The race to sequence the human genome - Tien Nguyen
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- Опубліковано 11 жов 2015
- View full lesson: ed.ted.com/lessons/the-race-to...
This video was created with support from the U.S. Office of Research Integrity: ori.hhs.gov.
In 1990, The Human Genome Project proposed to sequence the entire human genome over 15 years with $3 billion of public funds. Then, seven years before its scheduled completion, a private company called Celera announced that they could accomplish the same goal in just three years at a fraction of the cost. Tien Nguyen details the history of this race to sequence the human genome.
Lesson by Tien Nguyen, animation by Boico Visual House.
i still have no bloody clue what any of it means but thank you, great video
Yeah, why was it so?!
Felt
No same
😂
Understandable … have a great day
Although this was about the human genome, it focused more on how competition and collaboration can bring us forward in learning more.
Philip Cheung right it didn’t talk about the human genome project they did against native Americans
@@CAraujo091 Eh?
Shut up
J C L no u kid
Few others facts that should get mentioned with this. Not only did Celera work off of publicly available HGP to complete their sequence but C. Venter (who started that project) later admitted he swapped out all the other human DNA samples half way through the sequencing for his own, thus reducing the value of that sequence in mapping variations in the human genome due to diseases etc. He also attempted to then sell genetic information, an effort that he later abandoned as HGP was after all, public. If you were a researcher, HGPs sequences were not only available online, but you could order samples of bacteria carrying the pieces of the entire library, a process that was (and is today) is essential in many of the genomic experiments looking to isolate a specific gene or sequence for whatever reason. He undoubtedly accelerated the pace of HGPs research and props had to be given to him for that, and even later selling of the info can be seen as an effort to recoup some costs to the private company that funded the project, but alone, his effort would have been infinitely slower, less accurate, and far less stimulating to worldwide academic research and many wondered why he hadn't simply pitched in and helped the existing effort of the HGP rather than striking it out alone. Still, a very good short on DNA sequencing race. I remember this being hotly debated when I was in grad school.
We JUST sequenced 100% of the human genome (2022). I wonder who won the race.
Klaus Schwab and men behind the curtain.
I love the symbolism of the converging roads at the very end; representing our chromosomes ❤
Surprisingly the small animation in this video helped me clear my doubts about clone contig method used by the public funded hgp team!
This is like poetry to me, beautiful. I hope i get to live the day where we can take full advantage of our bodies.
be careful what you wish for
(issa joke but still.
anyways, did this comment spark some old memories?)
Nice Enzyme hats on the chefs cos they're chopping up proteins xD
Great video. Keep doing more. You are doing a great thing making information available to everyone in small cohesive fun forms. Bye
Bouta begin my studies in genetics and genomics next year! Cheers to the next generation!
It's such a generous approach to make an international collaboration with an open sharing of technology, so typical of the idealism of the 1990's. This was followed by the far more competitive wave starting near 1998, where it became more like everyone out for themselves, and whatever you can do I can do better type of attitudes which alienates people into jealous, competitive factions. So interestingly, I was born in 1990, when the Human Genome Project began, and my little brother was born in 1998, when Celera began to challenge it, and in a funny sort of way, my relationship with my little brother's paralleled greatly the ambitious and underhanded ways Celera attempted to overtake the Human Genome Project but failed miserably. Selfish, vain-ambitions don't pay, people. Even if Celera won, and I'm glad it didn't, we all know they couldn't have done it without massive help, unthanked for and unacknowledged by Celera with their smug founder, that they got from the Human Genome Project. So open sharing, international collaboration: 1. Self-centered, risk taking private interests: 0. As it should be.
I am absolutely impressed and garteful for such short clips on free social media platforms! I am writing my first essay for university about the HGP and it has to focus on various topics like the competetive race among the HGC and Celera Genomics but also about the different possible procedures they used for sequencing. The only points that are missing are the discussions about the emerged ethical issues but there must be some comprehensive informations about these topics somewhere too :-))))
why is the ginger girl sad in the thumbnail? Is it because she has no soul?
spot on
+Confuzzled Tomato What's a "soul"? And how can I study one?
+Confuzzled Tomato For gingers the area of the genome, that code for the human soul is filled up with thousands of copies of the genes for freckles and red hair. :)
oooh get rekt
Confuzzled Tomato yes
This history of the race to sequence the human genome does not mention that Celera could initially sequence faster than the public initiative because of their collaboration with Applied Biosytems which had invented a sequencer that was 10X faster than existing sequencers being used by the public project. Eventually, public labs started purchasing the faster sequencers so the whole project was completed well ahead of the initial 15 yr public plan .
Celera was spun out of Applied Bio
I think this just goes to show the power of competition.
+Shawn Ravenfire the power of open collaboration I would say?
Private sector lost, patented every gene it could, didn't share findings. Public sector gave us space travel, nuclear power, the Internet and human genome. Private companies just exploit the discoveries. Collaboration and cooperation is the way forward. Competitions is a waste of resources.
***** But it was competition against the private sector that motivated the public sector.
+ethelthecat1 I agree that competition is a waste of resources.
the power of competition AND collaboration. For if celera didn't get the chance to "steal" data from HGP, they wouldn't have made much progress. They gave up after then president announced that the human DNA cant be patented.
5 years later it is completely sequenced now!
Is it just me or did the voice not match the lip flaps?
+TickedOff Priest I agree :)
+TickedOff Priest I agree :)
it's just me. hahaha got hin
+TickedOff Priest yup
+TickedOff Priest Ìt wasn't just you
We've finished reading the Novel but we still don't understand the story. It's a loooong road ahead.
Great achievement. More like it would be nice.
the non-sync lip sync is really anoying and the voice didnt match the character. but still a great vid! :)
My mom's name is Tien Nguyen so I had to read the title twice since I was confused for a second.
No one cares
@@Luk3_lp bruh
@@Luk3_lp So skip the comment
When?
Nice video Tien!!!
illuminating...
The video is pretty misleading. It paints a very rosy picture of the two projects. The reality was that the private company did not do it because they were nice or looking out for the good of humanity. They wanted to patent every possible gene they could to profit off future medical procedures. As they patented more and more genes, the public group had to go through a web of bureaucracy that cost valuable time and tax dollars. Private companies are out for profit. That is it. Putting profit before human decency and scientific integrity, they almost prevented the free access to the genome at all. The reason why the public sector published their findings so fast was to prevent further patents. It became a necessity as failing to do so would lock the information forever away. Sad that people are this way, but at least something good came out of it.
The public effort had no need for such patents and didn't have to jump through any hoops to publish their results. They just didn't want others to be restricted by Celera's patents. But, yes Celera wanted to patent their discoveries, but that profit motive got the science completed a lot earlier than the government effort. Without a profit motive, we'd be much farther behind in new medical discoveries than we are now which means many more lives would've been lost without it.
These vids help me fall asleep
look up asmr :p
The ball earth is everywhere hypnotizing your mind....
I just noticed: "narration by Mr. Anderson" xD
nice!
I want my genome sequenced...now!
When the sequence is fully decoded, one of two things will happen:
- A new prosperous era for humanity, or....
- Our demise
I'm fine with either one
What can you do with a sequence? Can it be changed to cure mutilation for eg?
Why exactly didn't the first project let the second project win? Just because of rivalism?
I'll get the human genome for making into anthromorphic animals with CRISPR & splicing & the equipment is the best to create anthromorphic animals.
Only James Bedu Graham can solve the most complex problems in mathematics history
The human genome has finally been completely sequenced after 20 years
Just red an article about it🤯
I really hate that I can't speed up the videos on this channel without the video skipping.
yeah, reform....or something. .........idk.
I would love to contribute.
Was this not about gnomes?
Why was US department of Energy interested in conducting this project? 🤔
because yes
❤
I know that humans share the vast majority of their genome with each other, but how did the scientists record the variable sections and label them as variable?
"I don't know litte foot, l don't know" ~that one Dino from Land before time ~
you can compare them with genome hybridization experiments. Or sequence them directly.
*sigh* i just want an army of clones to do my bidding
*Rubs Hands* One day.... One day *EVIL LAUGH*
+DoucheCarlos On Twiter Would you serve a clone of yours? If not, don't expect it the other way around without using force.
+DoucheCarlos On Twiter you do know that clones are alive just like you and then would probably beat you up if you tried to force them to do thing MUWHAHAHAHAHA no clones for you :P
Was 25 April declared a national day?
After this, can we sequence the genomes of all our foods? Then ,we could make Genetically modified and entirely artificial foods safer to eat.
Science can unite this falling-apart world.
how can u use the overlapping genes
by overlapping them . haha got him
Its pronounced "Win" apparently
CLOUD ATLAS!!! HERE WE COME!!
The race to sequence the human genome... on segways.
hey guys human DNA was finally sequenced
Why isn't it mentioned that Celera used data generated and published by HGP for free and then wanted to charge money for their own discoveries?
you can get your genome sequenced nowadays for around $1000 usd :) well, a bit more
+l2noob4ul That 1k is also the premium price that civvies pay. It realy only cost around 150 to do.
The chef's name is one of the acids that make up DNA
+Omega Magnum Nevermind
Tien Nguyen?Is he Vietnamese?
Yup probably so
+Hoa PTNK oh,so proud.
+Lan Thương like almost all Viets are named Ngyuen lol... Vietnam should use Han characters for writing
+अतिरुचिर I'm Vietnamese and I'm named Ha O_O
+Lee Han Min good thing he said "almost", and not "all"
tien from dragon ball stopped martial artists and became a scientist 😳
add some background music please it's so so quiet inbetween word's
I want pg in human genetics carrier in fields
i hope arabic subtitle plllllz
Since the year 2000 the human Genome project may give humankind the opportunity to discover Genetic diseases and find a cure for the sake of Humanity for the 2020s.
Who in here is because Bionano Genomics can be the future of genome mapping?
How can it be that all scientists don't understand dna? The human genome? I tell you the key. All in universe is energy frequency and vibration. .
Knowledge is power🌋
Did this.....just say 3.2 billion base pairs long...wait...
who else here from online biology lessons?
🙋
Wonderful, now I know I am whacked, now they need to find out why.
sup
One day you will be able to download genetic code of a famous porn star and using a bionic 3D printer, you will be able to print a living replica.
And kill her when you get bored?
But what if she kills you, creates a clone army of you and tries to conquer the world?
ขอบคุณมากครับ สำหรับการบรรยายไทย
ไม่เช่นนั้น ก็ไม่เข้าใจเลยครับ
Sorry Tien, I think it's a bunch of bs between HGP and CELERA. I am not a Dr. Shiva supporter, but I think he has made more sense than these folks combined. Dr. VA Shiva.
Under 3⃣0⃣1⃣
hey hey hey
+ieuan davies goo-oodbye
no won liks u weave.
I can only see the left corner of the video.
+Oliwier EB Did you try going in and out of fullscreen mode? If that doesn't work, try refreshing.
I tried...
That's weird.
It's the first time this happened that it doesn't fix itself - I'm on a Nexus 10 (Android)
+Oliwier EB That's a problem with the youtube app. It happens sometimes when I watch videos on my nexus 6 and then switch into landscape mode. Closing the video and then reopening it always works for me.
Aalcer
No te ntndi ni vg no se ingles
Race and genetics in one sentence?
no everyone can afford this type of "medical analysis", that's make me wonder why is it so important for government or relevant to private company's.
I am here because of Bio Psychology.
Who else watch hataraku saibou
I wantes to be 1st comment.. :(
Unless Ashesi shares its knowledge it cannot claim to help mankind to prosper and flourish.
I will never respect PhD Holders who dont respect most of the common people in Ghana.
Being a professor does not make one more superior to those of us who never went outside Ghana.
ok
So early
ai will help sequence the
Damn it so I'll never know what it's like to have evolved dna so I can become an xmen 😤😤😤
CYBERNETICS FOR EVERYONE!!!!
Its been 5 yrs, hope ur not any closer.. 👽
What....................................
Anyone else still wondering
Idgaf if you like this comment
i didnt understand shit what is a genome and how the fuck do these people do these things with their machines
ah, those fucking people and their fucking shit machines! fuck!
DNA willnone day be iswd tl help mankind in the 21st Century.
Walking dead
The thundering muscle radiographically flood because helmet universally stamp athwart a willing leaf. addicted, mushy epoch
This clearly proves that competition between firms is a positive for the overall outcome of the product (faster, cheaper and good quality). Capitalism and competition between individuals or groups, overall, leads to better evolution outcomes. Capitalism is Freedom
+pi314 Except when "patents"(when they don't deserve them) halt research and development entirely, or worse hinder it such as medical patents, which are borderline unethical.
+pi314 The video is pretty misleading. It paints a very rosy picture of the two projects. The reality was that the private company did not do it because they were nice or looking out for the good of humanity. They wanted to patent every possible gene they cool to profit off future medical procedures. As they patented more and more genes, the public group had to go through a web of bureaucracy that cost valuable time and tax dollars. Private companies are out for profit. That is it. Putting profit before human decency and scientific integrity, they almost prevented the free access to the genome at all. The reason by the public sector published their findings so fast was to prevent further patents. It became a necessity as failing to do so would lock the information forever away.
I rly like this channel, i rly do, but maan i hate that intro. Its just playing with my nerves, the sound is so annoying and mindbugging, PLS fix it !
Fortnite season 3 battle pass is lit
More DNA manipulation to achieve a preconceived conclusion 🤷♂️
Maybe clear your throat next time you record your voice
I don't like that voice :v
i hate biology