is excreted in feces as a dry mass. This involves a complex metabolic pathway that is energetically costly in comparison to processing of other nitrogenous wastes such as #urea or #ammonia but has the advantages of reducing water loss & preventing #dehydration
Although foods such as #meat & #seafood can elevate serum urate levels, genetic variation is a much greater contributor to high serum urate.
Hyperuricemia (high levels of uric acid), which induces gout can be caused by:
• High intake of dietary purine, high-fructose corn syrup, and sucrose can increase levels of uric acid.
• Reduced excretion via the kidneys.
• #fasting or rapid #weightloss can temporarily elevate uric acid levels.
• Certain drugs, such as #thiazide #diuretics can increase blood uric acid levels by interfering with renal clearance.
• #Tumor #lysis #syndrome a metabolic complication of certain #cancers or #chemotherapy due to nucleobase and potassium release into the plasma.
• Pseudohypoxia (disrupted NADH/NAD+ ratio) caused by diabetic hyperglycemia and excessive alcohol consumption
Gout : A 2011 survey in the US indicated that 3.9% of the population had gout, whereas 21.4% had hyperuricemia without having symptoms
Excess blood uric acid can induce gout, a painful condition resulting from needle-like crystals of uric acid termed monosodium urate crystals precipitating in joints, capillaries, skin & other tissues. In humans, purines are metabolized into uric acid, which is then excreted in the urine. Consumption of large amounts of purine-rich foods, particularly meat & seafood, increases gout risk. Purine-rich foods include liver, kidney, and sweetbreads, & certain types of seafood, including anchovies, herring, sardines, mussels, scallops, trout, haddock, mackerel, & tuna. Moderate intake of purine-rich vegetables, however, is not associated with an increased risk of gout. Inflammation during attacks is treated with #nsaids #colchicine or #corticosteroids & urate levels are managed with allopurinol. #Allopurinol #Zyloric which weakly inhibits xanthine oxidase. #kidneystone can form through deposits of #sodium #urate #microcrystals . These uric acid stones are #radiolucent so do not appear on an abdominal plain #X-ray . Uric acid crystals can also promote the formation of calcium oxalate stones - seed crystals
Hyperuricemia is associated with of metabolic syndrome, including in children.
Disclaimer: Medicine is an ever evolving science and one should consult his family doctor before taking any drug etc.
Dr. Sarosh Ahmed Khan, MBBS; MD; FACP; FRCP (Edin)
Director and Senior Consultant Internal Medicine,
NaseeM Medical Center; Baghe Mehtab, Srinagar, Kashmir, JK 190019
#uricacidtreatment #uricacidsymptoms #uricacidkailaj #gouttreatment #gout_in_hindi
Courtesy:
Image from Freepiks www.freepik.co...
Image by brgfx on Freepik
Wikipedia.com SemanticScholar.org ResearchGate.net
Always good information... ❤
Glad you think so!
MashaAllah Sir Looking great in the outfit.
Very important Information
Do share with others. Thanks !
@@DiabeteswithDrSarosh
Absolutely Sir
Plz Make a video on Graves diseases
@@abroufashaie Sure 👍
A detailed explaining of gout/ uric acid. Thanks for making common ppl to understand. We're eager to listen in future too. Stay blessed Dr
Thanks for appreciating my efforts. Yes I did try to include as many points as possible so that understanding becomes easy. This problem of high Uric Acid and Gout is common in this part of the world especially in winter ❄️
Thanks again and Stay Blessed
Great Information ❤
Thanks for watching.
Well simplified for awareness....
It is a spoon feeding for learners...
I am happy you liked it. I am watching your informative videos too.
We will have a collab in the future. Inshallah
Dr. Sir, a very useful video at the ryt time, my mother is also suffering from UA accompanied by Gout.
I hope this video provided some clarifications as well as important information. Hope it helps you and others. Thanks for liking.
@@DiabeteswithDrSarosh Dr. Sir, definitely helped me to understand difference b/w 2. And medication & prevention. Thanks again
@@maqboolwani3634 Thanks again 👍😊
Say something about diabetes
Kindly check the Playlist and click on Diabetes in Hindi Urdu and you will find 47 videos on Diabetes. Hope you are benefitted.