FRAIL AF Trial : Dr. Akif Baig

FRAIL-AF pragmatic trial showed that switching INR-guided VKA treatment to an NOAC in frail older patients with nonvalvular AF is associated with more bleeding complications than continuing INR-guided VKA treatment
Albeit this trial was not powered to demonstrate differences in thromboembolic events, major bleeding in isolation, hemorrhagic stroke, or the composite of hemorrhagic and ischemic stroke, there was no clear signal that switching results in reduction of these outcomes in this trial population
This trial indicates that careful consideration should be applied when choosing between continuing VKA or switching from a VKA to an NOAC in older patients living with frailty.