Very informative, Mahalo. I'm almost 73 female, very active in weedwhacking, rock clearing by hand, and running a feline sanctuary. Had noted my strength-muscle had decline, which became worrisome. Since Nov 2021, I changed my diet and limited intake on calories, sugar and salt. Major positive noted difference in my health and strength recovering. Point is, the gut health is the key for overall better health.
I tried keto strictly for two years, lowered my carb intake to a minimum just vegetables, high fat, medium protein. No sugar or starches. Lost 35 pounds and 7 inches off my waist. No longer pre-diabetic, blood pressure back to normal, acid reflux gone in less then 2 weeks and never came back. My doctor labs are all normal now, everything improved dramatically. I am at the weight and waist I was in my 20s Diabetes runs on both sides of my family. Since in a couple of months I’ll be 70 I knew I had to do something or end up sick with body parts being cut off. Well it worked it’s been 4 years and I’m low carb now. I have bread and pasta occasionally and my body is handling it as a normal person. Always checking my blood sugar after having foods I know contain carbs. Still avoid sugar and starches and all processed foods like the plague. Cook 99% of my own meals, grow vegetables and mushrooms year round. I do not watch calories and eat as much as I want. Whatever fat intake I have is used by my body as fuel and burned off just doing everyday chores. I used to exercise a lot did me no good other then make my muscle hurt. I haven’t gained or lost a pound in 2 years. And I eat more cheese then Frenchman. Fat is fuel if your body remembers what to do with it……
@@kirstinstrand6292 Of curse, a natural one. Easy to prepare, good for health, delicious and adding exquise taste to proteins needed to keep the body în good shape.
I was disappointed to hear that they partnered with Nestlé. Nestlé is a corporate bully with high priced lawyers who keep the little guy out of the market. It's disgusting really. Something this important should be more accessible.
Hearing Nestle associated with this video has nearly made me immediately click away. It's makes me think of a biohacking conference hosted by McDonald's or something.
I became pointedly interested in research about ATP and mitochondria function problems after taking statins for twenty years, all the while increasing the doses at the same time I felt I was aging rapidly and finding difficulty walking at any distance or speed. I felt lactic acid was building up far too readily, and clearance was debilitatingly slow. I'm 76, so expected problems aging, but this degree of debilitation pointed to learning way back in college of Krebs cycle and mitochondria. I went on Pubmed, and in twenty minutes I found eight research papers describing all of these problems are frequently associated with statins in 5 to 20 % of those taking them, perhaps I was more severely affected than most, but none of my doctors ever suggested that this could be associated with drugs I was taking. Over the next two years, after going against advice and stopping the drugs, I improved every day. I now have 90% less pain levels, and can walk far more effectively again. All of this has piqued my attention for understanding metabolic problems and how there are many lifestyle changes available to improve bioenergetics. I'm all ears!
@Luke Schneider Yes, all of those, plus quercetin, Zn, liposomal C, D3 (up to 44 ng blood with 7000 IU/d winter and mid day sun in summer), low carbohydrate diet, fats, 95% OG diet, One meal/d restricted eating, organic farm work for exercise, daily hot tub jets to move large muscles around to circulate lymph well, very careful to avoid sources of lead, live in Oregon coast range so get onshore breezes reducing pollutants, I eat fatty meat, fish, veggies, avoid added sugar in anything but eat fruit, stopped drinking fruit juices though, Sleep far better but use CPAP, up to 7 hrs now from 4 to 5 while taking statins, forest bathe a lot for NIR gain, get massages, etc. I do drink morning coffee, which gets my mind zipping.. and have lots of mental projects... so far so good... far better than twenty years ago!
@Luke Schneider Thanks Luke, damned near killed myself fifteen years ago by listening to my partner saying I definitely need to drink more water. I thought, okay, yes I can see that, so in addition to taking the damned statins, I thought I'd be smart and combine more water intake plus getting it with all the good minerals and vitamins from fruit at the same time by only drinking huge amounts of juice instead. Bad mistake. All that sugar was devastating! Live and learn, hopefully faster next time. Take care!
With pivotal, seminal videos like this top quality gift to us, this channel has become one of my top favorites. Beyond cutting edge is the tip of the spear.
Hello maybe we should wait before taking it. Nicotinamide Riboside was also so much advised when it was launched for better mitochondrial fonction. And now, after years of people using it, studies are finding that as it improves mitochondrial fonction, it also improves cancer fonction and turns it to metastatic cancer... so, we should be careful with new molecules and wait.
$200 a bottle? I’m sure it’s worth every penny but unaffordable for most. I settled for organic powdered pomegranate I can add to my 8 Greens and beet powder drink. Delicious, affordable and effective.
Big salad of organic leafy greens before lunch ,probiotics ,kafer, kimache or any other natural probiotic , and digestive enzymes for older people is very good.
@@jeanninecathcart627Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints - PMC I have had relatives who were as sharp as 40 yr old at 90. Where I come from, Pomegranate is called heavenly fruit 😋
@@jeanninecathcart627 Apparently 40% of individual house gut bacteria capable of converting unspecified ingredient in pomegranate to urolithin-A, a substance claimed to promote Mitophage. Mitophage is a process where defective mitochondria are recycled.
I have been using Mitopure for a month now and I can clearly confirm a rise in my energy levels. Also when I do my strength training in the gym I notice increased power and shorter recovery times afterwards. i combine my Mitopure with 100% pure Pomegranate juice and I feel better than I did ever before. It really works.
Valuable, scientific and fascinating discussion between two highly qualified doctors covering various aspects of mitochondrial health & function and it's importance for whole of human health.
I am wondering if any mitopure users have reported better visual acuity. Since the rods and cones of the retina have more mitochondria than any other tissue it would make sense that improved vision would a way of measuring the effect
Maybe we need to know what kind of bacteria that metabolize pomegranate into urolithin A, so we could also take this kind of probiotic supplements to enrich our gut microbiome...
I appreciate the detail of this discussion and the free dissemination of information to the public. Thank you both. Two questions: 1 - Is there a test for ability to process pomegranate polyphenols into Urolithin A?, 2 - Are the specific gut microbiome activators(?) for Urolithin A found in common probiotic supplements/kefir/yogurt or in specific fermented food products? My point is that we should strive to keep simple foods as our medicine and limit the number of expensive and highly processed pill foods where possible.
Very effective ways of enhancing the mitochondria are 1) PQQ the most effective one for mitochondrial biogenesis (the built up of new mitochondria), 2) Methylene Blue, 3) Taurine, L-Carnitine and even Creatine. All of them are less costly than Urolithin and in a good combination not less effective
@@donnazukadley7300 sorry my mistake or rather typo It’s PQQ you’ll find plenty of information on the internet. The important thing here is, that PQQ is the only (!) supplement that leads to the growth of NEW mitochondria Here a short copy of the Wikipedia article, which however is not the best source „Pyrroloquinoline quinone (PQQ), also called methoxatin, is a redox cofactor and antioxidant. Quinoprotein glucose dehydrogenase is used as a glucose sensor in bacteria. PQQ stimulates growth in bacteria. History It was discovered by J. G. Hauge as the third redox cofactor after nicotinamide and flavin in bacteria (although he hypothesised that it was naphthoquinone). Anthony and Zatman also found the unknown redox cofactor in alcohol dehydrogenase. In 1979, Salisbury and colleagues as well as Duine and colleagues ….“
@@donnazukadley7300 Sorry my mistake or rather typo it should have said PQQ PQQ is the only supplement that will lead to biogenesis of NEW mitochondria. You’ll find tons of information about PQQ on the internet
Dr. Perlmutter is the only physician / researcher / scientist in videos who properly pronounces apoptosis! Sounds dumb, but having worked in a mitochondrial lab, I feel just slightly uplifited. [e.g., right before and after minute 13:30]. BTY, nothing is more astounding than methylene blue. In many cases, including pain + use prior to a hard workout, cause and effect are astonishing. No downside in the range of .5 to 2mg / kilogram of body weight. Dr. Perlmutter ought to interview Dr. Francisco Gonzalez-Lima, PhD at the University of Texas, Austin. He's the top guy on methlyene blue. A brilliant guy like out good doctor here.
@@moniryousefian8782 IF the thyroid hormones [T4, T3, T2, T1] are in good balance, and if idodine in the diet is sufficient, then yes, methylene blue will be of help to ALL tissues not functioning at their optimal level. Only mature red blood cells lack mitochondria. Hence, any condition or disease caused by insufficient energy production [ATP] in any gland, in any organ, or in any cellular organelle will benefit from methylene blue. MB corrects defects in the electron transport chain so that ATP production is normalized. However, if steriod hormones are too low, or even too high, nothing will help until you find the right doctor who can solve this problem with bioidentical hormones, or by using some other effective therapy. For me, methylene blue has been amazing for use before an intense workout in the gym. It also eliminated all my chronic pain I had for 6+ years.
I am curious to know the difference between a few mitochondrial support supplements if you are familiar with them. If you have worked in a mitochondrial lab, perhaps you would know? Two months ago, I was adversely affected by the popular fluoroquinolone antibiotic, Ciprofloxacin. If you're not familiar with it, you might Google Cipro Toxicity or FQ Toxicity or even Levaquin Tendonitis. There is a good video on Levaquin Tendonitis, which explains how mitochondria and even DNA are damaged by the fluoroquinolone class of antibiotics. People who have acute reactions to this can be adversely affected for life. I am hopeful this doesn't happen to me. Anyway, I was initially taking CoQ10 with PQQ, then when it ran out, I switched to MitoQ. And now I am very interested in Urolithin A but I have no idea if these supplements all do essentially the same thing or if I should combine any of them for greater results.
There should have been more opportunities and in depth questions for the person being interviewed, rather than making a disproportionate time showing the knowledge of the interviwer.
Agreed-Are you referring to the mind-boggling 190 seconds it took Perlm to ask his question from 11:41 to 14:55? Interviewers need to have pointed questions pre-written to lead the guest to new topics. It’s not supposed to be a conversation evenly split between the two.
RN here, best practice to increase gut microbiome is raw milk,(unpasteurized, unhomoginized), loaded with enzymes that feed your microbiome. Make your own kefir & yogurt.
I’m a 63yr old woman, open water swimmer, so pretty active. I’m trying Emface rejuvenation treatment on the muscles in my face and wonder if my athleticism will help enhance the treatment. Meaning, have I been keeping my mitochondria healthy and will it translate to the muscles targeted in this (expensive) treatment? Thanks!
I take Mitopure (Timeline brand). I am 56, male. I can't say too much about it at the moment because I exercise already and have been in shape for quite a while, but I can say one thing about it: it is costly and so it is pretty useless for most people because they can't afford it or can, but don't want to pay for it. The cost has to come down or this is a useless supplement.
I was blessed with the greatest gene of all. I cant taste most bitterness. Thus i eat massive kale salads because i didnt know they were bitter and just used it as lettuce 😂. I drink dark roast black coffee, the darker the better because i only taste the coffee flavor 😂. I eat 92-96% pure dark chocolate because i just taste the creamy and chocolate with zero bitter. I eat broccoli like no tommorow because i like the crunchyness. Thst simple gene gave me the keys to longevity
How about getting pomegranates, berries,nuts, mushroom (or buy ellagic acid, purify it when necessary), and have the proper bacteria in your gut? This one STUNNED me: 20:45 😮. Better pay $900 per year 😁
@@patriciagriffin1505 fruits inherently have sugar. The juices realistically have benefits, esp if you're juicing them yourself as store juice is pasteurized. However, their benefits are basically universally outweighed by the effects of the sugar content and resulting insulin spike. When you're doing what he's doing and just testing if ingesting the juice gives a specific result, fine. For overall health....skip it.
Make your own juice - no additives and drink with the fruit fiber and/or add fiber to juice. You want to blunt the glucose load while still gain health from juice.
@@kathb1683 Oh yay!! Please know though that low thiamine can show as normal on tests. There’s a lot of info here on YT! I hope it helps you! 😊 I like Allithiamine, as it’s a natural source, crosses the blood brain barrier, and 500mg is considered high dose.
I've been studying neurology intensively for the past 2 years because I've acquired covid induced Parkinson's, I know that mitochondria dysfunction is the latest discovery in neurological problems, mitochondria produce cell energy ATP but as a byproduct it produces damaging oxidative molecules which is the primary cause of Alzheimer's and Parkinson's...Urolithin A promotes mitochondria 8:18 recycling which eliminates bad ones and replacement with new.. I've also discovered that viral induced Parkinson's is curable because it's cause is also vagus nerve problems which the latent virus hides in the nerve
We're all about revitalizing your mitochondria! If you want to buy it from the scientists who made the discovery, we invite you to try our trio sample pack so you can experience Mitopure (Urolithin A) in different formats and see what works best for you. The $10 cost is reimbursed when you upgrade. www.timelinenutrition.com/shop/mitopure-sample-pack
Such an interesting topic. So to further the question about food sources for UrolithinA, is the idea that we have to first work on our microbiome diversity with an diverse plant based diet and then we can shift from a non producer to a producer ? Was that the point Dr Singh was making ?
It's great to hear from researchers. However, some of these researchers are involved in the development of supplements which they sell at astronomic prices. This leaves one to wonder whether their research is credible or not. Dr Singh is involved with MITOPURE UA supplement which sells at 5 bucks a day. Isn't it a clear conflict of interest and kind of unethical? to first create the need through these vlogs and then give a commercial solution for profiteering.
Heteroplasmy rates go up with age ( see work of Dr Douglas Wallace at CHOP ), additionally increasing one's redox rate, simply fasting 4-6 days will up regulate both mitophagy and mitobiogenesis, stacking them by staying in ketosis will do many other positive things, without chewing up muscle mass or protein thru gluconeogenesis.
The dr said ,exercise,and calorie restrictions,I think he made mistakes,he should say ..carbohydrates restrictions…not calories.We need good fat,but not sugar or carbohydrates,no no
Look into red light caps that you wear with red and NIR LEDs at 655 and 850nm. NIR penetrates skull to a depth of about 5cm, and has been shown to stimulate brain function and help with symptoms related to neurological disorders.
I wonder if there’s a connection between this & central sleep apnea. I’m not that overweight but suffer from it. Everytime I start to dose off I stop breathing. This happens throughout the night too. I’m constantly waking up. It’s a nightmare…
Can I just put out something that happened to me? I got it from breast implants. Those nasty things cause all kinds of autoimmune and neurological disorders! If you have them, get them out! I almost died and lost several organs because the toxins go haywire in your body.
@@Tinyteacher1111 coconut oil is anti viral,anti fungal ,and anti microbial ,,take 1 tablespoon in the morning and one before bedtime ,,it will get into blood stream and help ,,it is also an antioxident ,so will neutralize free radicals and slow aging
He already mentioned it in the interview - (1) Strength & Aerobic exercise (2) Caloric restriction/ Intermittent Fasting. For the specific natural alternative to the product mentioned , I would try Apple/Berries ( Pre-biotic) + Kefir/Yogurt (Probiotic) with some Pomegranate powder which is a relatively cheaper supplement. The missing factor is the specific gut microbiome which is going to vary individually.
So the walk endpoint was not statistically better: sounds like a failed trial to me. Plus this interviewee has got many monetary interests in pushing a narrative. Sounds like a sales person to me
The human species is completely reliant on mitochondrial health produced and passed on only by female mammals and yet look how women are subjugated all over the globe, we are such nihilistic beings. Oh and we’re destroying our only home. Have a great day everyone
You need to talk in modes of the immune system and % output of the muscular mitochondria open loop or various closed loop configs and output in bio-watts.
A very balanced diet, with fiber and complex fiber. Along with appropriate supplements. In addition to a regular multi vitamin, I find L-carnitine has helped me so significantly, I did further research about mitochondrial. And decided for an additional supplement. While eating, resting and activity, all in expected routine. That this additional supplement was enough, until, further improved research is done. That and along with, occasional alkaline water, for hydration benefit. Seasonally, I take further reasonable vitamin and mineral intake, with regular hormone and sleep aid. I find all these in balance. Have allowed me to continue to improve greatly, from burnout, and problems with chronic fatigue, specifically under strain and pressures. 🙂
Thankyou, this is very interesting. I wonder if this goes some way to explain why my friend was able to improve his time to run 100km by 1.5 hrs, without any extra training, when he changed his diet to whole food plant based.
Apparently, this only happens to a small percentage of the population butt I am back to normal now. If you get a brain boost from nad+ boosters mitopure may not be for you. it's vary addictive
Being diagnosed with something deadly as diabetes only God know how its feels when you suffering from such thanks gor your help #Drbante am good amd healthy indeed your herbs works
why can’t we just take probiotics with the right microbes that produce urolithin A? This is way more affordable than consuming supplements and effects aremore permanent.
David.....All Diseases being in the Gut As we well know... Have you seen my Autism page yet... I have sent my sons plan to Over 1000 families.. Your old Probiotics
The people who actually need this can’t afford it. Just more anti-aging for a bunch of rich people to support other rich people. No compassion for the people who got sick and lost everything. Shame.
*Dr's Perlmutter & Singh. - Since 1987 I've Hardly had the strength to speak,Think Or even get out of bed & Diaroea thru having a deadly mixture of 1) Chronic Fatigue Syndrome 2) M.E. & 3) Fibromyalgia!!... :( *They've made My life a LIVING HELL!!... :( * I Havn't had the inner/mental strength to fast Or Intermittent fast,Yet!!.. :( Yours Sincerely - alanccreaserathotmaildotcodotuk
YOUR ENEMIES....TO KIAH UNIVERSE CHILDREN FLESH AND DNA ...YOUR CONCERNS ARE HOW FAST CAN YOU DESTROY ME ...AND TAKE ADVANTAGE MY CHILDREN.... CONDEMNED SOUL..
Very informative, Mahalo. I'm almost 73 female, very active in weedwhacking, rock clearing by hand, and running a feline sanctuary. Had noted my strength-muscle had decline, which became worrisome. Since Nov 2021, I changed my diet and limited intake on calories, sugar and salt. Major positive noted difference in my health and strength recovering. Point is, the gut health is the key for overall better health.
Absolutely! Kim chen, saurercraut, pickled any vegetables. Now prebiotics in Apricots. We eat to feed our Gut Bacteria! (Some say)...amen.
I tried keto strictly for two years, lowered my carb intake to a minimum just vegetables, high fat, medium protein. No sugar or starches. Lost 35 pounds and 7 inches off my waist. No longer pre-diabetic, blood pressure back to normal, acid reflux gone in less then 2 weeks and never came back. My doctor labs are all normal now, everything improved dramatically. I am at the weight and waist I was in my 20s Diabetes runs on both sides of my family. Since in a couple of months I’ll be 70 I knew I had to do something or end up sick with body parts being cut off. Well it worked it’s been 4 years and I’m low carb now. I have bread and pasta occasionally and my body is handling it as a normal person. Always checking my blood sugar after having foods I know contain carbs. Still avoid sugar and starches and all processed foods like the plague. Cook 99% of my own meals, grow vegetables and mushrooms year round. I do not watch calories and eat as much as I want. Whatever fat intake I have is used by my body as fuel and burned off just doing everyday chores. I used to exercise a lot did me no good other then make my muscle hurt. I haven’t gained or lost a pound in 2 years. And I eat more cheese then Frenchman. Fat is fuel if your body remembers what to do with it……
@@kirstinstrand6292 fermented dairy is likely far better for actually surviving through the stomach
Wow! You are my hero!
@@kirstinstrand6292 Of curse, a natural one. Easy to prepare, good for health, delicious and adding exquise taste to proteins needed to keep the body în good shape.
Ah Nestlé. That amazing company that cares so for our health.
I was disappointed to hear that they partnered with Nestlé. Nestlé is a corporate bully with high priced lawyers who keep the little guy out of the market. It's disgusting really. Something this important should be more accessible.
I watched a Nestlé video on mitochondria and all they did was bash vitamins
Hearing Nestle associated with this video has nearly made me immediately click away. It's makes me think of a biohacking conference hosted by McDonald's or something.
I became pointedly interested in research about ATP and mitochondria function problems after taking statins for twenty years, all the while increasing the doses at the same time I felt I was aging rapidly and finding difficulty walking at any distance or speed. I felt lactic acid was building up far too readily, and clearance was debilitatingly slow. I'm 76, so expected problems aging, but this degree of debilitation pointed to learning way back in college of Krebs cycle and mitochondria. I went on Pubmed, and in twenty minutes I found eight research papers describing all of these problems are frequently associated with statins in 5 to 20 % of those taking them, perhaps I was more severely affected than most, but none of my doctors ever suggested that this could be associated with drugs I was taking. Over the next two years, after going against advice and stopping the drugs, I improved every day. I now have 90% less pain levels, and can walk far more effectively again. All of this has piqued my attention for understanding metabolic problems and how there are many lifestyle changes available to improve bioenergetics. I'm all ears!
@Luke Schneider Yes, all of those, plus quercetin, Zn, liposomal C, D3 (up to 44 ng blood with 7000 IU/d winter and mid day sun in summer), low carbohydrate diet, fats, 95% OG diet, One meal/d restricted eating, organic farm work for exercise, daily hot tub jets to move large muscles around to circulate lymph well, very careful to avoid sources of lead, live in Oregon coast range so get onshore breezes reducing pollutants, I eat fatty meat, fish, veggies, avoid added sugar in anything but eat fruit, stopped drinking fruit juices though, Sleep far better but use CPAP, up to 7 hrs now from 4 to 5 while taking statins, forest bathe a lot for NIR gain, get massages, etc. I do drink morning coffee, which gets my mind zipping.. and have lots of mental projects... so far so good... far better than twenty years ago!
@Luke Schneider Thanks Luke, damned near killed myself fifteen years ago by listening to my partner saying I definitely need to drink more water. I thought, okay, yes I can see that, so in addition to taking the damned statins, I thought I'd be smart and combine more water intake plus getting it with all the good minerals and vitamins from fruit at the same time by only drinking huge amounts of juice instead. Bad mistake. All that sugar was devastating! Live and learn, hopefully faster next time. Take care!
Statins are well known to cause liver and muscle damages.
Hi there I’m 77 years old and have never taken statins but do take NMN and I feel young. Plenty of energy. Consider trying it.
I took a high dose rosuvastatin for only 3 months. Six months later, I still have not recovered my stamina that I had before statins.
With pivotal, seminal videos like this top quality gift to us, this channel has become one of my top favorites. Beyond cutting edge is the tip of the spear.
Hello maybe we should wait before taking it. Nicotinamide Riboside was also so much advised when it was launched for better mitochondrial fonction. And now, after years of people using it, studies are finding that as it improves mitochondrial fonction, it also improves cancer fonction and turns it to metastatic cancer... so, we should be careful with new molecules and wait.
So much information so quickly my aging brain can scarcely keep up. Thank you David for this guest.
Fantastic interview, as always, Dr Perlmutter. I appreciate your podcast!
Thanks for watching!
$200 a bottle? I’m sure it’s worth every penny but unaffordable for most. I settled for organic powdered pomegranate I can add to my 8 Greens and beet powder drink. Delicious, affordable and effective.
Why pomegranate?
Big salad of organic leafy greens before lunch ,probiotics ,kafer, kimache or any other natural probiotic , and digestive enzymes for older people is very good.
@@jeanninecathcart627Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints - PMC
I have had relatives who were as sharp as 40 yr old at 90. Where I come from, Pomegranate is called heavenly fruit 😋
@@jeanninecathcart627 Apparently 40% of individual house gut bacteria capable of converting unspecified ingredient in pomegranate to urolithin-A, a substance claimed to promote Mitophage. Mitophage is a process where defective mitochondria are recycled.
May I recommend studying up on Oxalates?
Informative but I think more emphasis needs to b on how we get the precursor to this in our gut. What to do and eat
I have been using Mitopure for a month now and I can clearly confirm a rise in my energy levels. Also when I do my strength training in the gym I notice increased power and shorter recovery times afterwards. i combine my Mitopure with 100% pure Pomegranate juice and I feel better than I did ever before. It really works.
What a fantastic interview! There is so much good, useful, helpful information here. Stunning! Thank you.
Valuable, scientific and fascinating discussion between two highly qualified doctors covering various aspects of mitochondrial health & function and it's importance for whole of human health.
Berberine blunts mTOR as does Metformin. Berberine has several additional benefits than Metformin. Especially in the gut microbiome.
I am wondering if any mitopure users have reported better visual acuity. Since the rods and cones of the retina have more mitochondria than any other tissue it would make sense that improved vision would a way of measuring the effect
Maybe we need to know what kind of bacteria that metabolize pomegranate into urolithin A, so we could also take this kind of probiotic supplements to enrich our gut microbiome...
Pomegranate ellagitannins stimulate the growth of Akkermansia muciniphila in vivo.
I appreciate the detail of this discussion and the free dissemination of information to the public. Thank you both. Two questions: 1 - Is there a test for ability to process pomegranate polyphenols into Urolithin A?, 2 - Are the specific gut microbiome activators(?) for Urolithin A found in common probiotic supplements/kefir/yogurt or in specific fermented food products? My point is that we should strive to keep simple foods as our medicine and limit the number of expensive and highly processed pill foods where possible.
Such a great job done by Dr. Perlmutter over so many years! Thanks for the interesting, helpful content .
Supplements are costly and most people are not rich to buy such expensive products.
Very effective ways of enhancing the mitochondria are 1) PQQ the most effective one for mitochondrial biogenesis (the built up of new mitochondria), 2) Methylene Blue, 3) Taurine, L-Carnitine and even Creatine. All of them are less costly than Urolithin and in a good combination not less effective
I missed it. What is PPQ
@@donnazukadley7300 sorry my mistake or rather typo
It’s PQQ you’ll find plenty of information on the internet. The important thing here is, that PQQ is the only (!) supplement that leads to the growth of NEW mitochondria
Here a short copy of the Wikipedia article, which however is not the best source
„Pyrroloquinoline quinone (PQQ), also called methoxatin, is a redox cofactor and antioxidant.
Quinoprotein glucose dehydrogenase is used as a glucose sensor in bacteria. PQQ stimulates growth in bacteria.
History
It was discovered by J. G. Hauge as the third redox cofactor after nicotinamide and flavin in bacteria (although he hypothesised that it was naphthoquinone). Anthony and Zatman also found the unknown redox cofactor in alcohol dehydrogenase. In 1979, Salisbury and colleagues as well as Duine and colleagues ….“
@@donnazukadley7300 Sorry my mistake or rather typo it should have said PQQ
PQQ is the only supplement that will lead to biogenesis of NEW mitochondria.
You’ll find tons of information about PQQ on the internet
@@donnazukadley7300 my mistake or typo. It’s PQQ! You’ll find a ton of information if you google it
Most important nutrient vor mitochondria js NIR ,near infrared from sunlight especially morning and evening when the uv index is below 3
I believe I have statin-induced mitochondrial disfunction. Thank you for this information!
Dr. Perlmutter is the only physician / researcher / scientist in videos who properly pronounces apoptosis! Sounds dumb, but having worked in a mitochondrial lab, I feel just slightly uplifited. [e.g., right before and after minute 13:30].
BTY, nothing is more astounding than methylene blue. In many cases, including pain + use prior to a hard workout, cause and effect are astonishing. No downside in the range of .5 to 2mg / kilogram of body weight.
Dr. Perlmutter ought to interview Dr. Francisco Gonzalez-Lima, PhD at the University of Texas, Austin. He's the top guy on methlyene blue. A brilliant guy like out good doctor here.
What other benefits we get from using methylene blue ? Is it also good for hypothyroidism or adrenal fatigue?!
Greatly appreciated 🙏
@@moniryousefian8782 IF the thyroid hormones [T4, T3, T2, T1] are in good balance, and if idodine in the diet is sufficient, then yes, methylene blue will be of help to ALL tissues not functioning at their optimal level. Only mature red blood cells lack mitochondria.
Hence, any condition or disease caused by insufficient energy production [ATP] in any gland, in any organ, or in any cellular organelle will benefit from methylene blue. MB corrects defects in the electron transport chain so that ATP production is normalized.
However, if steriod hormones are too low, or even too high, nothing will help until you find the right doctor who can solve this problem with bioidentical hormones, or by using some other effective therapy.
For me, methylene blue has been amazing for use before an intense workout in the gym. It also eliminated all my chronic pain I had for 6+ years.
I am curious to know the difference between a few mitochondrial support supplements if you are familiar with them. If you have worked in a mitochondrial lab, perhaps you would know? Two months ago, I was adversely affected by the popular fluoroquinolone antibiotic, Ciprofloxacin. If you're not familiar with it, you might Google Cipro Toxicity or FQ Toxicity or even Levaquin Tendonitis. There is a good video on Levaquin Tendonitis, which explains how mitochondria and even DNA are damaged by the fluoroquinolone class of antibiotics. People who have acute reactions to this can be adversely affected for life. I am hopeful this doesn't happen to me.
Anyway, I was initially taking CoQ10 with PQQ, then when it ran out, I switched to MitoQ. And now I am very interested in Urolithin A but I have no idea if these supplements all do essentially the same thing or if I should combine any of them for greater results.
Please our Indian pharmaceutical companies should also try to produce these medicines..
There should have been more opportunities and in depth questions for the person being interviewed, rather than making a disproportionate time showing the knowledge of the interviwer.
Agreed-Are you referring to the mind-boggling 190 seconds it took Perlm to ask his question from 11:41 to 14:55?
Interviewers need to have pointed questions pre-written to lead the guest to new topics. It’s not supposed to be a conversation evenly split between the two.
Plus giving a solution to d listener for a change. Just a long winded Theory recital is of No help to us. Who has d time for it?
Very interesting. Thank you Dr. Perlmutter. Love your channel. Much appreciated.
Glad to know you're enjoying this content, thanks for tuning in!
Very cool (and soundly sophisticated) conversation.
Thank you for sharing,
have a wonderful day, Sir.
Good news for those who can absorb it.
Nestle' makes a lot of artificial color and flavored sugar filled foods and drinks. Do they really care about good health? JR
The cited study found a posiitive effect of metformin on the enrichment of gut bacteria.
Are any studies in Mitochondrial support point to "blue methylene"?
Go Huskies!! Great discussion, thank you!!
RN here, best practice to increase gut microbiome is raw milk,(unpasteurized, unhomoginized), loaded with enzymes that feed your microbiome. Make your own kefir & yogurt.
Is there a test to diagnose mitochondrial dysfunction?
This topic was so insightful. Thank you 🙏
Thanks for watching!
Recap,excercises,calories restrictions are effective in increasing mitochondria.
Valuable information. Where can i get the supplement?
Thank you, Dr. P., for pronouncing apoptosis correctly!
I’m a 63yr old woman, open water swimmer, so pretty active. I’m trying Emface rejuvenation treatment on the muscles in my face and wonder if my athleticism will help enhance the treatment. Meaning, have I been keeping my mitochondria healthy and will it translate to the muscles targeted in this (expensive) treatment? Thanks!
Fantastic field of research and findings. Thanks a lot for this very informative interview and remarkable transfer of knowledge!
Amazing ! Thank you both! ❤
Thx much sharing doctors
Thanks for watching!
I take Mitopure (Timeline brand). I am 56, male. I can't say too much about it at the moment because I exercise already and have been in shape for quite a while, but I can say one thing about it: it is costly and so it is pretty useless for most people because they can't afford it or can, but don't want to pay for it. The cost has to come down or this is a useless supplement.
If it is of no use then why use it?
very exciting indeed but urulithin A is a very expensive product for pensioners....at least in Australia.
What specific species of gut bacteria within the microbiome converts nutrients into Urolithin A?
Clostridiales and Ruminococcaceae
Thanks sir for bringing these new research
I was blessed with the greatest gene of all. I cant taste most bitterness. Thus i eat massive kale salads because i didnt know they were bitter and just used it as lettuce 😂. I drink dark roast black coffee, the darker the better because i only taste the coffee flavor 😂. I eat 92-96% pure dark chocolate because i just taste the creamy and chocolate with zero bitter. I eat broccoli like no tommorow because i like the crunchyness. Thst simple gene gave me the keys to longevity
Whoo watch out for all those oxelates!!
How about getting pomegranates, berries,nuts, mushroom (or buy ellagic acid, purify it when necessary), and have the proper bacteria in your gut?
This one STUNNED me: 20:45 😮.
Better pay $900 per year 😁
Juice? I’ve heard over & over not to drink juice. I’m confused
If you drink juice it has to be organic with NO sugar. Dr William Li on YT speaks of this
@@patriciagriffin1505 fruits inherently have sugar.
The juices realistically have benefits, esp if you're juicing them yourself as store juice is pasteurized. However, their benefits are basically universally outweighed by the effects of the sugar content and resulting insulin spike.
When you're doing what he's doing and just testing if ingesting the juice gives a specific result, fine. For overall health....skip it.
You’re right about juice of any kind. But you need to understand this guy is “selling”. I’m disappointed Dr Perlmutter is pushing this!
I don’t feel I am being sold anything other than optimal health - as for juice - excess sugar and additives - not healthy
Make your own juice - no additives and drink with the fruit fiber and/or add fiber to juice. You want to blunt the glucose load while still gain health from juice.
PLEASE do a study on Fibromyalgia! 💕💕💕
@@kath, please look into high dose thiamine (Vit B1), if you haven’t already! ❤
@@PeaceIsYeshua I certainly will! My neurologist just ordered a test for me!
@@kathb1683
Oh yay!! Please know though that low thiamine can show as normal on tests. There’s a lot of info here on YT! I hope it helps you! 😊 I like Allithiamine, as it’s a natural source, crosses the blood brain barrier, and 500mg is considered high dose.
Has urolithin A been used for post covid syndrome? Any information would be so appreciated.
I've been studying neurology intensively for the past 2 years because I've acquired covid induced Parkinson's, I know that mitochondria dysfunction is the latest discovery in neurological problems, mitochondria produce cell energy ATP but as a byproduct it produces damaging oxidative molecules which is the primary cause of Alzheimer's and Parkinson's...Urolithin A promotes mitochondria 8:18 recycling which eliminates bad ones and replacement with new.. I've also discovered that viral induced Parkinson's is curable because it's cause is also vagus nerve problems which the latent virus hides in the nerve
Vax injured nurse here searching for mitochondria help for my ridiculous exhaustion and muscle weakness after a day of work
Especially in human body h who, control the sharing of ATP in each organs in deferent quantity?
Can you provide a link to the published study discussed here.
Where's a link in your notes to read about the supplements you said are available in US for urolithin a?!!!
Amazon has celltrient (you can search Urothelin)
We're all about revitalizing your mitochondria! If you want to buy it from the scientists who made the discovery, we invite you to try our trio sample pack so you can experience Mitopure (Urolithin A) in different formats and see what works best for you. The $10 cost is reimbursed when you upgrade. www.timelinenutrition.com/shop/mitopure-sample-pack
Excellent interview!
Such an interesting topic. So to further the question about food sources for UrolithinA, is the idea that we have to first work on our microbiome diversity with an diverse plant based diet and then we can shift from a non producer to a producer ? Was that the point Dr Singh was making ?
what is so great about pomegranate
Wow, this reduces & will simplifies my life fir the better :)
It's great to hear from researchers. However, some of these researchers are involved in the development of supplements which they sell at astronomic prices. This leaves one to wonder whether their research is credible or not. Dr Singh is involved with MITOPURE UA supplement which sells at 5 bucks a day. Isn't it a clear conflict of interest and kind of unethical? to first create the need through these vlogs and then give a commercial solution for profiteering.
Heteroplasmy rates go up with age ( see work of Dr Douglas Wallace at CHOP ), additionally increasing one's redox rate, simply fasting 4-6 days will up regulate both mitophagy and mitobiogenesis, stacking them by staying in ketosis will do many other positive things, without chewing up muscle mass or protein thru gluconeogenesis.
Excellent, informative comment. Thanks for the contribution. I spent time in Doug Wallace's Lab at UCI. What a fantastic mentor he was.
The dr said ,exercise,and calorie restrictions,I think he made mistakes,he should say ..carbohydrates restrictions…not calories.We need good fat,but not sugar or carbohydrates,no no
Very informative but need to have written words spelled out so that I can do further research. Thank you.
You should be able to turn on close captioning with UA-cam
It’s in the program notes. If you tap the little down arrow under the video (right corner), you can see the notes. Click “more” to expand it.
@@DavidPerlmutterMDthe CC sometimes spells words off the wall crazy! 😅
What is recommended for those with brain damage.
Look into red light caps that you wear with red and NIR LEDs at 655 and 850nm. NIR penetrates skull to a depth of about 5cm, and has been shown to stimulate brain function and help with symptoms related to neurological disorders.
Scientist know v little about the Brain & Gut. It's all guess work
I wonder if there’s a connection between this & central sleep apnea. I’m not that overweight but suffer from it. Everytime I start to dose off I stop breathing. This happens throughout the night too. I’m constantly waking up. It’s a nightmare…
I have that too and only weigh 95 lbs!
coconut oil should help your problem according to my long hours of constant research ,,your welcome
@@holyhellal How?
Can I just put out something that happened to me? I got it from breast implants. Those nasty things cause all kinds of autoimmune and neurological disorders! If you have them, get them out! I almost died and lost several organs because the toxins go haywire in your body.
@@Tinyteacher1111 coconut oil is anti viral,anti fungal ,and anti microbial ,,take 1 tablespoon in the morning and one before bedtime ,,it will get into blood stream and help ,,it is also an antioxident ,so will neutralize free radicals and slow aging
Is it possible to increase mito function without expensive supplements? I'm a senior 😢
He already mentioned it in the interview - (1) Strength & Aerobic exercise (2) Caloric restriction/ Intermittent Fasting. For the specific natural alternative to the product mentioned , I would try Apple/Berries ( Pre-biotic) + Kefir/Yogurt (Probiotic) with some Pomegranate powder which is a relatively cheaper supplement. The missing factor is the specific gut microbiome which is going to vary individually.
@@petermathews1515 I started eating Natto, a superfood...vile tasting!
@@robynhope219Nattokinase capsules are expensive!
selling something..
I would like to know if taking Mitopure blunts hormesis. You say that U-A is an anti-inflammatory is why I'm asking.
Presumably cutting down on fructose means reducing my intake of berries and other fresh fruit??
Ad for a supplement
So the walk endpoint was not statistically better: sounds like a failed trial to me. Plus this interviewee has got many monetary interests in pushing a narrative. Sounds like a sales person to me
The human species is completely reliant on mitochondrial health produced and passed on only by female mammals and yet look how women are subjugated all over the globe, we are such nihilistic beings. Oh and we’re destroying our only home. Have a great day everyone
You need to talk in modes of the immune system and % output of the muscular mitochondria open loop or various closed loop configs and output in bio-watts.
A very balanced diet, with fiber and complex fiber.
Along with appropriate supplements. In addition to a regular multi vitamin, I find L-carnitine has helped me so significantly, I did further research about mitochondrial. And decided for an additional supplement. While eating, resting and activity, all in expected routine. That this additional supplement was enough, until, further improved research is done.
That and along with, occasional alkaline water, for hydration benefit.
Seasonally, I take further reasonable vitamin and mineral intake, with regular hormone and sleep aid.
I find all these in balance. Have allowed me to continue to improve greatly, from burnout, and problems with chronic fatigue, specifically under strain and pressures. 🙂
You are wrong
Carnivore diet, no supplements.
Thank you
May I ask which brand of vitamin and minerals do you take and also which brand of L - carnitine ?!
Appreciate it 🙏
@@bzynkapatrycja
Could you please share what exactly do you eat daily in carnivore diet ?
What kind of meat any vegetable?
@@moniryousefian8782 just meat. Mainly ruminant animals.
Maybe eggs
Role of neuroleptic drugs on mitochondrial function?
What if you have a mitochondrial syndrome like MELAS?
Thankyou, this is very interesting. I wonder if this goes some way to explain why my friend was able to improve his time to run 100km by 1.5 hrs, without any extra training, when he changed his diet to whole food plant based.
I took mitopure for 6 days. And it made me lose sleep my body is hooked on it this is torture.
Apparently, this only happens to a small percentage of the population butt I am back to normal now. If you get a brain boost from nad+ boosters mitopure may not be for you. it's vary addictive
Mini stroke december baby aspirin crestor.05, but now i get very quickly tired ...when climing stairs and burning sensation in legs? 59years old .
Read about berberine, intermittent fasting and keto.
Check out B1 UA-cam videos on neuropathy
Where can we get his product
Being diagnosed with something deadly as diabetes only God know how its feels when you suffering from such thanks gor your help #Drbante am good amd healthy indeed your herbs works
Follow Dr. Vishroop if you suffer dibetct
What is mytopagia?
why can’t we just take probiotics with the right microbes that produce urolithin A? This is way more affordable than consuming supplements and effects aremore permanent.
David.....All Diseases being in the Gut
As we well know...
Have you seen my Autism page yet...
I have sent my sons plan to
Over 1000 families..
Your old Probiotics
Can you please share me your page.. I need help for my son
May I ask what kind of probiotics helped your son , is it helping for other gut issues like leaky gut too ?!
Appreciate your help 🙏
@@ksdseq3104 waiting for reply
(F.M.T.) fecal microbiome transplant researchers are working on a fix for autism now. Another buzz word (M.T.T.) microbiome transfer therapy.
@@moniryousefian8782
Garden of Life
Primal Defense
Banana powder mixed I
Ice cream
Yoghurt
Or custard
Dr. Perlmutter, are you a whole foods plant based food consumer?
I eat a plant-forward diet
@@DavidPerlmutterMD I think that means you eat plants as the biggest part of your diet. Ok, very good 😋
@@thinkinoutloud.1 Correct!
@@DavidPerlmutterMD I’m going to look that up.
Methylene blue
Comment for algorithm
What about those who tell us how DANGEROUS nuts are ? 😯
The people who actually need this can’t afford it. Just more anti-aging for a bunch of rich people to support other rich people. No compassion for the people who got sick and lost everything. Shame.
You’re selling the supplements is a conflict of interest.
🏝
🥰💘
Shared xxxxxxx n
Dump ALL incumbents.
lmao nice ad. this is ridiculous at this point.
India needs officers like you and you fled to Switzerland. Very sad 😡
Yeah, but can he cook?😅
Bloody gaddar
*Dr's Perlmutter & Singh. - Since 1987 I've Hardly had the strength to speak,Think Or even get out of bed & Diaroea thru having a deadly mixture of 1) Chronic Fatigue Syndrome 2) M.E. & 3) Fibromyalgia!!... :( *They've made My life a LIVING HELL!!... :( * I Havn't had the inner/mental strength to fast Or Intermittent fast,Yet!!.. :(
Yours Sincerely - alanccreaserathotmaildotcodotuk
YOUR ENEMIES....TO KIAH UNIVERSE CHILDREN FLESH AND DNA ...YOUR CONCERNS ARE HOW FAST CAN YOU DESTROY ME ...AND TAKE ADVANTAGE MY CHILDREN.... CONDEMNED SOUL..