This chemical may be a life saver! I detected a gastric bleed in one of my patients a few weeks ago because I smelled that “metallic smell.” After noticing no notable bleeding source and running some tests and labs it pointed to a GI bleed. All thanks to (probably) 1-octen-3-one.
@@Mr_Lesbian Someone else's blood already tastes different to your own blood, so like the video says, only part of the taste/smell probably comes from this molecule, the rest of it is composed of other compounds that are probably rather unique to your own skin. Now, if you lick a piece of raw meat, you will find that the blood tastes even more different, because it's from another species. Also, if you taste metal, you should probably see a doctor.
@@Mr_Lesbian If you accidentally bite your tongue, the blood tastes the same. For that matter, red meats that are rich in heme iron have that faint 'bloody' iron taste. Maybe there are compounds in your mouth that react to the iron the same way as your skin?
I used to make lemon curd and whenever I made it, it inevitably had a metallic taste/smell. And because I had strained the curd through a metal sieve and somehow the acidity from the lemon probably caused some reaction and therefore my curd always ended up with a metallic taste/smell. I guess that metallic taste/smell probably was something leeching off some of the metal and chemically reacted to have similar properties of the chemical you made. Who knows. I suck at chemistry.
Idk dude theres also a double bond there. The difference between a hydroxyl group and a carbonyl group is pretty significant in terms of what type of intermolecular forces and reactions are possible. The electronegativity of the O-H is very different than the C-O
It get's better. The only difference between the taste of caraway and the taste of spearmint is the shape of the molecule. Chemically it's the same molecule, but one is a mirror image of the other.
A lot of things done in school I love but never cared about in lux now that I am out of school 2 years I'm way more educated and in front in life than the good good students who are now in uni meanwhile I work and building my cv and went to the army...school makes you want to either follow the sheep or be a fail...fuck that
I think this is a big problem that should be fixed. The human mind is naturally curious and like me i love watching documents, videos and reading about all kinds of things where I learn something of how the things in this world works but at school that curiosity fades away
School: oh no, you made a mistake, you suck and will suck forever therefore you failed the exam Real life: shit I fucked up, oh well it is what it is, let's try again
I've had this weird dish with watery baked eggs and a little bit of ham, and it always makes forks taste way more metallic than usual for some reason. It must be something with the way the eggs were done or something.
Maybe the eggs were overcooked? Eggs develop a sulfur ring on the outside of the yoke when overcooked. It takes a greenish-gray hue. Not an expert so don't take my word but it might be the sulfur reacting with the forks.
@@JonathanSchrock ham is usually preserves with nitrates I think. I wonder if combination of nitrates and something in eggs will amplify metallic taste. I have no chemistry background or knowledge so strictly hypothetical. Glad your description isn’t your moms cooking lmao!
@@ivyssauro123 I actually think it's more positive. It's more like he's become a metal connoisseur. He can now detect the faint differences between various metals. I think it would be interesting to get desensitized to the smell like he has, and try to identify the sub-aromas in various metallic smells.
Edit out the misused big term king -- I am the only Queen / Lady / Princess, so only my protectors (the alphas) are a king / mr / lord / sir / prince etc!
Just found this channel randomly few days ago.. pretty good mad scientist content even for people like me that are stuck at elementary school chemistry level and never looked into it more then that. Well done!
Angel Of Death I used to be such a fucking annoying kid, because I used to have good grades, and make fun of the kids in my class that that can’t understand anything like I do, now I look back at my self and think “I’m a dick” it’s like making fun of people because they’re ugly.
Daniel Kintigh, he’s not ‘always making mistakes.’ He is just extremely transparent about his process, including his somewhat cavalier attitude for his yield. He does this as a hobby and typically does not go out of his way to if something is too much work. His actual mistakes and clumsiness are pretty far and few between. He’s by far one of the safest amateur chemists on UA-cam. Check NurdRage if you want to see a very professional chemist attitude with great regard for safety. They’re very similar though NileRed is more casual.
this is probably going to sound retarded, but i honestly believe metal has a smell and it does, just because it doesn't fit the narrative or rule of what a smell should be doesnt mean it isnt, there is many things in science and such that break the laws they apply. like the popular one with people saying bees technically shouldn't be able to fly under there own weight to the ratio of the size of there wings, so are they flying? yes, is that bending the possibility that people have said otherwise? yes. same i think with metals, although not being relevant to that. i just dont understand how every metal ive had the experience of seeing all had different smells, regardless of people touching. ive smelt metal used by others for a large period of time and it had the EXACT same smell.
He made the worst smelling mixture of substances and didn't think it was too bad. His friends/coworkers didn't agree. People have different sensitivities but probably too many chemicals have contributed to hyposmia. I experienced complete anosmia with Covid several times. Now probably hyposmia at the right nostril. Glad I didn't lose it all.
it's not doing it for me. it looks like it's only there to entice children which is a rather tired trend many hundreds of youtubers have been following over the last several months to get the algorithm to give them more attention
I bought new keys and smelled them. I was like: What is this type of metal?! After 2 days or so, the keys started to smell "metal" like any metallic object. This is when I realized that the smell was something else... OMG THIS IS WHY BLOOD SMEEL LIKE METAL THX FOR YOUR WORK Nile!!
There should be some sort of legitimate award show or system for youtubers of this caliber providing this kind of content.. Instead of streamy's or whatever hyping up these so called "influencers"
My aut-spec ass can't figure out whether you called it "diphenhydramine" as part of the joke or not, but either way, I need you to know that that was thing that made me actually snort out loud. That, a chemistry confusion joke, made me snort out loud. Congratulations internet person, you have done the impossible. Have a good evening. Edit: this replys section is filled with a terrifying amount of emojis, holy shit. ...wait crap was i supposed to use one..? Uhhh,,, fucking,,, 😬..? _Idk maybe someone will explain this shit to me if I'm visibly confused enough_
I am a "super-taster". As a kid, our well water entered via iron pipes at the kitchen side of our house. On the other side were the bath and bedrooms. The bathroom water was connected by long copper pipes to the supply at the kitchen. I can still recall the disagreeable copper taste of the bathroom water vs. kitchen water and dislike that flavor to this day. My father of course thought I was being difficult when I'd complain of having to drink bathroom water rather than the tastier kitchen water. I can also detect a distinct flavor of water sitting in iron pipes for too long yet, the iron flavor is not as disagreeable as the copper. I'm certain I can discern a difference in flavor between iron, nickel and copper. I detect no flavor in gold, silver or stainless steel. Is there research in the field of tasting rather than smelling metal?
@3:46 "I'm going to do chemistry for something weird and see if it does stuff to my brain." The greatest justification for a scientific experiment ever.
It made me think of Alexander Shulgin, author of the books PIHKAL and TIHKAL (Phenethylamines and Tryptamines I Have Known And Loved), where he describes how to synthesize different psychotropic drugs as well as what effects they had on him as he tested them.
Great presentation. The description of 'metallic smell' sometimes also comes when ppl complain about smelly air coming from an hvac duct. Usually a slightly dirty one. If it's new, a top candidate might be oil residues from production of the duct.
fascinating! I always assumed the “metal smell” was from some form of oxidation of metal, but had no idea it was actually from skin oils. cool to know!
It's from some other oxidation or oils too. Sometimes you can smell some stinking smell without touching it, when it gets rainbow stained, on a rusting parapet, or near a tram when it rains. The latter one is really stinky and made going to high school very challenging in the morning
@@christopherstewart9874yeah what's up with that? I can smell copper and iron... Why can't I smell the same thing on other coins? And why does my blood smell and taste like a penny??
@@chem1417 _Spend days of hard work to make in large quantity, then isolate and purify a chemical that is also "produced" (sorta-kinda), in miniscule amounts, when our "skin oils" get in contact with coin and other metalic objects_, you mean?
@@randomperson1934 _"This sentence is grammatically correct, but it's wordy, and hard to read"_ - yeah, right. Go and tell that to James Joyce, heh heh... Y'see, I grew up reading books by Stanisław Lem, and oftentimes in his writings a sentence was like half a page long - but then Slavic languages (and in fact any other language with a proper grammar, that is with declension and inflections - be it German, French, Greek, Latin and others) tend to use long sentences, which are non-issue for their native speakers. English, on the other hand, being a highly developed Creole language fares poorly in this aspect, so native speakers tend to keep their sentences short - and since they do so, all the time, they do not have much exercise in "composing and understanding highly complex multi-tiered compound sentences", and thus when they see one they just perplexed. "It's all Greek to me"... Yes, I am aware of this problem - I encountered it before; many years ago I tried to explain some complex issue to a certain English gal, and she cut me in half-sentence saying "I already forgot what was at the beginning of the sentence". Which in turn really puzzled me, and I thought "how come, how bizarre - here I am, a non-native English speaker, and I have no problem with following such constructs - yet she, who's been speaking this language every day of her life for well over twenty years..." Yes, she has been, but I digress here. Y'see, my point (in my previous comment) was NOT to make a convoluted piece of speech (read: "writing"), but merely to point out to my "disagreeator" [disagreeator - a person with whom we are in disagreement], that he missed the point of the exercise done by Nile Red, which was... Well, we all know what it was, don't we? Therefore no need to explain, QED. And yes, my "CHOICE OF WORDS" might not be the best of the best, but y'know - that's the problem with non-native speakers... "Grammarly's cutting edge technology helps" - well, it doesn't really help much - in fact, most of the time it is more distraction and annoyance than "help". The problem with "artificial intelligence" is that it is still more "artificial" than "intelligence" - Tom Scott has made couple of videos on the subject "why computers suck at translation" and related issues - if you're interested here are links: Why Computers Suck At Translation: ua-cam.com/video/GAgp7nXdkLU/v-deo.html Crash Blossoms and Being Drunk - Ambiguity: ua-cam.com/video/ldT2g2qDQNQ/v-deo.html The Sentences Computers Can't Understand, But Humans Can: ua-cam.com/video/m3vIEKWrP9Q/v-deo.html and - to some extent - The Hidden Rules of Conversation: ua-cam.com/video/IJEaMtNN_dM/v-deo.html All of those videos show how complex, context-dependent and vague/ undefined in "zero-one" fashion all natural languages are - and therefore how confusing they can be for any "IA parser". It's like the problem with spellchecker - should I type, by mistake, "steel" instead of "still" no spellchecker would pointy it as a mistake - but if I type "pyta" in Polish text (a verb, third person singular, present tense - "[he] asks"; the personal pronoun is omitted, as Slavic languages are "pro-dop/ null subject" languages) Word would flag it as an "obscene word" - since "pyta" (a noun, feminine gender, singular, nominative case) is kinda vulgar, albeit dated, term for "penis". And about "compelling, understandable writing that makes an impact on your reader" - sorry, I don't give a... erm, "I couldn't care less" whether a half-educated and/ or "thickish" reader would "understand" my writing, find it "compelling" or whether it would make any "impact" on him or her (I hope I'm not misgenderrymandering anybody, heh heh...). But, kidding aside - the truth is I DON'T CARE. I'm doing my writings with an educated and sharp-witted reader in mind - and if someone finds reading my comments difficult, then my advice can be summed up in a two-word sentence. (Which is "don't read", in case anyone wonders...). And yes, absolutely - I could just say that right at the beginning, but... now you know. Still, "better late then never", as my auntie used to say whenever she was late for a train... Cheers!
@@randomperson1934 Sorry, seems like I didn't get it (the joke). My first reaction was like "whaaaa...? What the eff...?" - is it some comment made by a bot "employed" to advertise that Grammarly "miracle" ("miracle" being the fact they actually make any money off it...). So I just decided to treat you to some complex sentences... and see what comes off of it. Just for fun, or for kicks - and a little linguistical exercise as well, as "practice makes perfect". ;-) Cheers!
Being a teacher is hard, being a great teacher even more so. I'm sure most were interested but highschoolers and college ppl for years would have to break one down.\ Not to mention administration. Vs doing cool fun research or becoming a drug kingpin.
i have very little to no sense of smell, which at first totally kills taste in pretty much everything. after a few years taste gets more nuanced and you get to find that stuff that doesn't smell, like metals, do taste like stuff. for my work i deal a lot with different and somewhat exotic alloys, and especially aluminium alloys can be distinct in taste. mostly because aluminium by itself taste mostly of spiky sand, so metals like zinc and copper can still be made out. Iron tastes very heavily like blood, which seems to be a hard wired alarm taste so it overrules a lot, except for lead, which is so sweet it can overpower iron.
what I've learned from watching nile red is that chemistry is really just "what happens when i combine these two highly specific substances in this very specific way at this very specific temperature range?"
WOW the quality of the videos are at another level. Not even the visual quality but your ideas, writing and directing has been raised to a whole new level. Awesome stuff mate!
Soon as you stated metal has no smell , i thought it was our own smell. Especially with my experience touch door knobs and smelling my hand after wards.
@@VentDeux You touch filthy doorknobs that others have handled, probably after thev have used the toilet, and then put your hand to your face. But I'm an idiot. Can you hear me laughing at you, sniffer?
It’s surprising to me there are still reactions we don’t fully understand or can’t explain. Being mostly non-scientific, I assumed finding what happens would be easily solvable if we know the beginning state, end state and input.
@@Rahul-fp1gy IISER Bhopal. He is actually the founding director of our college. It was under his supervision that this 200 acre beautiful campus was made from scratch. His work is remarkable.
@@kipbush5887 In the case of chemistry, pretty much all these guys know is beginning state, end state and inputs. They propose different intermediates and mechanistic pathways which would explain the formation of product from the given set of reactants (,catalysts and enzymes as well in some cases). Then they try to prove the existence of the intermediates using various methods, whichever comes to be true, is finally accepted as a mechanism of a reaction. Like for example: one of the most common intermediates of chemical reactions is a carbocation which is just simply formed by ionisation of a C-H bond in a hydrocarbon. Now that task of ionising C-H bond in a hydrocarbon is very very difficult since the carbon doesn't really want to give away the H. In short hydrocarbons are really bad acids. But with the help of NMR spectroscopy and with one the best acids among the hydrocarbons(a tertiary compound), existance of carbocations was proved!
Hi. Perfumer here. This is probably my absolute favorite thing about perfumery, is the chemistry. Also how everyone interprets smells differently and we all have different experiences with scent. The brain pathway that interprets what you're smelling goes straight to the amygdala and hippocampus and directly links the fragrances to memories (IE the smell of fresh brewed coffee, fresh baked bread, the salty ocean). It's the strongest for of memory recall we have as humans. All of the fragrances i have made are based solely on memories and experiences i have had. Love seeing you make and synthesize aroma compounds i use all the time and want to use. Keep up the great work!
I can definitely get behind that memory thing. My dad uses a cologne from Mercedes that smells exactly like the smell of the old action figures from the 80's (ghostbusters, He-Man, G.I. Joe, etc) when you first opened the package. Takes me back to childhood birthdays and Christmases opening figures for the first time.
That explains why having something with my partner's smell on it is so insanely effective at making me feel better mentally when they're not there physically! I always end up embarrassedly requesting they leave a shirt or something at my place so I can sleep with it because I have insane insomnia that's greatly reduced by sleeping next to my partner, and having a shirt or something of theirs to smell when trying to sleep when they're not at my place overnight helps me sleep so much it's kinda insane. I give the shirt back when it doesn't smell like them anymore 😅😂. I'm also Native and we tend to have an insane sense of smell, which I definitely do. I genuinely thought everyone could smell things the way I can and only learned that was not typical by accidentally freaking people out with my accuracy up to 3 days after someone cooked something benign, for example. When I saw an ENT (ear, nose, throat) specialist for what was thought to be an ear infection, I mentioned in passing I have a crazy good sense of smell, and they were intrigued, and by an MRI found out I have larger sinuses than average by a significant size difference, which in theory lets me smell things better. I also have a much larger than average lung capacity (found when I was tested for asthma) and the theory by my doctors from both of those is that because I'm full-blooded Indigenous where our traditional lands are high-altitude, we evolved to have both of those so we literally take in more air with each breath, which helps you to have much more stamina with less oxygen than what's "typical". It's now been studied on Nepalise people specifically that they also have both of these things, and that their bodies are definitely genetically different from the altitude to compensate for the lower amount of oxygen. I can tell when food is bad by smell way before anyone else can - sometimes people don't believe me, pull out said food, and then eventually reluctantly admit I was right - and if someone wears something that smells like lotion, if they were indoors I can literally track them down very long distances like a damn bloodhound lmao, including to what door to outside the exited to and a small ways outside. I always smell things way before anyone else does, which once literally saved my entire school because I smelled and traced a gas leak that wasn't strong enough for anyone else in the building to detect. not joking or bragging, just one of the many things that's happened that empirically proved my sense of smell is abnormal. I obviously smell things no one else does (except the majority of my also Native friends/cousins/etc) not needing it to be even detectable by most people to tell exactly what it is and oftentimes very accurately how long ago the smell originated. Example: I accidentally freaked out my math tutor out a bit by walking in her kitchen to the table where we usually sat and telling her she had lasagna specifically the night before, including telling her accurately she had made the sauce herself and what spices she put in the sauce, as well as that she had made pancakes and eggs the morning before. I was exactly correct on the foods and times. She just stared at me flabbergasted. I started doing that for fun every time I came to her house, and freaked out her daughter too lmao. She tutored a lot of students and also taught piano, and began asking her students if they could smell anything after they walked in the kitchen on the days I came or the day before, and not a single one ever smelled anything but me. I can also tell different wines apart by smell alone; I don't drink, but I figured it'd be a fun party trick to pull (it is). I've had people my entire life tell me I should become a sommelier or work in perfumes because I can not only detect the tiniest amounts of smells, but also accurately tell different notes in the smell apart. Just thought as someone in the perfume industry you might find that amusing/interesting, and that you and/or people you know also in the industry might have had really similar experiences. It's a blessing and a curse haha. Obviously smelling things much more intensely than average works on both good and bad smells...
Hey, a perfumer. Nice. Can I ask you a question? See, I hate all perfumes. They more or less disgust me. Even a tiny whiff of them is extremely unpleasant for my nose. All except for one. I believe it is called "I love love by moschino" or something like that. Basically shuts down my brain and makes my heart beat faster. Is there any explanation you can provide me as to why that one single perfume is not only the one I can tolerate, but also the one I can honestly say I have a very hard time resisting? Seriously though, I don't use perfumes, colognes, deodorant or even aftershave. My laundry detergent is basically just pure washing nuts. I have to basically go to another city to get the only kind of soap I tolerate. You'd think I hate all unnatural smells, but that one just...bugs me, as in "moth to a flame." Anyway...any ideas on how this is possible?
Your IR spectrum showed a little OH-stretch vibration, so your main contaminant is probably some unreacted 1-octen-3-ol. Could that be why it smelled earthy directly from the vial?
You could synthesize cis-3-hexenyl cyclopropane carboxylate, the smell of Rainforest :D (according to the German Wikipedia, article: Cyclopropancarbonsäure) Condensation of 1,2-dibromoethane with diethylmalonate, followed by simultaneous decarboxylation and ester hydrolysis; finally esterification with cis-3-hexenol. ;)
If memory serves, there's a bacteria that lives on brass(or maybe on the corrosion that forms on it) which causes the distinctive smell that it has. As you say, it really doesn't make sense to be able to actually smell metal in pretty much all cases, but it certainly seems that there are a lot of things that are co-occurrent which can allow for some level of differentiation.
High yield is honestly something you should expect after multiple attempts and lots of streamlining. Despite being as careful as he is, he is lucky to get these yields with so many steps and products involved, often doing these as a first attempt.
NileRed has quite high yields compared to my friend at uni. His yield is normally below 10% and in labs of inorganic chemistry. I don't understand how he manages to get so little without pouring it down the drain.
I am a chemist in the pharmaceutical industry. More recently I have been doing more proposals, but my graduate research was synthetic inorganic chemistry, and professionally I was more of a synthetic organic chemist. These videos are awesome, and make me miss working in a lab. It also reminds me that I miss undergrad and grad research less... I don't think I could distill off solvent without a rotovap, and a combiflash would have been pretty awesome. It would be cool to try to reproduce the exact reaction that goes on when the oil of your skin comes in contact with metal.
If you're a synthetic organic chemist I have a lab you can work in. Well it's actually more of a garden shed, but perfectly fine for the task. And there are no measuring flasks but I have lots of empty soda bottles and stuff that I have marked up with a felt-tip pen. And I made a fume cupboard using a vacuum cleaner so it's all safe, I guess...
@@coskunagra1636 when I was 4 I tasted the blood after one of my teeth fell off and I was dumb when I was 4 so I also liked my coats zip Wich was made of iron soooo
This works for human smelling, we can't know for sure how animals interpret smells, they might be able to pick up more nuance than us and wouldn't probably be tricked by pennies with human skin oils on them.
@@Sulq Nile has always been like that. He doesn't edit out the errors/failures. He says (truthfully) that it accurately shows us the process of how lab work (and life) goes. Its ok to make mistakes, its how we learn
I can smell the difference between the types of paint I've encountered so far (minus watercolor). Car-friendly paint is metallic, while acrylic/oil-based paint smells like plastic.
That's the most complete, professionnal, scientific, rationnal video from Nile. I love this channel, and all the knowledge/tehnique beneath thoses videos. A pharmacy/pharmacology student from France
7:40 "There ended up being an error; I have no Idea how this happened" I was super confused, "What, did he put in the completely wrong chemical, did he do something out of order?" Oh. . . he just dropped the vial.
If you define "smelling" as taking in air past olfactory receptors, then yes. If you define "smelling" as taking in air past olfactory receptors which are activated in response, then probably not? If they were activated, we should perceive a smell, right?
I've smelt it in non-skin oil situations though. Most notably wiping up some spilled saltwater on an old coffee table with metal decor. The smell was strong
Same here, especially sanding down rusted metal on say a car frame, it definitely smells like metal afterwards when it’s all freshly opened up to the air.
Also, looking at other studies about this, the findings are the smells are “due to body oils or other impurities within the metals”… that was from 2006, and everything after that focuses on the body oils and ignores the “other impurities” part. Specifically this is Virginia Tech and the article says “We are the first to demonstrate that when humans describe the “metallic” odor of iron metal, there are no iron atoms in the odors. The odors humans perceive as “metallic” are really by-products of the metals reacting with skin or impurities in the metal itself”. So all these following articles and videos insinuating the only way you can smell metal is if you touch it is misleading imo. You can smell iron when acid touches it, when you sand/scrape it down or when you otherwise oxidize the impurities in it. It’s sort of “click baiting” the idea that it’s not actually iron particles you’re smelling, but that applies to all kinds of smells, it’s regularly not actually particles of the thing you’re smelling but some other chemical reaction.
Holy crap in my opinion this is seriously one of the coolest videos of yours! I work with metal all day and I'm starting to study organic chemistry in my spare time and this blew my mind. When your friends immediately said it smelled like metal that must have felt good, instant verification! I'm always going to think about 1-octen-3-one when I touch metal now. :) You inspire me so much, I hope you know how much your videos mean to me, and as soon as I can I will buy your merch and support you on patreon. :)
Your sample likely contains just a bit of water, or maybe some unreacted 1-octen-3-ol, judging by that small peak at 3500. Overall I'd say that's a pretty clean spectrum.
I remember watching this when it just came out. Here I am, 5 years later, sitting with some new coins that are nice and shiny, and one that I've been handling that's tarnished and smells of "metal". This is proof that these videos are useful years later. I knew you mentioned why they smelled, I just forgot the specifics. :)
I was in a few metal bands. Groupies were only an 80s thing and it was for bands that played stadiums at that time. You are lucky if you see even 1 or 2 girls at a metal show. The smells I found were marijuana, beer, and sweaty dudes.
How chemistry differs in your life and in science is so fun, like: How do you get metal smell naturally: touch it with your skin and hey here's that funny smell How do scientists get metal smell: so we need like a week to make pure 1-octen-3-one from closest chemical and it still smells like mushrooms and not metal
I mean, if a crab that owns a fast food restaurant can smell a penny from a mile away, I bet humans can.
Yeah, the one thing thats weird is the fact that a sponge works there and not a spoon
imagine if you used 1-octane-3-one to bait Mr krabs into a trap
Ha Ha!
@@ratrandom2360 don't you mean arg arg arg arg arg?
Scent carries better under water?
This man’s making robot perfume
Why would a robot want to smell like what it smells when people touch it?
Oh, that really came out sounding wrong.
@@DjZorlag exactly what i thought xD i also dont think robots can smell 🤔
Only if you Program them too😆
And technically he made human perfume for robots.
Troy White you can’t just program a robot to smell
You cant taste it either: ua-cam.com/video/CilWAKc8Ul8/v-deo.html
Realy? I feel like there is a taste that certin metala have but ima have to perfectlt clean som raw metal and do the lick test
So you're tasting a reaction of your saliva to the metal?
3rd comment
@@Quarksi i guess it could be that
How about being exposed to high levels of radioactivity ?
This chemical may be a life saver! I detected a gastric bleed in one of my patients a few weeks ago because I smelled that “metallic smell.” After noticing no notable bleeding source and running some tests and labs it pointed to a GI bleed. All thanks to (probably) 1-octen-3-one.
omg no way, I hope they're doing well now.
Nice to see this!
Blood contains 1-octen-3-one, that's why if you are bleeding and smell the blood it gives off an odor similar to metal.
Once you've smelled GI bleed, you know it forever.
That's crazy
Congratz, you made pure essence of spoon.
@Tickleshits A metal band name
@@endofmidsummer i saw what you did there buddy lol
Tell the cashier it’s Essence of Coin and then you can just buy anything
@@burnttoast6974 lmaoo
I laughed way too much at this.....
*smells a penny”
normal people: that smells like metal
nilered: that smells like 1 - o c t e n - 3 - o n e
Oof. XD.
nah its 1-octen-3-own
This angers me for some reason
Jake Hooper actually, it’s 1-octen-3-one. The one is pronounced ‘own’ for some reason.
nilered: that smells `stinky`
Also metal just smells like blood so I’ve always chalked it up to “iron in blood, iron is metal, logic”
I mean, when you’re smelling blood you’re smelling the iron reacting to your skin oils... so I guess it does have the same smell
blood also tastes like metal
@@angriispaghetti6108 I wonder if clean blood tastes of metal...
@@Mr_Lesbian Someone else's blood already tastes different to your own blood, so like the video says, only part of the taste/smell probably comes from this molecule, the rest of it is composed of other compounds that are probably rather unique to your own skin. Now, if you lick a piece of raw meat, you will find that the blood tastes even more different, because it's from another species.
Also, if you taste metal, you should probably see a doctor.
@@Mr_Lesbian If you accidentally bite your tongue, the blood tastes the same. For that matter, red meats that are rich in heme iron have that faint 'bloody' iron taste. Maybe there are compounds in your mouth that react to the iron the same way as your skin?
I used to make lemon curd and whenever I made it, it inevitably had a metallic taste/smell. And because I had strained the curd through a metal sieve and somehow the acidity from the lemon probably caused some reaction and therefore my curd always ended up with a metallic taste/smell. I guess that metallic taste/smell probably was something leeching off some of the metal and chemically reacted to have similar properties of the chemical you made. Who knows. I suck at chemistry.
So the only difference between the smell of a mushroom and the smell of metal is a single hydrogen? That's kinda mind blowing tbh
And the difference between table salt and bleach is one oxygen.
@@Chum3c yeah but those are both really small molecules, consisting of only a few atoms
Idk dude theres also a double bond there. The difference between a hydroxyl group and a carbonyl group is pretty significant in terms of what type of intermolecular forces and reactions are possible. The electronegativity of the O-H is very different than the C-O
@@Chum3c this not quite comparable to what's going on here.
It get's better. The only difference between the taste of caraway and the taste of spearmint is the shape of the molecule. Chemically it's the same molecule, but one is a mirror image of the other.
"there ended up being an error" is my new favorite way to say "i fucked up"
yes
we don't fuck up. we have happy accidents.
That's very reminiscent of a lab report write up. Heavy use of 'passive voice'.
its my kid friendly way
@@korlyboy282 *shoots sibling by accident*
ANOTHER HAPPY ACCIDENT! :D
Approximately 80 % of this video went straight over my head, but it was still fascinating...
Thx.
pete robinson saaaaamm
Same here.
How ? He explains everything so well and simple, what's not to understand? Was pretty straight forward.
bout 35%
@@disarray0921 a lot of the things he explained required prior knowledge to understand, for example when he was explaining chemical formulas.
Amaizing, loved it! For some people panic attacks start with a smell of "metal". In that sense, for me, there's now a lot more to elucubrate on that
chemistry is actually fascinating when you dont have to swot for an exam
A lot of things done in school I love but never cared about in lux now that I am out of school 2 years I'm way more educated and in front in life than the good good students who are now in uni meanwhile I work and building my cv and went to the army...school makes you want to either follow the sheep or be a fail...fuck that
I think this is a big problem that should be fixed. The human mind is naturally curious and like me i love watching documents, videos and reading about all kinds of things where I learn something of how the things in this world works but at school that curiosity fades away
@@marioskarakatsanis5351 the army doesn't make u sheep? lmao ok buddy
School: oh no, you made a mistake, you suck and will suck forever therefore you failed the exam
Real life: shit I fucked up, oh well it is what it is, let's try again
@Jacob King A school with final exams like every school lol
Having worked in an aluminium factory making profiles, I can attest to this. The packing section always smelled way more than the rest of the factory.
Your most likely smelling oxides metals among other things like the slag and other impurities
@@Chris-rg6nm Yes, but as soon as it enters your nostrils, it oxidizes and gives off the smell.
Worked in a steel warehouse, my idea of what metal smells like is the distinct grease and cleaner.
I always thought that Aluminium was odorless even with skin oils tbh
@@amcghie7 It stains, so there is oxidation. People think it's inoxidable, but it forms a layer of aluminiumoxide on the surface.
I love the concept of describing being clumsy as "there was an error"
Lol I’m going to use that
Mistakes were made lol
lab report question: what are the possible errors in this experiment
nilered: me being clumsy
And the fact that he was so shocked by his mistake haha! 😂
There was only little happy accidents
I've had this weird dish with watery baked eggs and a little bit of ham, and it always makes forks taste way more metallic than usual for some reason. It must be something with the way the eggs were done or something.
I think your mom cooks weird. Lol jk. But watery baked eggs sounds… different?
Maybe the eggs were overcooked? Eggs develop a sulfur ring on the outside of the yoke when overcooked. It takes a greenish-gray hue. Not an expert so don't take my word but it might be the sulfur reacting with the forks.
@@karlcarlsburg9641 Believe me, that's not my mom's cooking, thank goodness
@@JonathanSchrock ham is usually preserves with nitrates I think. I wonder if combination of nitrates and something in eggs will amplify metallic taste. I have no chemistry background or knowledge so strictly hypothetical. Glad your description isn’t your moms cooking lmao!
@@karlcarlsburg9641 I think they mean poaching
"This entire process
s t a n k" - Nilered 2019
🤣🤣🤣🤣
The smell of “S T A N K” is created by the chemical octenium-(III)Fe hypochlorite. Hahahahaha just kidding.
Stank is past tense of stink
@@SoMNoMW *stinked
@@urmomsmymom1276 *stunken
"I no longer have this idea that it's a metallic smell" is the saddest thing in this video. Rip Nile perception of metal
That was actually slightly saddening
@@ivyssauro123 I actually think it's more positive. It's more like he's become a metal connoisseur. He can now detect the faint differences between various metals. I think it would be interesting to get desensitized to the smell like he has, and try to identify the sub-aromas in various metallic smells.
He disenchanted his world.
Go listen some Iron Maiden and come back. Let the paresthesia cure you.
Edit out the misused big term king -- I am the only Queen / Lady / Princess, so only my protectors (the alphas) are a king / mr / lord / sir / prince etc!
"you can't smell salt"
joke's on you, my dad's been smelling our salt though a straw for the last 30 minutes
You can smell salt in salt mines and when they boil salt water in huge quantities to make salt.
good idea, that must've been it
That's cocaine he's snorting not salt
@@austiningalsbe6078 wtf is a cokeainn
@@austiningalsbe6078 r/woooooooosh
Just found this channel randomly few days ago.. pretty good mad scientist content even for people like me that are stuck at elementary school chemistry level and never looked into it more then that. Well done!
It's amazing one person can make such good content. It's better than anything I ever saw in school or on TV.
I love how you respect everyone's intelligence and provide us with all the information. And somehow manage to make it interesting.
Angel Of Death I used to be such a fucking annoying kid, because I used to have good grades, and make fun of the kids in my class that that can’t understand anything like I do, now I look back at my self and think “I’m a dick” it’s like making fun of people because they’re ugly.
@Angel Of Death making fun of someones intelligence is like making fun of an arsonist and an orphanage,who are they going to tell,their parents?
“There ended up being an error”
*Throws vile into beaker
That gave me a laugh
Skatole was vile. This was just a vial. :P
@@SouseMouse Now, if only it turned out that he can also play the viol...
Discovers 1-octen-3-one makes you clumsy.
"I honestly have no idea how this happened, tho..."
I make this sort of 'error' on a daily basis. I have no coordination.
_guitar at beginning of video on metal_
*That's METAL*
Hell yeah brother \m/
Meta metal even...
that was a HARD joke, the IRONy
Nailed it.
Oh man I can just SMELL THE MUSIC
Nilered 3 years ago: easily smells the substance
Nilered making super stinky stuff: I can't smell it
lmaoooo
Man this is really getting professional! Not that you weren't before, but the new studio looks absolutely amazing. Also sound quality!
Daniel Kintigh, he’s not ‘always making mistakes.’ He is just extremely transparent about his process, including his somewhat cavalier attitude for his yield. He does this as a hobby and typically does not go out of his way to if something is too much work. His actual mistakes and clumsiness are pretty far and few between. He’s by far one of the safest amateur chemists on UA-cam. Check NurdRage if you want to see a very professional chemist attitude with great regard for safety. They’re very similar though NileRed is more casual.
A pile of trash and wood offcuts in the corner is very professional :D
@@MattGDesign He's just moved studio. Things are probably still being constructed.
@@-vermin- I know, just kidding, it looks pretty smart nonetheless :D
this is probably going to sound retarded, but i honestly believe metal has a smell and it does, just because it doesn't fit the narrative or rule of what a smell should be doesnt mean it isnt, there is many things in science and such that break the laws they apply.
like the popular one with people saying bees technically shouldn't be able to fly under there own weight to the ratio of the size of there wings, so are they flying? yes, is that bending the possibility that people have said otherwise? yes.
same i think with metals, although not being relevant to that.
i just dont understand how every metal ive had the experience of seeing all had different smells, regardless of people touching.
ive smelt metal used by others for a large period of time and it had the EXACT same smell.
I feel like I've been tricked into watching a chemistry video but that's exactly what I clicked on.
Yeah, the Algorithm suggested this to me for days. Finally clicked it. Wasn't disappointed.
1k liker! 👍
Lol
Man, I swear you're like the Bob Ross of chemistry videos
yeah...no
O my gosh. I feel the same way Cristi POP.
More like the Mo Rocca of chemistry. I keep waiting for him to say lowkey funny shit.
That made me laugh for some odd reason 😂
Happy accidents...
He made the worst smelling mixture of substances and didn't think it was too bad. His friends/coworkers didn't agree. People have different sensitivities but probably too many chemicals have contributed to hyposmia. I experienced complete anosmia with Covid several times. Now probably hyposmia at the right nostril. Glad I didn't lose it all.
Loving the new lab and background! Keep up the good work.
Thanks!
But who wrote “hi bae”?
I suspect his friends where allowed to play with the chalk when they came over..
Or they just found it on their own..
it's not doing it for me. it looks like it's only there to entice children which is a rather tired trend many hundreds of youtubers have been following over the last several months to get the algorithm to give them more attention
@@rattyboi7646 probably that fine woman who sniffs his vial?
*paper calls for pulling a vacuum*
NileRed: Nah doesn't matter
Future NileRed: Okay am pulling a vacuum
Scientist 1: "Okay, Kevin, weigh it in a vacuum."
Scientist 2: "We don't have one, Jeff."
Scientist 1: "Weigh it near a vacuum *cleaner* then... "
22:27 HE'S NOT WAFTING THE FUMES!! HE'S BREAKING THE RULES OF SCIENCE!!
FINALLY SOMEONE NOTICED
HE'S GONNA GET SUSPENDED
middle school science teachers in a 100 mile radius: *winces in pain*
AHHHH
_gets written up_
I bought new keys and smelled them. I was like: What is this type of metal?!
After 2 days or so, the keys started to smell "metal" like any metallic object. This is when I realized that the smell was something else...
OMG THIS IS WHY BLOOD SMEEL LIKE METAL THX FOR YOUR WORK Nile!!
Yes, we can smell metal. Look at the blacksmith! They have smelt metal.
ha ha shut up
Live Wire be a dead wire
bruh
@@livewire9437 booooooooooooooooooooooo
Dad joke on point
“You can’t smell metal.”
Fire Fighter at Chernobyl: "Do you taste metal?''
Me, an intellectual: "Doth thou detect any traces of 1-octen-3-one via the nasal orifices or rather the buccal orifices?"
@@TheHappyWanderer Dost*
Someone’s been watching HBO
Braydon Garrett me boi
uhhhhhh movieninja.io
"There was an error," that is by far one of my favourite things Nile has ever said.
It was pretty funny 😂
He clumsy as fuq fr
Fr that was very funny
then you go over to nile blue
@@Asterion-t5r ? I don't understand English please
Oh F***! That mercury vapor demonstration was mind blowing.
There should be some sort of legitimate award show or system for youtubers of this caliber providing this kind of content.. Instead of streamy's or whatever hyping up these so called "influencers"
This is very niche
I do hope some contest include science separate from education, but I think it will take awhile
Man, awards are overrated, and people like him dont need awards to be legitamised
@@ChrisChoi123 He deserves to be recognized for his achievements and contributions to this community and science as a whole.
@Gabriel Well done, troll. You go back to not having your parents love you.
@@givemesubssoicangetaplaybu5183 Obviously his parents love him... otherwise they wouldn't let him live in their basement.
"You know spoons? It smells like spoons" is still my favourite quote from this video (29:28)
yeah, i've heard of them.
Isnt it on his wall now?
Y'know spoons?
There is no spoon.
Ya know? SPOONS?
Nile Red: ugh it’s probably just diphenhydramine-oxide-physono-duo-hydro phosphate
Me: duh why dudnt u think of that sooner.
Ugh no. He said it was triphenophosphiateoxide. Duh. My gosh. People these days. 😤
lol diphenhydramine 😂
No its- die⚰ pen🖋 hi👋 dyanamite🧨 ox🐂 eyed👀 python's🐍 son👪 deo🌬 hi👋 drone🛸 fox🦊 paste🥣
@@hahano61 😂😂😂👏👏👏👍👍👍
My aut-spec ass can't figure out whether you called it "diphenhydramine" as part of the joke or not, but either way, I need you to know that that was thing that made me actually snort out loud. That, a chemistry confusion joke, made me snort out loud. Congratulations internet person, you have done the impossible. Have a good evening.
Edit: this replys section is filled with a terrifying amount of emojis, holy shit. ...wait crap was i supposed to use one..? Uhhh,,, fucking,,, 😬..? _Idk maybe someone will explain this shit to me if I'm visibly confused enough_
I am a "super-taster". As a kid, our well water entered via iron pipes at the kitchen side of our house. On the other side were the bath and bedrooms. The bathroom water was connected by long copper pipes to the supply at the kitchen. I can still recall the disagreeable copper taste of the bathroom water vs. kitchen water and dislike that flavor to this day. My father of course thought I was being difficult when I'd complain of having to drink bathroom water rather than the tastier kitchen water. I can also detect a distinct flavor of water sitting in iron pipes for too long yet, the iron flavor is not as disagreeable as the copper. I'm certain I can discern a difference in flavor between iron, nickel and copper. I detect no flavor in gold, silver or stainless steel. Is there research in the field of tasting rather than smelling metal?
Thus a new hobby was born:
Connoisseur Metal-Smelling.
but.. you cant smell.. metal
Violet Payne
does put a smile on my face
Maybe that's why Joe Biden sniffs young women's hair all the time?
⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻⸻ what the fuck of a username
@3:46
"I'm going to do chemistry for something weird and see if it does stuff to my brain."
The greatest justification for a scientific experiment ever.
Randall Stephens that’s also what Dr Hofmann said on the 19th April 1943
dannyboy12244 He most certainly did not say that, on that fateful day. With that said: *drops a tab*
It's certainly fitting coming from a Chemist.
It made me think of Alexander Shulgin, author of the books PIHKAL and TIHKAL (Phenethylamines and Tryptamines I Have Known And Loved), where he describes how to synthesize different psychotropic drugs as well as what effects they had on him as he tested them.
How do you think crack was made?
Me: decides to watch video at 2am
(halfway through) wait what was this about
4:55am i had to re rewind n remind myself
Sheeps i tinke
Too much reefer
thats what im doing rn and i have school today oops
ME TOO
Great presentation. The description of 'metallic smell' sometimes also comes when ppl complain about smelly air coming from an hvac duct. Usually a slightly dirty one. If it's new, a top candidate might be oil residues from production of the duct.
fascinating! I always assumed the “metal smell” was from some form of oxidation of metal, but had no idea it was actually from skin oils. cool to know!
same!! It's surprising it's the actual metal that reacts with your sweat oils and not just with oxygen
It's from some other oxidation or oils too. Sometimes you can smell some stinking smell without touching it, when it gets rainbow stained, on a rusting parapet, or near a tram when it rains. The latter one is really stinky and made going to high school very challenging in the morning
What is strange, though, is that nickels smell different than pennies. I can't smell quarters or dimes.
Spoiilerrss
@@christopherstewart9874yeah what's up with that? I can smell copper and iron... Why can't I smell the same thing on other coins?
And why does my blood smell and taste like a penny??
“But there was an error.” *Drops vial into beaker*
Vial
Shubhangi Kundu that’s what I said. Lol I edited it... It’s ironic I got this notification after watching a Vsauce video about Homonyms!
"I've never done something so clumsy before"
Twenty minutes later, chucks a penny
Well, that was after the error. :D
Soumalya Pramanik same
it definitely messed with his brain =D
it's really cool that you did all this to end up with a molecule that can be made by rubbing your fingers against a nail for a few seconds
Yay, another NileRed video! I genuinely love this channel! Keep up the good work!
"it might seem very simple... (25 minutes left in the video)"
yea I know how this goes
spends days of hard work to make a chemical that is simply made by touching a coin
@@chem1417 _Spend days of hard work to make in large quantity, then isolate and purify a chemical that is also "produced" (sorta-kinda), in miniscule amounts, when our "skin oils" get in contact with coin and other metalic objects_, you mean?
No look, I read this comment AS HE SAID IT lmao
@@randomperson1934 _"This sentence is grammatically correct, but it's wordy, and hard to read"_ - yeah, right. Go and tell that to James Joyce, heh heh...
Y'see, I grew up reading books by Stanisław Lem, and oftentimes in his writings a sentence was like half a page long - but then Slavic languages (and in fact any other language with a proper grammar, that is with declension and inflections - be it German, French, Greek, Latin and others) tend to use long sentences, which are non-issue for their native speakers. English, on the other hand, being a highly developed Creole language fares poorly in this aspect, so native speakers tend to keep their sentences short - and since they do so, all the time, they do not have much exercise in "composing and understanding highly complex multi-tiered compound sentences", and thus when they see one they just perplexed. "It's all Greek to me"...
Yes, I am aware of this problem - I encountered it before; many years ago I tried to explain some complex issue to a certain English gal, and she cut me in half-sentence saying "I already forgot what was at the beginning of the sentence". Which in turn really puzzled me, and I thought "how come, how bizarre - here I am, a non-native English speaker, and I have no problem with following such constructs - yet she, who's been speaking this language every day of her life for well over twenty years..."
Yes, she has been, but I digress here. Y'see, my point (in my previous comment) was NOT to make a convoluted piece of speech (read: "writing"), but merely to point out to my "disagreeator" [disagreeator - a person with whom we are in disagreement], that he missed the point of the exercise done by Nile Red, which was... Well, we all know what it was, don't we? Therefore no need to explain, QED.
And yes, my "CHOICE OF WORDS" might not be the best of the best, but y'know - that's the problem with non-native speakers... "Grammarly's cutting edge technology helps" - well, it doesn't really help much - in fact, most of the time it is more distraction and annoyance than "help". The problem with "artificial intelligence" is that it is still more "artificial" than "intelligence" - Tom Scott has made couple of videos on the subject "why computers suck at translation" and related issues - if you're interested here are links:
Why Computers Suck At Translation:
ua-cam.com/video/GAgp7nXdkLU/v-deo.html
Crash Blossoms and Being Drunk - Ambiguity:
ua-cam.com/video/ldT2g2qDQNQ/v-deo.html
The Sentences Computers Can't Understand, But Humans Can:
ua-cam.com/video/m3vIEKWrP9Q/v-deo.html
and - to some extent - The Hidden Rules of Conversation:
ua-cam.com/video/IJEaMtNN_dM/v-deo.html
All of those videos show how complex, context-dependent and vague/ undefined in "zero-one" fashion all natural languages are - and therefore how confusing they can be for any "IA parser". It's like the problem with spellchecker - should I type, by mistake, "steel" instead of "still" no spellchecker would pointy it as a mistake - but if I type "pyta" in Polish text (a verb, third person singular, present tense - "[he] asks"; the personal pronoun is omitted, as Slavic languages are "pro-dop/ null subject" languages) Word would flag it as an "obscene word" - since "pyta" (a noun, feminine gender, singular, nominative case) is kinda vulgar, albeit dated, term for "penis".
And about "compelling, understandable writing that makes an impact on your reader" - sorry, I don't give a... erm, "I couldn't care less" whether a half-educated and/ or "thickish" reader would "understand" my writing, find it "compelling" or whether it would make any "impact" on him or her (I hope I'm not misgenderrymandering anybody, heh heh...).
But, kidding aside - the truth is I DON'T CARE. I'm doing my writings with an educated and sharp-witted reader in mind - and if someone finds reading my comments difficult, then my advice can be summed up in a two-word sentence. (Which is "don't read", in case anyone wonders...).
And yes, absolutely - I could just say that right at the beginning, but... now you know. Still, "better late then never", as my auntie used to say whenever she was late for a train... Cheers!
@@randomperson1934 Sorry, seems like I didn't get it (the joke). My first reaction was like "whaaaa...? What the eff...?" - is it some comment made by a bot "employed" to advertise that Grammarly "miracle" ("miracle" being the fact they actually make any money off it...).
So I just decided to treat you to some complex sentences... and see what comes off of it. Just for fun, or for kicks - and a little linguistical exercise as well, as "practice makes perfect". ;-)
Cheers!
You sound like an actually interested chemistry teacher
Being a teacher is hard, being a great teacher even more so.
I'm sure most were interested but highschoolers and college ppl for years would have to break one down.\
Not to mention administration.
Vs doing cool fun research or becoming a drug kingpin.
A what now?
Zooted
Doogie Howser M.D. for Millennials lol
He smells like an interesting chemistry teacher
i have very little to no sense of smell, which at first totally kills taste in pretty much everything. after a few years taste gets more nuanced and you get to find that stuff that doesn't smell, like metals, do taste like stuff. for my work i deal a lot with different and somewhat exotic alloys, and especially aluminium alloys can be distinct in taste. mostly because aluminium by itself taste mostly of spiky sand, so metals like zinc and copper can still be made out. Iron tastes very heavily like blood, which seems to be a hard wired alarm taste so it overrules a lot, except for lead, which is so sweet it can overpower iron.
what I've learned from watching nile red is that chemistry is really just "what happens when i combine these two highly specific substances in this very specific way at this very specific temperature range?"
it's like baking, but more difficult and more dangerous!
Temperature and pressure
@@Crow.c baking is, in fact, chemistry
Baking²
I like pizza!!!!!!
So THIS is where "Y'know, Spoons?" came from!
Can you provide time stamps?
@@peceminecraftjem2151 around 29:28
i came down here looking for this comment
WOW the quality of the videos are at another level. Not even the visual quality but your ideas, writing and directing has been raised to a whole new level.
Awesome stuff mate!
Soon as you stated metal has no smell , i thought it was our own smell. Especially with my experience touch door knobs and smelling my hand after wards.
I cringe at the thought of you doing that, but you do you.
@@captaintrips2980 you gotta be a special kind of stupid , to be bothered by a man smelling his own hand . God forbid I use my senses . Idiot
@@VentDeux You touch filthy doorknobs that others have handled, probably after thev have used the toilet, and then put your hand to your face. But I'm an idiot. Can you hear me laughing at you, sniffer?
One of the authors of the paper Dr. Vinod K singh is the ex-director of our college. Glad to see his research being put to good work here!
Which college?
It’s surprising to me there are still reactions we don’t fully understand or can’t explain. Being mostly non-scientific, I assumed finding what happens would be easily solvable if we know the beginning state, end state and input.
@@Rahul-fp1gy IISER Bhopal. He is actually the founding director of our college. It was under his supervision that this 200 acre beautiful campus was made from scratch. His work is remarkable.
@@kipbush5887 In the case of chemistry, pretty much all these guys know is beginning state, end state and inputs. They propose different intermediates and mechanistic pathways which would explain the formation of product from the given set of reactants (,catalysts and enzymes as well in some cases). Then they try to prove the existence of the intermediates using various methods, whichever comes to be true, is finally accepted as a mechanism of a reaction. Like for example: one of the most common intermediates of chemical reactions is a carbocation which is just simply formed by ionisation of a C-H bond in a hydrocarbon. Now that task of ionising C-H bond in a hydrocarbon is very very difficult since the carbon doesn't really want to give away the H. In short hydrocarbons are really bad acids. But with the help of NMR spectroscopy and with one the best acids among the hydrocarbons(a tertiary compound), existance of carbocations was proved!
"I was left with this nice white powder.."
"Hold up... what is this guy making?"
1-octen-3-one?
Its literally what the entire video is about.
Were you even paying attention?
@@miyukiteishi9051 r/wooooooosh
@@johnt8703 woooooooooooooooooooow
@@miyukiteishi9051 I was making a joke... :)
@@nathant.3299 What's the joke?
Hi. Perfumer here. This is probably my absolute favorite thing about perfumery, is the chemistry. Also how everyone interprets smells differently and we all have different experiences with scent. The brain pathway that interprets what you're smelling goes straight to the amygdala and hippocampus and directly links the fragrances to memories (IE the smell of fresh brewed coffee, fresh baked bread, the salty ocean). It's the strongest for of memory recall we have as humans. All of the fragrances i have made are based solely on memories and experiences i have had. Love seeing you make and synthesize aroma compounds i use all the time and want to use. Keep up the great work!
woahhhh
I can definitely get behind that memory thing. My dad uses a cologne from Mercedes that smells exactly like the smell of the old action figures from the 80's (ghostbusters, He-Man, G.I. Joe, etc) when you first opened the package. Takes me back to childhood birthdays and Christmases opening figures for the first time.
That explains why having something with my partner's smell on it is so insanely effective at making me feel better mentally when they're not there physically! I always end up embarrassedly requesting they leave a shirt or something at my place so I can sleep with it because I have insane insomnia that's greatly reduced by sleeping next to my partner, and having a shirt or something of theirs to smell when trying to sleep when they're not at my place overnight helps me sleep so much it's kinda insane. I give the shirt back when it doesn't smell like them anymore 😅😂.
I'm also Native and we tend to have an insane sense of smell, which I definitely do. I genuinely thought everyone could smell things the way I can and only learned that was not typical by accidentally freaking people out with my accuracy up to 3 days after someone cooked something benign, for example. When I saw an ENT (ear, nose, throat) specialist for what was thought to be an ear infection, I mentioned in passing I have a crazy good sense of smell, and they were intrigued, and by an MRI found out I have larger sinuses than average by a significant size difference, which in theory lets me smell things better. I also have a much larger than average lung capacity (found when I was tested for asthma) and the theory by my doctors from both of those is that because I'm full-blooded Indigenous where our traditional lands are high-altitude, we evolved to have both of those so we literally take in more air with each breath, which helps you to have much more stamina with less oxygen than what's "typical". It's now been studied on Nepalise people specifically that they also have both of these things, and that their bodies are definitely genetically different from the altitude to compensate for the lower amount of oxygen. I can tell when food is bad by smell way before anyone else can - sometimes people don't believe me, pull out said food, and then eventually reluctantly admit I was right - and if someone wears something that smells like lotion, if they were indoors I can literally track them down very long distances like a damn bloodhound lmao, including to what door to outside the exited to and a small ways outside. I always smell things way before anyone else does, which once literally saved my entire school because I smelled and traced a gas leak that wasn't strong enough for anyone else in the building to detect. not joking or bragging, just one of the many things that's happened that empirically proved my sense of smell is abnormal. I obviously smell things no one else does (except the majority of my also Native friends/cousins/etc) not needing it to be even detectable by most people to tell exactly what it is and oftentimes very accurately how long ago the smell originated. Example: I accidentally freaked out my math tutor out a bit by walking in her kitchen to the table where we usually sat and telling her she had lasagna specifically the night before, including telling her accurately she had made the sauce herself and what spices she put in the sauce, as well as that she had made pancakes and eggs the morning before. I was exactly correct on the foods and times. She just stared at me flabbergasted. I started doing that for fun every time I came to her house, and freaked out her daughter too lmao. She tutored a lot of students and also taught piano, and began asking her students if they could smell anything after they walked in the kitchen on the days I came or the day before, and not a single one ever smelled anything but me. I can also tell different wines apart by smell alone; I don't drink, but I figured it'd be a fun party trick to pull (it is). I've had people my entire life tell me I should become a sommelier or work in perfumes because I can not only detect the tiniest amounts of smells, but also accurately tell different notes in the smell apart.
Just thought as someone in the perfume industry you might find that amusing/interesting, and that you and/or people you know also in the industry might have had really similar experiences. It's a blessing and a curse haha. Obviously smelling things much more intensely than average works on both good and bad smells...
Hey, a perfumer. Nice.
Can I ask you a question?
See, I hate all perfumes. They more or less disgust me. Even a tiny whiff of them is extremely unpleasant for my nose.
All except for one. I believe it is called "I love love by moschino" or something like that. Basically shuts down my brain and makes my heart beat faster.
Is there any explanation you can provide me as to why that one single perfume is not only the one I can tolerate, but also the one I can honestly say I have a very hard time resisting?
Seriously though, I don't use perfumes, colognes, deodorant or even aftershave. My laundry detergent is basically just pure washing nuts. I have to basically go to another city to get the only kind of soap I tolerate.
You'd think I hate all unnatural smells, but that one just...bugs me, as in "moth to a flame."
Anyway...any ideas on how this is possible?
@@traditionalnative Meanwhile I have asthma and allergies all year round. Cool name btw
Didn’t realize that this was 30 minutes because of how entertaining it is
9:05
Now you can’t fool me, that’s actually just a running stick man.
Super Sophisticated LOL 😂
With a big ass leg
Lmao
Decapitaded at 9:16
Your IR spectrum showed a little OH-stretch vibration, so your main contaminant is probably some unreacted 1-octen-3-ol. Could that be why it smelled earthy directly from the vial?
either that or hydration of the ketone in the presence of water
The scientific level of youtube comments has just gone through the roof on this one (tips hat)
@@e_neko mlady
I want to understand what these people are saying. I'm going to become a chemist, if only for the purpose to return to these comments.
@@Splarff lmao im picking chemical engineering, so I might return to this thread as well, see ya in 3 to 5 years!
You could synthesize cis-3-hexenyl cyclopropane carboxylate, the smell of Rainforest :D (according to the German Wikipedia, article: Cyclopropancarbonsäure)
Condensation of 1,2-dibromoethane with diethylmalonate, followed by simultaneous decarboxylation and ester hydrolysis; finally esterification with cis-3-hexenol. ;)
Rouven R it’s that easy.
I don’t speak oganesson
Dammit, if it was about 7 years ago, when I was studying organic chemistry, I probably would have a much better understanding of this comment.
How do we get him to see this?
@@TheDapperDog402 so now that you're not, you completely forgot all of your studies?
If memory serves, there's a bacteria that lives on brass(or maybe on the corrosion that forms on it) which causes the distinctive smell that it has. As you say, it really doesn't make sense to be able to actually smell metal in pretty much all cases, but it certainly seems that there are a lot of things that are co-occurrent which can allow for some level of differentiation.
My coins have a very weird cent to them
Bruh
Bruh
*bruh*
Bruh
Bruh
Make a few ug of 1 - o c t e n - 3 - o n e :
Smells like metal...
Make > 1g of 1 - o c t e n - 3 - o n e :
Smells like...
Heavy Metal.
Puts 1g of 1 - octen - 3 - one on blackened steel :
*Black Metal*
Add 1,5-pentanediamine and 1-octen-3-one on a sythe and you'll get DEATH METAL
add 1g of 1 - octen - 3 - one to a led lamp and boom
*POWER METAL*
Can't be a NileRed video without a low yield 😂
Ouch.
Can't be a NileRed video without some connection to 1-octen-3-ol
"Low yield is better than no yield" Lmaooooo
High yield is honestly something you should expect after multiple attempts and lots of streamlining. Despite being as careful as he is, he is lucky to get these yields with so many steps and products involved, often doing these as a first attempt.
NileRed has quite high yields compared to my friend at uni. His yield is normally below 10% and in labs of inorganic chemistry. I don't understand how he manages to get so little without pouring it down the drain.
I am a chemist in the pharmaceutical industry. More recently I have been doing more proposals, but my graduate research was synthetic inorganic chemistry, and professionally I was more of a synthetic organic chemist. These videos are awesome, and make me miss working in a lab. It also reminds me that I miss undergrad and grad research less... I don't think I could distill off solvent without a rotovap, and a combiflash would have been pretty awesome.
It would be cool to try to reproduce the exact reaction that goes on when the oil of your skin comes in contact with metal.
If you're a synthetic organic chemist I have a lab you can work in. Well it's actually more of a garden shed, but perfectly fine for the task. And there are no measuring flasks but I have lots of empty soda bottles and stuff that I have marked up with a felt-tip pen. And I made a fume cupboard using a vacuum cleaner so it's all safe, I guess...
@@captaincat1743 Where does the "fume cupboard" vent to? Eh, either way its probably the best offer I've had in a while. When do I start?
you may not be able to smell metal...
but you wont take the iron flavour from me
*Vampire*
hey did you realize dat blood tastes as same as iron?
@@coskunagra1636 r/wooosh
@@coskunagra1636 when I was 4 I tasted the blood after one of my teeth fell off and I was dumb when I was 4 so I also liked my coats zip Wich was made of iron soooo
@@redfatass r/wooooshwithFourOs
If the blood hypothesis were correct, I wonder if predators would be tricked into following coins that we've dropped.
LOL
oh that must be confusing for predators when people litter pennies
This works for human smelling, we can't know for sure how animals interpret smells, they might be able to pick up more nuance than us and wouldn't probably be tricked by pennies with human skin oils on them.
@@kallianz Unless... the predators are hunting humans... the kind with holes in their pockets.
The TROUBLESHOOTING skill here is damn insane ._.
Yes, it made it a lot more interesting video than just getting it right on the first try.
@@Sulq Nile has always been like that. He doesn't edit out the errors/failures. He says (truthfully) that it accurately shows us the process of how lab work (and life) goes. Its ok to make mistakes, its how we learn
I can smell the difference between the types of paint I've encountered so far (minus watercolor). Car-friendly paint is metallic, while acrylic/oil-based paint smells like plastic.
NileRed: "you can't smell metal".
Chernobyl: "you can taste it tho."
Darren Murphy do you mean iron in your blood
Darren Murphy lol
I thought it had to do with the tremendous amount of gamma radiation present interfering with the brain's taste circuits.
Tom Foolery that might happen too but if you ever smell penny’s randomly that’s means you have a bloody nose or you have internal bleeding
Hum yes the very smart people
*Metal might be odorless but Grunge smells like teen spirit...*
Best comment 😂
Yash Kshirsagar win!
Oh no.
I lost
Great joke I rate it 9/11
That's the most complete, professionnal, scientific, rationnal video from Nile.
I love this channel, and all the knowledge/tehnique beneath thoses videos.
A pharmacy/pharmacology student from France
Lol wtf, same..
Agree, this is the best video.
Cool! I'm a pharmacy student in the US :)
@Jonas Unfortunately, I don't like much of dyeing videos :/ But very interresting though
Rotavaps are so great. I just realized what a luxury they are. They safe you so much time and trouble.
7:40 "There ended up being an error; I have no Idea how this happened"
I was super confused, "What, did he put in the completely wrong chemical, did he do something out of order?"
Oh. . . he just dropped the vial.
I'd probably make that type of error every day 😋
NileRed:spitting straight facts
Me: *intensly sniffing scissors and anything else metal on my desk*
LMAO WHY IS THIS LEGIT ME EYE-
Make sure to find an old school thermometer and sniff the mercury, just to cover all bases.
you can smell metal but it wont smell like anything
@@emailhook534 As explained in the video... no, mercury still has no odour!
@@emailhook534 can you smell, that smelly smell
If you define "smelling" as taking in air past olfactory receptors, then yes.
If you define "smelling" as taking in air past olfactory receptors which are activated in response, then probably not? If they were activated, we should perceive a smell, right?
You can smell metal but it can't smell you.
Sounds like some Confucianism saying.
I've smelt it in non-skin oil situations though. Most notably wiping up some spilled saltwater on an old coffee table with metal decor. The smell was strong
Same here, especially sanding down rusted metal on say a car frame, it definitely smells like metal afterwards when it’s all freshly opened up to the air.
Also, looking at other studies about this, the findings are the smells are “due to body oils or other impurities within the metals”… that was from 2006, and everything after that focuses on the body oils and ignores the “other impurities” part.
Specifically this is Virginia Tech and the article says “We are the first to demonstrate that when humans describe the “metallic” odor of iron metal, there are no iron atoms in the odors. The odors humans perceive as “metallic” are really by-products of the metals reacting with skin or impurities in the metal itself”.
So all these following articles and videos insinuating the only way you can smell metal is if you touch it is misleading imo. You can smell iron when acid touches it, when you sand/scrape it down or when you otherwise oxidize the impurities in it. It’s sort of “click baiting” the idea that it’s not actually iron particles you’re smelling, but that applies to all kinds of smells, it’s regularly not actually particles of the thing you’re smelling but some other chemical reaction.
Holy crap in my opinion this is seriously one of the coolest videos of yours! I work with metal all day and I'm starting to study organic chemistry in my spare time and this blew my mind. When your friends immediately said it smelled like metal that must have felt good, instant verification!
I'm always going to think about 1-octen-3-one when I touch metal now. :)
You inspire me so much, I hope you know how much your videos mean to me, and as soon as I can I will buy your merch and support you on patreon. :)
It's always so satisfying to see him simply poke at a liquid with a stick and see it turn into something completely different
Idk. Went to watch a metal band once. Smelled like weed.
Must have been dweeby metal.
on a techno party, toilets smell clean at 5am.
DO NOT BLEACH that concerns me
how does weed smell
MLG Darklight a lot like weed.
I found brass to give the strongest smell after holding it in my hands for a while.
Your sample likely contains just a bit of water, or maybe some unreacted 1-octen-3-ol, judging by that small peak at 3500. Overall I'd say that's a pretty clean spectrum.
Chemists be like 28:14
Yep the characteristic broad peak at around 3400-3500. I dont really like IR spectroscopy too much, but for a comparison like this, should be enough.
Yup, in French, at least at my college, we call it the OH potato :P pretty much the only thing that stuck with me from the IR spectrum analysis!
I really like you leaving the mistake in the video (7:39) plus all the background to the reactions!
People can learn from mistakes. In my opinion, the best channels leave them in.
I have no idea why I clicked on this video, but 31 minutes later, I'm happy with that decision
I remember watching this when it just came out. Here I am, 5 years later, sitting with some new coins that are nice and shiny, and one that I've been handling that's tarnished and smells of "metal". This is proof that these videos are useful years later. I knew you mentioned why they smelled, I just forgot the specifics. :)
so this is why you have “you know, sPoOnS” on the board
I was just about to write this
@@xeonthemechdragon me too
where?
@@adityamathur6938 at the end
NileRed: "Ah, now I can keep this 1-octen-3-one to myself."
Man in Penguin Suit: "I SMELL PENNIES"
"You can't smell metal"
No dip sherlock, you listen to it
Nice one.
lol
\m/
I don't know if you have ever been to a metal concert but.... you definitely smell it.
nah man I always taste it to be sure.
You can i actually can smell it a lot
Metal smells like hairspray, beer, and groupies, or so I’ve heard...
I was in a few metal bands. Groupies were only an 80s thing and it was for bands that played stadiums at that time. You are lucky if you see even 1 or 2 girls at a metal show. The smells I found were marijuana, beer, and sweaty dudes.
@@JonDoe-ef4tz ewh, sweaty dudes.
If it did
"but... there ended up being an error" is the funniest thing I have heard from this man
"Mistakes were made"
How chemistry differs in your life and in science is so fun, like:
How do you get metal smell naturally: touch it with your skin and hey here's that funny smell
How do scientists get metal smell: so we need like a week to make pure 1-octen-3-one from closest chemical and it still smells like mushrooms and not metal
The smell of fresh guitar strings under your fingers is in the top 5 feelings that can be felt.
Him: "I was left with this nice, white powder."
FBI: Wait so-
Breaking bad
Mitsuru Chan you're goddamn right
Dude if a chemical isn’t a white powder it isn’t really normal. Most chemicals are colorless.
@@royalrice5191 white is a color. colorless would be invisible.
tychodancer you get what I mean. They are clear or white
I SMELL PENNIES
i thought pennies was a completely different word
¿? Me too 😂
I can only smell your dirty, dirty hands trying to have a grab at my pennies
I smell radio waves in my head. ua-cam.com/video/2LqO43QYz08/v-deo.html
ua-cam.com/video/tYsIXAeitoI/v-deo.html is what you said made me think of
Wow Nilered beautiful work on the new lab/studio! Great video as always.
i love that metallic smell